ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Pengfei Shan,Yingwen Lu,Weilin Lu,Xiangping Yin,Haiwei Liu,Daai Li,Xiaoyue Lian,Weiping Wang,Zhongyu Li,Zhihui Li
The low utilization efficiency of pesticides exerts an adverse impact on the environment and human health. Polymer-related controlled-release nanosized pesticide systems provide a promising and efficient way to overcome the problem. In this work, a biodegradable and light-responsive amphiphilic polymer was synthesized via 1,1,3,3-tetramethylguanidine-promoted polyesterification under mild conditions (low temperature, no vacuum, and no inert gas protection). We used this polymer to fabricate a light-triggered controlled-release nanosized pesticide system. The herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), was selected as a model drug to show its potential as a controlled-release pesticide system. It was found that the 2,4-D-loaded polymeric nanoparticles were stable without the treatment of UV, while the release rate of 2,4-D from the nanoparticles gradually increased after treatment with UV light. Pot trial showed that the 2,4-D-loaded polymer nanoparticles showed a good herbicidal effect. Finally, toxicity studies suggested that the polymer can reduce toxicity to nontarget organisms.
研究领域:
环境科学
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材料科学
·
农业科学
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DOI
高影响因子
Applied Sciences-Basel
·
2019
·Vol. 9
·期 18
·3847
·
IF 2.217
Mingtang Tan,Peiyun Li,Wenhui Yu,Jinfeng Wang,Jing Xie
This study aimed to investigate the effects of glazing with sodium polyacrylate (SP) and D-sodium erythorbate (DSE) on the quality changes of squid during frozen storage. Frozen squid samples were randomly divided into seven groups: (1) CK (unglazed); (2) WG (distilled water-glazed); (3) SG (0.1% SP -glazed); (4) SG-1DSE (0.1% SP with 0.1% DSE -glazed); (5) SG-3DSE (0.1% SP with 0.3% DSE-glazed); (6) SG-5DSE (0.1% SP with 0.5% DSE-glazed); (7) WG-1DSE (0.1% DSE-glazed). The efficacy of the different coatings was evaluated using various indicators, such as water holding capacity (WHC), pH value, low field nuclear magnetic resonance (LF-NMR), color, malondialdehyde (MDA) content value, free amino acids (FAAs) content, intrinsic fluorescence intensity (IFI) and the total sulfhydryl content (SH) content. Intrinsic fluorescence intensity (IFI) and low field nuclear magnetic resonance (LF-NMR) were used as fast monitoring techniques to monitor changes in quality of squid samples. The results showed that compared with the CK and WG groups, coating with either SG or DSE alone resulted in reduced rate of moisture loss (p< 0.05), lipid oxidation (p< 0.05) protein degradation (p< 0.05) and prolonged its shelf-life. The combination of glazing treatment with SG and DSE (groups SG-1DSE, SG-3DSE and SG-5DSE) further improved the protective effects of coating, particularly in the SG-3DSE group. Therefore, the glazing of SG-3DSE is recommended to be used to control the quality of frozen squid and to prolong its shelf-life during frozen storage.Keywords:squid;glazing;frozen storage;sodium polyacrylate;D-sodium erythorbate;quality
研究领域:
食品科学
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海洋生物学
·
保鲜技术
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DOI
高影响因子
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
·
2020
·Vol. 31
·期 6
·1216-1224
·
IF 1.399
Han Qing,Wei Lanlan,Deng Guozhe,Sun Ying,Deng Jianjun,Tang Zigang,Fan Jinhui,Wang Xia,Kang Xuejun
The detection of vitamin D in complex samples is challenging because of the instability of vitamin D in sample preparation. To resolve this problem, packed-fiber solid-phase extraction (PFSPE) has been successfully developed for the pre-treatment of samples containing vitamin D2 (D2) and vitamin D3 (D3) in dairy products. Based on PFSPE, vitamin D could avoid oxidation because of the shorter extraction time. The adsorbent materials, polystyrene/polypyrrole (PS/PPy) nanofibers, were prepared by electrospinning of PS and in situ polymerization of PPy on the surface of PS nanofibers. The linearity was within the range of 1-2000 ng mL−1 in dairy solution, and the recoveries were 91.9-109.1% with a relative standard deviation (RSD) < 13.6%. Therefore, the prepared method could be used for the detection of D2 and D3 in dairy products.
