Nature Communications
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2024
·Vol. 15
·期 1
·1-13
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IF 14.7
Zhang Lei,Chen Lu,Wang Siheng,Wang Shanshan,Wang Dan,Yu Le,Xu Xu,Liu He,Chen Chaoji
Self-powered skin attachable and detachable electronics are under intense development to enable the internet of everything and everyone in new and useful ways. Existing on-demand separation strategies rely on complicated pretreatments and physical properties of the adherends, achieving detachable-on-demand in a facile, rapid, and universal way remains challenging. To overcome this challenge, an ingenious cellulose nanofiber-mediated manifold dynamic synergy strategy is developed to construct a supramolecular hydrogel with both reversible tough adhesion and easy photodetachment. The cellulose nanofiber-reinforced network and the coordination between Fe ions and polymer chains endow the dynamic reconfiguration of supramolecular networks and the adhesion behavior of the hydrogel. This strategy enables the simple and rapid fabrication of strong yet reversible hydrogels with tunable toughness ((Value max -Value min )/Value max of up to 86%), on-demand adhesion energy ((Value max -Value min )/Value max of up to 93%), and stable conductivity up to 12 mS cm −1 . We further extend this strategy to fabricate different cellulose nanofiber/Fe 3+ -based hydrogels from various biomacromolecules and petroleum polymers, and shed light on exploration of fundamental dynamic supramolecular network reconfiguration. Simultaneously, we prepare an adhesive-detachable triboelectric nanogenerator as a human-machine interface for a self-powered wireless monitoring system based on this strategy, which can acquire the real-time, self-powered monitoring, and wireless whole-body movement signal, opening up possibilities for diversifying potential applications in electronic skins and intelligent devices.
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Current Research in Food Science
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2025
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IF 7
Xuexue Zheng,He Xie,Wenjie Fu,Chao Wang,Tengfei Hu,Xingchang Ou,Jian'an Huang,Zhonghua Liu,Qin Li
While extensive research has focused on the flavor of Fu brick tea (FBT), the perceptual interactions among its aromatic components remain unclear. To address this, twenty representative aroma compounds were selected from FBT to determine their thresholds and evaluate their interactions by analyzing threshold changes before and after mixing. The results revealed discrepancies between the determined thresholds and literature values, particularly for α -terpineol, methyl heptenone, and geranylacetone, which demonstrated ratios of 73.54, 6.62, and 6.41, respectively. Mixtures with similar aromas or structures exhibited synergy, whereas those with differing aromas or structures displayed masking effects. Additionally, the odor compound ( E )-nerolidol was added to the tea infusion at a concentration below its threshold level to investigate its impact on the overall aroma perception of FBT through sensory analysis and electronic nose assessments. The findings indicated that sub-threshold compounds could significantly influence the overall aroma profile of FBT.
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REACTIVE & FUNCTIONAL POLYMERS
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2025
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IF 5.1
Tong Zhang,Weiyin Chen,Wenxin Zhang,Lusheng Liao,Chengpeng Li,Peng Zhang
Flexible electronic skin ( E -skin) demands materials with skin-like softness, self-healing capability, and antibacterial properties for long-term wearable applications. Here, we developed a series of self-healing, antibacterial zwitterionic polydimethylsiloxane (PDMS) elastomers via a facile photo-polymerization strategy. The elastomer was synthesized by crosslinking acrylate-terminated PDMS (PDMS-IU-MA) with zwitterionic sulfobetaine methacrylate (SBMA) using reactive hyperbranched polysiloxane (HPBSi) containing methacrylate groups as a multifunctional mediator. The resulting material exhibited remarkable antibacterial effects against E. coli and S. aureus , attributed to the zwitterionic SBMA moieties, while the dynamic hydrogen-bonding network formed by urethane/urea groups enabled self-healing ability. The mechanical properties, self-healing efficiency, and antibacterial performance were systematically tuned by varying the SBMA content. Furthermore, a conductive E -skin capable of precisely monitoring human motion through resistance changes was fabricated by integrating liquid metal (LM) microdroplets into an optimized PDMS matrix. This work provides a scalable strategy to integrate antimicrobial protection, self-healing, and strain sensing into E -skin for next-generation wearable electronics.
