MOLECULAR PHARMACEUTICS
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2014
·
IF 4.787
Yanping Li,Yangyang Zhou,Bowen Qi,Tao Gong,Xun Sun,Yao Fu,Zhirong Zhang
Parkinson’s disease (PD) has become one of the most deadly diseases due to a lack of effective treatment. Herein, N-3,4-bis(pivaloyloxy)dopamine-3-(dimethylamino)propanamide (PDDP), a brain-specific derivative of dopamine, was designed and synthesized, which consists of a brain targeted ligand, N,N-dimethyl amino group, and two dipivaloyloxy groups for lipophilic modification. PDDP was investigated both in vitro and in vivo by comparing with L-DOPA and another derivative (BPD) without N,N-dimethyl amino group. PDDP showed a more pronounced accumulation in mouse brain microvascular endothelial cells (bEnd.3) than BPD via an active transport process. The increased cellular uptake of PDDP was proven to be mediated by putative pyrilamine cationic transporters. Following intravenous administration, the concentration of PDDP in the brain was 269.28-fold and 6.41-fold higher than that of L-DOPA and BPD at 5 min, respectively. Additionally, PDDP effectively attenuated the striatum lesion caused by 6-hydroxydopamine (6-OHDA) in rats. More importantly, PDDP presented antioxidant and antiapoptotic effects on 6-OHDA-induced toxicity in human neuroblastoma cells (SH-SY5Y). Thus, N,N-dimethyl amino group-based PDDP represents an effective and safe treatment for PD.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Binhang Wang,Libo Sun,Tong Wang,Yujie Cao,Xiang Li,Wenhao Xu,Jie Zhang,Yun Tang
Ordered mesoporous Metal-Organic Frameworks ( meso MOFs), integrating mesopores and micropores, address mass transfer limitations characteristic of microporous materials, thus broadening their application spectrum. However, the synthesis of meso MOFs has been predominantly achievable in aqueous media, rather than in organic solvents, which are more conducive to the growth and stabilization of MOFs. This is primarily attributed to the challenge in forming stable and uniform micelles from block copolymers within organic systems. In this work, meso MOFs are synthesized within N,N-dimethylformamide (DMF) media for the first time, via a micellar microphase separation method facilitating by introducing trace water into the organic solvent DMF. These meso MOFs, featuring non-exposed spherical mesopores and inherent microporosity, demonstrate significantly enhanced performance in the accumulation of reactants, and such characteristics render these materials ideal nanoreactors, endowing them with superior adsorption and degradation capabilities. The adsorptive and degradation removal of tetracycline (TC) by m MIL-101 reached 93.7 %, with its efficiency in both adsorption and degradation of TC being significantly higher than that of traditional MIL-101. This synthetic approach expands the scope of meso MOFs preparation in organic solvents, providing insights for designing a new generation of meso MOFs with diverse compositions and structures, promising applications across various fields and advancing MOF-based technologies.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Xu Liu,Yuheng Zhao,Jun Ma,Yimo Zhang,Hui Zhang,Zhongqing Liu,Yuefeng Liu
The catalytic oxidation of H 2 S into element sulfur using nanocarbon materials is an effective means to solve environmental pollution and realize resource utilization of sulfur. Defect engineering and heteroatom doping are effective strategies for tuning the electronic structure of carbon materials to enhance their catalytic performance. Therefore, rationally exploiting the synergistic effects between defects and heteroatom sites, and elucidating the underlying catalytic mechanisms are essential for the development of high-performance carbon-based catalysts. In this study, we design and synthesize a series of N-doped carbon catalysts containing structural defects, which exhibit significantly enhanced desulfurization performance. Experimental results demonstrate that the NDC-700 catalyst exhibits excellent catalytic activity (95.0% H 2 S conversion and 94.4% S selectivity at 190 °C) and stability (>80 h) while maintaining high performance with high O 2 partial pressures and in the presence of impurity gases such as steam, CO 2 , and CO under mild conditions in continuous mode (≤ 200 °C). XPS analysis, kinetic studies, and oxygen activation experiments reveal that the catalytic performance improves with increasing defect density, despite a decrease in pyridinic N content. DFT calculations further indicate that defect structures substantially alter the local charge distribution around pyridinic N sites, promoting the adsorption and activation of H 2 S and O 2 , ultimately improving catalytic performance. This study elucidates the synergistic interaction between defects and N sites, and further confirms the critical role of defects in enhancing the catalytic function of N-doped carbon materials.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Linsen Li,Zhuwei Yang,Xiao Yang,Hui Xiong,Zhao Jiang,Tao Fang
