IEEE SENSORS JOURNAL
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2024
·
IF 4.3
Chen Ma,Dingnan Lu,Fangyuan Zhou,Jiayue Luo,Huihui Gan,Weidong He,Pradeep U. Kurup,David Z. Zhu
Due to the almost-complete dependence on clinical diagnosis, current Helicobacter pylori (H. pylori) epidemiological statistics suffer from fragmented geographical coverage and lagged data updating worldwide. Acquiring information based on the quantitative detection of biomarkers from domestic wastewater provides a promising way for the future H. pylori epidemiological study. Here, we report wastewater-adapted electrochemical competitive immunosensor (WECI). This method focuses explicitly on detecting H. pylori cytoplasmic ureB in wastewater and contains a series of designs to overcome the challenges brought by the complicated analytical matrix. The developed WECI achieved a practical detection range from 10 pg mL $^{-{1}}$ to 5.0 ng mL $^{-{1}}$ ( ${R}^{{2}}$ = 0.996) and showed the corresponding limit of detection (LoD) and limit of quantification (LoQ) of 0.37 and 1.4 pg mL $^{-{1}}$ , respectively. It can be prepared within 6 h and kept highly sensitive for at least six weeks. When testing real wastewater samples, WECI resulted in an average biomarkers recovery rate of 70.9%, which was remarkably higher than the average of 47.0% achieved using qPCR, indicating the excellent applicability toward actual wastewater detection. Our reported WECI is the first study to quantitatively detect H. pylori ureB from wastewater, opening up new vistas for H. pylori epidemiological study.
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Coatings
·
2024
·Vol. 14
·期 6
·771
·
IF 2.9
Xia Zhao,Jingfu Song,Jingyi Lin,Guoqing Wang,Gai Zhao
Micro-arc oxidation (MAO) coatings of aluminum alloy have great potential applications due to their high hardness and wear resistance. However, the micro-pores and defects formed in the discharge channels during the MAO process limit its application in the corrosion field. This study delves into the impact of h-BN nanoparticles into MAO coatings on their structure, corrosion resistance, phase composition, and tribological properties. The results show that the incorporation of h-BN particles reduces the porosity and surface roughness of the coating while enhancing its hardness and wear resistance. The best corrosion resistance is obtained at a concentration of 2 g/L h-BN. An analysis of worn surface morphology, corrosion resistance, and friction coefficient change was conducted to evaluate the performance of this coating. This method provides a new approach to enhance the surface hardness and wear resistance of aluminum alloys, which is significant for expanding the application of aluminum alloys in corrosion environments.
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COMPOSITES SCIENCE AND TECHNOLOGY
·
2024
·
IF 8.3
Fan Xie,Qiaoling Liu,Xiyi Dai,Haitao Wei,Zhaoqing Lu
Multi-functional electromagnetic interference (EMI) shielding materials are crucial for advanced electronic devices, requiring low thickness, exceptional shielding performance, and stability, especially in extreme conditions. In this study, the hollow sandwich MXene/h-AgNWs/ANF (AMAgMA) composite films were fabricated via template sacrificing method and layer-by-layer vacuum assisted filtration. Specifically, the hollow MXene was created using PMMA as the template, together with AgNWs for the conductive layer, while ANF provided stability and high temperature resistance as the protective layer. The optimized EMI shielding efficiency (SE) reached 88.2 dB for a film thickness of 93 μm, with an SSE/t value of 18160 dB cm 2 ·g −1 , which was attributed to the hollow structure and continuous double conductive network design. Remarkably, EMI SE of the films maintained even after 70 days of exposure to oxidation, acid, alkali, salt, and ultrasonic treatment thanks to the sandwich design. Additionally, the composite films displayed excellent heat transfer and thermal stability (530 °C), alongside notable flame retardancy and self-extinguishing properties. The superior EMI shielding performance and stability in extreme environments suggest a promising application potential in advanced electronics.
