BIOCHEMICAL PHARMACOLOGY
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2024
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IF 5.3
Jin Wu,Xiang Li,Hepeng Nie,Yue Shen,Zixiang Guo,Catherine Huihan Chu,Kunzhan Cai,Chunbo Tang
Diabetes-related hyperglycemia inhibits bone marrow mesenchymal stem cell (BMSC) function, thereby disrupting osteoblast capacity and bone regeneration. Dietary supplementation with phytic acid (PA), a natural inositol phosphate, has shown promise in preventing osteoporosis and diabetes-related complications. Emerging evidence has suggested that circular (circ)RNAs implicate in the regulation of bone diseases, but their specific regulatory roles in BMSC osteogenesis in hyperglycemic environments remain elucidated. In this study, in virto experiments demonstrated that PA treatment effectively improved the osteogenic capability of high glucose-mediated BMSCs. Differentially expressed circRNAs in PA-induced BMSCs were identified using circRNA microarray analysis. Here, our findings highlight an upregulation of circEIF4B expression in BMSCs stimulated with PA under a high-glucose microenvironment. Further investigations demonstrated that circEIF4B overexpression promoted high glucose-mediated BMSC osteogenesis . In contrast, circEIF4B knockdown exerted the opposite effect. Mechanistically, circEIF4B sequestered microRNA miR-186-5p and triggered osteogenesis enhancement in BMSCs by targeting FOXO1 directly. Furthermore, circEIF4B inhibited the ubiquitin-mediated degradation of IGF2BP3, thereby stabilizing ITGA5 mRNA and promoting BMSC osteogenic differentiation. In vivo experiments, circEIF4B inhibition attenuated the effectiveness of PA treatment in diabetic rats with cranial defects. Collectively, our study identifies PA as a novel positive regulator of BMSC osteogenic differentiation through the circEIF4B/miR-186-5p/FOXO1 and circEIF4B/IGF2BP3/ITGA5 axes, which offers a new strategy for treating high glucose-mediated BMSC osteogenic dysfunction and delayed bone regeneration in diabetes.
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Materials Science & Engineering C-Materials for Biological Applications
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2019
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IF 4.959
Xin Tang,Xuan Zhang,Yingqi Chen,Wentai Zhang,Junyu Qian,Hanaa Soliman,Ai Qu,Qijun Liu,Shimin Pu,Nan Huang,Guojiang Wan
It remains challenging to build up a multifunctional coating onto biodegradable magnesium (Mg) for biomedical use. In this study, a small amount of titanium dioxide (TiO 2 ) has been incorporated in situ into phytic acid (PA) coating when it was chemically deposited on Mg substrate targeted to biodegradable implant applications. Ultraviolet (UV) irradiation was utilized in the liquid phase deposition of TiO 2 to improve the quality of coating (PA&TiO 2 -UV). This PA&TiO 2 -UV coating was compact, thicker and more hydrophilic compared with sole PA or TiO 2 coating. The PA&TiO 2 -UV coated Mg presented a seven times lower electrochemical corrosion current density as well as significantly slower in vitro degradation rate up to 500 h in phosphate buffer saline as compared to the direct PA coated Mg. In addition, the UV irradiation showed remarkably to promote the MC3T3-E1 pre-osteoblast cells adhesion and proliferation especially after 7 days of culture. Further, the PA&TiO 2 -UV coating adhered more firmly on Mg substrate after 90° bending than the other coatings, indicating a better mechanical compliance on Mg substrate. These results make this PA&TiO 2 -UV complex coating bodes well for biodegradation slowing-down, osteo-compatible as well as mechanical compliant modification of Mg for orthopedic implants applications.
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Nanoscale
·
2017
·Vol. 9
·期 10
·3555-3560
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IF 7.367
Zonghua Pu,Ibrahim Saana Amiinu,Chengtian Zhang,Min Wang,Zongkui Kou,Shichun Mu
Applications of highly-efficient and durable non-precious metal electrocatalysts for hydrogen evolution reaction (HER) have great potential to relieve the energy crisis. Here, we demonstrate a green method for fabrication of a number of transition metal phosphides (TMPs) by pyrolyzing melamine and self-assembled phytic acid (PA) cross-linked metal complexes. The obtained materials consisting of TMP nanoparticles (NPs) are encapsulated in N,P-codoped carbon (NPC). Among TMPs, the resultant FeP NPs encapsulated in the NPC matrix (FeP NPs@NPC) show the highest HER activity at all pH values. At a current density of 10 mA cm−2, FeP NPs@NPC displays overpotentials of 130, 386 and 214 mV in 0.5 M H2SO4, 1.0 M phosphate buffer solution (PBS) and 1.0 M KOH, respectively. Additionally, the encapsulation by NPC effectively prevents FeP NPs from corrosion, exhibiting almost unfading catalytic activity after 10 h testing in acidic, neutral and basic electrolytes. More importantly, other TMPs wrapped in NPC (CoP NPs@NPC and Ni2P NPs@NPC) can be easily obtained by this method, which also exhibit relatively high activity toward HER. Therefore, this generic synthesis strategy opens a door for unprecedented design and fabrication of novel low-cost TMP based electrocatalysts for HER and other electrochemical applications.