Liquid organic hydrogen carriers (LOHCs) are considered as promising candidates for large-scale hydrogen storage, which offers significant advantages in terms of hydrogen storage density, ease of storage and transportation. NPhCZ (N-phenylcarbazole)/18H-NPhCZ (perhydro-N-phenylcarbazole) is proposed as a typical system with high hydrogen storage capacity. However, low dehydrogenation activity and selectivity of catalysts restrict the cyclic efficiency of hydrogen storage. In this study, the efficient catalysts are designed by the immobilization of ultrafine, highly dispersed Pd nanoparticles onto Ni, N co-doped carbon materials through wet chemical reduction. The Pd/Ni@NC-10 catalyst exhibits the highest catalytic performance with 100 % conversion, 81.9 % selectivity of NPhCZ and 6.48 wt% hydrogen release amount. Combined with XRD, HRTEM, Raman, XPS, H 2 -TPR, N 2 physisorption characterization methods and DFT calculations, it is found that the doped Ni, N species could synergistically increase the dispersion of loaded Pd nanoparticles, as well as regulate the electronic state around Pd, which in turn accelerates the rate of the rate-limiting step. The evident interaction between Pd nanoparticles and Ni, N co-doped carbon brings the enhancement of dehydrogenation efficiency. Besides, the spent catalysts are measured by XRD, TEM, XPS and evaluated for the dehydrogenation reaction, indicating that Pd/Ni@NC-10 shows good structural stability, durability and recyclability. It provides practical guidance for the design of LOHCs dehydrogenation catalysts.
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INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Juping Yuan,Benkun Qi,Shuyi Li,Zhaoliang Cui,Yinhua Wan,Jianquan Luo,Zhenzhou Zhu
The increasing demand for sustainable filtration has driven the development of cellulose-based ultrafiltration membranes using green solvents. In the present study, microcrystalline cellulose (MCC) was dissolved in a co-solvent system combining N-methylmorpholine-N-oxide (NMMO) and a choline chloride (ChCl)/lactic acid (LA) deep eutectic solvent (DES) and cast into regenerated cellulose (RC) membranes via the nonsolvent-induced phase separation (NIPS). The effects of dope solution composition, preparation conditions, and post-treatment on membrane performance were systematically evaluated. Results indicated that dissolving 6 wt% MCC in an NMMO/DES mixture, with a mass ratio 80:20 (DES comprised ChCl and LA in a 1:2 molar ratio), followed by casting at 60 °C using a 300 μm knife gap, produced membranes with a permeability of around 30 L/m 2 ·h·bar (LMH/bar) and a bovine serum albumin (BSA) rejection rate of approximately 96 %. Replacing the water coagulation bath with a 40 % (v/v) ethanol aqueous solution increased permeability to about 46 LMH/bar while maintaining a high BSA rejection of about 93 %. Moreover, Hansen solubility parameters were utilized to assess the thermodynamic interactions among the polymer, solvent, and nonsolvent, elucidating their effect on membrane structure and performance. These findings highlight the potential of sustainable solvent system for fabricating RC membranes, thereby advancing sustainable filtration technologies.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 9
·1-17
·
IF 2.8
Zhang Rui,Ma Haihong,Zhou Zhengfa,Xu Weibing,Ren Fengmei
A modified silicone oil containing nitrogen, phosphorus, and sulfur was synthesized by the reaction of n-butyl thiophosphoric triamine (NBPT) and epoxidized silicone oil (ETSO), and named NBSO. The successful synthesis of NBSO was confirmed by Fourier infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). The flame retardant and smoke suppression properties of NBSO were investigated by open flame ignition method and cone calorimetry test (CCT). The results showed when the molar ratio of NBPT to ETSO was 1:1, the flame height of the modified silicone oil was significantly reduced, and compared with ETSO, the total smoke release (TSR) and the total heat release (THR) of NBSO was reduced by 67.6% and 68%, respectively. Thermogravimetric analysis (TGA), infrared thermogravimetric coupling (TG-IR), thermal field emission scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) techniques were used to analyze the mechanism of flame retardant and smoke inhibition. The results indicate that compared with ETSO. NBSO has a slower thermal decomposition rate and releases less flammable gas.In the condense phase, nitrogen, phosphorus, silicon, and sulfur could improve the carbon forming ability through synergistic effect. At the same time, a silicon oxide layer was formed on the outer surface of the carbon layer, which could increase the flame retardation and smoke suppressing effect.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Fangshuo Jia,Yujuan Zhang,Xiaolong Ma,Zihao Zheng,Fuqiang An,Tuoping Hu