研究领域:
分析化学
·
食品科学
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DOI
高影响因子
Applied Chemistry for Engineering
·
2025
·Vol. 36
·期 1
·36-42
·
IF 0.6
Gyu Won Woo,Eun Kwang Lee
본 연구에서는 스크린 인쇄 기술을 활용하여 유연 기판인 polyimide (PI) 필름에 내부 이온 게이트 유기 전기 화학 트랜지스터(internal gated transistor, IGT)를 제작하였다. 기존의 복잡한 공정 없이 저비용으로 제작하였으며, 유기 전기 화학 트랜지스터(OECT)의 채널로 주로 사용되는 전도성 고분자인 poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (PEDOT:PSS)와 D-소르비톨을 혼합하여 외부 전해질 없이 채널 내에서 자체적으로 이온 (de)doping 메커니즘을 구현하였다. 그 결과, 스크린 인쇄 IGT는 기존 OECT 대비 향상된 전도성과 성능 지표를 나타냈다. D-소르비톨 첨가 후 PEDOT:PSS의 시트 저항 값이 기존 대비 약 1/2로 감소하여 전도성이 향상되었고, 표면 결정성 또한 개선되었다. 전기적 성능 평가에서 IGT는 OECT 대비 출력 곡선 특성(VGS = 1.6 V)에서 약 4배 증가한 것으로 나타났으며, ION/IOFF 비율은 약 4.3배 높았다. 이동도 계산 결과 OECT는 0.6987 F V-1 s-1 cm-1, IGT는 0.9578 F V-1 s-1 cm-1로 IGT가 높은 값을 보였고, 시간 응답 속도 상수 τ는 τOECT = 0.50 s, τIGT = 0.34 s로 더 빠른 응답 속도를 나타내었다.
The device fabricated in this study was an internal ion-gated organic electrochemical transistors (IGTs) using screen printing technology on a flexible polyimide (PI) film substrate. This fabrication method is a cost-effective and simple method without existing deposition techniques or complicated processes. The conductive polymer, poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (PEDOT:PSS), commonly used as a channel material in organic electrochemical transistors (OECTs), was blended with D-sorbitol to enable a self-ion (de)doping mechanism within the channel, eliminating the requirement for an external electrolyte. The screen-printed IGT exhibited enhanced conductivity and performance compared to conventional OECTs. Analysis of the physical and chemical properties of PEDOT:PSS with D-sorbitol revealed a significant reduction in sheet resistance. The surface analysis further confirmed an enhancement in crystallinity. Electrical performance evaluation involved a comparative study with conventional OECTs. The IGT device demonstrated a 4 times increase in output curve characteristics at VGS = 1.6 V compared to OECTs. Additionally, the ION/IOFF ratio was 4.3 times higher for the IGT. Calculations of µC* to assess device mobility indicated a notable improvement, with values of 0.9578 F V-1 s-1 cm-1 for IGT compared to 0.6987 F V-1 s-1 cm-1 for OECTs. In time constant analysis, τOECT = 0.50 s and τIGT = 0.34 s indicate that IGTs have a faster response time.
研究领域:
材料科学
·
电子工程
·
化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF THERMOPHYSICS
·
2020
·Vol. 41
·期 5
·1-12
·
IF 0.794
Mo Songping,He Lijuan,Jia Lisi,Chen Ying,Cheng Zhengdong
Thermophysical properties are important parameters that influence the performance of phase change materials (PCMs) and heat transfer fluids. Micro/nanoencapsulation is an effective technique for preventing leakage and enhancing thermophysical properties of PCMs. In the present study, novel d -mannitol nanocapsules with inorganic shells were synthesized as a medium-temperature PCM. The nanocapsulation was confirmed by scanning electronic microscopy. The specific heat and thermal diffusivity of the nanocapsules and their suspension with heat transfer oil as base fluid were measured by a differential scanning calorimeter and light flash apparatus. The thermal conductivity of the nanocapsule suspension was measured using a hot-disk thermal constants analyzer. The viscosity of the nanocapsule suspension was measured by a rotational rheometer. The results show that the thermal conductivity and thermal diffusivity of the nanocapsules were enhanced compared to the bulk of the PCM due to the inorganic shell. The specific heat, thermal conductivity, and viscosity of the nanocapsule suspension were increased compared to the base fluid. The potential of the nanocapsule suspension as a heat storage and transfer fluid was evaluated.
