MICROPOROUS AND MESOPOROUS MATERIALS
·
2015
·
IF 3.453
Lijuan Feng,Jie Sha,Yao He,Shaopeng Chen,Bingxin Liu,Haixia Zhang,Changli Lü
A novel fluorescence resonance energy transfer (FRET)-based ratiometric nanosensor is reported for toxic Hg 2+ ions detection. Poly(p-phenylenevinylene) (PPV) chain was encapsulated into the pores of mesoporous silica nanoparticles (MSNs) by ion-exchange and in situ polymerization , and used as the energy-transfer donor. A spirolactam rhodamine-B derivative (SRhB), as an ion recognition element and energy-transfer acceptor, was embedded in the pores of MSNs to form PPV@MSN@SRhB as the nanosensor . The presence of Hg 2+ in the dispersion solution of nanoparticles can induce the ring-opening reaction of the SRhB moieties and lead to the occurrence of FRET process , affording the nanoparticle system a ratiometric sensor for Hg 2+ ions. The nanoparticle sensor can selectively detect Hg 2+ ions with a detection limit of 200 nM (ca. 40 ppb). It has been found that the fabricated FRET-based scaffold with the conjugated polymer as a donor exhibited high environmental stability and was more preferred for the accurate ratiometric sensing . Moreover, the FRET-based ratiometric nanosensor can be applicable in a relatively wide pH range (pH = 5–8) in solution.
研究领域:
分析化学
·
纳米生物技术
·
环境毒理学
·
分子传感
·
材料科学
✓ 已验证
DOI
高影响因子
PHYSIOLOGIA PLANTARUM
·
2024
·Vol. 176
·期 1
·e14194
·
IF 5.4
Kai Su,Jing Yuan,Ran Wang,Lanlan Huang,Jian Zhan,Xueqiong Zhang,Shanping Wan,Xinhua He,Hans Lambers,Fuqiang Yu,Yanliang Wang
Ectomycorrhizal (EM) fungi play important roles in nutrient cycling and plant community establishment in forest ecosystems. Effects of EM formation on global alterations of the transcriptome and metabolome during plant-fungal interaction and the key metabolites involved in EM development are largely unknown. Here, dual RNA-Seq and untargeted metabolomic analyses were used to reveal stage-specific and core responses of Pinus yunnanensis and Lactarius deliciosus during mycorrhizal colonization. We found that L. deliciosus colonization in P. yunnanensis roots induced different transcriptional changes across three interaction stages, with a small core of genes consistently regulated at all stages. Concentrations of retinol (vitamin A) and retinoic acid increased while that of B group vitamins decreased during EM formation, which was coordinately regulated by these two plant-fungus partners, with L. deliciosus possibly playing a dominant role. Exogenous retinol altered the diameter and mantle thickness of P. yunnanensis - L. deliciosus EM tips and affected host plant growth and phosphorus acquisition . In the absence of L. deliciosus, exogenous retinol increased the root diameter and the number of root tips of P. yunnanensis . Furthermore, the concentration of auxin increased, but that of abscisic acid decreased during EM formation, and the genes involved in plant hormone signal transduction were gradually activated, and auxin and cytokinin signal transduction potentially played a positive role in this EM symbiosis. In conclusion, we propose that the interaction of P. yunnanensis and L. deliciosus alters vitamin metabolism, which may further affect plant hormone biosynthesis and signal transduction, modulating root morphology and EM traits.
研究领域:
真菌学
·
植物科学
·
分子生物学
·
生态学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 46
·12566-12574
·
IF 5.976
Xiaohui Li,Lei Zhou,Miroslav D. Dramićanin,Qiang Tang,Xiping Jing,Jianxin Shi,Yiqin Xu,Mingmei Wu
Broad emission with a full and continuous color spectrum realized by crystal engineering is extensively desired to simulate natural sunlight and improve the white color quality. Herein, new insight into the modulation of B site order–disorder and intrinsic oxygen defects for complex perovskite (A3B′B2′′O9) Sr3−xScxZnNb2O9 (0 ≤ x ≤ 0.1) phosphors is demonstrated for broad-band emission via crystal engineering. We elucidate that the spectrum of Sr3ZnNb2O9 synthesized at an optimal temperature exhibits two emission bands under near-ultraviolet excitation (λex = 374 nm) which is readily available from near ultraviolet chips. The two broad emission bands can be ascribed to charge transfer from the empty 4d (t2g)-orbitals of Nb5+ ions to the filled 2p-orbitals of O2− ions and the intrinsic oxygen defects. Further, as a proposed strategy to optimize the luminescence property of Sr3ZnNb2O9 (SZN), we realized A-site nonequivalent doping to induce B-site disordering and cancel the luminescence quenching which results from B site ordering. The A-site nonequivalent doping efficiently offsets intrinsic oxygen defects, as validated by systematic analyses of experiments and DFT calculations. Consequently, the novel phosphor Sr3−xScxZnNb2O9 (x = 0.1) shows a high color rendering index (Ra = 82.2) and negligible color shift. In addition, its emission intensity is enhanced by ∼70 times as compared to the pristine Sr3ZnNb2O9.
