Small
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2018
·Vol. 14
·期 31
·1800785
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IF 9.598
Luming Xu,Jia Liu,Jiangbo Xi,Qilin Li,Bingcheng Chang,Xianming Duan,Guobin Wang,Shuai Wang,Zheng Wang,Lin Wang
Despite the therapeutic usefulness of near-infrared irradiation (NIR)-induced potent photothermal effects (PTE) and photodynamic effects (PDE), they inevitably damage normal tissues, often posing threat to life when treating tumors adjacent to key organs or major blood vessels. In this study, the frequently overlooked, “weak” PTE and PDE (no killing capability) are employed to synergize chemotherapy against multidrug resistance (MDR) without impairing normal tissues. An NIR-responsive nanosystem, gold (Au)-nanodot-decorated hollow carbon nanospheres coated with hyaluronic acid, is synthesized as a doxorubicin (DOX) carrier with excellent photothermal and photodynamic properties. Upon low-level infrared irradiation, the mild heat of weak PTE moderately boosts DOX unloading, meanwhile the weak PDE moderately disturbs the P-glycoprotein function for retaining intracellular DOX by impairing mitochondrial ATP production. These two “moderate” alterations are quantitatively and functionally sufficient to augment the efficacy of chemotherapy in reversing MDR without damaging neighboring tissue. Thus, this work creates a gold-dot-decorated nanocarbon spheres based nanosystem for trimodal therapy, reveals the therapeutic value of the frequently ignored weak PTE/PDE, and demonstrates that synergizing with chemotherapy to overcome drug resistance does not necessarily require potent PTE/PDE.
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JOURNAL OF CONTROLLED RELEASE
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2025
·
IF 11.5
Xiaoyu Cheng,Chunling Wang,Junchao Xu,Yubiao Huang,Zhuo Chen,Liyue Zhong,Chong Du,Guangjun Nie,Yinlong Zhang
Antithrombotic drugs are widely used to prevent thrombotic events in patients with cardiovascular diseases. However, they all carry varying degrees of bleeding risk. Currently, there are no approved reversal agents for antiplatelet medications, which limits their further clinical application and poses challenges in managing bleeding complications. In this proof-of-concept study, we explore the feasibility of a reversal agent system using ticagrelor and a corresponding liposome-based antidote. Specifically, we developed an azide-functionalized ticagrelor derivative (Tic-N 3 ) and a clickable DBCO-modified liposome (Lipo-DBCO) to enable controlled reversal of antiplatelet activity. Our findings demonstrate that the azide modification does not compromise the antiplatelet efficacy and biocompatibility of ticagrelor. The antiplatelet effects of Tic-N 3 were successfully reversed by Lipo-DBCO, as validated through platelet aggregation assays and in vivo mouse models of tail bleeding and liver injury. Additionally, we investigated the thiol-maleimide pairing as an alternative system, enhancing the versatility of our approach. This strategy reveals the possibility and clinical application prospects of antiplatelet drug reversal agents, offering a promising solution for the safe management of bleeding risks associated with antiplatelet therapy.
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TOXICON
·
2024
·
IF 2.6
Xuelin Chen,Kun Zhang,Hanlei Wang,Xia Zhao,Yumei Zhang
Kochiae Fructus (KF) is a traditional Chinese medicine, which has been used to delay aging and treat inflammation, such as rubella, eczema, cutaneous pruritus, etc . In order to fully understand the traditional medicinal value of KF, we evaluated the antioxidant properties and oral safety of its ethanolic extract. Considering flavonoids and phenolics in medicinal plants generally have strong antioxidant activity, we firstly detected the total flavonoids and phenolics contents of KFEE and its fractions. Secondly, we evaluated the antioxidant activities of KFEE and its fractions. Finally, we evaluated the oral safety of KFEE by the acute and 28-day subacute toxicities. The n-butanol fraction (ENBF) possessed the highest phenolics and flavonoids with values of 77.30 ± 3.17 mg gallic acid equivalents/g and 228.81 ± 7.56 mg rutin equivalents/g, respectively. The results of antioxidant tests showed that ENBF possessed potent antioxidant ability. Among them, the high antioxidation capacity observed in ENBF could be attributed to its rich content of flavonoids and phenolics. The results of toxicological studies showed that the LD 50 value of KFEE was 6000 mg/kg BW, and the no observed adverse effect level (NOAEL) of KFEE was 600 mg/kg BW. According to the standards of the American Academy of Sciences for the classification of toxic substances, KFEE can be classified as practically non-toxic substance, which provided valuable evidence for the oral safety of KF as a natural aging delay medicine.
