Pharmaceutics
·
2020
·Vol. 12
·期 2
·144
·
IF 4.421
Ziyue Xi,Wei Zhang,Yali Fei,Mingshu Cui,Luyao Xie,Lu Chen,Lu Xu
This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)—combined with mesoporous silica nanoparticles (MSNs) as carriers were investigated. The IMC–SDs were prepared using the solvent evaporation method and characterized by solubility analysis, infrared (IR) spectroscopy, powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), and differential scanning calorimetry (DSC). It was confirmed that IMC successfully changed into an amorphous state after loading into the designed carriers. The in vitro release and stability experiments were conducted to examine the in vitro dissolution rates of IMC–SDs combined with HPMC and Kollicoat IR as PIs which both improved approximately three-fold to that of the pure drug. Finally, in vivo studies and in vitro parallel artificial membrane penetration (PAMPA) experiments ensured the greater ability of enhancing the dissolution rates of pure IMC in the gastrointestinal tract by oral delivery. In brief, this study highlights the prominent role of HPMC and Kollicoat IR as PIs in MSN SD systems in improving the bioavailability and gastrointestinal oral absorption efficiency of indomethacin.
研究领域:
药剂学
·
药物递送系统
·
材料科学
·
药代动力学
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DOI
PubMed
高影响因子
BIOMATERIALS
·
2019
·
IF 10.273
Zheng Liu,Feng Ren,Hao Zhang,Qiang Yuan,Zhilin Jiang,Hanghang Liu,Qiao Sun,Zhen Li
Rare-earth nanoparticles (RE NPs) with narrow long wavelength emissions have been recently investigated for their potential application for fluorescence imaging in the second near-infrared window (NIR-II). Previously these RE NPs have a very limited application in the diagnosis and treatment of deep-seated tumors such as brain tumors, due to their weak fluorescence in the range of 1300–1700 nm. Herein, we report a significant enhancement of more than 10 times regular emission of NaNdF 4 nanoparticles at 1340 nm wavelength by coating them with an inert layer of NaLuF 4 , followed by sensitizing with a near-infrared dye (IR-808). We deliver these highly bright nanoparticles into the brain by using focused ultrasound to temporarily open the blood-brain barrier (BBB), and then detect the orthotopic glioblastoma by fluorescence imaging at 1340 nm. The images obtained from long wavelength fluorescence ( i.e. 1340 nm) exhibited better resolution and contrast compared to the short wavelength fluorescence ( i.e. 1060 nm). Our study not only provides insights for enhancing often overlooked emissions of rare-earth nanoparticles for NIR-II fluorescence imaging of deep-seated tumors, but also demonstrates great potential of focused ultrasound based technology in delivering nanotheranostic agents.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
神经科学
·
光学成像
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产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Zaigang Zhou,Cheng Li,Chao Li,Lei Zhou,Shuo Tan,Weibin Hou,Congying Xie,Long Wang,Jianliang Shen,Wei Xiong
It is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand-1 (PD-L1) overexpression and transforming growth factor-β (TGF-β) excessive secretion would accelerate DNA damage repair and trigger T cell exclusion to limit RT efficacy. However, existing drugs or nanoparticles can hardly address these obstacles of highly effective RT simultaneously, effectively, and easily. In this study, it is revealed that inducing mitochondria dysfunction by using oxidative phosphorylation inhibitors like Lonidamine (LND) can serve as a highly effective multi-immune pathway regulation strategy through PD-L1, collagen, and TGF-β co-depression. Then, IR-LND is prepared by combining the mitochondria-targeted molecule IR-68 with LND, which then is loaded with liposomes (Lip) to create IR-LND@Lip nanoadjuvants. By doing this, IR-LND@Lip more effectively sensitizes RT by generating more DNA damage and transforming cold tumors into hot ones through immune activation by PD-L1, collagen, and TGF-β co-inhibition. In conclusion, the combined treatment of RT and IR-LND@Lip ultimately almost completely suppressed the growth of bladder tumors and breast tumors.