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ACS Sustainable Chemistry & Engineering
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2024
·
IF 7.1
Jia’nan Zhang,Zizhen Liu,Yihan Wang,Bo Yu
l-Homoserine is proven to be a promising precursor for the synthesis of l-phosphinothricin, which is a broad-spectrum herbicide with low toxicity. To enhance the sustainability of the process, the utilization of nonfood carbon sources for l-homoserine production is highly sought-after. Acetate, which can be captured from C1 gases, has the potential to become the most abundant feedstock for biomanufacturing. In this study, we systematically engineered the Escherichia coli strain to generate l-homoserine from acetate. The production of l-homoserine from acetate was initially achieved by deleting branch pathways, activating the glyoxylate shunt, and enhancing the synthetic pathway. The strain’s tolerance and acetate assimilation capabilities were strengthened through adaptive laboratory evolution. Reducing the flux toward gluconeogenesis further facilitated the production of l-homoserine. Finally, the engineered strain produced 15.96 g/L l-homoserine solely from CO2-derived acetate and formate in a 5 L fermentor via a fed-batch process. This study provides insights into the development of a low-carbon bioeconomy for the herbicide industry.
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JOURNAL OF FOOD SCIENCE
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2025
·Vol. 90
·期 9
·e70571
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IF 3.4
Xiaoya Meng,Zhongyu Li,Zili Xia,Dongdong Chen,Zijing Yuan,Yang Han,Heng Zhang,Xia Sun,Jun Seop Lee,Usmanova Surayo Rakhmatzhanovna,Bobokalonov Jamshed Tolehmurodovich,Wenping Zhao
An electrochemical aptasensor based on Ti 3 C 2 T x (MXene) and cDNA-PAA was established for sensitive detection of aflatoxin B1 (AFB1) in peanuts. The high specific surface area of Ti 3 C 2 T x (MXene) contributed to improve electrochemical efficiency and enhancing sensor stability which were characterized by the Randles−Sevcik equation. The self-made polyacrylic acid (PAA) nanogel was added with aptamer complementary chain (cDNA) to form cDNA-PAA nano gel composite, which could realize the synergistic amplification of the difference between the electrochemical signals before and after the addition of AFB1. The sensing effect of cDNA-PAA was validated using DPV. Methylene blue (MB) was modified at the proximal 3′ termini of the aptamer (Apt-MB), meanwhile AuNPs was used to immobilize Apt-MB and improve the efficiency of electrochemical reactions. The competition between AFB1 and cDNA-PAA combined with Apt MB resulted in a significant change in the electrochemical signal current. In addition, the constructed electrochemical aptasensor had a lower detection limit of 1.0 × 10 −3 ng/L for AFB1 under optimal detection conditions, and a detection range of 1 to 1000 ng/L. Moreover, peanuts with different concentrations of AFB1 were used as actual detection samples. Through the constructed sensor detection, the spiked recovery rates within the spiking range of 50 to 500 ng/mL were 97.76% to 101.84% ( n = 3).
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PHYTOMEDICINE
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2024
·
IF 6.7
Yonggui Song,Meixizi Lai,Zhou Liao,Zhentao Zhang,Genhua Zhu,Ming Yang,Zhifu Ai,Qin Zheng,Dan Su
Background Since the pathogenesis of depression is complex, antidepressant therapy remains unsatisfactory. Recent evidence suggests a link between depression and lipid metabolism. Saikosaponin (SS) exhibits antidepression and lipid-regulating effects in modern pharmacology. However, it is unknown whether lipid regulation is the key mechanism of the SS antidepressant effect and how it works. Purpose In this study, we investigated the relationship between the antidepressant activity of SS and the regulation of lipid metabolism and explored potential mechanisms. Methods APOE -/- mice, in combination with the chronic unpredictable mild stress (CUMS) model, were used to study the relationship between SS antidepressant activity and lipid metabolism through behavioral, electrophysiological techniques, and non-targeted lipidomics. Western blot, primary cell culture technology, and laser speckle cerebral blood flow imaging were employed to elucidate potential mechanisms. GraphPad Prism was used for statistical analysis, and p < 0.05 was considered statistically significant. Results APOE -/- mice exhibit more severe depressive-like behavior and dysregulation of sphingolipid metabolism in CUMS. SS alleviates depressive behavior and cortical sphingolipid metabolism disorder caused by CUMS, but has no effect on APOE -/- mice. SS alleviates the imbalance between ceramide (Cer) and sphingomyelin (SM) through acidic sphingomyelinase (AMSase). In addition, SS regulates neuronal glutamate release via sphingolipid metabolism, thereby alleviating the CUMS-induced inhibition of neurovascular coupling (regulates metabotropic glutamate receptor and IP3 receptor), which ameliorates the reduction of cerebral blood flow in depressed mice. Conclusion Our study highlights the role of lipid metabolism in the antidepressant activity of SS and explores its underlying mechanisms. This study provided new insights into the better understanding of the antidepressant mechanisms of phytomedicine while increasing the possibility of lipid metabolism as a therapeutic strategy for depression.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Xiaohai Zhang,Yijie Wang,Lei Zhang,Xinru Zhang,Yajie Guo,Bao Hao,Yongqiang Qin,Qiang Li,Lei Fan,Helei Dong,Qiulin Tan