研究领域:
材料科学
·
热力学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Luyao Huang,Yuntian Lou,Dawei Zhang,Lingwei Ma,Hongchang Qian,Yuting Hu,Pengfei Ju,Dake Xu,Xiaogang Li
In this study, antibacterial surfaces with a “disperse-then-kill” synergy were prepared by embedding d -cysteine ( d -cys) functionalised silver nanoparticles (AgNPs) onto polydopamine-coated stainless steel. The as-prepared surface exhibited excellent antibacterial performance against the gram-negative Escherichia coli and Pseudomonas aeruginosa PAO1 and gram-positive Staphylococcus aureus . This component of d -cys could inhibit the formation of mature biofilms and maintain bacteria in dispersed and planktonic states, which further facilitates the bacterial-killing action enabled by the AgNPs. The cooperation of these two components presents a new strategy for developing antibacterial surfaces with a stronger and more durable performance. Furthermore, the as-prepared surface did not exhibit an apparent cytotoxicity based on the results of real-time cell analyzer (RTCA) and a cell viability kit-8 assay (CCK-8 assay). Given these results, the proposed antibacterial strategy demonstrated a potential to inhibit bacterial adhesion and biofilm formation on surgical devices and medical implants.
研究领域:
材料科学
·
生物材料
·
生物医学工程
·
微生物学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Fuping Wang,Xinyi Peng,Zhengpeng Zhong,Mingchen He,Qinyan Lu,Yifan Li,Huaiyang Liu,Wang Li,Guobao Chen,Bo Zhou,Zhongmin Chen
A non-isotopic methanol-releasing probe detects HCC early via breath. • Selectively cleaved by β-galactosidase in HCC for tumor-specific signal. • A low-cost dual-sensor array enables real-time exhaled methanol detection. • Distinguishes early-stage tumor-bearing mice from controls (< 2 mm). • Offers a portable, affordable screening tool for primary healthcare. Early detection is crucial for improving therapeutic outcomes in hepatocellular carcinoma (HCC), yet the widespread implementation of low-cost, accessible screening for high-risk populations remains a significant challenge. To address this issue, we investigated the β-galactosidase–methanol signaling axis using a hydrophilic, cell-membrane-impermeable probe, methyl-β-D-galactopyranoside (MGP). This probe is selectively hydrolyzed by β-galactosidase, which is overexpressed in the HCC microenvironment, releasing methanol—an easily volatile, non-isotopic, and metabolically inert volatile organic compounds (VOCs). Methanol levels in exhaled breath were quantified using a custom-designed sensor array. Through in vitro enzymatic assays, cellular studies, and animal experiments, we demonstrated that methanol concentrations in tumor-bearing mice (with tumor diameters <2 mm) were significantly elevated compared to healthy controls, and these levels positively correlated with tumor volume. Our findings highlight the potential of Me-β-Gal in addressing critical barriers to early HCC detection. With further validation, this approach could potentially improve clinical management for high-risk populations, including patients with liver cirrhosis.