研究领域:
肿瘤学
·
免疫疗法
·
纳米技术
·
放射生物学
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DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 52
·期 2
·907-916
·
IF 2.047
Shao Mengyao,Hu Bin,Ge Shengyan,Zhou Xingfu
Ti/TiO 2 / SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes modified with three kinds of TiO 2 interlayer materials were fabricated. TiO 2 macroporous membrane (MAc) substrate was prepared by direct calcination, and TiO 2 nanotubes (NTs) and TiO 2 mesoporous membrane (MEs) substrate were fabricated by anodic oxidation under different conditions. The study shows that the TiO 2 -nanotube-based anode reduces crack morphology and provides a larger surface area for loading the electrochemically active materials. TiO 2 -NTs as the optimized interlayer improve the oxygen evolution potential (OEP) from 1.49 to 1.85 V and increase the current density of the oxidation peak from 0.28 to 0.55 mA cm −2 , which enhances the oxidative degradation ability of the electrode. In addition, the service life of the Ti/TiO 2 -NTs/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes is 3.18 times longer than that of the Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes according to accelerated life tests. The degradation rate of methylene blue (MB) wastewater with an initial concentration of 20 mg L −1 reaches 99.14% under 5.0 V within 5 min by using Ti/TiO 2 -NTs/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes, which is 1.67 times more than that of the Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes. Graphical Abstract
Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes modified with three kinds of TiO 2 interlayer have been
fabricated. The service life of the optimized Ti/TiO 2 -NTs/SnO 2 -Sb-IrO 2 /SnO 2 -Sb-Ni electrode is
3.18 times longer than that of the Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes. The degradation rate of
the optimized electrode reaches 99.1 % within 5 min, which is 1.67 times more than that of the
Ti/SnO 2 -Sb-Ir/SnO 2 -Sb-Ni electrodes.
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xinyan Wang,Yuting Zhang,Jian Zhang,Chengpeng Shao,Jiaxing Yang,Yuning Zhang,Ruoyi Li,Zheng Xing
In this study, a Z-type heterojunction photocatalyst CoWO 4 /CS/BiOCl-10 was constructed by hydrothermal synthesis for the efficient removal of norfloxacin (NOR) contaminants in water. X-ray photoelectron spectroscopy (XPS) combined with Fourier transform infrared spectroscopy (FT-IR) confirmed that the hydroxyl group in the chitosan (CS) molecule was bonded with the oxygen atom on the surface of CoWO 4 through hydrogen bonding to form a directional charge transport channel, which greatly improved the photocatalytic degradation efficiency of CoWO 4 /CS/BiOCl-10, and the degradation rate was as high as 98.30 % within 90 min under 300 W xenon lamp irradiation. Optoelectronic measurements show that the interfacial potential difference drives electrons to migrate along the Z-path. Density functional theory (DFT) and liquid chromatography-mass spectrometry (LC-MS) were used to identify intermediates in the NOR degradation process, revealing the degradation pathway of NOR through piperazine ring cleavage and defluorination. The kinetics of NOR degradation intermediates were revealed using two-dimensional correlation spectroscopy (2DCOS) techniques. Rice seed germination experiments have shown that the degraded NOR solution is virtually non-toxic, greatly reducing the environmental impact. This study provides a new strategy for the development of efficient photocatalytic systems through the synergistic regulation mechanism of hydrogen bonding and heterojunction.
研究领域:
环境科学
·
材料科学
·
光催化
·
水处理
·
化学工程
·
光谱学
·
毒理学
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产品关联
DOI
高影响因子
FIRE SAFETY JOURNAL
·
2025
·
IF 3.3
Haoran Jiang,Yong Hu,Yong Jiang,Rong Qiu,Hui Huang
Due to the increased risk of phosphate depletion, there is an increasing demand for low-phosphorus or bio-based phosphorus flame inhibitors. Therefore, two novel composites with biologically-based phosphorus sources that chelate transition metal ions were synthesized via assembly method, i.e., Mn-PMC and Ni-PMC, the structure and binding states of the composites were examined by SEM, TEM, FTIR, XRD, XPS, BET and TGA. The results indicated that Mn-PMC and Ni-PMC (ⅰ) are nanoscale materials with well dispersed, (ⅱ) have an amorphous structure and have sites that bind to other substances, (ⅲ) contain no halogen elements. Then the combustion inhibition experiments of downward flame spread and TG-IR-MS analysis revealed (ⅰ) that the inhibition efficiency of the two prepared inhibitors was higher than that of commercial phosphate-containing inhibitor ADP. Among them, Ni-PMC had the best suppression effect, and the flame of cellulose sample containing it would automatically extinguish after igniting with a smallest dosage, (ⅱ) two inhibitors reduced the laminar flame velocity and flame temperature. (ⅲ) their flame suppression mechanism was indicated as that the pyrolysis releases inert gas to dilute the free radical concentration. This work is helpful for the development of efficient transition metal fire extinguishing agents to replace traditional phosphorus resources.