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BIOELECTROCHEMISTRY
·
2024
·
IF 4.8
Guiyin Li,Wenzhan Li,Yu Zhou,Xiaohong Tan,Qing Huang,Jintao Liang,Zhide Zhou
Glypican-3 (GPC3) is exclusively overexpressed in most Hepatocellular carcinoma (HCC) tissue but not in normal liver tissue, making it a promising biomarker for the precise detection of HCC. In this paper, a label-free light-addressable potentiometric sensor (LAPS) decorated by platinumpalladium-hemin-reduced graphene oxide nanocomposites (PtPd@H-rGO NCs) was constructed for determination of GPC3. The GPC3 aptamer (GPC3 Apt ) and PtPd@H-rGO NCs were modified on the surface of silicon-based LAPS chip to build sensitive unit of LAPS system. A readout photocurrent elicited from a modulated light source, registers the localized surface potential change. When a bias voltage is provided to the LAPS system, the GPC3-GPC3 Apt complexes formed by the specific reaction between GPC3 and GPC3 Apt at the sensing interface can cause the sensitive membrane surface potential to change, resulting in the photocurrent-voltage (I-V) curves generate a corresponding offset response. Therefore GPC3 concentration can be determined by monitoring the potential shifts (△V). Under optimal conditions, the potential shift is linearly related to the concentration of GPC3 in the range of 0.001–3.00 μg/mL with the limit of detection (LOD) of 0.0001 μg/mL. The LAPS has a good analytical performance with good specificity, reproducibility and stability, and can be used for the detection of GPC3 in actual serum samples, which provides a broad application prospect for the combined application of LAPS and aptamers in biooassay.
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高影响因子
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
·
2025
·
IF 3.4
Wei Shen,Zilong Yang,Xiaolin Guo,Hongxiao Jin,Wenxiang Chai,Hongliang Ge,Dingfeng Jin
Amino acid ionic liquids (AAILs) are potential green substitutes of aqueous amine solutions for carbon dioxide (CO 2 ) capture. In this study, we prepared three amino acid ionic liquids, constructed from tetrabutylphosphine hydroxide in combination with glycine, histidine, and arginine. We have conducted a comprehensive study on the CO 2 absorption capacity of structures containing single, double, and triple N–H groups. The solubility of CO 2 in [P 4444 ][Gly], [P 4444 ][His] and [P 4444 ][Arg] were measured experimentally over a temperature range of 30–110 °C and up to a pressure of 0.75 MPa. The results indicate that the solubility of carbon dioxide in amino acid ionic liquids decreases with increasing temperature, while it increases with increasing pressure. The optimal CO 2 absorption conditions of three amino acid ionic liquids were determined to be 50 °C, 0.75 MPa. Moreover, CO 2 absorption capacity of three amino acid ionic liquids followed the order: [P 4444 ][Arg] > [P 4444 ][His] > [P 4444 ][Gly]. Studies on the recycling and regeneration of amino acid ionic liquids verified their reusability in the process and confirmed that the reaction between AAILs and CO 2 could be reversed at 140 °C. Finally, the recycle capacity and CO 2 removal efficiency of [P 4444 ][Gly], [P 4444 ][His] and [P 4444 ][Arg] were evaluated.
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Nanomaterials
·
2025
·Vol. 15
·期 5
·401
·
IF 4.3
Xiaoxiao Peng,Haiyan Jing,Lan Yu,Zongdeng Wu,Can Su,Ziyu Ji,Junjie Shu,Hua Tang,Mingzhu Xia,Xifeng Xia,Wu Lei,Qingli Hao
To significantly improve the tribological performance of epoxy resin (EP), a novel h-BN/MoS2composite was successfully synthesized using spherical MoS2particles with lamellar self-assembly generated through the calcination method, followed by utilizing the “bridging effect” of a silane coupling agent to achieve a uniform and vertically oriented decoration of hexagonal boron nitride (h-BN) nanosheets on the MoS2surface. The chemical composition and microstructure of the h-BN/MoS2composite were systematically investigated. Furthermore, the enhancement effect of composites with various contents on the frictional properties of epoxy coatings was studied, and the mechanism was elucidated. The results