International Journal of Nanomedicine
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2020
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IF 5.115
Wei Xin,Yumei Wang,Xianmou Guo,Kaijun Gou,Jing Li,Sanming Li,Lin Zhao,Heran Li
Purpose The aim of this study was to improve the oral bioavailability and anti-inflammatory activity of the poorly soluble drug ibuprofen (IBU) by employing a new kind of poly(ethyleneimine)s (PEIs)-based mesocellular siliceous foam (MSF) called B-BMSF@PEI as drug carrier.Methods B-BMSF@PEI was biomimetically synthesized by using PEIs as templates, catalysts and scaffolds under ambient conditions, and the structural characteristics, including size, morphology, mesoscopic structure and pore properties, were estimated by TEM, SEM, FTIR and N2 desorption/adsorption measurement. Then, IBU was incorporated into B-BMSF@PEI at the drug:carrier weight ratio of 1:1. The structural features of IBU before and after drug loading were systemically characterized. IBU and B-BMSF@PEI were then subject to in vitro drug release study and wettability analysis. Finally, in vivo pharmacokinetics and anti-inflammatory pharmacodynamics studies were carried out to evaluate the efficacy of B-BMSF@PEI on improving the oral adsorption of IBU.Results The results demonstrated that B-BMSF@PEI was a meso–meso porous silica material with foam appearance. It consisted of uniform spherical cells (40 nm) with interconnected pore networks. IBU can be successfully loaded into B-BMSF@PEI with high efficiency (as high as 39.53%), and crystal IBU was effectively converted to an amorphous state during this process. Benefiting from the great architectures of B-BMSF@PEI, IBU/B-BMSF@PEI performed good wetting property and significantly improved the dissolution rate in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Notably, IBU exhibited very satisfactory relative bioavailability (681.4%) and anti-inflammatory effects (the inhibition rates were between the ranges of 113.5% to 1504.3%).Conclusion B-BMSF@PEI with bimodal mesoporous system and interconnected nanopores was obtained owing to the dynamic self-assembly functions of PEIs. It had superiority in drug loading and could improve the oral adsorption of ibuprofen to a satisfactory level.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2020
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IF 4.939
Mengjie Feng,Qi Zhang,Shigang Sun,Xinsheng Zhang,Shuozhen Hu
Iron, nitrogen, sulfur co-doped Fe/N/C catalyst (poly-AT/Me–Fe/N/C) with the structure of graphene-like nanosheets around carbon nanoparticles were successfully synthesized for oxygen reduction reaction (ORR). 2-Aminothiazole and melamine were utilized as the dual-nitrogen-source. The results showed that 2-Aminothiazole, as the nitrogen and sulfur source, contributed to in-situ synthesizing graphene-like nanosheets around KJ-600 carbon nanoparticles with high specific surface area (1098 m 2 /g). Proper method to introduce melamine during the synthesis could increase the content of pyridinic-N and Fe-N x moieties in the catalyst without changing the morphology. Due to the high surface area and high content of pyridinic-N and Fe-N x moieties, the obtained poly-AT/Me–Fe/N/C catalyst exhibited high electrochemical activity and stability with the half-wave potential of 0.84 V (RHE) in 0.1 M NaOH solution, which is merely 17 mV lower than commercial Pt/C. The electron transfer number was 3.83, indicating a nearly 4e − transfer for the ORR with low HO 2 − yield.
