ENERGY & FUELS
·
2025
·
IF 5.3
Cuiping Tang,Xinqi Liu,Yong Chen,Xiaoya Zang,Jinan Guan,Deqing Liang
During the production and transportation of natural gas, hydrate formation and accumulation in pipelines can lead to blockages, resulting in gas leakage, economic losses, and safety hazards. Recently, the development of superhydrophobic antigas hydrate coatings for pipelines has been identified as an effective strategy to mitigate pipeline plugging. Although superhydrophobic surfaces can effectively reduce the adhesion strength of hydrates to the wall, they tend to promote surface gas enrichment and water molecule ordering, thereby accelerating hydrate nucleation and growth. Furthermore, the microstructure of superhydrophobic surfaces is relatively fragile and susceptible to damage, which limits their long-term stability and reliability. This study proposes a hydrophilic gel coating, Zr4+/DMSO-Gel, which can delay the nucleation induction period of methane hydrates on solid surfaces and reduce their growth rate. Microscopic observations revealed that the coating induced partial decomposition of methane hydrate, resulting in the formation of a large water layer, which can reduce wall adhesion. Furthermore, Raman spectroscopy was employed to analyze the structure of surface water molecules, revealing the mechanism by which the coating inhibits hydrate formation. The results showed that strong hydrogen bonding interactions between the coating surface and water molecules resulted in the predominance of bound water (BW) on the surface, while the proportion of tetra-coordinated hydrogen-bonded water (4-HBW) was reduced, thereby inhibiting the formation of hydrate cage structures. These findings not only provide a novel approach for the development of hydrate-resistant coatings but also offer new insights into antiplugging strategies for natural gas pipelines.
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高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 36
·期 39
·2404772
·
IF 27.4
Ning Sun,Zhichuan Zheng,Zhuangzhuang Lai,Junjie Wang,Peng Du,Tianping Ying,Haifeng Wang,Jianchun Xu,Runze Yu,Zhiwei Hu,Chih-Wen Pao,Wei-Hsiang Huang,Ke Bi,Ming Lei,Kai Huang
While high-entropy alloys, high-entropy oxides, and high-entropy hydroxides, are advanced as a novel frontier in electrocatalytic oxygen evolution, their inherent activity deficiency poses a major challenge. To achieve the unlimited goal to tailor the structure–activity relationship in multicomponent systems, entropy-driven composition engineering presents substantial potential, by fabricating high-entropy anion-regulated transition metal compounds as sophisticated oxygen evolution reaction electrocatalysts. Herein, a versatile 2D high-entropy metal phosphorus trisulfide is developed as a promising and adjustable platform. Leveraging the multiple electron couplings and d–p orbital hybridizations induced by the cocktail effect, the exceptional oxygen evolution catalytic activity is disclosed upon van der Waals material (MnFeCoNiZn)PS 3 , exhibiting an impressively low overpotential of 240 mV at a current density of 10 mA cm −2 , a minimal Tafel slope of 32 mV dec −1 , and negligible degradation under varying current densities for over 96 h. Density functional theory calculations further offer insights into the correlation between orbital hybridization and catalytic performance within high-entropy systems, underscoring the contribution of active phosphorus centers on the substrate to performance enhancements. Moreover, by achieving electron redistribution to optimize the electron coordination environment, this work presents an effective strategy for advanced catalysts in energy-related applications.
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高影响因子
BMC MICROBIOLOGY
·
2024
·Vol. 24
·期 1
·1-12
·
IF 4
Liu Xiaoju,Xiong Yanpeng,Peng Renhai,Zhang Yufang,Cai Shuyu,Deng Qiwen,Yu Zhijian,Wen Zewen,Chen Zhong,Hou Tieying
Multi-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin member 8 (TRPM8) agonist, has potential antineoplastic properties. Here, we reported the antibacterial and antibiofilm activities of D-3263. Minimum inhibitory concentrations (MICs) against S. aureus , Enterococcus faecalis and E. faecium were ≤ 50 µM. D-3263 exhibited bactericidal effects against clinical methicillin-resistant S. aureus (MRSA) and E. faecalis strains at 4× MIC. Subinhibitory D-3263 concentrations effectively inhibited S. aureus and E. faecalis biofilms, with higher concentrations also clearing mature biofilms. Proteomic analysis revealed differential expression of 29 proteins under 1/2 × MIC D-3263, influencing amino acid biosynthesis and carbohydrate metabolism. Additionally, D-3263 enhanced membrane permeability of S. aureus and E. faecalis . Bacterial membrane phospholipids phosphatidylethanolamine (PE), phosphatidylglycerol (PG), and cardiolipin (CL) dose-dependently increased D-3263 MICs. Overall, our data suggested that D-3263 exhibited potent antibacterial and antibiofilm activities against S. aureus by targeting the cell membrane.