Flexible pressure sensors with porous structures have a wide range of applications in many fields, including in flexible electronic skin, medical diagnosis, and human–computer interaction. As such, the fabrication of pressure-sensitive layers with porous structures capable of superior performance has become a significant research hotspot. Herein, we report a mechanically-sensitively enhanced structure of surface patchy protrusions and porous composites which can be used to accurately monitor limb movement, pulse, and breathing. Notably, the flexible pressure sensor exhibits high sensitivity (21.457 kPa −1 ), wide detection range (0.11–11.022 kPa), rapid response/recovery time (41.84 ms/20.82 ms), and excellent stability and cycle repeatability (up to 6000 cycles). Further, the pressure sensor array can act as an electronic skin to detect the pressure distribution. We further propose a newly developed miniaturized flexible wireless feedback system equipped with five pressure sensors. Using the detected pressure as input, the accurate recognition of nine gestures (98.22 %) was achieved with the help of a convolutional neural network (CNN) model.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Jiayi Zhang,Zichun Song,Jiuying Cui,Wenbo Li,Song Huang,Bo Ling,Kai Zhang,Xianjiu Liao,Jihua Wei
The human gastrointestinal system contains the conditional pathogen Escherichia coli ( E. coli ), which is a significant cause of vomiting and diarrhea—both of which can be fatal in extreme cases. Given the surge in hospital infections and water pollution, the development of early detection and diagnosis procedures is imperative. This study proposes an electrochemical biosensor for E. coli detection, utilizing nucleic acid aptamers as recognition elements and using E. coli-2571 as an example. It is based on the CRISPR/Cas gene-editing technology. Specifically, the collateral cleavage activity of Cas12a shifts the electrochemical signal after loading the DNA sequence tagged with an electrochemical signal onto the gold electrode, which ultimately enables the identification of E. coli . The biosensor has a detection limit of 13.1 CFU/mL and exhibits a good linear relationship in the concentration range of 10 2 ––10 7 CFU/mL. It was effectively used for the quantitative detection of E. coli in milk and pure water, with a recovery rate ranging from 93.12 % to 98.93 %. The biosensor offers a rapid, precise, affordable, and sensitive tool for E. coli detection. It is anticipated to become a powerful instrument for identifying microorganisms that pose a risk to public health and human health.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2020
·Vol. 24
·期 10
·5911-5925
·
IF 4.486
Dafeng Yang,Zhousheng Yang,Lei Chen,Dabin Kuang,Yang Zou,Jie Li,Xu Deng,Songyuan Luo,Jianfang Luo,Jun He,Miao Yan,Guixia He,Yang Deng,Rong Li,Qiong Yuan,Yangzhao Zhou,Pei Jiang,Shenglan Tan
Natural products were extracted from traditional Chinese herbal emerging as potential therapeutic drugs for treating cardiovascular diseases. This study examines the role and underlying mechanism of dihydromyricetin (DMY), a natural compound extracted from Ampelopsis grossedentata , in atherosclerosis. DMY treatment significantly inhibits atherosclerotic lesion formation, proinflammatory gene expression and the influx of lesional macrophages and CD4-positive T cells in the vessel wall and hepatic inflammation, whereas increases nitric oxide (NO) production and improves lipid metabolism in apolipoprotein E-deficient ( Apoe − / − ) mice. Yet, those protective effects are abrogated by using NOS inhibitor L-NAME in Apoe − / − mice received DMY. Mechanistically, DMY decreases microRNA-21 (miR-21) and increases its target gene dimethylarginine dimethylaminohydrolase-1 (DDAH1) expression, an effect that reduces asymmetric aimethlarginine (ADMA) levels, and increases endothelial NO synthase (eNOS) phosphorylation and NO production in cultured HUVECs, vascular endothelium of atherosclerotic lesions and liver. In contrast, systemic delivery of miR-21 in Apoe − / − mice or miR-21 overexpression in cultured HUVECs abrogates those DMY-mediated protective effects. These data demonstrate that endothelial miR-21-inhibited DDAH1-ADMA-eNOS-NO pathway promotes the pathogenesis of atherosclerosis which can be rescued by DMY. Thus, DMY may represent a potential therapeutic adjuvant in atherosclerosis management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Huiwen Hou,Didi Gao,Na Lu,Wen Tang,Wenjie Liu,Feiyan Zhao,Xinqing Gao,Hanlin Wang,Yuhan Di,Hui Zhang,Hailong Wang,Feng Sun,Haining Tan