demonstrate that the uniform decoration of h-BN enhances the chemical stability of MoS2in friction tests, and the MoS2prevents oxidation and maintains its self-lubricating properties. Consequently, due to the protective effect of h-BN and the synergistic interaction between h-BN and MoS2, the 5 wt % h-BN/MoS2composite exhibited the best friction and wear resistance when incorporated into EP. Compared to pure EP coatings, its average friction coefficient and specific wear rate (0.026 and 1.5 × 10−6mm3N−1m−1, respectively) were significantly reduced. Specifically, the average friction coefficient decreased by 88% and the specific wear rate decreased by 99%, highlighting the superior performance of the h-BN/MoS2-enhanced epoxy composite coating.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Xuanlin Li,Wenchao Shi,Xiner Li,Zhe Dong,Shili Zhao,Tian He,Yang Tong,Xiang Li,Beibei Chen
Creating high-quality and highly adaptable self-lubricating surfaces at the interface of mechanical components is significant in extending the lifespan of equipment. Due to the limitations of the performance of a single nanofiller, its enhanced polymer-based coatings often struggle to meet the requirements of harsh working environments. In this study, the 2D/2D nanohybrid of graphitic carbon-nitrogen (g-C 3 N 4 ) supporting h-BN nanosheets (BNNSs) was prepared using the facile calcination method. Furthermore, its tribological enhancement on epoxy (EP) composite coating was evaluated by sliding against 440 C steel ball. The “soft phase” of g-C 3 N 4 and “hard phase” of BNNSs in 2D/2D BNNSs/g-C 3 N 4 nanohybrid could integrate the multiple advantages and provide synergistic enhancement for epoxy self-lubricating composite coating. The BNNSs/g-C 3 N 4 demonstrated the optimal lubricating properties for EP compared to single BNNSs or g-C 3 N 4 . Compared with the pure EP coating, the friction coefficient and wear rate of the 0.5 wt% BNNSs/g-C 3 N 4 /EP coating were reduced by approximately 74.5 % and 80.9 %, respectively. The outstanding tribological properties of BNNSs/g-C 3 N 4 /EP were mainly due to the synergistic enhancement of BNNSs and g-C 3 N 4 nanosheets and the lubricating effect of high-quality transfer film.
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JOURNAL OF CONTROLLED RELEASE
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2016
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IF 7.441
Xiangting Zhuang,Tingting Wu,Yongdan Zhao,Xiaomeng Hu,Yuling Bao,Yuanyuan Guo,Qingle Song,Gao Li,Songwei Tan,Zhiping Zhang
Nanoimmunotherapy, the application of nanotechnology for sustained and targeted delivery of antigens to dendritic cells (DCs), has attracted much attention in stimulating antigen-specific immune response for antitumor therapy. In order to in situ deliver antigens to DCs for efficient antigen presentation and subsequent induction of strong cytotoxic T lymphocytes (CTL) response, here we developed a multi-peptide (TRP2 180–188 and HGP100 25–33 ) and toll-like receptor 4 agonist (monophosphoryl lipid A) codelivery system based on lipid-coated zinc phosphate hybrid nanoparticles (LZnP NPs). This delivery system equips with the chelating property of zinc to realize the high encapsulation efficiency with antigenic peptides and the influence on immune system with adjuvant-like feature. The combination of H-2K b and H-2D b -restricted peptides could provide multiple epitopes as the target of specific MHC alleles, making tumor more difficult to escape from the surveillance of immune system. The formulated LZnP nano-vaccine with the size of 30 nm and outer leaflet lipid exhibited antitumor immunity as the secretion of cytokines in vitro and increased CD8 + T cell response from IFN-γ ELISPOT analysis ex vivo . The antitumor effects were further evidenced from the prophylactic, therapeutic and metastatic melanoma tumor models compared with free antigens and single peptide-loaded nano-vaccines. These results validate the benefit of LZnP-based vaccine for antitumor immunity and indicate that co-delivery of tumor antigens along with adjuvant may be an optimized strategy for tumor immunotherapy .