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PubMed
高影响因子
Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-21
·
IF 8.9
He Qiongyao,He Wu,Ren Yanlin,Wu Wenbin,Dong Hui,Yuan Gang,Ren Huihui,Wang Xinwei,Lu Fuer,Wang Dingkun
Ferroptosis, an iron-dependent form of programmed cell death, is closely associated with tubular damage in diabetic nephropathy (DN). Glutathione peroxidase 4 (GPX4) is an important anti-oxidant enzyme, and plays a crucial role in protecting against ferroptosis. However, the regulatory mechanism of GPX4 expression levels in renal tubular epithelial cells (RTECs) remains elusive. This study reveals that ferroptosis occurs in the late-stage of DN, and the GPX4 level is significantly downregulated in DN patients, animal models and cell models. By applying database predictions, luciferase reporter assays and chromatin immunoprecipitation, we find that vitamin D receptor (VDR) transcription factor promotes GPX4 expression and plays a key role in inhibiting ferroptosis of RTECs. VDR knockout exacerbates ferroptosis in RTECs and worsens renal function, while intraperitoneal injection of VDR agonist paricalcitol significantly improves renal injury. Proteomics analysis suggests that E3 ligase PRPF19 mediates ubiquitination degradation of VDR and is an important therapeutic target for DN. Therefore, through molecular docking, targeted fishing technology using high-performance affinity beads, and surface plasmon resonance (SPR), we screen and identify berberine (BBR) as a novel inhibitor of PRPF19, which offers renal protection by inhibiting VDR degradation and tubular ferroptosis. These findings elucidate the role of ferroptosis in DN renal tubular injury, and suggest that PRPF19 is a promising therapeutic target.
研究领域:
医学
·
分子生物学
·
肾脏病学
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Zengfang Huang,Chaoyue Zhou,Xiaotong Zhang,Haoyu Xue,Wenxi Liao,Liucheng Mao,Jinying Yuan,Lei Tao,Yen Wei
Organic fluorescence dyes with long wavelength emission are attracting people’s interests in bioimaging, cells tracing and medical diagnosis due to their many advantages. This contribution exhibited a novel red fluorescent monomer BDPPA with traditional tetraphenylethylene (TPE) and phenothiazine (PHT) as structural units, which showed aggregation-induced emission enhancement (AEE) effects together with the twisted intramolecular charges transfer (TICT) owing to its D-A-D’ structure. The maximal emission wavelength of BDPPA located at 592 nm with a shoulder peak at 629 nm. Afterwards, the amphiphilic PEG-BD copolymers was acquired by RAFT polymerization of BDPPA and PEGMA. When the feeding ratio of BDPPA increased from 10.0 % to 20.0 %, the ratio of BDPPA in PEG-BD copolymers correspondingly increased from 9.6 % to 20.9 %. The obtained amphiphilic PEG-BD could self-assemble into fluorescence organic nanoparticles (FONs) with about 150 nm diameter in H 2 O solution. Owing to their TICT effect and D-A-D’ structure, both BDPPA and PEG-BD copolymers showed obvious fluorescence in THF solvent, and their intensity firstly decreased and then grew with the increase of water concentration, indicative of the obvious aggregation-induced emission enhancement (AEE). From the calculations of energy quantum, the difference ΔE of BDPPA decreased to 3.09 eV from 3.53 eV of its substrate PHT, which was very favourable for the long wavelength emission and cell imaging. Moreover, due to the long wavelength emission, excellent water solubility and biocompatibility, and AEE effect, the obtained PEG-BD FONs revealed the promising application in biological imaging field.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Shuai Zhang,Yifei Zhao,Jiadong Zhou,Hong Ming,Chun-Hai Wang,Xiping Jing,Shi Ye,Qinyuan Zhang
Manganese (II) compounds are promising luminescent candidates for white light-emitting diodes (WLEDs) applications. However, the forbidden d - d transition of Mn 2+ ion makes the absorption of blue light and emission relatively weak without a sensitizer. The strategy of isolating MnX n (X is the ligand) with some ionic liquids is used to design two new hybrid compounds in this study, focusing on the orbital hybridization to relax the parity selection rule of the d - d transition. A large hindrance of the organic cations in the two new Manganese (II) hybrids enables a large Mn-Mn distance (up to ~ 10 Å) to form zero-dimensional (0D) structures, and the Mn sites in both compounds have a low site symmetry ( C 2 or C 1 ). The 0D structure of MnX n polyhedral is beneficial to isolatedly investigate the orbital hybridization of the ligand and Mn 2+ ion. A higher orbital hybridization extent for Mn-Br bond is evidenced by Density Functional Theory (DFT) simulation. This conclusion leads to the strong and stable green light emissions under preferable blue light (460 nm) excitations, giving photoluminescence quantum yields (PLQYs) as high as 76%. The WLEDs fabricated with these compounds have presented high luminous efficiency up to ~130 lm/W and survived multiple stability tests. The research favors the discovery of ideal Mn compounds for displays and lighting applications.
