JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Fujie Yan,Yunyun Yang,Lushuang Yu,Xiaodong Zheng
Main components of Apios americana leaves extract (ALE) were flavonoid C-glycosides, including vitexin (46.7%), schaftoside (18.9%), and orientin (4.32%). In vitro, ALE restored glucose consumption, glucose uptake, and glycogen content in glucose-induced hepatic cells. Exposure of HepG2 cells to high glucose resulted in reactive oxygen species and O2– accumulation, while ALE alleviated these increases by 47 ± 0.68 and 68 ± 0.74%, respectively. Glucose increased c-Jun N-terminal kinase (JNK) and decreased extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 phosphorylation, while ALE reduced p-JNK and p-p38 but not p-ERK1/2, accompanied by nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1, and NAD(P)H quinine oxidoreductase 1 downregulation. In vivo, the lifespan of Caenorhabditis elegans was more violently shortened by paraquat under hyperglycemia, while ALE protected this damage in N2 worms (2.6 times extension) but not in daf-16 mutants. Furthermore, p38/PMK-1 and Nrf2/SKN-1 expressions in worms were suppressed by glucose, which were reversed by ALE treatment. These results suggest that ALE prevents glucose-induced damage via regulating specific mitogen-activated protein kinases and Nrf2 pathways.
研究领域:
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Raji Govindan,Xu-Jia Hong,Palanivel Sathishkumar,Yue-Peng Cai,Feng Long Gu
Metal-organic framework (MOF)-derived hybrids are promising electrode materials in electrochemical energy storage , owing to their high surface area that offers enormous redox sites and excellent conductivity. In this work, MOF-derived cerium oxide/carbon integrated with molybdenum disulfide (CeO 2 /C/MoS 2 ) hybrid is developed as an electrode material for supercapacitor . Remarkably, integration of CeO 2 /C with small amount of MoS 2 has considerably enhanced the electrochemical performance. Moreover, CeO 2 /C/MoS 2 hybrid exhibited both surface and diffusion-controlled mechanism towards charge storage. The CeO 2 /C/MoS 2 hybrid showed an outstanding specific capacitance (specific capacity) of 1325.67 F g −1 (397.70 C g −1 ) and excellent cyclic stability with capacitance retention of 92.8% after 1000 charging-discharging cycles, which is significantly higher than that of CeO 2 /C (727.49 F g −1 ) or else that of MoS 2 (300.33 F g −1 ) at 1 A g −1 . In addition, asymmetric supercapacitor (ASC) fabricated with CeO 2 /C/MoS 2 hybrid and activated carbon (AC) showed remarkable electrochemical performance with high specific capacitance (110.55 F g −1 ), excellent cyclic stability (even after 1000 cycles) and high energy density of 34.55 Wh kg −1 at a power density of 666.7 W kg −1 . Thus, MOF derived CeO 2 /C integrated MoS 2 hybrid is a potential electrode material for the ASCs.
研究领域:
材料科学
·
电化学能源存储
✓ 已验证
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Jie Liu,Lin Yang,Wenju Jiang,Zhongde Dai,Lu Yao,Junfeng Zheng,Xingjian Wang
In this study, the Cu/C@Zeolite catalysts with carbon-zeolite bifunctional support was developed by using the zeolite-induced one-pot homogeneous synthesis of CuBTC composite (CuBTC@Zeolite). Three different zeolites (ZSM-5, 13X, NaY) and the activation conditions were discussed. Originating from the defective structure of CuBTC in the composite and its interactivity with the zeolite, compared to Cu/C, the Cu/C@zeolite catalysts had the hierarchical pore system, a higher content of oxygen vacancies, stronger redox properties, and more active Cu sites with smaller particle sizes and more Cu + /Cu 2+ coexisting valence states, in synergy with acid sites, all of these contributing to the improved catalytic activity for VOCs oxidation removal. The activity of toluene catalytic oxidation indicated by T 90 was in the order of Cu/C@NaY (268.5 °C) > Cu/C@ZSM-5 (280.0 °C) > Cu/C@13X (287.0 °C) > Cu/C (320.0 °C). They also performed a better activity for acetone and ethyl acetate oxidation, obtaining the lowest T 90 at 217.0 and 231.5 °C respectively when the Cu/C@NaY used. Moreover, the Cu/C@NaY and Cu/C@ZSM-5 performed good water resistance and stability, suggesting the potential in practical application scenarios. These findings underscored the potential of Cu/C@Zeolite catalysts for addressing complex VOCs in simultaneous catalytic oxidation.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Rui Liu,Yunpei Cui,Na Chai,Lei Yang,Xiufeng Zhang,Qianqian Nie,Hesheng Yu