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Chunli Fan,Mingying Cao,Qiuju Zheng,Youfa Cheng,Ping Wang,Jinyu Feng
The evaluation of the flow direction of platinum group elements (PGEs) during gold-copper ore mining is challenging due to the uneven distribution and low content. Therefore, it is vital to accurately and simultaneously determine ultra-trace PGEs Pt, Pd, Rh, and Ir in gold mining residue samples. In this study, a method to simultaneously determine ultra-trace Pt, Pd, Rh, and Ir in gold mining residue is reported using Sb–Cu fire assay, microwave digestion, and inductively coupled plasma-mass spectrometry (ICP-MS). The Sb–Cu fire assay was used to enrich Pt, Pd, Rh, and Ir, obtaining Sb–Cu alloy particles that concentrate these elements. An optimal microwave method was employed to digest the Sb–Cu alloy particles. In ICP-MS, the collision reaction interface was used to eliminate the interferences of other elements and improve the accuracy. Moreover, the matrix-matched multi-external standards combined with internal standard calibration were utilized to reduce the error. High concentrations of Au, Ag, and Pb showed no interferences with Pt, Pd, Rh, or Ir determination. The limits of detection for Pt, Pd, Rh, and Ir were 0.018, 0.052, 0.064, 0.035 ng·g−1, respectively, and the relative standard deviation was 5.18, 4.66, 1.55, and 3.17%. Additionally, the determination of Pt, Pd, Rh, and Ir in standard reference materials showed good agreement with the certified values. In summary, a reliable and efficient method is provided to determine various PGEs which is of great significance for gold-copper ore mining.
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Mengyao Chen,Chunling Yin,Leqian Hu,Xinyao Lin,Liuchuang Zhao,Zhimin Liu,Peng Li
Quality of Cortex Fraxini is closely related to its clinical efficacy and drug safety. Traditional quality assessment methods are either non-objective or time-consuming. It is imperative to establish a rapid method for quality detection and evaluation of Cortex Fraxini . In this study, fourier transform infrared spectroscopy (FT-IR) and near-infrared spectroscopy (NIR) combined with chemometrics were used for rapid quantitative analysis of the main active components in Cortex Fraxini . Partial least squares regression (PLSR) combined with variable select by competitive adaptive reweighted sampling (CARS) algorithm gave rise to good predictions of the content of the three active components with R 2 values greater than 0.98. Furthermore, the quality evaluation results of Cortex Fraxini cannot be simply derived from data on the content of active ingredients. This study used technique for order preference by similarity to an ideal solution (TOPSIS) method and consistency analysis to evaluate the quality of Cortex Fraxini from five geographical origins. Two methods respectively realized the quality superiority ranking and quality consistency grading of Cortex Fraxini samples. The evaluation results showed that Cortex Fraxini derived from SN had the best performance in quality and was consistent with the standard of genuine regional herbs. This study introduces an effective technique for swift identification of the primary active compounds in Cortex Fraxini , as well as for an overall assessment of its quality. The combination of spectroscopic techniques and chemometrics provides a rapid and efficient method for the quality analysis of Cortex Fraxini .
研究领域:
药物分析
·
光谱技术
·
化学计量学
·
中药
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DOI
高影响因子
NORDIC PULP & PAPER RESEARCH JOURNAL
·
2021
·Vol. 36
·期 1
·21-32
·
IF 1.04
Guozheng Chen,Jinquan Wan,Yongwen Ma,Yan Wang
The macroscopic and microscopic properties of old newsprint pulp with xylanase, MLac/Glu (modified laccase-glutamate system), and X-MLac/Glu (xylanase synergistic modified laccase-glutamate system) pretreatment was investigated by means of fiber quality measurements (FQA), attenuated total reflectance-infrared spectroscopy (ATR-IR), headspace gas chromatography (HSGC), X-ray diffract ion method (XRD), Low-temperature nitrogen absorption and scanning electron microscopy (SEM). Results showed that, compare with the control pulp, the brightness and lightness (
L
∗
) of hydrogen peroxide bleached pulp after X-MLac/Glu pretreatment increased by 5.86 % ISO and 3.58 %, respectively. FQA analysis revealed that coarseness and fine fiber content increased slightly. The content of carboxyl groups and water retention value increased remarkably by 31.11 % and 39.22 %, respectively. The paper physical analysis showed that the paper strength properties have improved significantly. The crystallinity of cellulose decreased by 3.82 % due to X-MLac/Glu pretreatment. ATR-IR analysis indicated some non-cellulose components are removed. The BJH average pore size and BET specific surface area increased after enzyme pretreatment. The SEM analysis showed that through X-MLac/Glu treatment the fiber surface becomes rough and the connections between the fibers become tighter, more fibrils appeared.