研究领域:
材料科学
·
光电
·
光子学
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JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2026
·Vol. 40
·期 5
·e70877
·
IF 3.6
Shangyun Lu,Jing Gao,Huixia Zhang,Chao Fan,Ziling Liu,Qi An,Mengge Ren,Yuchen Bai,Fubin Qiu
Patulin (PAT) is a mycotoxin that grows on various fruits and grains, and its toxicity research mainly focuses on organ toxicity. However, the research on its impact on nutritional metabolism is still unclear. Vitamin D is an important nutrient and has been reported to have multiple physiological functions. Vitamin D deficiency has been reported to be associated with the risk of developing diseases such as fatal cancers, autoimmune disorders, cardiovascular disease, neurocognitive function impairment, and type 2 diabetes. However, vitamin D need to be converted into biologically active forms through two steps of hydroxylation in the liver or kidney by 25-hydroxylase (CYP2R1) and 25-hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1). In this study, we found that PAT can cause liver and kidney injury, and affect the levels of activated vitamin D products 25(OH)D and 1,25(OH) 2 D. Specifically, we demonstrated that PAT affects the hydroxylation of vitamin D by downregulating 25-hydroxylase (CYP2R1) and 25-hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) expression and interfering their substrate binding sites. This study can provide a basis for a more comprehensive assessment of the impact of environmental pollution, food safety, and other issues on human health.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yarui Wang,Chengzhuo Yu,Sen Wang,Jin Xu,Fanglan Geng,Silong Wang,Jitao Lv,Lixia Zhao,Yawei Wang
Humic acids (HA) released during algal bloom poses a key challenge for efficient photocatalytic degradation of Microcystin-LR (MC-LR) due to their scavenging function on active species. Herein, MIL-101(Fe)/TiO 2 -P25 (M/P) was constructed to diminish the inhibitory effect of HA on the photocatalytic degradation of MC-LR. Results showed that MC-LR could be efficiently removed assigning to the photogenerated holes (h + ) and superoxide radical (O 2 •− ) oxidation under visible light irradiation, where the carboxy groups of D -glutamic acid (Glu) and methyl- D -aspartic acid (MeAsp), and Adda side chain related to MC-LR biotoxicity were selectively destroyed to achieve MC-LR detoxication. More importantly, HA exerted non-inhibitory effect on MC-LR removal by M/P. The counteracting mechanisms were studied. Firstly, the location of TiO 2 in the pore structure of MIL-101(Fe) could occupy the adsorption sites of HA, and decrease the HA adsorption on M/P. Furthermore, XPS analyses suggested the coordination of unsaturated Fe metal sites on the surface of M/P hybrids complexed with –OH and –COOH of HA, which could accelerate the electron transfer and reduce hole consumption. Thus, the inhibitory effect of HA was alleviated during photocatalytic MC-LR treatment. This work offers a possible way to remove MC-LR in an abundant HA matrix water system efficiently.
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高影响因子
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
·
2017
·
IF 1.31
Fengzhe Wang,Xuan Liu,Longbao Feng,Qiyu Zhu,Shina Yan,Rui Guo
The development of nanomedicine has provided advanced treatment opportunities for many diseases. Simvastatin, a widely used anti-lipidaemic drug, has potential for the treatment of orthopaedic diseases. However, the clinical application of simvastatin is limited because of its hydrophobicity and lack of distribution in osseous tissue. In this study, an amphiphilic nanoparticle, poly(d,l-lactide-co-glycolide)–poly(ethyleneglycol)–poly(d,l-lactide-co-glycolide), was synthesised to improve the biocompatibility of simvastatin. The haemocompatibility of the poly(d,l-lactide-co-glycolide)–poly(ethyleneglycol)–poly(d,l-lactide-co-glycolide) copolymer was investigated through its aggregation, morphology and lysis of human red blood cells, along with its impact on the clotting function according to the activated partial thromboplastin time, prothrombin time and thromboelastographic assays. The results demonstrated that the poly(d,l-lactide-co-glycolide)–poly(ethyleneglycol)–poly(d,l-lactide-co-glycolide) copolymer with a concentration lower than 10 mg/mL had little impact on the aggregation, morphology or lysis of red blood cells, or on blood coagulation. Therefore, the copolymer may be a strong alternative candidate as an effective and safe drug carrier.
