CHINESE JOURNAL OF POLYMER SCIENCE
·
2013
·Vol. 31
·期 4
·691-701
·
IF 1.27
Tan Lin,Xing Jin-xing,Cao Fu-hu,Chen Li-juan,Zhang Chong,Shi Rong-hua,Wang Yan-mei
A series of double-hydrophilic double-grafted PMA- g -PEG/PDMA copolymers, which contained poly(methacrylate) (PMA) as backbone, poly(ethylene glycol) (PEG) and poly( N,N -dimethylacrylamide) (PDMA) as side chains synthesized successfully by using reversible addition-fragmentation chain transfer (RAFT) polymerization and atom transfer radical polymerization (ATRP), were used as physical coatings for the evaluation of protein-resistant properties by capillary electrophoresis (CE). Electroosmotic flow (EOF) measurement results showed that the PMA- g -PEG/PDMA copolymer coated capillaries could suppress electroosmotic mobility in a wide pH range (pH = 2.8–9.8) and EOF mobility decreased with the increase of copolymer molecular mass and PDMA content. At the same time, protein recovery, theoretical plate number of separation and repeatability of migration time demonstrated that antifouling efficiency was improved with the increase of molecular mass and PEG content.
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BIOMATERIALS
·
2013
·
IF 7.604
Zhiwei Li,Chao Wang,Liang Cheng,Hua Gong,Shengnan Yin,Qiufang Gong,Yonggang Li,Zhuang Liu
Magnetic targeting that utilizes a magnetic field to specifically delivery theranostic agents to targeted tumor regions can greatly improve the cancer treatment efficiency. Herein, we load chlorin e6 (Ce6), a widely used PS molecule in PDT , on polyethylene glycol (PEG) functionalized iron oxide nanoclusters (IONCs), obtaining IONC–PEG–Ce6 as a theranostic agent for dual-mode imaging guided and magnetic-targeting enhanced in vivo PDT. Interestingly, after being loaded on PEGylated IONCs, the absorbance/excitation peak of Ce6 shows an obvious red-shift from ∼650 nm to ∼700 nm, which locates in the NIR region with improved tissue penetration. Without noticeable dark toxicity, Ce6 loaded IONC–PEG (IONC–PEG–Ce6) exhibits significantly accelerated cellular uptake compared with free Ce6, and thus offers greatly improved in vitro photodynamic cancer cell killing efficiency under a low-power light exposure. After demonstrating the magnetic field (MF) enhanced PDT using IONC–PEG–Ce6, we then further test this concept in animal experiments. Owing to the strong magnetism of IONCs and the long blood-circulation time offered by the condensed PEG coating, IONC–PEG–Ce6 shows strong MF-induced tumor homing ability, as evidenced by in vivo dual modal optical and magnetic resonance (MR) imaging. In vivo PDT experiment based magnetic tumor targeting using IONC–PEG–Ce6 is finally carried out, achieving high therapeutic efficacy with dramatically delayed tumor growth after just a single injection and the MF-enhanced photodynamic treatment. Considering the biodegradability and non-toxicity of iron oxide, our IONC–PEG–Ce6 presented in this work may be a useful multifunctional agent promising in photodynamic cancer treatment under magnetic targeting.