研究领域:
材料科学
·
发光材料
·
固态化学
·
荧光粉
·
光学材料
✓ 已验证
DOI
高影响因子
NEUROSCIENCE
·
2024
·
IF 2.9
Xuejing Hou,Shanshan Xiao,Xiaohong Xu,Mingze Qin,Xuebing Cheng,Xiangping Xu
Epilepsy is a progressive neurodegenerative disease highlighted by recurrent seizures, neuroinflammation, and the loss of neurons. Microglial dysfunction is commonly found in epileptic foci and contributes to neuroinflammation in the initiation and progression of epilepsy. Glycoprotein non-metastatic melanoma protein B (GPNMB), a transmembrane glycoprotein, has been involved in the microglial activation and neuroinflammation response. The present study investigated the functional significance of GPNMB in epilepsy. A proven model of epilepsy was established by intraperitoneal injection of pilocarpine to male Sprague Dawley rats. Lentivirus vectors carrying GPNMB or GPNMB short hairpin RNA (shGPNMB) were injected into the hippocampus to induce overexpression or knockdown of GPNMB. GPNMB expression was significantly upregulated and overexpression of GPNMB in the hippocampus reduced seizure activity and neuronal loss after status epilepticus (SE). We here focused on the effects of GPNMB deficiency on neuronal injury and microglia polarization 28 days after SE. GPNMB knockdown accelerated neuronal damage in the hippocampus, evidenced by increased neuron loss and neuronal cell apoptosis. Following GPNMB knockdown, M1 polarization (iNOS) and secretion of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α were increased, and M2 polarization (Arg1) and secretion of anti-inflammatory cytokines IL-4, IL-10, and TGF-β were decreased. BV2 cells were used to further confirm the regulatory role of GPNMB in modulating phenotypic transformations and inflammatory cytokine expressions in microglia. In conclusion, these results indicated that GPNMB suppressed epilepsy through repression of hippocampal neuroinflammation, suggesting that GPNMB might be considered the potential neurotherapeutic target for epilepsy management and play a protective role against epilepsy by modulating the polarization of microglia.
研究领域:
神经科学
·
神经病学
·
免疫学
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2010
·Vol. 31
·期 21
·1886-1891
·
IF 4.263
Wei Xiong,Hanfu Wang,Yanchun Han
Novel dendritic triblock co-oligomer (14G2A3) consisting of ester dendrons and aniline oligomer was synthesized and found to self-assemble into fibrils in THF. Studies reveal that the formation of the fibrils originates from both of the amphiphilic interactions between the ester dendrons and oligoaniline, as well as the intermolecular π-π stacking among oligoanilines. The shape effect of dendrons on molecular packing was comparatively analyzed with packing parameter against its linear analogous compound. At the same time, the driving forces that dominate the final aggregating state of the block oligomer were separately investigated using the bulky-group protecting method, which allows release of the intermolecular π-π stacking of oligoaniline in a controlled manner. Results show that both the introduction of dendrons and the intermolecular π-π stacking will increase the packing parameter of the block oligomer and, consequently, cause the self-assembly morphology to evolve step by step from micelles to vesicles and finally to fibrils. The fibrils can form complexes with SWNTs to increase solubility in THF. The effective fluorescence quenching accompanied also opens a gate for the block co-oligomer to have potential applications in organic electronic devices.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2014
·Vol. 2015
·期 3
·631-637
·
IF 3.154
Laichun Luo,Lanlan Meng,Yangqiu Peng,Yongning Xing,Qi Sun,Zemei Ge,Runtao Li
Graphical A facile ZnCl 2 -promoted one-pot three-component synthesis of thiazolo[4,5- b ]pyridines and thieno[2,3- b :4,5- b′ ]dipyridines is described. This approach involves a tandem S N 2/Thorpe–Ziegler cyclization/Friedländer reaction to give fused pyridines in moderate to good yields. A ZnCl 2 -promoted one-pot synthesis of multisubstituted thiazolo[4,5- b ]pyridines and thieno[2,3- b :4,5- b′ ]dipyridines from mercaptonitrile salts, α-bromo ketones and ketones has been developed. This approach involves a tandem S N 2 alkylation/Thorpe–Ziegler cyclization/Friedländer reaction, which allows the creation of two hetero rings and four new bonds in a single operation. The reaction proceeds smoothly under solvent-free conditions to afford fused pyridines in moderate to good yields.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