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高影响因子
TETRAHEDRON
·
2018
·
IF 2.377
Mengxuan Chen,Weiyun Chai,Rongyao Zhu,Tengfei Song,Zhizhen Zhang,Xiao-Yuan Lian
Secondary metabolites from marine-associated actinomycetes are important source for the discovery of novel bioactive compounds. In this study, an actinomycete Streptomyces sp. ZZ446 was isolated from coastal soils and different media were used to culture this isolated marine actinomycete. It has been found that this actinomycete in the liquid medium of 2216 E with sea salt produced five new compounds of streptopyrazinones A−D ( 1 – 4 ) and N -acetyl- l -isoleucine- l -leucinamide ( 5 ) as well as six known diketopiperazines ( 6 – 11 ) and one alkaloid ( 12 ). Structures of the new compounds were determined by extensive NMR analyses, HRESIMS data, electronic circular dichroism (ECD) calculation, chemical degradation , Marfey's method, and X-ray diffraction analysis. This type of streptopyrazinones A−D ( 1 – 4 ) is rarely found in the natural resources. New compounds 1 – 5 showed activity in inhibiting the growth of Candida albicans and methicillin-resistant Staphylococcus aureus .
研究领域:
微生物学
·
药物化学
·
天然产物研究
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高影响因子
CHEMISTRY OF MATERIALS
·
2026
·
IF 7.1
Shiyue Sun,Jie Zhu,Tingting Li,Shaolin Du,Yunzhe Ke,Chenfei Yang,Yajing Sun,Xiaotao Zhang,Shuaishuai Ding,Wenping Hu
The design of molecular magnets with programmable spin states at room temperature is challenging for quantum materials. Although organic charge transfer (CT) cocrystals offer a promising framework for tuning spin states through electronic coupling, the deliberate design of donor (D)-acceptor (A) pairs and based on orbital-regulation strategy to mediate effective magnetic interactions has remained unexplored. Here we prove that CT cocrystals provide a platform where metal orbital characteristics govern magnetic strength, while the ordered CT lattice mediates long-range exchange interactions to support collective magnetic ordering. We obtained C60-H2TPP, C60-CuTPP, C60-CoTPP with successively increasing ferromagnetism at 300 K. Through orbital-regulation strategy, the substitution of metal ion Cu2+ with Co2+ precisely reorients the unpaired electron orbital from an alignment parallel to the donor molecule plane to one that points directly toward the C60 molecule. This spatial orientation leads to a significant enhancement in saturation magnetization, revealing that the orbital orientation of the D and A molecules can systematically govern the ferromagnetic ground state in cocrystals. Our results support orbital-regulation strategy as an effective design principle for room-temperature molecular magnets, with implications for spintronic applications based on organic quantum materials.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Xurui Zhao,Xiufeng Wang,Yijie Sheng,Shuizhi Lin,Shuping Xu,Zhixiang Hu,Xueping Ling,Cuixue Chen,Mingfeng Cao,Haiyang Cui,Yinghua Lu
Phosphatidylserine (PS), a major brain phospholipid, supports the central nervous system’s health and may alleviate cognitive decline, including in Alzheimer’s disease. A key challenge in green enzymatic PS synthesis is the suppression of hydrolysis while enhancing PLD-catalyzed transphosphatidylation. Here, we developed a mechanism-guided engineering strategy for Streptomyces antibioticus phospholipase D (SaPLD). The substitution of W187I increased the PS yield to 58.3%, while V380W improved thermostability. Combining beneficial mutations generated SaPLD-R7 (W187I/V380W/G381A), which overcame the activity–stability trade-off and achieved up to 95.8% PS yield using the enzyme produced by 5 L scale fermentation. Molecular dynamics simulations showed that SaPLD-R7 enhanced substrate binding and catalysis by shortening the key active site distances and reducing local flexibility. Solvent contact and energy analyses further indicated improved stability. This work establishes a structure–mechanism–function framework for enhancing PLD transphosphatidylation and provides a robust enzymatic route for high-efficiency PS production as a valuable functional food ingredient.
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