Hepatocellular carcinoma (HCC) is among the most prevalent and deadly cancers worldwide, with high recurrence and metastasis rates that significantly impact patient survival. Targeted therapy has emerged as a promising alternative to conventional treatments. This offers tumor-specific drug delivery while minimizing adverse systemic effects. In this study, we present folate acid (FA)-carboxymethylated mannan (CM)- monomethyl auristatin E (MMAE) conjugate (FA-CM-MMAE, FCMMM), an innovative glycosylated dual-target nanoparticle designed for the precise delivery of MMAE to HCC cells. These nanoparticles utilize FA and CM as their targeting ligands and exhibit pH-responsive drug release in acidic tumor microenvironments. This allows enhanced specificity and reduces off-target toxicity. In vitro studies have demonstrated that FCMMM nanoparticles selectively deliver MMAE to HepG2 cells via receptor-mediated pathways, alleviating MMAE-associated toxicity in normal cells. Furthermore, in vivo experiments in HCC-bearing mouse models have shown efficient tumor-specific accumulation of the drug, significant inhibition of tumor growth, and markedly lower levels of systemic toxicity than MMAE. This dual-targeting strategy integrates precise tissue targeting with controlled drug release. It addresses critical limitations of traditional HCC therapies such as nonspecific drug distribution, systemic toxicity, and drug resistance mechanisms. FCMMM shows potential as a next-generation nanoparticle platform for safer, more effective chemotherapeutic intervention in hepatic cancer.
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TALANTA
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2025
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IF 6.1
Luyang Zhao,Yang Song,Guoyang Xie,Hengyi Xu
A colorimetric assay based on the Fe/Al bimetallic organic framework NH 2 -MIL-53(Fe, Al) was developed for the sensitive detection of Escherichia coli O157:H7 ( E. coli O157:H7), a critical pathogen threatening food safety. The framework’s high specific surface area facilitated efficient antibody immobilization, whereas the incorporation of Al 3+ enhanced electron transfer between Fe 2+ /Fe 3+ , thereby significantly boosting peroxidase activity. The optimized NH 2 -MIL-53(Fe, Al) exhibited 1.4-fold and 4.9-fold higher relative absorbance than NH 2 -MIL-53(Fe) and NH 2 -MIL-53(Al), respectively. And it demonstrated 40-fold and 2-fold greater affinity for TMB and H 2 O 2 , respectively, compared to the natural enzyme. By integrating a dual-recognition system based on antibody and aptamer, the method enabled rapid detection with a limit of detection of 10 1 CFU/mL in colorimetric mode. Its successful application in complex matrices, including lettuce, juice, pool water, and chocolate milk, had yielded satisfactory recovery and precision, confirming its promising potential for food safety monitoring.
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npj Flexible Electronics
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2025
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IF 15.5
Pan Yinuo,Yang Chunbing,Du Zhaoqun
With technological advancements, consumer demands for textile functionality and intelligence have increased substantially. Next-generation E-textiles should enable multidirectional force sensing while ensuring high levels of wearer comfort. However, existing electronic textiles are insufficient to simultaneously monitor the direction and degree of strain, and sweat accumulation can lead to poor comfort. Here, inspired by the asymmetric gradient structure of human skin, Janus double-layer woven electronic textile (JDET) was designed. Through material-structure-function biomimetic design, bidirectional bending recognition and moisture management function are integrated into the device. A high-sensitivity strain sensing unit (GF = 1402.94) was constructed using a single wrapped yarn and conductive materials. Combined with a double-layer fabric structure design, a plain weave layer woven with hydrophilic sensing yarn and a twill weave layer woven with hydrophobic polyester yarn formed a dual gradient structure of fabric wettability and porosity, resulting in excellent unidirectional moisture transport capability. The asymmetric design of the sensing layer enables JDET to selectively identify bending directions (−180°–180°), and has good stability (>8000 s) in bending cycle testing. In addition, JDET has been successfully applied to human motion monitoring and Morse code interaction systems. This asymmetric gradient structure design of textiles provides ideas for the design of the next generation of intelligent electronic textiles.
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