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
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2024
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IF 1.7
Hu Man-Na,Qu Xue-Jing,Chen Xiao-Lan,He Dan,Wang Guo-Ya,Liu Jia-Hui,Roy Tania,Kurniawan Alfin,Zhou Chun-Hui
Bone adhesives are known as a promising fracture treatment material because they can quickly heal broken bones. However, the existing bone adhesives have the disadvantages of weak binding ability to bone tissue, non-absorption, or difficulty in curing under wet conditions, which limits their wide application in the field of bone tissue engineering. In this study, the raw material of magnesium phosphate bone adhesive was modified, and the composite material of magnesium phosphate bone repair was prepared by the method of solid–liquid blending crosslinking. Mineral-organic composite, a new type of bone adhesive was prepared using calcined dolomite and montmorillonite as mineral components, phytic acid and gelatin as organic components. The compressive strength, porosity and bonding strength of the magnesium phosphate-based bone adhesive were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. When the dosage of dolomite is 8 wt% and the concentration of gelatin is 9 wt%, the adhesion strength of the bone adhesive is 2.04 MPa after 168 h placement. And the compressive strength of the bone adhesive was 6.66 MPa after 168 h placement. After the prepared bone adhesives were immersed in SBF solution for 14 and 21 days, EDS analysis showed that the accumulated material was bone-like hydroxyapatite, indicating that the prepared bone adhesives had good osteogenic activity. In addition, it was also found that the bone adhesive had fluid absorption ability and no cytotoxicity. So, conclusively it can be stated that such newly synthesized bone adhesive has significant medical potential.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
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IF 4.539
Ran Wang,Chong Cai,Di Wang,Zhiwei Liu,Lili Gao,Tifeng Jiao
In this work, a new type of self-assembled phytic acid-graphene oxide composite foam (PAGF) was prepared by hydrothermal method. In addition, Au nanoparticles (Au NPs) and Fe 3 O 4 particles were loaded onto PADF to obtain PAGF@Au&Fe 3 O 4 composite by a simple one-step method. The addition of graphene oxide (GO) can effectively prevent the agglomeration of Au NPs and weaken its surface passivation. The results of SEM, XRD, XPS and BET proved the successful preparation of the composite and its large specific surface area. Moreover, the synthesized PAGF@Au&Fe 3 O 4 composite showed good catalytic performance for p-nitrophenol (4-NP) and o-nitroaniline (2-NA) solutions with the rate constant (k) values of 0.0799 min −1 and 0.0546 min −1 , respectively. Due to the addition of Fe 3 O 4 , the composite exhibited good stability and recyclability, and maintained high catalytic efficiency after 8 cycles of catalytic process. The current work provides new ideas for developing novel graphene oxide-based composite materials and their catalytic degradation of organic pollutants.
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JOURNAL OF SEPARATION SCIENCE
·
2024
·Vol. 47
·期 13
·2400154
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IF 2.8
Hao Wang,Simin Li,Xinyan Wang,Xinyue Li,Minzhi Jiang,Shiying Chen,Zaiqi Hu,Haitian Li,Yuzhen Xu,Lei Jin
Glycosylation and phosphorylation rank as paramount post-translational modifications, and their analysis heavily relies on enrichment techniques. In this work, a facile approach was developed for the one-step simultaneous enrichment and stepwise elution of glycoproteins and phosphoproteins. The core of this approach was the application of the novel titanium (IV) ion immobilized poly(glycidyl methacrylate) microparticles functionalized with dendrimer polyethylenimine and phytic acid. The microparticles possessed dual enrichment capabilities due to their abundant titanium ions and hydroxyl groups on the surface. They demonstrate rapid adsorption equilibrium (within 30 min) and exceptional adsorption capacity for β-casein (1107.7 mg/g) and horseradish peroxidase (438.6 mg/g), surpassing that of bovine serum albumin (91.7 mg/g). Furthermore, sodium dodecyl sulfate-polyacrylamide gel electrophoresis was conducted to validate the enrichment capability. Experimental results across various biological samples, including standard protein mixtures, non-fat milk, and human serum, demonstrated the remarkable ability of these microparticles to enrich low-abundance glycoproteins and phosphoproteins from biological samples.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Sen Zeng,Xiaojie Gao,Huiyun Chen,Qianting Wang,Junhui Si,Zhixiang Cui