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ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 3
·353-360
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IF 2.049
Sifan XU,Shuqi YE,Yunhui XU,Feifan LIU,Yushun ZHOU,Qian YANG,Hailong PENG,Hua XIONG,Zhong ZHANG
To achieve a rapid, sensitive, and economical method for the detection of ascorbic acid (AA) in the presence of Fe3+, a nitrogen and sulfur co-doped carbon dots (N,S-co-CDs) based fluorescence sensing system was developed. In this work, N,S-co-CDs were successfully synthesized via a one-step microwave-assisted method within 2.5 min using ammonium citrate and L-cysteine as precursors. The fluorescence of N,S-co-CDs was quenched (off ) by Fe3+ through a static-quenching mechanism. Subsequently, the fluorescence was recovered (on) after introducing AA into the quenched system, which was attributed to the reduction effect of AA for Fe3+. Therefore, a switch-on sensor (N,S-co-CDs/Fe3+ system) was developed for AA detection. Under optimal conditions, the limit of detection (LOD) of 2.31 μmol/L for AA was obtained over a linear range from 0 to 150 μmol/L. Furthermore, the proposed sensing method was successfully applied to detect AA in processed fruit juice with satisfactory results. The most important is that the sensor derived from a microwave-assisted method has simple and eco-friendly synthesis processes, is rapid, and has high detection efficiency. Therefore, such a switch-on sensor may be a promising candidate sensor for AA detection in processed fruit samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
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IF 5.162
Jing-Yu Liu,Xiao-Xiao Hou,Zhuo-Yu Li,Shu-Hua Shan,Ming-Chang Chang,Cui-Ping Feng,Yin Wei
The fruiting body of Hericium erinaceus has been used to treat digestive system disorder-related diseases for over 2000 years in China. A novel polysaccharide, HEFP-2b, was obtained from H. erinaceus fruiting bodies. Physical and chemical analysis showed that HEFP-2b consisted of fucose, galactose, glucose, and mannose in molar ratio of 11.81:22.82:44.28:21.09, and that its molecular weight was 3.252 × 10 4 Da. The backbone of HEFP-2b consisted of →6)-linked-α-D-Glc p -(1→ and →4)-β-D-Gal p -(1→ and →3,6) -α-D-Man p linkage, with two side-branching units of (1→ and →6)-β-D-Gal p and (1→ and →4)-α-D-Man p , terminated by Glc and Fuc. The results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell cycle arrest experiments revealed that HEFP-2b considerably inhibited the growth of colon cancer cells (HCT-116) in vitro . The growth inhibitory effects of HEFP-2b correlated with their ability to arrest the cell cycle at the S -phase. Our results will provide valuable information for future studies on HEFP-2b as a novel health-promoting functional food ingredient that can be used for treating colon cancer.
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CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Hanwen Guo,Aitang Zhang,Hucheng Fu,Hanwen Zong,Fuhao Jin,Kai Zhao,Jingquan Liu
Practical applications of flexible electrochemical energy storage devices are still limited by the lack of robust mechanical structures and high capacitive storage capabilities. Herein, the 3D CeCoS x -SA/GF porous aerogels are designed and prepared based on sodium alginate, which possess a special structure that can be explained by the so-called “egg-box” model. Each metal ion can be paired with the carboxyl and hydroxyl groups of the G monomer on two adjacent sodium alginate molecular chains. Melamine foam is used as carrier for graphene/sodium alginate impregnation and plays an important role on significantly limiting the agglomeration of graphene nanosheets due to their strong π-π stacking. The fabricated electrode based on CeCoS x -SA/GF shows an excellent electrochemical capacitance of 873.3F/g at the current density of 1A/g. In addition, the capacitance retention rate can still remain 87.1 % after 5000 cycles at a high current density of 8 A/g. Moreover, the fabricated all-solid state asymmetric supercapacitor device assembled with CoCeS x -SA/GF and active carbon shows an energy density of 29.58 Wh kg −1 at a power density of 801 W kg −1 . For practical applications, the fabricated supercapacitor device can power a multifunctional display for 28 mins and illuminate a small light bulb for 3 mins. Moreover, the KOH/polyvinyl alcohol gel-electrolyte was used to fabricate high-strength and flexible CeCoS x -SA/GF/PVA/KOH composite film electrode, which can be bent at various angles (0°-180°) and can be twisted into various shapes. Notably, the CeCoS x -SA/GF/PVA/KOH composite film can lift plastic bottles containing 500 mL (500 g) and 1000 mL (1 kg) water, respectively, indicating that it has great application potential for wearable and portable electronic devices.
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ACS Sustainable Chemistry & Engineering
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2019
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IF 6.97
Chunhe Yu,Xiaohua Jiang,Dongmiao Qin,Guichun Mo,Xiangfei Zheng,Biyang Deng
S,N-Codoped carbon quantum dots (SNCQDs) with a quantum yield (QY) of 23% have been synthesized using lotus root as a carbon source and glutathione (GSH) as a nitrogen and sulfur source. The obtained SNCQDs exhibited many excellent features such as a simple preparation process, high fluorescence QY, satisfactory photostability, superior water solubility, and biocompatibility. The SNCQDs combined with Cu2+ were used as a novel off–on nanoprobe for 6-thioguanine (TG). Initial fluorescence is significantly quenched in this sensing system via electron transfer from SNCQDs to Cu2+. Fluorescence is recovered after adding TG owing to Cu2+–TG complex formation between Cu2+ and TG. A novel off–on fluorescent nanoprobe was presented for highly sensitive determination of TG. Under optimal conditions, the nanoprobe exhibited a wide linearity range of 0.005–80 μmol/L for TG and a detection limit of 1.6 nmol/L. The designed off–on nanoprobe was successfully utilized for detecting TG in plasma and urine of a leukemia patient and imaging of TG in living T24 cells.