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
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2024
·
IF 1.7
Zhang Chao,Wen Tingchi,Qiao Lijun,Guo Ming,Li Qihua,Lu Zhenghua,Zhu Zhenyuan,Lu Meiling
Honokiol (HK) is an active compound in the traditional Chinese medicine Magnolia officinalis , which has antibacterial and disease-resistant effects on pathogenic microorganisms. However, due to its poor water solubility, its application is severely limited. In this study, Methyl-β-Cyclodextrin (M-β-CD) was used to encapsulate honokiol to improve its water solubility. The inclusion complex of HK with M-β-CD (HK/M-β-CD IC) were prepared by freeze-drying method, Phase solubility studies indicate that HK with M-β-CD forms inclusion complex in a stoichiometric ratio of 1:1. However, considering that the inclusion process is reversible. In order to obtain inclusion complex with higher encapsulation efficiency, we use response surface optimization to optimize the encapsulation process. The encapsulation efficiency of the obtained inclusion compound is 87.64%.The structure of inclusion complex was characterized by FTIR, TGA, SEM, XRD and NMR. The molecular docking was used to predict the structure of inclusion complex. In addition, compared with free HK, the solubility of the inclusion complex in water was significantly enhanced, about 1228 times that of the free HK. And it enhances the antibacterial activity against Trichoderma koningii .
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Yingjian Ma,Junyao Li,Qinshu Yang,Fengyu Li,Lei Wang,Pengkun Yan,Xinyu Guo,Rui Zhao,Yucheng Gu,Yong Xu,Xuemin Wu
Based on the modified cross-linking of the degradable natural polymers chitosan oligosaccharides (COS) and gelatin (GEL) via introduction of a functional bridge 3,3′-dithiodipropionic acid, this study constructed an environmentally responsive dinotefuran (DNF) delivery system (DNF@COS-SS-GEL). The introduction of the disulfide bond (−S–S–) endowed DNF@COS-SS-GEL with redox-responsive properties, allowing for the rapid release of pesticides when stimulated by glutathione (GSH) in the simulated insect. Compared with commercial DNF suspension concentrate (DNF-SC), DNF@COS-SS-GEL showed superior wet spreading and retention performance on cabbage leaves with a reduced contact angle (57°) at 180 s and 4-fold increased retention capacity after rainfall washout. Nanoencapsulation effectively improved the UV-photostability with only a 31.4% decomposition rate of DNF@COS-SS-GEL at 96 h. The small scale and large specific surface area resulted in excellent uptake and transportation properties in plants as well as higher bioactivity against Plutella xylostella larvae. This study will help promote sustainable agricultural development by reducing environmental pollution through improved pesticide utilization.
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Small
·
2025
·
IF 12.1
Ren-Yi Sun,Fang Wang,Yi Tan,Jin-Le Li,Zhi-Shuo Jiang,Cong Deng,Fei Song,Yu-Zhong Wang
Photothermal hydrophobic surfaces offer a promising solution for mitigating ice hazards under low-temperature, high-humidity conditions via solar-driven de-icing. However, surface contamination can compromise photothermal efficiency, while fabric-applicable coatings must also provide flexibility, breathability, durability, and safe thermal regulation (≈50 °C). Current systems require further optimization to balance these demands for practical use. Here, a nanorod-embedded photothermal strategy is presented that integrates superhydrophobicity, anti-icing, and de-icing capabilities with environmental robustness in fabrics. The composite comprises a polypyrrole-loaded cellulose nanocrystal inner layer for photothermal conversion and a fluoroalkyl silane-modified silica top layer for superhydrophobicity. The synergy between hierarchical micro–nano roughness and photothermal activation enables an “external repellency, internal heating” mechanism, effectively overcoming the limitations of passive coatings. This dual-functional architecture achieves a solar absorption rate of 97.2% and reaches 53.1 °C under 100 mW cm⁻ 2 irradiation, while remaining safe for human contact and maintaining breathability (moisture permeability: 6.86 × 10 3 g·m⁻ 2 ·d⁻¹). It delays freezing by 417 s at −15 °C and reduces the melting time of an ice cube by 53.2% under 1-sun illumination. The fabric exhibits appreciable chemical stability, abrasion resistance, flexibility, and robustness under extreme conditions, ensuring long-term performance. This work offers a scalable solution for outdoor and personal protective equipment in cold environments.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jin Huang,Kai You,Xiangmei Liu,Yi Wang,Congyang Mao,Chaofeng Wang,Yufeng Zheng,Shengli Zhu,Zhaoyang Li,Hui Jiang,Zhenduo Cui,Jie Shen,Shuilin Wu