Water electrolysis coupling methanol oxidation is an energy-efficient hydrogen generation technology, while obtaining high-value formic acid, however, superior catalysts are often required to achieve efficient hydrogen production. Herein, the n - n heterojunction (NiCo 2 S 4 -MoS 2 ) composed of NiCo 2 S 4 nanoparticles uniformly dispersed on ultrathin MoS 2 nanosheet arrays has been prepared through hydrothermal-pyrolysis process. At a current density (j) of 10 mA cm −2 , the potentials of NiCo 2 S 4 -MoS 2 for methanol oxidation reaction (MOR) and hydrogen evolution reaction (HER) are respectively 1.282 V and −36 mV with very high selectivity for formic acid. Importantly, under the same conditions, by using the n - n heterojunction as electrodes, the voltage (1.355 V) of the methanol electrolysis is 216 mV lower than that of the water electrolysis. Meanwhile, at higher j of 100 mA cm −2 , the voltage of the methanol electrolysis is only 6.8 % higher than the original after 150 h chronopotentiometry (CP) test. The outstanding performance of NiCo 2 S 4 -MoS 2 exceeds that previously reported in most literature, which is primarily attributed to the fact that the built-in electric field (BEF) derived from the Fermi level (E F ) difference between NiCo 2 S 4 and MoS 2 , accelerates the charge transfer, optimizes the electronic structure of the heterojunctions, and thus improving the electrical conductivity. Furthermore, MoS 2 nanosheet arrays with large specific surface area provide a fast charge/mass transfer channel, uniformly dispersed NiCo 2 S 4 and defect sites produce abundant active sites. And the superior hydrophilicity and aerophobicity of the heterojunction surface accelerate the reaction kinetics. Finally, density functional theory (DFT) calculations show that the formation of the heterojunction optimizes the electron density and d-band center of composites, thus enhancing H* adsorption and CH 3 OH dehydrogenation kinetics.
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WATER RESEARCH
·
2025
·
IF 12.4
Jung-Hyun Son,Wen-Long Wang,Peng-Hui Liu,Hang Su,Ju-Won Lee,Min-Yong Lee,Qian-Yuan Wu
This study investigates the enhancement of ozonation efficiency through the introduction of manganese ions (O 3 /Mn(II)) that significantly improve the degradation of ozone-persistent organic pollutants. Manganese ions accelerate hydroxyl radical generation by catalyzing ozone decomposition, thereby facilitating more effective oxidative reactions. The application of O 3 /Mn(II) to degrade N, N-Diethyl-3-toluamide (DEET) achieved a decomposition efficiency of 3.6 to 4.1 times higher than ozonation alone. The promotive effect was highly pH-dependent, with the observed rate constant ( k obs ) for O 3 /Mn(II) reaching 97.05 M −1 s −1 at pH 4, approximately 3.3 times greater than ozonation alone, and 686.93 M −1 s −1 at pH 7, around 1.7 times higher. O 3 oxidation contributed approximately 1% to the overall process, while hydroxyl radicals accounted for approximately 80%, and manganese species accounted for approximately 20%. Furthermore, the oxidation state of manganese significantly influenced the cooperative oxidation efficiency, with Mn(VII) achieving the highest k obs (680.87 M −1 s −1 ), while Mn(IV) exhibited the lowest (304.6 M −1 s −1 ). Additionally, intermediate products formed during DEET oxidation were identified using Orbitrap technology, elucidating various degradation pathways (such as decarboxylation, tri-hydration, and aromatic ring opening). These findings provide valuable insights into enhancing ozonation processes for environmental remediation.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 2
·B49
·
IF 3.12
Di Liu,Fangxin Hu,Han Zhang,Cong Zhang,Shihong Chen
A sandwich electrochemiluminescence (ECL) biosensing system for soybean agglutinin (SBA) detection was developed with AuPt@C60 nanoflowers (AuPt@C60 NFs) as a novel co-reactant accelerator to enhance the performance of N-(aminobutyl)-N-(ethylisoluminol) (ABEI). In this strategy, nanoflower-liked AuPt@C60 complex served as a matrix for loading a large sum of ABEI and galactosamine (Gal) by Au-N and Pt-N bonds to achieve the nanocomposite Gal-ABEI-AuPt@C60 NFs. Dissolved oxygen was used as a co-reaction reagent, while AuPt@C60 complex acted as a co-reactant accelerator for dissolved oxygen to enhanced the ECL emission of ABEI. Gal, as an identifying element, was highly loaded by electrodeposited gold nanoparticles (Dp Au) on the electrode to recognize SBA, and further combine with Gal-ABEI-AuPt@C60 NFs to form a sandwich model. As a result, the proposed SBA biosensor exhibited a wide linear range from 1.0 ng·mL−1 to 5.0 μg·mL−1 and a low detection limit of 0.33 ng·mL−1. In addition, the biosensor displayed an excellent selectivity and an acceptable stability and reproducibility. The combination of AuPt@C60 NFs and ABEI provided a new ECL sensing platform without exogenous co-reactant.