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Polymer Chemistry
·
2015
·Vol. 7
·期 4
·899-904
·
IF 5.52
Kaikai Ding,Liyan Shi,Ling Zhang,Tian Zeng,Yihua Yin,Ying Yi
A novel amphiphilic polymer–pesticide conjugate was synthesized by conjugation of PEG with the photolabile o-nitrobenzyl group followed by grafting dichlorophenoxyacetic acid (2,4-D), which can self-assemble into photoresponsive micelles in aqueous solutions for a controlled release of the herbicide. 1H NMR and FT-IR confirmed the structure of the synthesized conjugate. TEM observations showed that the micelles had a core–shell configuration. DLS and TEM measurements showed that the average diameters of the micelles decreased by about 40 nm after 365 nm UV irradiation. 1H NMR and UV-Vis studies confirmed that the photoresponse may be ascribed to the photolytic cleavage of o-nitrobenzyl as the connecting arm in the polymeric chain. No release of the micelles was detected without light, while the cumulative release rate from the micelles increased gradually upon solar-simulating radiation, reaching 99.6% in 8 h.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Li Piao,Peng Xiang,Yangyang Zhou,Wei Zhao,Ting Yang,Shan Xia,Guanghui Gao,Kexin Chen,Dan Li
Overexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive hydrogel. The hydrogel is a triblock copolymer composed of polyethylene glycol (PEG) and poly (lactide glycolide) (PLGA). Based on the excellent temperature sensitivity, carrier capacity, swelling property and biocompatibility, the hydrogel can absorb the liquid around the tumor by injection and release EGF continuously at low concentration. The inhibitory effect of hydrogel on tumor growth is fully confirmed by an implanted tumor mouse model with human cervical cancer cell lines (HeLa) using triple-immunodeficient NCG mice. Compared with free EGF, the EGF-loaded hydrogel can hardly induce surface plasmon resonance (SPR) response, which proves that hydrogel can effectively weaken cytoskeleton rearrangement and inhibit cell migration by continuously releasing low concentration EGF. In addition, the EGF-loaded hydrogel can reduce cell proliferation by delaying the progress of cell cycle progression. Taken together, the hydrogel can effectively protect tumor microenvironment from the stimulation of high concentration EGF, delay cancer cellular processes and tumor growth, and thus providing an approach for inhibiting tumor recurrence of CC.
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Journal of Pharmaceutical Investigation
·
2024
·
IF 5.3
Zhou Limei,Shang Yunxia,Wang Yaru,Wei Xiaohui
Purpose Ulcerative colitis (UC) is a chronic and non-specific inflammatory bowel disease that poses a serious threat to individuals' health and lives. Notoginsenoside R1 (R1) alleviates various symptoms caused by UC effectively. However, the application of R1 is somewhat restricted due to its low bioavailability and nontargeted delivery in vivo. Consequently, it is imperative to develop novel strategies to overcome the aforementioned limitations and enhance the efficacy of this drug. To enhance R1's efficacy and targeting ability, polyethylene glycol poly (lactic-co-glycolic acid) nanoparticles loaded with R1 (R1@PEG–PLGA NPs) modified by transferrin (Tf) were prepared in this study and named R1@Tf–PEG–PLGA NPs. Methods R1@PEG–PLGA NPs and R1@Tf–PEG–PLGA NPs were prepared through nanoprecipitation, and the characterization methods were as follows: First, the surface morphology of the NPs was studied through transmission electron microscopy. Second, particle size, polydispersity index (PDI), and zeta potential were measured with a Malvern particle size analyzer, and the Tf grafting rate on the surface of the NPs was determined by using a bicinchoninic acid protein quantification kit. Third, high-performance liquid chromatography was used in determining the drug load (DL), entrapment efficiency (EE), and in vitro release of the prepared preparation. In addition, the fluorescence intensities of fluorescent-labeled NPs absorbed and ingested in Caco-2 cells were observed through in vitro experiments using fluorescence microscopy; the effects of incubation time, incubation temperature, and endocytosis inhibitors on the uptake of nanoparticles were compared; and the uptake-transport mechanism was explored. Finally, in vivo experiments were performed using the oxazolone (OXZ)-induced UC model in Sprague–Dawley (SD) rats to assess the pharmacodynamic effects and tissue distribution of the prepared NPs. Results The experimentally prepared R1@Tf–PEG–PLGA NPs were round particles with particle size and PDI of 153.50 ± 2.01 and 0.11 ± 0.01, respectively. In addition, the DL of R1@Tf-PEG-PLGA NPs was 24.26% ± 0.18%, and the EE was 50.32% ± 0.86%. Furthermore, R1@Tf–PEG–PLGA NPs had a slower cumulative release rate in vitro than R1 and R1@PEG–PLGA NPs. Fluorescence results showed that under the same conditions, Caco-2 cells took up more Tf-PEG–PLGA NPs than they took up PEG–PLGA NPs. Studies on the cellular uptake mechanism of absorption and uptake determined that the PEG–PLGA NPs entered the cells mainly through fovea-mediated endocytosis, whereas the Tf–PEG–PLGA NPs entered the cells mainly through fovea-mediated and lattice protein-mediated endocytosis. In vivo intestinal tissue distribution results in OXZ-induced SD rats showed that R1@Tf–PEG–PLGA NPs were more enriched in the colon than R1 and R1@PEG–PLGA NPs, and pharmacodynamic evaluation showed that R1@Tf–PEG–PLGA NPs exhibited more pronounced effects in ameliorating colonic injury. Conclusion R1@Tf–PEG–PLGA NPs showed significant colonic targeting and anti-UC effect, showing promising applications.