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Beibei Li,Qingchao Wang,Xiaoxi Wang,Peixin Chen,Xinyu Zi,Yanping Ma,Qiaoya Xuan,Ying Cheng,Shihan Zhang,Hanke Feng,Wenjie Zhai,Yahong Wu,Yumiao Zhao,Xiaowen Zhou,Xiaoshuang Niu,Wenshan Zhao
Effective cancer immunotherapy is often hindered by V-domain Ig suppressor of T cell activation (VISTA) signaling and myeloid-derived suppressor cells (MDSCs) within tumor microenvironment (TME). Here, we report D-peptide-nanodrug conjugates that synergize VISTA blockade and innate activation to overcome these constraints. We developed Reorpn7, a proteolytically stable D-peptide VISTA inhibitor with high binding affinity and in vitro serum stability. This inhibitor was co-loaded with a toll-like receptor 7/8 (TLR7/8) agonist (R848) into an matrix metalloproteinase-2 (MMP-2) responsive poly lactic-co-glycolic acid (PLGA) nanoplatform (r7PL-PLGA@R848). Upon enrichment in the TME, MMP-2 responsive cleavage enables the precise release of the VISTA-targeting peptide Reorpn7 and the TLR7/8 agonist R848, thereby achieving synergistic therapeutic effect of VISTA blockade and innate immune activation. In MC38 tumor models, this nanosystem significantly increased intratumoral CD8 + T cell infiltration and achieved robust antitumor efficacy without obvious systemic toxicity. Mechanistically, the platform reshaped the TME from an inhibitory milieu into an immunosupportive one by coordinating checkpoint blockade, myeloid reprogramming, and T cell recruitment. This stimuli-responsive paradigm offers a translatable strategy to overcome immune checkpoint blockade resistance in challenging malignancies.
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产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2026
·
IF 6
Qingpo Yang,Shangkang Xie,Zixiang Xing,Jie Liu,Yufeng Shen,Ling Huang,Rubo Fang,Feng Feng,Chunshan Lu,Qingtao Wang,Chong Yao,Qunfeng Zhang,Xiaonian Li
The shielding effect effectively suppresses the chemical adsorption between platinum and sulfur species and hinders the formation of Pt-S bonds. • Electrons transfer from Pt to the carbon encapsulation layer to construct metal-carbon interfacial structures, which endows the catalyst with superior hydrogenation activity in sulfur-containing environments. • Carbon-encapsulated structure enhances the structural stability and sulfur resistance of the catalyst. • Experimental characterizations combined with DFT calculations elucidate the underlying reaction mechanism. The presence of sulfur-containing impurities in industrial feedstocks leads to the rapid deactivation of metal-based catalysts, which originates from the specific recognition between the d orbitals of metallic active sites and the p orbitals of sulfur. In this work, a carbon-encapsulation catalyst strategy was employed to shield this specific d–p orbital recognition effect. The Pt-base catalyst showed a sharp 92.28% loss in activity after sulfur poisoning, whereas the carbon-encapsulated catalyst maintained high efficiency and stability, sustaining a reaction rate of 83.41 min –1 even at high mercaptan concentrations (7945 ppm). Moreover, it exhibited excellent reusability with negligible deactivation after five cycles. Characterization and density functional theory (DFT) calculations revealed that the carbon shell serves as “armor” for Pt active sites, physically isolating them from sulfur impurities and suppressing the hybridization between Pt nanoparticles (Pt NPs) and the S 2p orbitals. Meanwhile, Pt nanoparticles induce electron transfer to the carbon layer, converting it into a conductive “metallic carbon” that enhances hydrogenation activity. This work provides new insights into the anti-sulfur poisoning mechanism of catalytic hydrogenation. Download: Download high-res image (255KB) Download: Download full-size image
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Jing-Jing Liu,Si-Dian Miao,Zhan-Yi Wang,Ya-Han Zhu,Bin-Bin Jiang,Shuang-Shuang Long,Shu-Qin Gao,Ying-Wu Lin
The anti-glycation effects and mechanisms of eight quinone-related compounds, primarily sourced from medicinal and edible plants, were evaluated in this study. In vitro glycation experiments were conducted to study the structural perturbation induced by d -ribose on human myoglobin (HMb) in the presence of the tested compounds. Spectroscopic and electrophoretic analyses indicated that among the four benzoquinone-related substances, thymoquinone and its structurally closest analogue 2,5-dimethyl-1,4-benzoquinone, exhibited significant inhibitory effects on the d -ribose-induced glycation, thereby maintaining protein structural stability, reducing advanced glycation end products (AGEs) formation, and attenuating the covalent protein modification by d -ribose. In contrast, 1,4-benzoquinone and hydroquinone (a reduction product of 1,4-benzoquinone) promoted HMb denaturation through the Michael addition mechanism. Of the two naphthoquinones, juglone and plumbagin, showed anti-glycation effects, whereas the anthraquinones emodin and chrysophanol showed no significant effects. Nano-HPLC-MS/MS analysis further showed that thymoquinone was more effective in preventing glycation than juglone and plumbagin. This study investigates the mechanisms underlying glycation inhibition by quinones, revealing that the presence of dual β -substituted carbons on the benzoquinone ring is critical for stabilizing protein conformations and suppressing glycation. It provides a preliminary mechanistic basis and identifies candidate molecules for potential applications of quinones in retarding glycation, such as in managing diabetic complications or inhibiting glycation reactions during food processing.