This study developed an amorphous MoO 2 –C hollow spherical cocatalyst (MOC) derived from Mo-polydopamine, and hybridized it with ZnIn 2 S 4 to form ZnIn 2 S 4 /MoO 2 –C (ZMC) composites. Various characterizations were conducted to analyze the crystal structure, morphology, and photoelectrical properties of the ZMC composites. The prepared ZMC composites were evaluated for photocatalytic hydrogen evolution under simulated sunlight. Furthermore, nanorod-like MoO 2 –C cocatalyst (A-MOC) and ZnIn 2 S 4 /A-MOC (A-ZMC) composites were prepared to investigate the impact of carbon source on catalytic activity. Results show that the addition of MOC cocatalyst significantly enhances the hydrogen evolution rate of ZnIn 2 S 4 from 0.54 to 20.61 mmol g −1 h −1 , and increases the apparent quantum efficiency at 420 nm from 1.66 % to 8.63 %. The hydrogen evolution rate of the optimal ZMC is 1.26 times that of the optimal A-ZMC (16.28 mmol g −1 h −1 ). The crystal structure and morphology of MoO 2 –C determined by carbon source affect the photocatalytic hydrogen evolution performance of ZnIn 2 S 4 . Insight mechanism analysis indicates that the formation of a Schottky junction facilitates the separation of photogenerated electron-hole pairs, thereby enhancing the photocatalytic hydrogen evolution activity. Finally, the ZMC composite catalyst retains 89 % of its original hydrogen evolution performance after 5 cycles over 15 h, demonstrating good stability and promising prospects for real-world applications.
研究领域:
材料科学
·
催化
·
纳米技术
·
能量转换
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2024
·Vol. 18
·期 10
·1-10
·
IF 4.3
Jia Hongwei,Yue Xiaoyang,Hou Yuying,Huang Fei,Cao Cuiyao,Jia Feifei,Liu Guanhua,Zheng Xiaobing,Liu Yunting,Jiang Yanjun
Unspecific peroxygenases exhibit high activity for the selective oxyfunctionalization of inert C(sp 3 )-H bonds using only H 2 O 2 as a clean oxidant, while also exhibiting sensitivity to H 2 O 2 concentration. CdS-based semiconductors are promising for the photosynthesis of H 2 O 2 owing to their adequately negative potential for oxygen reduction reaction via a proton-coupled electron transfer process, however, they suffer from fast H 2 O 2 decomposition on the surface of pristine CdS. Therefore, [Cp*Rh(bpy)H 2 O] 2+ , a highly selective proton-coupled electron transfer catalyst, was anchored onto a supramolecular polymer-grafted CdS nanoflower to construct an efficient integrated photocatalyst for generating H 2 O 2 , mitigating the surface issue of pristine CdS, increasing light absorption, accelerating photonic carrier separation, and enhancing oxygen reduction reaction selectivity to H 2 O 2 . This photocatalyst promoted the light driven H 2 O 2 generation rate up to 1345 µmol·L −1 ·g −1 ·h −1 , which was 2.4 times that of pristine CdS. The constructed heterojunction photocatalyst could supply H 2 O 2 in situ for nonspecific peroxygenases to catalyze the C-H oxyfunctionalization of ethylbenzene, achieving a yield of 81% and an ee value of 99% under optimum conditions. A wide range of substrates were converted to the corresponding chiral alcohols using this photo-enzyme catalytic system, achieving the corresponding chiral alcohols in good yield (51%–88%) and excellent enantioselectivity (90%–99% ee).
研究领域:
生物化学
·
材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
Water
·
2025
·Vol. 17
·期 9
·1309
·
IF 3
Xiaoyan Ma,Rongbin Quan,Wenqing Cao,Weijie Zhang,Su Jiang,Jiao Feng,Jiulong Wang,Stefanos Giannakis
Electrochemical reduction is a promising strategy for the dechlorination of halogenated organic compounds, offering advantages such as enhanced electron transfer efficiency and increased hydrogen atom concentration. It has garnered significant attention for application in mitigating halogenated disinfection by-products (DBPs) in drinking water, owing to its high efficiency and simple operation. In this study, trichloroacetic acid (TCAA), a representative DBP, was selected as the target contaminant. A novel composite cathode comprising a metal–organic framework MIL-53(Fe)@C supported on an Nd magnet (MIL-53(Fe)@C-MAG) and its dechlorination performance for TCAA were systematically investigated. The innovative aspect of this study is the magnetic attachment of the MOF catalyst to the carbonized cathode surface treated through carbonization, which fundamentally differs from conventional solvent-based adhesion methods. Compared to the bare electrode, the MIL-53(Fe)@C-MAG achieved a TCAA removal efficiency exceeding 96.03% within 8 h of contact time. The structural characterization revealed that the α-Fe0crystalline phase serves as the primary active center within the MIL-53(Fe)@C catalyst, facilitating efficient electron transfer and TCAA degradation. The scavenger experiments revealed that TCAA reduction involves a dual pathway: direct electron transfer and atomic hydrogen generation. The modified MIL-53(Fe)@C-MAG electrode exhibited robust electrolytic performance over a broad pH range of 3–7, with TCAA removal efficiency showing a positive correlation with current density within the range of 10–50 mA/cm2. Furthermore, the electrode maintained exceptional stability, retaining more than 90% removal efficiency after five consecutive operational cycles. The versatility of the system was further validated by the rapid and efficient dechlorination of various chlorinated DBPs, demonstrating the broad applicability of the electrode. The innovative magnetic composite electrode demonstrates a significant advancement in electrochemical dechlorination technology, offering a reliable and efficient solution for the purification of drinking water contaminated with diverse halogenated DBPs. These results provide valuable insights into the development of electrolysis for dechlorination in water treatment applications.