Periodontitis represents a chronic inflammatory disorder triggered by multi-species oral bacterial infection of periodontal tissues. If left untreated, this condition can culminate in severe consequences, including alveolar bone resorption and loss of tooth support architecture. Given these clinical challenges, the development of a safe and effective strategy for plaque elimination and dental whitening remains a critical unmet need in periodontal care. To address this, we report the design and fabrication of polyvinyl alcohol (PVA)-based hydrogel loaded with tannic acid @ nanocellulose nanoparticles (PTAN). This novel composite system demonstrates dual functionality: robust antibacterial activity and biocompatible teeth-whitening efficacy. Under ultrasonic irradiation, the cavitation-generated mechanical forces drive targeted attachment of tannic acid @ nanocellulose nanoparticles (TAN) to bacterial surfaces. This process induces bidirectional impact and frictional forces, rendering bacterial cell walls mechanically sensitive. Additionally, it promotes the production of hydroxyl radicals and singlet oxygen, while enhancing the transmission of tannic acid-mediated death signals to pathogens. Concurrently, the hydrogel's porous architecture synergizes with the polyphenolic binding capacity of tannic acid to pigmented substrates. This dual-mechanism enables efficient capture and adsorption of chromogenic molecules within the hydrogel matrix. Collectively, our findings establish PTAN hydrogel as a rapid, highly effective, and biocompatible strategy for simultaneous plaque removal and dental decolorization, offering promising translational potential for clinical periodontal therapy.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Wei He,Yawei Du,Chuncao Li,Ji Wang,Yang Wang,Con Dogovski,Rui Hu,Zhiyong Tao,Chen Yao,Xinsong Li
Artesunate (ARS) is the only artemisinin-based intravenous drug approved for treatment of malaria in the clinic. ARS is rapidly metabolized in vivo to short lived (∼30–45 min) but fast acting, dihydroartemisinin (DHA). The short half-life of DHA necessitates multiple dose administration to circumvent the risk of recrudescence and development of artemisinin resistance. In this work, we report a stable, safe and potent alternative artemisinin-based injectable nanocomplex consisting of dimeric artesunate-choline conjugate (dACC) micelles coated with hyaluronic acid (HA). Firstly, dACC was synthesized by one-step esterification of two artesunate molecules with 3-(dimethylamino)-1,2-propanediol followed by quaternization. After that, dACC was self-assembled into cationic nanomicelles and further coated with anionic small molecular weight HA. The HA-coated dACC nanocomplex (dACC/HA nanocomplex) has a narrow size distribution of about 30 nm. Hemolytic toxicity and cytotoxicity studies revealed a favorable bio-safety profile. Finally, in vitro and in vivo studies showed the dACC/HA nanocomplex possess superior safety and antimalarial efficacy compared to ARS. Taken together, the dACC/HA nanocomplex is a promising injectable alternative to the traditional clinically used artesunate.
研究领域:
药剂学
·
传染病学
·
纳米医学
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CONSTRUCTION AND BUILDING MATERIALS
·
2026
·
IF 8.9
Peike Wang,Chenxiao Dong,Guangliang Tan,Xiaohong Ma,Kang Kang,Guotao Sun
The development of sustainable and fire-safe thermal insulation materials is critical for enhancing building energy efficiency and safety. This study reports the fabrication of porous composites reinforced with fly ash-derived silica and nanocellulose/poly (vinyl alcohol) via directional freezing and vacuum-assisted impregnation. By adjusting the silicate modulus, the interfacial interactions and pore-wall reinforcement were controlled, resulting in improved mechanical strength, thermal resistance, and flame retardancy. The optimized composite exhibits a compressive strength of 22.6 MPa and achieves a UL-94 V-0 rating, indicating excellent structural stability and fire safety. Although its thermal conductivity (∼0.287 W/(m·K)) is higher than that of ultralight insulation materials, the composite provides moderate thermal resistance together with high mechanical robustness and improved fire safety, making it more suitable for fire-safe thermal barrier applications rather than ultralow-k insulation. Compared to conventional insulation materials, the developed composite demonstrates a balanced combination of mechanical robustness, thermal resistance, and fire protection. This work provides a sustainable strategy for converting industrial solid waste into multifunctional fire-safe thermal barrier materials and offers new insights into the design of multifunctional bio-based porous composites for sustainable construction.