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ACS Applied Energy Materials
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2023
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IF 6.4
Ziming Qiao,Zhipeng Yang,Mengke Li,Yi Feng,Xiongwei Qu,Hemi Qu,Xiaojie Zhang
Two quaternary pyridinium-type cationic-based porous organic frameworks (DB-POF and LB-POF) were first synthesized via “one-pot” polymerization and were incorporated into a PEO/LiTFSI matrix as fillers to prepare a series of solid polymer electrolytes (SPEs) . The obtained quaternary pyridine-type cationic-based POFs not only have higher polarizability through the characteristic of skeleton charge but also have a stable structure and simple preparation, making them a good candidate material for achieving rapid Li+ conductivity in SPEs. Therefore, POFs could be incorporated into PEO-based SPEs that will have a positive impact on the ion transport capacity and the mechanical properties of SPEs and also increase the stability of the lithium metal anode. Among the obtained membranes, the PEO-LB-10% electrolyte exhibits the best ion conductivity, up to 5.8 × 10–4 S cm–1 at 90 °C, and has outstanding mechanical properties, and the tensile strength can reach 8.61 MPa. Significantly, the Li–S battery containing the PEO-LB-10% electrolyte indicates superior electrochemical performance, with an excellent initial discharge specific capacity of 906 mAh g–1 at 0.2 C. After 500 cycles at 1 C, its capacity remained at 472 mAh g–1, with an attenuation rate of 0.037% per cycle.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Peiyao Bai,Shilin Wei,Qiang Ru,Lang Xu
The development of dynamic electrocatalysts whose active sites evolve under operating conditions represents a frontier in catalysis. An important challenge is to identify suitable pre-catalytic sites and supports that direct dynamic processes toward highly active species while stabilizing them. Here we embed atomically dispersed six-coordinate FeO 6 sites in a 3D-opened multiscale S-doped porous carbon, serving respectively as pre-catalytic sites and supports for electrochemical nitrate reduction to ammonia. During repeated voltammetric scans, the current density increases continuously, revealing dynamic transformation of the FeO 6 sites into residual single-atom sites and newly formed Fe 0 nanoparticles. Integrated in situ and theoretical studies elucidate a dissolution-migration-reduction pathway: deeply embedded FeO 6 single-atom sites dissolve and migrate through interconnected pore channels and are electrochemically reduced to Fe 0 nanoparticles stabilized by the S-doped surface. The dynamically generated Fe 0 nanoparticles show higher nitrate reactivity than the single-atom Fe moieties. Further analysis reveals a crossover mechanism merging the normal and hydroxylamine pathways, accounting for the high ammonia electrosynthesis performance. These findings establish a design principle for dynamic electrocatalysis by pairing a metastable pre-catalytic site with a hierarchically porous sulfur-doped carbon support, converting site evolution from an uncontrolled process into a controllable route for generating and stabilizing highly active species.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2023
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IF 6.2
Ren Xie,Shucheng Liu,Yongchao Rao,Abdou Karim,Xiaosi Qi,Haifu Huang,Haicheng Xuan
The requirements of the morphology and material properties in common make it possible to integrate the two functional electrodes, hydrogen electrocatalyst and supercapacitor , into one material system. The order of electrochemical performance of core materials was ranked as NiCoP > NiCo 2 S 4 > NiCo 2 O 4 . By constructing core/shell heterostructure, Ni-Co-X/Co(OH) 2 composites achieved the boost of electrochemical performance than individual Ni-Co-X. Particularly, the NiCoP/Co(OH) 2 composite synthesized under optimal conditions presented both excellent catalytic activity and charge storage capability. The NiCoP/Co(OH) 2 composite needed small overpotential of 73 mV to drive current density of 10 mA cm −2 in 1 M KOH, displayed Tafel slope of 75 mV dec −1 and long-term stability over 15 h without obvious fluctuation. Moreover, the NiCoP/Co(OH) 2 composite showed high specific capacitance of 1604 F g −1 at 1 A g −1 , delivered remarkable rate capability of 81.8 % at 20 A g −1 and cyclic stability with 91.8 % capacity retention over 5000 cycles. The impressive electrochemical properties of NiCoP/Co(OH) 2 composite is attributed to the enriched active sites, enhanced electronic conductivity and strong synergistic effect. Our research provides insights and effective strategies for the design and synthesis of integrated electrodes for hydrogen electrocatalysts and supercapacitors.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 42
·19775-19781
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IF 3.3
Xueyan Wu,Yang Yang,Yan Lv,Xiuli Zhang,Jiaxin Li,Jixi Guo
The development of efficient and stable catalysts for the oxygen reduction reaction (ORR) is crucial to enable practical large-scale application of Zn–air batteries (ZABs). This study investigates the utilization of N, S co-doped coal-based activated carbon materials, synthesized through facile reactions, which exhibit high specific surface area and abundant active sites. The results of material characterization and experiments indicate that co-doping with N and S can effectively modify the charge distribution of coal-based activated carbon materials, increase the active sites, and ultimately enhance their performance in the oxygen reduction reaction (ORR). The N, S-AC catalyst exhibits remarkable catalytic activity for the ORR in alkaline electrolytes, demonstrating a high half-wave potential (E1/2 = 0.79 V), ultimate current density (jL = 6.35 mA cm−2) and stability, as well as considerable tolerance to methanol. The N, S-AC-based ZAB also demonstrates exceptional performance, achieving a maximum power density of 142 mW cm−2 and a specific capacity of 804 mA h gZn−1. This study not only simplifies the preparation process for heteroatom-doped coal-based activated carbon catalysts but also explores practical applications for ZABs.