PHYTOTHERAPY RESEARCH
·
2025
·
IF 6.3
Qian Hu,Mengyao Wang,Meng Chen,Jinjin Wang,Ting Niu
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous subtype of non-Hodgkin lymphoma, with two-thirds of patients relapsing or resisting existing therapies, highlighting the urgent need for effective treatments. Toosendanin (TSN), a triterpenoid from Meliae Cortex, exhibits significant anti-cancer activity by modulating cell survival and proliferation. This study investigates the anti-lymphoma effects and underlying mechanisms of TSN, proposing it as a potential therapeutic agent to address the challenges of DLBCL. Network pharmacology, molecular docking, and transcriptome sequencing were employed to predict TSN's anti-DLBCL potential. Findings were validated through in vitro and in vivo experiments, including cell viability assays, flow cytometry, quantitative PCR, Western blotting, reverse experiments with small-molecule inhibitors or genetic editing, and a cell-derived xenograft (CDX) model. Bioinformatics analyses revealed TSN's strong binding affinity to PI3Kα/β and Polo-like kinase 1 (PLK1). Experiments showed that TSN downregulated the PI3K/Akt signaling pathway and reduced PLK1 mRNA and protein levels, inducing apoptosis, cell cycle arrest, and cell death in DLBCL cells. RNA sequencing and metabolic assays indicated TSN upregulated cholesterol biosynthesis in DLBCL cells. Co-treatment with a statin enhanced TSN's anti-DLBCL effects while mitigating hepatic and pulmonary toxicity. This study identifies TSN as a dual inhibitor of PI3K and PLK1 with significant therapeutic potential for DLBCL. It also proposes a lipid-modulating strategy to enhance TSN's cytotoxicity while reducing adverse effects, offering a promising approach to improve DLBCL treatment outcomes.
研究领域:
肿瘤学
·
药理学
·
分子生物学
·
生物信息学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2023
·Vol. 16
·期 3
·1053
·
IF 3.4
Yanpei Dang,Tianhao Li,Yangzhong Zhao,Liantai Duan,Jianning Zhang,Ke Chen,Liu He,Qing Huang,Chuanzhuang Zhao,Yujie Song
Polyborosilazanes with controllable B/N ratio were synthesized using high-boron-contentm-carborane, dichloromethylsilane, and hexamethydisilazane. After high-temperature pyrolysis, Si–B–C–N quaternary ceramics with SiC and B4C as the main phases were obtained. The B/N ratio in the precursors corresponded to the change in the feeding ratio of carborane and dichloromethylsilane. The effects of boron content and B/N ratio on the ceramic precursors and microphase structure in Si–B–C–N quaternary ceramics were explored in detail through a series of analytical characterization methods. A high boron content results in a significant increase in the ceramic yield (up to 71 wt%) of polyborosilazanes, and at the same time, the B/N molar ratio was regulated from 28.4:1 to 1.62:1. The appearance of the B4C structure in the Si–B–C–N quaternary ceramics through the regulation of the B/N ratio, has rarely been reported.Keywords:polyborosilazane;SiBCN;carborane;polymer derived ceramics;B/N ratio;microphase evolution
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2019
·Vol. 34
·期 12
·2057-2066
·
IF 1.982
Mingjing Zhang,Xiaofang Zhang,Pengzhi Guo,Jie Lv,Xunchang Wang,Junfeng Tong,Yangjun Xia
Two wide band gap conjugated polymers, namely PBDT-TT25 and PBDT-TT36, derived from (4,8-bis(4,5-dioctyl-thiophen-2-yl)benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl)bis(trimethylstannane) with 2,5-dibromothieno[3,2-b]thiophene (TT25) or 3,6-dibromothieno[3,2-b]thiophene (TT36), have been synthesized by simply altering the linker positions of thieno[3,2-b]thiophene unit. The impact of linker positions on the energy levels, aggregation, active layer morphology, and optical and photovoltaic properties was evaluated systemically. We found that the absorption was greatly broadened, and the highest occupied molecular orbital (HOMO) energy level was elevated as the result of the significantly reduced twist angle on the polymer backbone when the linker positions changed from 3,6-isomer to 2,5-isomer. Therefore, the optimal inverted polymer solar cells exhibited a 1.87 times enhancement in power conversion efficiencies (PCE), which was mainly ascribed to the higher short circuit current densities (JSC) and fill factor (FF) of the devices mainly benefited from the widened, stronger absorption, higher hole mobility, and more ordered structure.