Membrane technology is regarded as one of the most effective approaches for microalgae dewatering in the biofuel production industrial and oil/water emulsion separation. However, it inherently suffers from the issue of membrane fouling, particularly irreversible membrane fouling, which is hard to remove by physical methods. Herein, a robust superhydrophilic membrane combined with photo-Fenton self-cleaning property was developed for microalgae dewatering and oil/water emulsion separation. Phytic acid (PA) and Fe III formed a hydrophilic PA-Fe III complex on the polyethersulfone (PES) membrane as the precursor for the in situ growth of β-FeOOH nanorods. When used for microalgae filtration, the irreversible fouling that blocked membrane pores could be degraded by the photo-Fenton reaction. Hence, the obtained PES/PA@β-FeOOH membrane possessed a flux recovery rate (FRR) of 90.2 % (within 30 min), which was significantly higher than that of the PES membrane (32.9 %). The proteins and polysaccharides (extracellular organic matter) attached on the PES/PA@β-FeOOH membrane with photo-Fenton cleaning were 11.2 and 9.1 mg/m 2 , which was considerably lower than that of PES after hydraulic cleaning (184.1 and 334.9 mg/m 2 ). Moreover, due to the superhydrophilic, the prepared PES/PA@β-FeOOH membrane also exhibited excellent oil/water emulsion separation ability. This work presents a facile and mild strategy to design an anti-fouling coating with superhydrophilic and photo-Fenton activity, which can be used in membrane technology for microorganism filtration and wastewater treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xu Yang,Yuandong Zhang,Changpeng Wang,Bingyao Wang,Xiaoxu Liang,Hui Li,Hongyao Ding,Si Yu Zheng
Conductive hydrogels are ideal candidates for flexible electronics owing to their excellent biocompatibility and flexibility. However, achieving excellent mechanical strength and conductivity simultaneously remains a significant challenge. Herein, we report a mechanically robust and ionically conductive hydrogel that can be readily fabricated via a two-step strategy involving polymerization of a hybrid network composed of poly(acrylamide- co ‑sodium acrylate), gelatin and carboxymethyl chitosan followed by immersion in a mixed solution of phytic acid and magnesium sulfate. Phytic acid reinforced hydrogen bonding interactions and acted as dynamic crosslinkers. Sulfate ions promoted the hydrophobic aggregation and triple helices formation via the Hofmeister effect, and magnesium ions coordinated with carboxy groups among the polymer network. These newly formed interactions synergistically strengthened the hydrogel network. The resulting hydrogel exhibited exceptional tensile strength, high stretchability, and remarkable toughness, yet low modulus. Additionally, the incorporation of free ions endowed the hydrogels with high conductivity, making them suitable for flexible strain sensors. These hydrogel-based sensors demonstrated excellent linear responsiveness over a wide strain range with satisfactory sensitivity, thus enabling accurate monitoring of diverse human motions from large joint bending to subtle vocal vibrations. This work presents an effective strategy to design conductive and tough hydrogels for flexible electronics.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 12.5
Shijia Gu,Guohua Dong,Xiaoxiao Tan,Xinjia Zhang,Tianyuan Xiao,Chao Wang,Yushu Wang,Wenzhi Zhang
The development of coated slow-release fertilizers (SRF) utilizing low-cost and abundantly available biomass materials is still a significant challenge in sustainable agricultural production. Herein, based on the citric acid and phytic acid co-esterified natural starch (NS) derivatives (CAPAS) and cellulose acetate (CAc), a novel full biomass-based coated urea (CAPAS-CAc@urea) SRF was developed by utilizing multiple impregnation coating technology. The experimental results demonstrate that the synthesized CAPAS possesses higher hydrophobicity, film-forming ability, and a well-developed cross-linked network structure, ultimately leading to enhanced mechanical properties, hydrophobicity, and biodegradability of the CAPAS-CAc film. Importantly, the resulting CAPAS-CAc@urea SRF shows superior nutrient slow-release properties, endowing a cumulative N slow-release rate ∼ 77.5% (48 h) in water and ∼ 58.9% (29 d) in soil, which is approximately five times slower than that of uncoated urea. Kinetic fitting indicates that the N release of the prepared CAPAS-CAc@urea complies with the First-order kinetics model, which is governed by a Fickian diffusion mechanism. The results of the sugar sorghum pot experiment verify that CAPAS-CAc@urea exhibits the prominent function for promoting plant growth, primarily through improving root development. Consequently, this study provides a novel route for advancement of environmentally-friendly coated SRF with degradable biomass materials in the sustainable agriculture.