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MEDICINAL CHEMISTRY RESEARCH
·
2019
·Vol. 28
·期 9
·1388-1401
·
IF 1.72
Chen Xin,Liu Xiujie,Qiu kai,Xu Xiang,Li Caiwen,Wang Yan
According to the bio-isosterism theory, a series of N , N ’-disubstitutedphenyl-4-ethoxylbenzene-1, 3-disulfonamides ( 5a - p ) were designed and synthesized by two steps of reactions including chlorosulfonation and ammonolysis. The structures of all compounds have been confirmed by IR, 1 H-NMR, 13 C-NMR, and ESI-MS spectra. The in vitro anti-platelet aggregation activities were evaluated by Born’s test induced by adenosine diphosphate (ADP) and arachidonic acid (AA), respectively. The biological evaluation results revealed that compound 5h had the lowest IC 50 value (0.32 μM) and the highest inhibition rate (40.9 %) that of three positive control agents clopidogrel (0.41 μM, 23.5 %), aspirin (0.53 μM, 28.9 %), and picotamide (0.76 μM, 32.7 %). Afterwards, compounds with higher activities were selected to further study in vitro cytotoxicity via cell counting kit-8 (CCK-8) assay. The cytotoxicity results indicated that compound 5h had simultaneously the lowest cytotoxicity, while other compounds had no significant relationship between the anti-platelet activities and cytotoxicities. Based on above in vitro anti-platelet activity data, the SAR (Structure Activity Relationship) of the target compounds was preliminarily summarized. In general, N , N ’-disubstitutedphenyl-4-ethoxylbenzene-1, 3-disulfonamides have the potential of further study and very likely become safer and more effective anti-platelet agents.
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MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
·
2020
·
IF 2.506
Xingchen Liu,Yihan Liu,Qi Cao,Ying Wu,Xueyun Huo,Xiaoyan Du,Zhenwen Chen
Age is an important factor in the evaluation of chemical toxicology. Chemical carcinogenic compounds can induce genomic mutations. However, few studies have been conducted on the association between genomic mutation frequency, such as microsatellite instability (MSI), and the age of mice treated with a nitrosourea mutagen. In the current work, we treated young (6 weeks) and old (10 months) mice with N -methyl- N -nitrosourea (MNU) for 4 months; the MSI frequency was then measured using polymerase chain reaction (PCR) and short tandem repeat (STR) scanning. The percentage of animals with MSI in the old group was significantly higher than that in the young group (100% and 75%). The frequency of MSI events was significantly different between the two groups as well (15.8% for old and 9.4% for young). The ratio of MSI loci displayed no obvious difference between the two groups. In addition, a few loci, including D15Mit5 and D8Mit14 exhibited the highest frequency of MSI events. Since specific loci showed increased MSI in the present study and a higher frequency in previous studies, these loci could be regarded as “hot spot”. These results suggested that old mice would be more susceptible to this mutagen, and prone to accrue MSI. The hot spot microsatellite loci are potentially useful markers for genomic instability analysis.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jingwei Zhu,Yu Liu,Benlin He,Wenyu Zhang,Lifang Cui,Sudong Wang,Haiyan Chen,Yanyan Duan,Qunwei Tang
The back interface issues including numerous defects and imperfect contact, mismatched energy level are regarded as the key detrimental factors causing serious charge recombination and energy loss ( E loss ) and inferior charge extraction to achieve high efficiency Hole transport materials-free (HTMs-free) carbon-based Perovskite solar cells (PSCs). To address this drawback, an effective interface engineering via depositing N, N'-Dicyclohexylcarbodiimide (DCC) at PVSK/Carbon back interface is creatively implemented to passivate CsPbBr 3 surface defects through forming interaction between N atoms with lone pair electrons and uncoordinated ions (eg Pb 2+ and Cs + ions) to suppress the defect states induced non-radiative recombination and E loss . Concurrently, the smoothness and valence band of PVSK film with DCC modification are increased to improve the contact and band alignment at back interface, respectively, remarkably accelerating hole extraction and transportation and also reducing E loss as well as charge recombination. As a result, the comprehensive performance of DCC interface modified HTMs-free carbon-based CsPbBr 3 PSCs is significantly enhanced, especially the champion efficiency boosts to 10.16% from 6.60% of the control PSC. Furthermore, owing to the enhanced hydrophobicity and decreased imperfections of PVSK film with DCC modification, the optimized device without any encapsulation displays an excellent long-term stability under 85% RH air condition at 85 °C over 1200 h.
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