ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Hongjing Wang,Shiqian Jiao,Songliang Liu,Shengqi Wang,Tongqing Zhou,You Xu,Xiaonian Li,Ziqiang Wang,Liang Wang
Electrochemical water splitting is one hopeful strategy for hydrogen production, and designing efficient hydrogen evolution electrocatalysts under universal pH is one of the most critical topics. Here, we have successfully prepared mesoporous bimetallic core–shell nanostructures with Au nanowires (Au NWs) as cores and mesoporous Rh as shells (Au@mRh NWs). Due to the one-dimensional structure and mesoporous core–shell structure, Au@mRh NWs possess more active sites and provide the synergistic effect, leading to the great improvement of the electrochemical activity toward the hydrogen evolution reaction under a wide range of pH. The present work proposes a versatile strategy for preparing a bimetallic core–shell structure with a mesoporous shell, which is highly promising for more electrocatalytic applications.
研究领域:
材料科学
·
电化学
·
催化化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Seongeom Jeong,Siyoung Byun,Sanghyun Jeong
A pH-responsive membrane represents a promising avenue for sustainable water treatment, yet its broader application remains limited by stability and reusability concerns. In this study, a polyvinyl alcohol/chitosan (PVA/CS) hydrogel membrane was fabricated and systematically evaluated for its pH-dependent transport behavior and dye removal performance. The hydrogel membrane exhibited distinct pH responsiveness, achieving the highest water flux (22.45 ± 0.66 L m −2 h −1 bar −1 ) at neutral pH (6.5) when tested using pure water. Flux declined under acidic conditions (3.43 ± 0.26 L m −2 h −1 bar −1 ) due to CS swelling and under alkaline conditions due to polymer chain densification. At pH 2, the membrane removed both cationic and anionic dyes with efficiencies exceeding 99.9 % removal. Under neutral conditions, cationic dyes (crystal violet, methylene blue) were consistently removed (>97 %). In contrast, anionic dyes, including Congo red and methyl orange, showed significantly lower rejection (66.04 % and 24.57 %, respectively), attributable to electrostatic repulsion and size-dependent transport. Importantly, the PVA/CS hydrogel membrane demonstrated regeneration capability, enabling up to three reuse cycles with >99 % dye rejection and limited flux decline for cationic dyes at pH 6.5. CS's reversible swelling-contraction behavior facilitated the recovery of membrane performance. Overall, these findings demonstrate that PVA/CS hydrogel membranes functions as pH-responsive separation platforms capable of chemical-free regeneration and limited reuse across a range of pH conditions. In particular, this study experimentally clarifies how intrinsic pH responsiveness can be leveraged to enable regeneration without chemical treatment, while also highlighting the need for further optimization to address performance limitations toward anionic contaminants.
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2016
·
IF 7.441
Yongju He,Zhigui Su,Lingjing Xue,Hui Xu,Can Zhang
Pretreatment of lung cancer cells with epidermal growth factor receptor (EGFR) inhibitor erlotinib has been recently reported that could dramatically synergize their apoptotic response to DNA damage agent doxorubicin (DOX). To translate this synergistic therapy into in vivo anticancer therapy and clinical practice, we designed a novel pH-sensitive charge conversion nanocarrier (M-HHG 2 C 18 -L) that contained erlotinib/DOX combination and produced a sequential staggered drug release for synergistic lung cancer therapy. In this study, a synthetic zwitterionic oligopeptide lipid (1,5-dioctadecyl- l -glutamyl2-histidyl-hexahydrobenzoic acid, HHG 2 C 18 ) was used to construct a pH-sensitive lipid bilayer (HHG 2 C 18 -L), which was subsequently applied to coat amino-functionalized mesoporous silica nanoparticles (MSN-NH 2 ). Erlotinib and DOX were separately incorporated into HHG 2 C 18 -L and MSN-NH 2 respectively to obtain pH-sensitive charge conversion erlotinib/DOX co-delivery nanoparticles (M-HHG 2 C 18 -L(E + D)). We confirmed that M-HHG 2 C 18 -L(E + D) were able to reverse surface zeta potential from negative to positive at tumor extracellular pH, thus facilitating the targeted cancer cell internalization. Furthermore, as erlotinib was sequestered in the exterior lipid bilayer and the controlled release ability of MSN-NH 2 , erlotinib released faster than DOX during the cellular transport. Additionally, HHG 2 C 18 -L became more positive at tumor intracellular pH and enhanced Coulombic repulsion with MSN-NH 2 , leading to increased sequential staggered release of erlotinib and DOX. Due to the pretreatment and time-staggered inhibition of EGFR with erlotinib and the enhanced intracellular release of DOX to the nucleus, the maximized synergistic cell killing effect was achieved. Compared to non-sensitive erlotinib/DOX co-delivery nanoparticles (M-SPC-L(E + D)) and simultaneous DRUG coadministration. M-HHG 2 C 18 -L(E + D) with sequential staggered drug release and pH-sensitive charge conversional properties showed great synergistic effects in antiproliferation and apoptosis of A549 human cancer cells in vitro. The in vivo study demonstrated that M-HHG 2 C 18 -L(E + D) exhibited considerable tumor accumulation and potent suppression of tumor growth in Lewis lung carcinoma tumor bearing mice. It was also demonstrated that M-HHG 2 C 18 -L(E + D) showed no systemic toxicity and possessed distinguished effect on extending survival period. These results suggested that M-HHG 2 C 18 -L(E + D) had great potential application in cancer treatment.