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高影响因子
Small Methods
·
2025
·Vol. 9
·期 12
·e01317
·
IF 9.1
De'en Guo,Yi Yang,Qingrui Cai,Bingchen He,Xingyu Gao,Heng Peng,Junhao Xue,Conghua Zhou
Carbon- electrode (CE) based, hole-conductor-free mesoscopic perovskite solar cells (meso-CPSCs) offer the merits of high stability and low cost, but they contain a large number of nanosized perovskite (PVSK) crystallites in the CE region. These crystallites contribute little to light absorption, but bring risks of charge recombination. Herein, a three-step holistic treatment is introduced to address this issue, such as treatment-1 (T1): partial CE peeling; treatment-2 (T2): octylammonium iodide modification; and treatment-3 (T3): coating of a secondary layer of CE. Low-temperature meso-CPSCs are chosen as the model platform to perform the strategy. It is observed that the strategy removes the redundant PVSK crystallites, induces the formation of tilt-stacked two-dimensional (2D) PVSK, and strengthens interfacial contact of PVSK/CE, which reduces the recombination risks and facilitates interfacial charge-extraction, and finally elevates the power conversion efficiency (PCE) of the low-temperature meso-CPSCs from 14.25(±0.69)% to 16.05(±0.40)%(optimized to 17.28%). The efficiency is further upgraded to 18.07% after additional optimization on internal resistance and substrate transparency. Such performance achieves an increment of ≈50% when comparing to the efficiency of ≈12% that was firstly reported in 2020. In more, the T 80 lifetime of ≈525 h has been obtained during the quasi-maximum power point tracking test in open air (device unsealed).
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GREEN CHEMISTRY
·
2025
·
IF 9.2
Kaihao Mo,Peng Cui,Dongni Liu,Cailan Chen,Hanyu Zhang,Minmeng Tang,Peiwen Wu,Yan Huang,Haiyan Ji,Wenshuai Zhu
In extraction processes, the low mass transfer efficiency of conventional ionic liquids is a refractory problem. Herein, a porous ionic liquid (PIL), β-CD-900-PIL, was innovatively constructed by combining a porous carbon material (β-CD-900) derived from β-cyclodextrin polymer with imidazole bis-trifluoromethylsulfonylimide ionic liquid ([C12mim][NTf2]). The N2 sorption isotherm and CO2 adsorption confirmed the porosity of β-CD-900 and the PIL. With the dispersion amount of β-CD-900 as 20 wt%, the extraction efficiency of naphthalene by β-CD-900-PIL reached 66.6%, which was 24% higher than that of the ionic liquid. After three extractions, the naphthalene content decreased from 500 mg L−1 to 5 mg L−1. The high extraction efficiency was attributed to the high porosity and abundant π–π and C–H⋯π interactions between PILs and naphthalene. The more than 99% extraction performance, low viscosity and low preparation cost make β-CD-900-PIL an ideal extractant for polycyclic aromatic hydrocarbons in the petrochemical industry.
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JOURNAL OF ORGANIC CHEMISTRY
·
2019
·
IF 4.745
Shanjian Mao,Yinbo Wan,Haiyun Peng,Li Luo,Guisheng Deng
Pd(PPh3)2Cl2-catalyzed selective tandem cyclization/oxidation of available conjugated diazo ene-yne-ketones under O2 atmosphere led to the formation of diazo trisubstituted furans. The Rh2(OAc)4-mediated selective C(sp2)–H insertion at the ortho-position of 2-aryl group (R1) of the furan moiety under N2 atmosphere occurred to construct naphthalene cycle, affording trifunctionalized naphtho[1,2-b]furans. C(sp2)–H insertion at the 4-position of the furan ring, and Wolf rearrangement of diazo moiety have not been observed.
研究领域:
有机化学
·
合成化学
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 5
·1258-1262
·
IF 2.726
Zhang Xingcong,Zhong Yunzhu,Chen Hongyu,Cheng Yujie,Sun Qingdi,Zhang Hao,He Qian,Zhang Ying,Guo Guanghui,He Xiaohui,Ji Hongbing
Through screening Ce precursors and pyrolysis temperatures [Ce(acac) 3 as Ce precursors and pyrolysis at 900 °C], zeolitic imidazolate framework-8(ZIF-8) derived nitrogen-doped carbon supported cerium single atom catalyst(Ce 1 /NC) is successfully prepared by ball milling method. The Ce 1 /NC catalyst exhibits exceptional catalytic performance in the selective oxidation of saturated C-H bonds in aromatic compounds, e.g. , 91% conversion and 99% selelctivity can be achieved in the oxidation of ethylbenzene to acetophenone under mild reaction conditions.
研究领域:
催化化学
·
材料科学
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危险品化学品经营许可证（带存储）