研究领域:
材料科学
·
光伏技术
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yongyang Zhu,Shaoyang Shen,Liuzhang Ouyang,Jiangwen Liu,Hui Wang,Zhenguo Huang,Min Zhu
Magnesium borohydride (Mg(BH 4 ) 2 ) is widely regarded as a promising hydrogen storage material due to its high capacity; however, it is still challenging to synthesize Mg(BH 4 ) 2 with low cost. Traditionally, Mg(BH 4 ) 2 has been mainly produced using other borohydride as the starting materials via exchange reactions. Herein, we report an economical method to synthesize Mg(BH 4 ) 2 by converting B-O bonds in widely available borates or boric acid to B-H. The borates or boric acid is ball-milled with MgH 2 under ambient conditions to form Mg(BH 4 ) 2 with high yield (>80%). Mg(BH 4 ) 2 was also successfully generated by reacting low-cost Mg with boric acid. Compared with previous approaches, this method avoids expensive boron sources such as LiBH 4 , NaBH 4 , and B 2 H 6 , and does not require high pressure H 2 gas and high temperatures, and therefore significantly reduces costs. This method could be an alternative to the current Mg(BH 4 ) 2 synthesis processes.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2019
·Vol. 38
·期 3
·298-310
·
IF 2.804
Feng Cong-Shu,Chen Yun,Shao Jun,Li Gao,Hou Hao-Qing
In this study, the poly(D-lactide)-block-poly(butylene succinate)-block-poly(D-lactide) (PDLA- b -PBS- b -PDLA) triblock copolymers with a fixed length of PBS and various lengths of PDLA are synthesized, and the crystallization behaviors of the PDLA and PBS blocks are investigated. Although both the crystallization behaviors of PBS and PDLA blocks depend on composition, they exhibit different variations. For the PDLA block, its crystallization behaviors are mainly influenced by temperature and block length. The crystallization signals of PDLA block appear in the B-D 2–2 specimen, and these signals get enhanced with PDLA block length. The crystallization rates tend to decrease with increasing PDLA block lendth during crystallizing at 90 and 100 °C. Crystallizing at higher temperature, the crystallization rates increase at first and then decrease with block length. The crystallization rates decrease as elevating the crystallization temperature. The melting temperatures of PDLA blocks increase with block lengths and crystallization temperatures. For the PBS block, its crystallization behaviors are mainly controlled by the nucleation and confinement from PDLA block. The crystallization and melting enthalpies as well as the crystallization and melting temperatures of PBS block reduce as a longer PDLA block has been copolymerized, while the crystallization rates of the PBS block exhibit unique component dependence, and the highest rate is observed in the B-D 2–2 specimen. The Avrami exponent of PBS crystallites is reduced as a longer PDLA block is incorporated or the sample is crystallized at higher temperature. This investigation provides a convenient route to tune the crystallization behavior of PBS and PLA.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Run Cai,Likun Wen,Yihua Cao,Yindan Wu,Yichen Song,Xinyu Wang,Hanyang Zhou,Yurui Zhang,Xiaoping Dai,Xin Zhang
The benzene-methanol alkylation offers a strategic route to valorize methanol surplus and meets the growing demand for high-purity aromatics. For industrially viable shaped catalysts, achieving a balance between sufficient acidity and optimal diffusion capacity remains critical. Traditional shaping methods using binders inadvertently compromise mass transfer efficiency within zeolite crystals while introducing strong acid sites that disrupt the tailored weak-acid properties. To overcome these limitations, we developed a dual-approach strategy employing 1) B-Mg-co- substitution in ZSM-5 frameworks to effectively suppress ethylbenzene generation while enhancing catalytic durability, and 2) recrystallization-driven structural engineering to create binder-free architectures featuring cheese-like macropore. Intelligent gravimetric analysis (IGA) and fluorescence probe diffusion mapping further reveals three-dimensionally interconnected micro-meso-macroporous networks that facilitate enhanced molecular transport for both small and bulky aromatic species. The optimized catalyst demonstrates remarkable stability during extended operation (1008 h) under 460 °C, 0.4 MPa and 2.5 h −1 , achieving 45–50 % benzene conversion (X B ) with toluene selectivity (S T ) ~50 %, C 8 selectivity (S C8 ) ~37 %, C 9+ selectivity (C 9+ ) ~ 14.0 %, and yield of EB in C 8 (Y EBinC8 ) <9 %. This work establishes a morphology-directed synthesis protocol for isomorphously substituted zeolites, offering a scale-up manufacturing route for acid site-engineered catalysts that combine hierarchical porosity with optimized Brønsted-Lewis acid synergy.
研究领域:
催化化学
·
材料科学
·
化学工程
·
石油化学加工
·
纳米多孔材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）