研究领域:
药学
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Pharmaceutics-X
·
2025
·
IF 6.4
Yang Yu,Yili Zhao,Yujiao Zou,Chanyi Lu,Ni Li,Zhiyuan Shi,Xin Li,Xixi Lai
Ultra-sensitive pH-responsive drug delivery system designed to operate within the slightly acidic microenvironment of tumors are highly desired for hydrogel applications in cancer therapy. In this study, 4-Formylbenzoic acid modified polyvinyl alcohol (PVA-FBA, PF) was synthesized and utilized as a carrier for encapsulating the anticancer drug Doxorubicin (Dox). This was subsequently crosslinked with polyethylenimine (PEI) via benzoic-imine bond to form drug-loaded PVA-FBA/PEI hydrogel (D-PFP). The D-PFP hydrogel was characterized using various techniques. The results indicated that the optimal conditions for hydrogel preparation involved using PF-0.25 polymer, which had an aldehyde group content of 0.82 mmol/g, as the precursor, along with a 12 wt% precursor solution for crosslinking with a 5 wt% PEI solution. The resulting hydrogel exhibited good structural stability and favorable morphology. Drug release studies indicated that the hydrogel demonstrated minimal drug leakage under physiological conditions (pH 7.4), while exhibiting a significantly higher drug release rate at pH 6.8, thereby underscoring its superior pH sensitivity. Rheological evaluations further confirmed its injectability and self-healing properties. Moreover, the hydrogel displayed excellent cytocompatibility and significantly inhibited cancer cell activity at pH 6.8. These characteristics suggest the potential of this hydrogel as a drug delivery system with ultra-sensitive drug release properties, particularly for future applications in chemotherapy for cancer.
研究领域:
材料科学
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生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Today
·
2025
·
IF 10.9
Yating Qin,Yan Lin,Chao Tian,Yujie Qi,Shuling Wang,Xiaoyuan Chen,Wenxing Gu
Immune checkpoint blockade (ICB) therapy has emerged as a promising avenue for the treatment of malignant tumors. Nonetheless, the efficacy of this approach is constrained by low anti-tumor immunity and restricted intratumoral delivery of immune checkpoint inhibitors (ICIs) in solid tumors. In this study, a pH-responsive nanocomplex (BRM/PTX/aPD-1) was developed for the active transport of aPD-1 and PTX, thereby enhancing cancer chemoimmunotherapy. BRM/PTX/aPD-1 was prepared by using dynamic and reversible benzoic-imine bonds cross-linked bovine albumin (BSA), anti-PD-1 antibody (aPD-1) and PTX-loaded polylysine dendrimers. In the acidic tumor microenvironment, BRM/PTX/aPD-1 exhibited a charge reversal from negative to positive due to the hydrolysis of the β-carboxylic amide structure, which triggered cation-induced transcytosis. This process enabled active transport of adequate amounts of BRM/PTX/aPD-1 to the tumor parenchyma, where it was degraded by further hydrolysis of benzoic-imine bonds and effectively released aPD-1 and PTX. The nanocomplex demonstrated notable intratumoral permeability both in vitro and in vivo , particularly enhancing the delivery of aPD-1. Additionally, the nanocomplex showed robust anti-tumor activity in an orthotopic breast cancer model, significantly inhibiting tumor proliferation and preventing the progression of lung metastasis. This pH-responsive nanocomplex presents a promising platform for improved intratumoral delivery of ICIs and emerges as a practical solution for overcoming tumor immunosuppression.