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产品关联
DOI
高影响因子
Applied Sciences-Basel
·
2025
·Vol. 15
·期 13
·7318
·
IF 2.5
Jiawei Cui,Yan Li,Ming Yan
D-allulose is a rare sugar with promising applications in food and health industries, owing to its low caloric value and multiple health benefits. In this study, we systematically investigated a thermostable D-allulose 3-epimerase (TcDAEase) fromThermogemmatispora carboxidivoransfor food-compatible continuous production. The enzyme exhibited remarkable thermostability, with over 70% activity retained at 80 °C, and showed broad pH tolerance across the range of 8.0 to 13.0. Notably, TcDAEase exhibited high catalytic activity toward D-allulose and D-fructose even without the addition of metal ions. Moreover, food-grade Mg2+was identified as enhancing enzyme activity by 14.3%, thus ensuring compliance with Generally Recognized as Safe (GRAS) standards for food applications. To improve industrial applicability, the enzyme was immobilized using a chitosan-diatomaceous earth (DE) matrix via three-step adsorption–crosslinking–embedding strategy. The immobilized TcDAEase achieved 48.7% ± 2.4% activity recovery and retained 90.3% ± 1.5% activity over seven reaction cycles. Furthermore, continuous production of D-allulose was realized in a packed-bed reactor, operating stably at 60 °C, pH 8.0 and 5 mM Mg2+for 150 days, producing 756 kg of D-allulose with a conversion yield exceeding 89.7% of the theoretical maximum. Overall, this study provides a feasible strategy for the continuous and efficient production of high-value-added D-allulose in the food industry.
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高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2026
·
IF 2.5
Dan Guo,Bangyu Li,Hua Huang,Xinshuai Zhang
1,5-Anhydro-D-glucitol (1,5-AG), a 1-deoxy form of glucopyranose, is a major dietary-derived polyol in the human body and serves as a sensitive clinical marker for short-term glycemic control in diabetic patients. Its phosphorylated derivative, 1,5-anhydro-D-glucitol-6-phosphate (1,5-AG6P), is a non-canonical metabolite formed when glucose phosphorylating enzymes erroneously act on 1,5-AG. Accumulation of 1,5-AG6P is associated with neutrophil dysfunction. Recently, the Zhang group reported a gut bacterial pathway for 1,5-AG catabolism, in which the key enzyme is a glycyl radical enzyme (GRE) responsible for the ring-opening C−O cleavage of 1,5-AG6P. In this report, through a synergistic analysis of sequence similarity network (SSN) and genome neighborhood network (GNN) of this GRE homologs, we uncovered novel ATP-dependent 1,5-AG kinases belonging to the ROK family (PF00480). These enzymes exhibit higher catalytic efficiencies for 1,5-AG than for D-glucose, driven by both a smaller K M and a larger k cat . The substrate preference contrasts with that of other hexokinases and ADP-dependent glucokinases, which typically show a marked preference for D-glucose. This study expands the biocatalytic toolbox for the enzymatic synthesis of 1,5-AG6P, offering a more efficient and convenient approach, and reinforces the value of the “genomic enzymology” strategy applicable for enzyme function discovery.
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PubMed
高影响因子
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