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JOURNAL OF CHROMATOGRAPHY A
·
2015
·
IF 4.169
Yan-Bo Luo,Xue Li,Xing-Yi Jiang,Bao-Dong Cai,Feng-Peng Zhu,Hong-Fei Zhang,Zai-Gen Chen,Yong-Qiang Pang,Yu-Qi Feng
In this study, magnetic graphene was used as modified quick, easy, cheap, effective, rugged and safe (QuEChERS) adsorbent for the determination of organochlorine pesticide (OCPs) residues in tobacco. To achieve the optimum conditions of modified QuEChERS procedure toward target analytes, several parameters affecting the clean-up efficiency including the amount of the adsorbent and clean-up time were investigated. Under the optimized conditions, a method for the determination of 26 OCPs residues in tobacco was established by coupling the modified QuEChERS procedure to on-line gel permeation chromatography–gas chromatography–tandem mass spectrometry (on-line GPC–GC–MS 2 ). The limits of detection of proposed method for 26 OCPs residues ranged from 0.01275 to 3.150 ng/g. And good linearities of the proposed method were obtained with coefficients of determination ( R 2 ) greater than 0.9985 for all target analytes. Good reproducibility of method was obtained as intra- and inter-day precisions, the relative standard deviations were less than 11.1 and 15.0%, respectively. The apparent recoveries were in the range of 64–126% at different concentrations for real samples. Compared with the reported methods for the determination of OCPs residues in tobacco, the proposed method has the advantages of simple to operate, low cost and high clean-up ability. Finally, the method was successfully applied to the analysis of OCPs residues in real samples.
研究领域:
分析化学
·
环境科学
·
食品安全
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NANO LETTERS
·
2025
·
IF 9.1
Hongyu Qin,Xiaoyang Chen,Fei Gao,Qifan Liu,Haiming Lv,Yan Huang
Conductive polymer-based electrochromic materials (ECMs), distinguished by their wide color tunability and low cost, are limited particularly in terms of their optical modulation range and response time; meanwhile, their monomers pose significant risks to human health and the environment. In this work, we report a nontoxic polyaniline (PANI)-based derivative, poly(N-phenylglycine) (PNPG). By introducing carboxyl groups onto the nitrogen atoms of the polymer backbone, the conjugated and electronic structure of the polymer was modified, thus reducing the bandgap of PNPG and facilitating charge transportation. Therefore, PNPG demonstrates a remarkable optical modulation amplitude (85% at 778 nm) and a broad color gamut (CIE chromaticity coordinate ranges: x, 0.26–0.4; y, 0.29–0.47). Furthermore, PNPG is successfully integrated into both rigid and flexible electrochromic devices. This work offers a solution for the development of high-performance, nontoxic conductive polymers, highlighting the potential for advanced applications in smart electronics.
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INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
·
2025
·
IF 3.5
Yabo Liang,Tangrui Fan,Fei Cheng,Jinheng Zhang,Shihao Zuo,Botong Chen,Evgeny Lomakin,Daria Bondarchuk,Hao Liu,Xiaozhi Hu
This study focused on bonding strength improvement between aluminum alloy and carbon fiber reinforced polymer (CFRP) composite. Laser engraving method was used to create grooves on surface of aluminum substrate, and resin pre-coating (RPC) was used to disperse high-viscosity resin into resin pre-coating solution to be introduced into pre-fabricated structure, which contributed to reducing bonding defects and constructing short aramid fiber/epoxy (SAFE) bonding layer after full evaporation of acetone to improve mechanical interlocking. The results showed bonding strength of composite with engraving space of 0.2 mm and RPC with short aramid fibers was 20.32 MPa, 220.4 % higher than the base. The failure mode was changed from debonding failure on aluminum surface to delamination failure of CFRP. The research confirmed laser engraving and RPC as simple and effective combined methods on improving bonding strength of aluminum-CFRP composites, which could provide a reference for other metal to manufacture high-performance hybrid composites.
研究领域:
复合材料科学
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材料连接技术
·
表面工程
·
先进制造
·
结构功能材料
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危险品化学品经营许可证（带存储）