研究领域:
肿瘤学
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药剂学
·
免疫学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Yushuang Lin,Nan Li,Weihao Xue,Hong Chen,Zhiruo Zhang,Zhao Dai
Achieving precise pore size tuning in nanofiltration membranes for Mg 2+ /Li + separation remains challenging due to the similar hydrated radii of the ions and the lack of real-time monitoring for dynamic adjustments. In this study, we developed a novel pH-responsive color-changing nanofiltration membrane with tunable pore sizes, enabling real-time monitoring and enhanced separation efficiency. By incorporating γ-cyclodextrin during interfacial polymerization, we achieved angstrom-level pore size tuning and reduced pH sensitivity. The color response of the membrane enables dynamic adjustments to the feed solution pH, optimizing pore radii to ∼0.41 nm, leading to a separation factor of 35.5. Molecular dynamics simulations and weight cut-off experiments confirmed that γ-cyclodextrin enhanced pore uniformity, resulting in a denser, more efficient membrane. This innovative approach offers a flexible and precise solution for Mg 2+ /Li + separation, demonstrating high permeance (15.5 L m −2 h −1 bar −1 ) and potential for applications in seawater desalination, resource recovery, and industrial ion separation.
研究领域:
膜科学
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分离技术
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材料科学
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化学工程
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环境科学
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 90
·73416-73423
·
IF 3.84
Yanan Xue,Xiaoyang Xia,Bo Yu,Xiaogang Luo,Ning Cai,Sihui Long,Faquan Yu
A surfactant-free and organic solvent-free one-pot method was utilized for the preparation of a pH-responsive alginate nanogel (pH-AN). Simply by mixing anionic sodium alginate (SA) with cationic doxorubicin (DOX) through electrostatic interactions, followed by in situ crosslinking with ionic calcium under ultrasound, a DOX-loaded pH-AN was obtained. The sizes of the nanogels can be tailored by varying the concentration of SA, the ratio of SA to ionic calcium and DOX. The nanogel was measured with a size range of 210 nm, and a polydispersity index of 0.208, as confirmed by transmission electron microscopy and dynamic light scattering. In vitro release profiles showed a significantly higher accumulative release at pH 5.0 than at pH 7.4, exhibiting apparent acid responsiveness. In vitro cytotoxicity tests clearly illustrated the remarkable inhibition to the growth of HeLa cells with an IC50 value of 0.26 μg mL−1. In contrast, NIH 3T3 cells displayed high tolerance. The plain nanogel exclusive of DOX was practically non-toxic. Confocal laser scanning microscopy observation demonstrated that DOX was efficiently internalized into HeLa cells through endocytosis, released into the cytoplasm, and then principally entered the nuclei. It is clearly suggested that a green and facile method was proposed to achieve a pH-responsive nanogel carrier for the delivery of drugs.
研究领域:
药剂学
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生物材料
·
肿瘤学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Changqin Ding,Yang Tian
The dysregulated pH is working as a mark of cancer. It is a challenge for developing a biosensor for targeted imaging in cancer cells and monitoring of intracellular pH . Here, a ratiometric fluorescence biosensor for pH determination was developed with targeted imaging into folate acceptor (FR)-rich cancer cells at the same time. AuNCs protected by bovine serum albumin (BSA) worked as reference fluorophore and fluorescein-isothiocyanate (FITC) acted as the response signal for pH. For targeted imaging of cancer cells, the AuNCs were simultaneously conjugated with folic acid (FA). The developed ratiometric biosensor can monitor pH with a wide linear range from 6.0–7.8 with a pKa at 6.84. Under every different pH condition , the probe showed high selectivity over various metal ions and amino acids with its fluorescence ratio stayed almost constant (<5%). It also showed good cyclic accuracy when pH switched between 6.0 and 8.0, as well as low cytotoxicity. The AuNC-based inorganic–organic nanohybrid biosensor showed good cell-permeability, low cytotoxicity, and long-term photostability. Accordingly, the pH biosensor was employed to gain targeted imaging in FR +ve Hela cells with FR −ve lung carcinoma cells A549 as comparison, and achieved to monitor the pH changes in Hela cells.