研究领域:
环境科学
·
材料科学
·
水处理工程
✓ 已验证
产品关联
DOI
高影响因子
Green Chemical Engineering
·
2022
·
IF 0
Jianguo Liu,Jiangmin Sun,Thishana Singh,Shanshan Lin,Longlong Ma
Although precious transition metals such as palladium, platinum, and iridium are widely used in hydrogenation reactions, the earth-abundant transition metal-catalyzed highly selective semi-hydrogenation of terminal alkynes to terminal alkenes remains poorly developed and a challenge. Herein we demonstrate the excellent selective, cost-effective semi-hydrogenation of terminal alkynes via a novel graphene encapsulated Ni@N/C catalyst. The graphene layer encapsulated nano-catalyst Ni@N/C could significantly avoid metal leaching and improve the stability of the catalyst. The strong interaction of nitrogen with the Ni nanoparticles regulates the activity of Ni towards selective semi-hydrogenation of terminal alkynes. Substrates having un-functionalized as well as functionalized substituents, and substrates having sensitive functional groups (olefins, ketones) which pose a challenge to hydrogenate, were semi-hydrogenated with excellent conversion (up to 99%) and selectivity (up to 99%) under optimized reaction conditions.
研究领域:
材料科学
·
催化化学
✓ 已验证
DOI
TALANTA
·
2025
·
IF 6.1
Wei Li,Xinrui Wang,Mingze Zhu,Xin Huang,Pacifique Hirwa Umutoni,Ting-Hsuan Chen,Jian Lu,Shih-Chi Chen,Guanming Tan,Bryan P. Yan,Bee Luan Khoo
Chronic inflammation remains a major global health concern, necessitating the development of advanced tools for continuous, precise monitoring. This study introduces a novel, clinically impactful triple-mode probe that integrates colorimetric, fluorescence, and surface-enhanced Raman scattering (SERS) signals, offering unparalleled multimodal detection capabilities. The probe's design leverages europium chelate-doped polystyrene nanoparticles (ECNPs), ensuring minimal signal cross-interference through a long Stokes shift. A key innovation is the development of a multimodal mapping algorithm that seamlessly integrates these optical signals, providing a sensitive and robust platform for biomarker detection with broad dynamic ranges. The probe's clinical relevance is demonstrated by its application in lateral flow assays (LFAs) for detecting C-reactive protein (CRP) levels, achieving a detection limit of 6.31 ng/mL and dynamic ranges from 23.13 to 2000 ng/mL, significantly outperforming single-mode detection methods. In clinical validation using urine samples from 31 patients, the triple-mode LFA showed excellent correlation (0.9377) and agreement (93.55%) with gold standard enzyme-linked immunosorbent assay (ELISA) results. This demonstrates that the proposed multimodal platform offers a highly sensitive, cost-effective, and versatile tool for monitoring inflammation and other disease biomarkers, with substantial potential for clinical applications in diagnostics and disease management.
研究领域:
临床诊断
·
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cell Reports
·
2025
·
IF 6.9
Mingfang Wang,Jia Zeng,Binbin Cui,Guangliang Wu,Xiayu Chen,Yikai Fu,Bing Gu,Yinyue Deng
It was previously demonstrated that intestinal pathogens have evolved different mechanisms to enhance their infection and colonization in the intestines of hosts. However, it is unclear how Shigella effectively survives in the presence of bile salts. Here, we report that the biofilm formation and pathogenicity of S . sonnei are induced by primary bile salts through the two-component system EvgS/EvgA. The response regulator EvgA controls the transcription of the cyclic AMP synthase-encoding gene. Furthermore, the effector protein CRP of the cyclic AMP (cAMP) signal not only positively controls the transcription of ydeH , a gene encoding cyclic di-GMP (c-di-GMP) synthase, but also forms a complex with YdeH to improve its catalytic production of c-di-GMP. Additionally, interacting with YdeH enhances the ability of CRP to bind to the promoter of ydeH . Our work provides insights into how S . sonnei utilizes cascade amplification of c-di-GMP to promote fitness and pathogenicity in response to primary bile salts.