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APPLIED SURFACE SCIENCE
·
2023
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IF 6.7
Jiaojiao Jiao,Zexiang Wang,Jing Wang,Tiantian Yao,Zongliang Chen,Chen Chen,Li Sun,Xian Zhao,Weiliu Fan
The reasonable design of g-C 3 N 4 (CN)-based homojunctions is a promising method to improve the photocatalytic performance. Controlling the interfacial charge-transport process is challenging. Herein, Ag and P-doped CN (ACN and PCN) were selectively synthesized. The band edges of CN move downward continuously with increasing Ag or P doping concentration. CN/4ACN (type-II), CN/8PCN (S-scheme) and 4ACN/8PCN (S-scheme) were formed by suitable energy level matching, and their charge transfer mechanisms were confirmed via VB-XPS, UPS and ESR analysis. In the presence of the hole sacrificant triethanolamine (TEOA), both CN/4ACN and 4ACN/8PCN exhibited better H 2 evolution reaction (HER) rate than CN/8PCN due to the improvement in conductivity caused by Ag doping. However, only CN/8PCN and 4ACN/8PCN exhibited HER coupled with tetracycline (TC) degradation performance owing to the high redox potential of the S-scheme. Benefiting from a good carrier transport property and high redox potential, 4ACN/8PCN exhibited the best HER rate (2305.6 μmol·g −1 ·h −1 ) with TEOA as the hole sacrificant, which was 11.7 times than that of pure CN, respectively, and achieved a high HER rate (117.8 μmol·g −1 ·h −1 ) coupled with simultaneous TC degradation. This study provides a basic understanding of CN homojunctions, which shows potential for expanded applications in photocatalytic H 2 evolution and pollutant degradation.
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Food Frontiers
·
2023
·
IF 9.9
Pengde Lu,Jinfen Chen,Ying Chen,Xingping Quan,Jiayue Liu,Yan Han,Yiyang Li,Li Yang,Jian-Bo Wan,Yonghua Zhao
Ulcerative colitis (UC) is a digestive disease with a high incidence and is difficult to be cured due to its complex etiology. It has evidenced that intestinal barrier dysfunction plays a predominant role in UC. 20( S )-protopanaxadiol saponins (PDS) isolated from Panax notoginseng possess anti-inflammatory and antioxidative activities, suggesting its potential of treating UC. Herein, the therapeutic effects of PDS against UC and underlying mechanisms in the aspect of intestinal barrier dysfunction were investigated in vivo and in vitro. The results showed PDS had protective effects against dextran sulfate sodium–induced colitis, including attenuating weight loss, disease activity index score elevation, colon length shortening, and histological lesions. Additionally, PDS reduced the colonic activity of myeloperoxidase and the cytokine levels of TNF-α, IL-6, and IL-1β, decreased MDA production, and elevated colonic activities of SOD and GSH-Px in the colitis mice. The expressions of proteins related to tight junction (TJ), including ZO-1, claudin-5, occludin, caveolin-1 (Cav-1), and Nrf2 were downregulated, whereas that of Keap1 was upregulated after colitis induction. These changes were reversed by PDS. Cav-1 expression was downregulated in lipopolysaccharides (LPS)- and H 2 O 2 -induced HCT116 cells, and the expressions of ZO-1, claudin-5, and occludin were suppressed in HCT116 cells stimulated by LPS and H 2 O 2 combined with Cav-1 small interfering RNA transfection, which were ameliorated by PDS, suggesting PDS targeted Cav-1 against intestinal barrier damage. Collectively, PDS alleviates inflammatory injury and oxidative stress by regulating the Nrf2/Keap1 pathway, contributing to targeting Cav-1 against intestinal epithelial TJ proteins loss. It suggests PDS might be a promising therapeutic natural product for UC treatment.
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