研究领域:
生物化学
·
医学诊断
·
纳米生物学
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DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2018
·Vol. 19
·期 5
·2395-2406
·
IF 2.666
Xiao Yu,Wang Shuang,Zong Qingyu,Yin Zongning
Single chemotherapeutic agent like paclitaxel (PTX) has shown some limitations in anti-tumor treatment, such as undesirable side effects, multidrug resistance, and high toxicity. In order to reduce the toxicity of PTX and increase the anti-tumor effect, folate-modified amphiphilic and biodegradable biomaterial was developed to co-deliver PTX and metformin (MET) for exerting the synergistic effect. PTX was physically entrapped in the hydrophobic inner core of the amphiphilic block copolymer by a solvent evaporation method, whereas MET was chemically conjugated to the hydrophilic terminals of copolymer via a pH-sensitive cis -aconityl linkage (Cis). The in vitro release behaviors of the drugs were analyzed by high-performance liquid chromatography (HPLC), and the synergistic effect of the drugs was evaluated by a Q value method. Results showed that drug-loaded micelles with an average size about 100 nm were successfully constructed. In acidic environments, the chemically conjugated MET was rapidly released after the breakage of sensitive bond between drug and copolymer. In vitro anti-tumor studies demonstrated that MET and PTX had a synergistic effect and co-delivery micelles induced higher cytotoxicity and apoptosis against 4T1 breast cancer cells than free drugs. Furthermore, folate-targeted co-delivery micelles increased the cellular uptake of drugs and were found to be effective for the treatment of solid tumor in vivo . These findings indicated that co-delivery of MET and PTX through the polymeric micelles is a promising strategy for cancer therapy.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Jiawei Tang,Muxi Wang,Hongming Li,Qingjian Liang,Zhongyan Zhang,Hong Liu,Jian Sun,Li-Jun Ma
The pyrene group is commonly used as a fluorophore in ratiometric fluorescence probes. However, these probes almost exclusively utilize the monomer/excimer of the pyrene group to achieve ratiometric fluorescence recognition for analytes. In the study, three structurally simple, mono-substituted pyrene derivatives, namely pyrene-1-ol ( Probe1 ), pyren-1-ylboronic acid ( Probe2 ), pyrene-1-carboxylic acid ( Probe3) utilize their protonation or deprotonation effects to influence the electronic excited state of the pyrene group, thereby achieving sensitive ratiometric fluorescence recognition of pH. Among them, Probe1 and Probe2 have been verified to function in alkaline environments with pH values ranging from 8.1 to 12.1 and 9.4 to 13.1, respectively, with p K a values of 8.9 and 11.1. Meanwhile, Probe3 performs optimally in weak acidic conditions with a pH range of 2.3–5.2, having a p K a value of 4.8. Additionally, three fluorescence probes exhibit excellent photo-stability, recyclability, and resistance to ionic interference. Furthermore, the three probes can also achieve ratiometric fluorescence detection of pH in environmental water sources such as tap water and Pearl River water, as well as fluorescence response to pH in living GS cells of epinephelus coioides.
研究领域:
分析化学
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生物医学工程
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环境科学
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Ying Liu,Qingyun Ma,Zhixuan Wang,Xinxin Shang,Yuting Lan,Guoping Guan,Lu Wang
Thrombosis and infection are the primary challenges limiting the clinical application of small-diameter artificial blood vessels. Numerous studies have focused on improving the hemocompatibility of artificial vascular materials, addressing properties such as anticoagulant activity, antithrombogenicity, low hemolysis rates, and reduced platelet adhesion. However, there has been comparatively less attention given to the antibacterial properties of these materials. This study utilizes polyester braided tubes and PVA/PAAm hydrogel materials, combined with surface modification techniques, to develop a pH-responsive antibacterial hydrogel artificial blood vessel graft. The hydrogel surface was grafted with a polymer brush hierarchical structure, and antimicrobial peptide MLT was immobilized to confer antibacterial properties. Additionally, 2,3-dimethylmaleic anhydride (DMMA) was covalently attached as a shielding group to achieve an environment-responsive strategy. The research demonstrates that this artificial blood vessel graft exhibits structural stability, excellent mechanical properties, and good cellular and hemocompatibility. Furthermore, it exhibits pH-responsive capabilities, triggering efficient antibacterial activity in low pH environments. The modified antibacterial hydrogel artificial blood vessel material shows low hemolysis rates, excellent anticoagulant properties, and reduced platelet adhesion. Therefore, the strategy of combining MLT with DMMA may effectively enhance the hemocompatibility and responsive antibacterial performance of artificial blood vessel materials.
研究领域:
生物医学工程
·
材料科学
·
组织工程
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2015
·Vol. 293
·期 9
·2617-2624
·
IF 1.865
Yan Zhihu,Dai Caili,Zhao Mingwei,Zhao Guang,Li Yuyang,Wu Xuepeng,Liu Yifei,Du Mingyong
Dual-stimulated wormlike micelles regulated by pH and temperature in a surface active ionic liquid system comprising of a cationic surfactant ( N -cetyl- N -methylpyrrolidinium bromide (C 16 MDB)) and an aromatic dibasic acid (pyrocatechol) were investigated. Such a system can be reversibly switched between liquid-like and gel-like states on adjusting the solution pH value. The rheology, light scattering techniques and cryogenic-transmission electron microscopy (cryo-TEM) results show the growth of spherical micelles into long and entangled wormlike micelles was responsible for the changes in flow properties such as high viscosity, shear-thinning behaviour and Maxwell-type dynamic rheology. The nuclear magnetic resonance results reveal the binding capacity of pyrocatechol to C 16 MDB is proposed as the key factor of the unusual rheological and micellar responses of this pH-stimulated system. In addition, with the increase of temperature, molecular motion of surfactant molecules becomes more active, which endow the property of thermo-stimulated to the surface active ionic liquid system.
研究领域:
化学
·
材料科学
·
胶体与界面科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）