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ChemistrySelect
·
2025
·Vol. 10
·期 46
·e04751
·
IF 2
Zhiyan Ma,Like Dou,Hai Liang,Weifang Han
Phase change materials (PCMs) typically exhibit low thermal conductivity (TC) and limited light absorption, which restrict their application in solar thermal utilization. In this study, boron nitride microrod-supported copper (Cu@BNR) was developed as a multifunctional filler and incorporated into polyethene glycol (PEG) to fabricate PEG-based composite PCMs. The incorporation of Cu promotes the formation of a continuous thermal network and enhances photothermal conversion capability. Due to this unique structure, the PEG/Cu@BNRs composite containing 10 wt% Cu@BNRs achieves a TC of 1.344 W·m −1 K −1 , representing 5.1-fold and 2.2-fold increase compared to pure PEG and PEG/BNRs, respectively. Under simulated sunlight (100 mW cm −2 ), the PEG/Cu@BNRs composite reaches a photothermal conversion efficiency of 91.2% and demonstrates excellent shape stability and cycling reliability. As a thermal interface material in LED systems, the PEG/Cu@BNRs composite significantly reduces operating temperatures, confirming its practical thermal management capabilities. Consequently, the prepared composite PCMs integrate solar energy conversion, efficient heat conduction, and thermal storage functions, making them suitable for sustainable energy applications. Graphical Boron nitride microrod-supported copper (Cu@BNR) was developed as a multifunctional filler and incorporated into polyethene glycol (PEG) to fabricate PEG-based composite PCMs. The PEG/Cu@BNRs composite PCMs exhibit excellent heat transfer performance and high photothermal conversion efficiency.
研究领域:
材料科学
·
纳米技术
·
能量转换
·
热管理
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Plants-Basel
·
2023
·Vol. 12
·期 12
·2296
·
IF 4.5
Ying Qi,Lingling Ma,Muhammad Imran Ghani,Qiang Peng,Ruidong Fan,Xiaojing Hu,Xiaoyulong Chen
Passion fruit is known to be sensitive to drought, and in order to study the physiological and biochemical changes that occur in passion fruit seedlings under drought stress, a hypertonic polyethylene glycol (PEG) solution (5%, 10%, 15%, and 20%) was used to simulate drought stress in passion fruit seedlings. We explored the physiological changes in passion fruit seedlings under drought stress induced by PEG to elucidate their response to drought stress and provide a theoretical basis for drought-resistant cultivation of passion fruit seedlings. The results show that drought stress induced by PEG had a significant effect on the growth and physiological indices of passion fruit. Drought stress significantly decreased fresh weight, chlorophyll content, and root vitality. Conversely, the contents of soluble protein (SP), proline (Pro), and malondialdehyde (MDA) increased gradually with the increasing PEG concentration and prolonged stress duration. After nine days, the SP, Pro and MDA contents were higher in passion fruit leaves and roots under 20% PEG treatments compared with the control. Additionally, with the increase in drought time, the activities of antioxidant enzymes such as peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) showed an increasing trend and then a decreasing trend, and they reached the highest value at the sixth day of drought stress. After rehydration, SP, Pro and MDA contents in the leaves and roots of passion fruit seedlings was reduced. Among all the stress treatments, 20% PEG had the most significant effect on passion fruit seedlings. Therefore, our study demonstrated sensitive concentrations of PEG to simulate drought stress on passion fruit and revealed the physiological adaptability of passion fruit to drought stress.Keywords:Passiflora edulisSims;drought stress;hypertonic polyethylene glycol;physiological characteristics
研究领域:
植物生理学
·
农学
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Nanomaterials
·
2025
·Vol. 15
·期 24
·
IF 4.3
Sixing Zhang,Guangyao Zhao,Zhen Li,Zhehui Zhao,Jiakang Yao,Geng Qiao,Zongkun Chen,Yuwei Wang,Donghui Zhang,Yu Han