研究领域:
制浆造纸科学
·
生物技术
·
材料科学
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DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-23
·
IF 10.2
Pan Yi,Liu Longcai,He Yichen,Ye Luyi,Zhao Xin,Hu Zhiming,Mou Xiaozhou,Cai Yu
Background Triple-negative breast cancer (TNBC) possesses special biological behavior and clinicopathological characteristics, which is highly invasive and propensity to metastasize to lymph nodes, leading to a worse prognosis than other types of breast cancer. Thus, the development of an effective therapeutic method is significant to improve the survival rate of TNBC patients. Results In this work, a liposome-based theranostic nanosystem (ILA@Lip) was successfully prepared by simultaneously encapsulating IR 780 as the photosensitizer and lenvatinib as an anti-angiogenic agent, together with banoxantrone (AQ4N) molecule as the hypoxia-activated prodrug. The ILA@Lip can be applied for the near-infrared (NIR) fluorescence diagnostic imaging of TNBC and its lymph node metastasis for multimodal therapy. Lenvatinib in ILA@Lip can inhibit angiogenesis by cutting oxygen supply, thereby leading to enhanced hypoxia levels. Meanwhile, large amounts of reactive oxygen species (ROS) were produced while IR 780 was irradiated by an 808 nm laser, which also rapidly exhausted oxygen in tumor cells to worsen tumor hypoxia. Through creating an extremely hypoxic in TNBC, the conversion of non-toxic AQ4N to toxic AQ4 was much more efficiency for hypoxia-activated chemotherapy. Cytotoxicity assay of ILA@Lip indicated excellent biocompatibility with normal cells and tissues, but showed high toxicity in hypoxic breast cancer cells. Also, the in vivo tumors treated by the ILA@Lip with laser irradiation were admirably suppressed in both subcutaneous tumor model and orthotopic tumor models. Conclusion Utilizing ILA@Lip is a profound strategy to create an extremely hypoxic tumor microenvironment for higher therapeutic efficacy of hypoxia-activated chemotherapy, which realized collective suppression of tumor growth and has promising potential for clinical translation.
研究领域:
肿瘤学
·
生物医学工程
·
药学
·
诊断成像
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DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2025
·Vol. 40
·期 4
·1169-1175
·
IF 1.1
Qu Yafen,Yu Yanling,Huang Biwu
[2-(3,4-epoxy-cyclohexyl)ethyl]dimethyltert-butylsilane was synthesized, using tert-butyldimethylsilane (TBDMS) and 1,2-epoxy-4-vinylcyclohexane (EVC) as the main raw materials and tris(triphenylphosphine) chlororhodium(I) [RhCl(Ph 3 P) 3 ] as the catalyst. [2-(3,4-epoxy-cyclohexyl)ethyl] dimethyltert-butylsilane is a novel kind of silicon-containing epoxide. The factors affecting the reaction yield, such as catalyst use, reaction time and reaction temperature, were investigated, and the synthesized product was characterized and analyzed by FT-IR and 1 H-NMR. A series of amine-curing resins were prepared with [2-(3,4-epoxy-cyclohexyl)ethyl]dimethyltert-butylsilane, bisphenol A epoxy resin (E-51) and modified amine (593 amine). The mechanical properties of cured splines with the different proportions of amine-curing resins were tested. When the content of 593 amine was 20%, the content of E-51 was 75% and the amount of [2-(3,4-epoxy-cyclohexyl) ethyl] dimethyltert-butylsilane was 5%, the mechanical properties of the cured splines were the best with the tensile strength being 23.3 MPa, the elongation at break being 7.8%, and the Young’s modulus being 421.3 MPa.
研究领域:
高分子化学
·
材料科学
·
有机合成
·
化学工程
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产品关联
DOI
高影响因子
Advanced Science
·
2020
·Vol. 7
·期 20
·2001681
·
IF 15.84
Daping Qiu,Jingyu Guan,Min Li,Cuihua Kang,Jinying Wei,Feng Wang,Ru Yang
Potassium-ion hybrid capacitors (PIHCs) have attracted tremendous attention because their energy density is comparable to that of lithium-ion batteries, whose power density and cyclability are similar to those of supercapacitors. Herein, a pomegranate-like graphene-confined cucurbit[6]uril-derived nitrogen-doped carbon (CBC@G) with ultra-high nitrogen-doping level (15.5 at%) and unique supermesopore-macropores interconnected graphene network is synthesized. The carbonization mechanism of cucurbit[6]uril is verified by an in situ TG-IR technology. In a K half-cell configuration, CBC@G anode demonstrates a superior reversible capacity (349.1 mA h g −1 at 0.1 C) as well as outstanding rate capability and cyclability. Moreover, systematic in situ/ex situ characterizations, and theory calculations are carried out to reveal the origin of the superior electrochemical performances of CBC@G. Consequently, PIHCs constructed with CBC@G anode and KOH-activated cucurbit[6]uril-derived nitrogen-doped carbon cathode demonstrate ultra-high energy/power density (172 Wh kg −1 /22 kW kg −1 ) and extraordinary cyclability (81.5% capacity retention for 5000 cycles at 5 A g −1 ). This work opens up a new application field for cucurbit[6]uril and provides an alternative avenue for the exploitation of high-performance PIHCs.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米技术
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）