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Reaction Chemistry & Engineering
·
2026
·
IF 2.9
Mingxin Xiao,Xinlei Jia,Yonghui Wang,FangZhou Ding,Xin Kang,Xinqi Xue,Lanjuan Xu,Jun Wang
Cotton fabric has found extensive applications in both civilian apparel and aviation interiors, owing to its exceptional breathability, lightweight nature, and design adaptability. Nevertheless, the comfort provided by civil aircraft seat covers is accompanied by intrinsic fire hazards, presenting a significant safety concern. Therefore, the efficient flame-retardant modification of cotton fabrics holds significant research value and application prospects. A layer-by-layer (LbL) self-assembly technique was employed to construct a phosphorus–nitrogen synergistic flame-retardant system on cotton fabric by alternately depositing chitosan (CS) and phytic acid (PA). The uniformity, thermal stability, and flame-retardant performance of the coating were balanced through systematic optimization of key parameters, including CS concentration, PA concentration, dipping time, and number of bilayers. The experimental results indicated a significant enhancement in the thermal stability and flame retardancy of the modified cotton fabrics. Among them, the C10/CS/PA sample exhibited the optimal overall performance, achieving a limiting oxygen index (LOI) of up to 36.2% and an increase in residual char yield of 17.4%. Furthermore, Raman spectroscopy analysis revealed that the ID/IG ratio of the C8/CS/PA sample, with a recorded value of 1.63, was considerably lower than the value of 2.70 for pristine cotton. This confirms that the phosphorus–nitrogen crosslinked network effectively promoted the formation of sp2-hybridized graphitic carbon, leading to the construction of a compact and intumescent char layer, thereby realizing a condensed phase-gas phase synergistic flame-retardant mechanism.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Zhoujia Liu,Peng Yan,Yixuan Bai,Zhiqian Zhang,Xiaogang Li,Weiwei Xiong,Junhao Zhang,Aihua Yuan,Fenfen Zheng
Transition metal phosphides (TMPs) have received widespread attention due to their high theoretical specific capacity and fast reaction kinetics. However, their poor conductivity and volume changes during the cycle limited their applications. Herein, we explore a facile and cost-effective way to prepare core–shell-like transition metal phosphides (TMPs: CoP , Ni 2 P, Cu 3 P) nanoparticles embedded into nitrogen doped porous carbon nanosheets (denoted as CoP@NDPCS, Ni 2 P@NDPCS, Cu 3 P@NDPCS) via biological material-driven assembly and self-template strategy. By self-assembled process, the amino and carbonyl groups in silk fibroin can chelate with metal ions, and then phytic acid added undergoes a coordination reaction with the metal components. Subsequently, core-shell TMPs nanoparticles supported by nitrogen doped porous carbon nanosheets were prepared by a one-step high-temperature calcination process. The obtained unique hybrid structure material with enough vacancy space to alleviate volume expansion exhibits ultra-high specific capacity and excellent cycling performance for the anode of lithium-ion batteries. The CoP@NDPCS, Ni 2 P@NDPCS and Cu 3 P@NDPCS electrodes exhibit the reversible capacities of 1014.2, 486.5 and 877 mAh g −1 at the current density of 500 mA g -1 , respectively. The remarkable lithium storage performance of TMP@NDPCS indicates that a reasonable structure designed by biological material-driven is an effective and promising method to enhance the lithium storage of transition metal phosphides.
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Innovative Food Science & Emerging Technologies
·
2025
·
IF 6.8
Jiyao Zhang,Shuyi Liu,Yajing Qi,Zhongwei Chen,Bin Xu
Encapsulating within zein/trehalolipid nanoparticles (Z/TL) via NaOH/phytic acid-driven method (PAPD) can improve water solubility and stability of carvacrol (CAR). However, this technique still has limitations including empirically determined parameters and potential risk of core material degradation. In this respect, we introduced a strategy of positioning dual critical pH based on specific attributes of wall and core materials. The finest alkalization endpoint for Z/TL was determined by monitoring conformational changes across pH 7–12. Meanwhile, the suitable pH of deprotonation was identified by assessing pH-dependent water solubility and chemical stability of CAR. Obtained information was applied to modify PAPD into PAPD’. The colloidal properties, encapsulation efficiency (EE), loading capability (LC), environmental stress resistance, and in vitro release behavior of nanoparticles prepared using PAPD’ and PAPD were systematically compared. The optimal alkalinization endpoint for Z/TL was determined to be pH 11.25. where the degree of hydrolysis would not increase further, but the acceleration of increase in aqueous solubility would reach its maximum. The optimal pH of deprotonation for CAR was pH 11, balancing high solubility with controllable degradation. PAPD’-nanoparticles exhibited a smaller size (99.36 nm), higher ζ-potential (−43.91 mV), and improved EE/LC (97.95 %/29.39 %). Enhanced stability, along with a sustained release profile were demonstrated. Consumption of NaOH/PA was also reduced while maintaining required efficacy. Overall, customized PAPD’ not only improves the processing adaptability and flexibility of fabricating protein-based nanoparticles but also provides a theoretical framework and practical paradigm for the rational design of nanocarriers for bioactive compounds.
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