With the advancement of new power systems, phase-change materials (PCMs), owing to their ability to convert and store electrical energy, are increasingly recognized as a key solution to the intermittency of power supply. Nevertheless, such materials face challenges, including leakage and low thermal conductivity, which lead to reduced utilization efficiency. In this study, guar gum was used as the macroscopic framework, while self-prepared and optimized silica aerogel microsheets served as the microscopic framework to synergistically encapsulate the polyethylene glycol (PEG). Titanium dioxide (TiO2) nanoparticles were incorporated to improve overall thermal conductivity, resulting in the composite PCM, GTS-PEG. In-depth characterization demonstrated effective PEG retention within the matrix, with a melting heat storage density of 164.16 J/g. Upon 30 min of continuous heating at 90 °C, the mass loss remained as low as 4.83%, indicating excellent thermal stability. The addition of TiO2increased thermal conductivity to 0.53 W/(m·K), representing a 140% boost over unmodified material. As a result, GTS-PEG not only successfully overcomes the leakage and thermal conductivity limitations of conventional PCMs but also, as a green and low-carbon innovative solution, paves a new path for the coordinated optimization and efficient conversion of power grid energy systems.
研究领域:
能源材料
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热能存储
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可持续能源系统
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纳米复合材料
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Shukai Cheng,Liuyan Zhu,Wanying Cui,Ran Hong,Maodong Xu,Zhenxia Song,Jian Zhao,Cuige Zhang,Chunmiao Xia,Rongli Zhang
Water-in-water (W/W) emulsions have emerged as a promising vehicle for delivering water-soluble compounds within food industry. However, in conventional W/W emulsions, the phase with a lower volume fraction typically serves as the dispersed phase, resulting in limited encapsulation capacity for bioactive substances. In this work, the relationships between the chemistry, wettability of chitosan-based colloidal particles (CS-based CPs), and the type, stability of W/W emulsion were investigated to gain deep insight into the phase inversion mechanism within a dextran-polyethylene glycol (Dex-PEG) aqueous two-phase system (ATPS) at a molecular level. The results demonstrated that the type of W/W emulsions can be tailored through manipulating the chemistry and wettability of CS-based CPs, independent of altering the phase volume ratios. Finally, highly dispersed phase emulsions (HDPEs) with Dex as the dispersed phase in PEG (D/P HDPEs) were fabricated by tuning the chemistry and wettability of CS-based CPs, which were then employed for the encapsulation of riboflavin. The encapsulation capacity significantly improved from 25 % (traditional W/W emulsions) to 66.7 % (D/P HDPEs stabilized by CS-based CPs). The fabrication of D/P HDPEs offers a novel strategy for delivering water-soluble bioactive substances with high encapsulation capacity, showing strong potential for applications in low-fat, low-calorie functional foods.
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DRUG DELIVERY
·
2017
·
IF 6.402
Xiao Hu,Feifei Yang,Yonghong Liao,Lin Li,Lan Zhang
This study investigated cholesterol–polyethylene glycol (PEG) comodified poly (ethyleneglycol)-poly (lactide) nanoparticles (CLS-PEG NPs) as a novel, biodegradable brain drug delivery system and included an evaluation of its in vitro and in vivo properties. To this end, coumarin-6 (C6), a fluorescent probe, was encapsulated into CLS-PEG NPs by an emulsion polymerization method. We reported that the use of CLS-PEG NPs led to a sustained drug release in vitro. Additionally, cell viability experiments confirmed their safety. The uptake and transport of CLS-PEG NPs, by bEnd.3 cells (an immortalized mouse brain endothelial cell line), was significantly higher than that of a control C6 solution. An investigation of the uptake mechanisms of different NP formulations demonstrated that cholesterol modifications may be the primary way to improve the efficiency of cellular uptake, wherein macropinocytosis may be the most important endocytic pathway in this process. An investigation of the transport mechanisms of CLS-PEG NPs also implicated macropinocytosis, energy and cholesterol in bEnd.3 cells lines. Following an intravenous (IV) administration to rats, pharmacokinetic experiments indicated that C6-loaded CLS-PEG NPs achieved sustained release for up to 12 h. In addition, IV delivery of CLS-PEG NPs appeared to significantly improve the ability of C6 to pass through the blood–brain barrier: the concentration of C6 found in the brain increased nearly 14.2-fold when C6 CLS-PEG NPs were used rather than a C6 solution. These in vitro and in vivo results strongly suggest that CLS-PEG NPs are a promising drug delivery system for targeting the brain, with low toxicity.