研究领域:
微生物学
·
分子生物学
·
感染与免疫
·
信号转导
·
病原生物学
·
环境应答
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Oncology Letters
·
2018
·Vol. 17
·期 1
·652-659
·
IF 1.664
Hongchao Han,Jie Xu,Weiwei Ji,Lisheng Wang,Aikun Wang
Transmembrane protein with epidermal growth factor (EGF)‑like and two follistatin motifs 2 (TMEFF2) is downregulated in human gastric cancer, and its levels are associated with tumor aggressiveness. Herein, a positive correlation was identified between serum vitamin C levels (µg/ml) and mRNA levels of TMEFF2 in gastric cancer tissue. TMEFF2 silencing promotes cell proliferation in GES‑1 normal human gastric epithelial cells and AGS human gastric adenocarcinoma cells. Notably, vitamin C and AG490 exerted antiproliferative effects on the two cell lines. The present study demonstrated that small interfering (si)‑RNA‑TMEFF2 exerts pro‑proliferative effects on GES‑1 and AGS cells. The results revealed that vitamin C significantly inhibited the growth of GES‑1 and AGS cells by reducing cell viability, decreasing the expression of proliferating cell nuclear antigen (PCNA), and blocking the STAT3 pathway. Moreover, siRNA‑TMEFF2‑induced enhanced cell viability and PCNA expression were significantly reversed by additional vitamin C treatment; notably, markedly enhanced TMEFF2 expression was observed. Upregulated TMEFF2 expression was observed in association with the antiproliferative effect of AG490. In conclusion, serum vitamin C content (µg/ml) was positively correlated with the mRNA levels of TMEFF2 in gastric cancer tissue. Exploring novel drugs that target TMEFF2 is a potential therapeutic strategy for blocking human GC.
研究领域:
肿瘤学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Huidong Tang,Qing Hu,Feng Jiang,Weihui Jiang,Jianmin Liu,Ting Chen,Guo Feng,Tao Wang,Wei Luo
The zircon-based encapsulation carbon black (C@ZrSiO 4 ) inorganic pigments with controllable size were successfully prepared by non-aqueous sol-gel method with the assistance of soft mechano-chemistry (SMC) activation precursors. The XRD and FT-IR results showed that the SMC activation enhanced the reactivity of precursors and facilitated the formation of ZrSiO 4 phase with the calcination temperature at 900–1050 °C, indicating the successfully synthesis of pure ZrSiO 4 phase. The average size of C@ZrSiO 4 inorganic pigments significantly declined from 45.20 to 4.50 μm with the increase of SMC activation time of precursors, however, the L* values of pigments increased from 24.11 to 46.35. It was mainly because of the decreased amounts of protected carbon in ZrSiO 4 matrix and the enhanced light reflectance, which lead to the slight color change from deep black to gray black tone. The colored glaze samples presented a black hue after applied in the ceramic glaze at 1200 °C. Moreover, the black hue intensity of glazed samples was higher than that of the corresponding C@ZrSiO 4 inorganic pigments, indicating the prepared pigments have excellent tinctorial strength and hiding power. These results ensure that the obtained C@ZrSiO 4 inorganic pigments possess the outstanding chromatic performance, excellent high-temperature stability, high chemical stability and suitable particle size, and exhibit great potential in the application of the industrial ceramic decoration.
研究领域:
材料科学
·
无机化学
✓ 已验证
DOI
高影响因子
Materials Today Energy
·
2021
·
IF 7.311
J. Yang,F. Mo,L. Huang,H. Liang,G. Sun,S. Peng
Black phosphorus/natural graphene (BP/NG) composite electrode material for all-solid-state lithium-ion batteries (ASSLIBs) was fabricated by a facile ball milling method. A C-P bond with characteristics of high ion and electron transfer was constructed, which unlocked the reversible cycling and rate performance of phosphorus. In addition, compounding black phosphorus (BP) with natural graphene (NG) can relieve the large internal stress caused by volume change during cycling and improve the stability of the long cycling and high-rate performance. At current density of 0.5 A g −1 , a high specific capacity of 750 mAh g −1 remained after 100 cycles, whereas at high current density of 1 A g −1 , the BP/NG anode material delivered a reversible capacity of ~300 mAh g −1 . Furthermore, the reaction controlling step of Li x P delithiation was revealed by kinetic measurement. In addition, when coupling BP/NG anode material with TiS 2 to assemble a full solid-state cell, it delivered a high capacity of 400 mAh g −1 after 30 cycles, indicating a potential of further application. This work expanded the candidate of anode materials for ASSLIBs and provided aid for the further application of all-solid-state batteries.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）