研究领域:
药剂学
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神经科学
·
生物医学工程
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Ping Wen,Qianqian Yan,Rui Dong,Yunyan Han,Ran Fang,Mingjin Fan
Severe competition between nanolubricant additives and polar lubricating oil molecules for the formation of lubricant films has been hindering the progress of green and advanced lubricants. In this work, based on the tautomerism of cyanuric acid molecule (trione and triol configurations), two kinds of triazine-based covalent–organic frameworks (COFs), that is, Ton-COFs and Tol-COFs, were synthesized as additives of the polar PEG 400 oil, realizing compromise between them by providing delicate interactions. The triazine matrix bonding with intense polar groups in the framework of additives offers more powerful interactions to competitively form the adsorbed lubricant film on the surface of the metal substrate over PEG 400 oil and also bolts PEG 400 oil molecules by the hydrogen bonding inside the pore of the framework to cooperatively bear against the load. Molecular quantum chemical calculations further confirm that Ton-COFs can produce a more intense interaction with Fe atoms in the form of coordination and ions···π than Tol-COFs, far beyond PEG 400, and the cross-sectional profile of the worn surface definitely exhibits a protective lubricant film only composed of Ton-COFs. Consequently, at the low concentration of 0.3 wt %, the excellent friction reduction (41.2%) and antiwear property (97.4%) are achieved for the Ton-COFs compared to pure PEG 400 oil; moreover, 28.6% and 79.0% for Tol-COFs at the essential concentration of 0.7 wt % are achieved. This finding provides a novel insight from molecules to materials into guiding the development of additives for advanced lubricants.
研究领域:
材料科学
·
润滑工程
·
量子化学
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2011
·
IF 2.78
Zhiyun Zhang,Jianchun Wang,Qin Tu,Nan Nie,Jun Sha,Wenming Liu,Rui Liu,Yanrong Zhang,Jinyi Wang
The current paper reports the synthesis of a highly hydrophilic, antifouling dendronized poly(3,4,5-tris(2-(2-(2-hydroxylethoxy)ethoxy)ethoxy)benzyl methacrylate) (PolyPEG) brush using surface initiated atom transfer radical polymerization (SI-ATRP) on PDMS substrates. The PDMS substrates were first oxidized in H 2 SO 4 /H 2 O 2 solution to transform the Si–CH 3 groups on their surfaces into Si–OH groups. Subsequently, a surface initiator for ATRP was immobilized onto the PDMS surface, and PolyPEG was finally grafted onto the PDMS surface via copper-mediated ATRP. Various characterization techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy, and X-ray photoelectron spectroscopy, were used to ascertain the successful grafting of the PolyPEG brush onto the PDMS surface. Furthermore, the wettability and stability of the PDMS–PolyPEG surface were examined by contact angle measurements. Anti-adhesion properties were investigated via protein adsorption, as well as bacterial and cell adhesion studies. The results suggest that the PDMS–PolyPEG surface exhibited durable wettability and stability, as well as significantly anti-adhesion properties, compared with native PDMS surfaces. Additionally, our results present possible uses for the PDMS–PolyPEG surface as adhesion barriers and anti-fouling or functional surfaces in biomedical applications.
研究领域:
材料科学
·
生物医学工程
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高影响因子
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