SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Zhaojie Fang,Zetong Liu,Joe Yeang Cheah,Xinyi Guan,Huijuan Li,Tao Jiang,Shengping Wang,Xinbin Ma
A novel core–shell CaO based adsorbent with Al-Zr co-modification was synthesized via a facile one-pot calcination method. The CO 2 capture capacity and long-term stability of the adsorbents with different Ca/Al/Zr molar ratios were investigated. The co-doping strategy significantly enhanced the CO 2 capture capacity of the calcium-based adsorbents. Specifically, the optimized Ca24Al1Zr0.3 adsorbent exhibited excellent CO 2 adsorption performance in long-term adsorption–desorption cycles, with the CO 2 capacity of 0.53 g-CO 2 /g-ads after 40 cycles. The synergistic effects of Al-Zr co-doping were analyzed from a microstructural perspective. The core–shell Ca24Al1Zr0.3 adsorbent with a CaZrO 3 outer shell featured minimized particle size, abundant mesoporous and macroporous structures, and uniformly distributed doping components. Under the combined effects of structural modification and metal doping, it manifested enhanced CO 2 capture capacity. Based on the CO 2 adsorption mechanism of CaO, this study revealed that Al-Zr co-doping promotes oxygen vacancy generation and improves CO 2 adsorption performance. The Ca24Al1Zr0.3 adsorbent demonstrated the highest oxygen vacancy content and the most pronounced positive shift in Ca 2p binding energy. This shift enhanced electron-donating capability of calcium, effectively facilitating O 2− migration and CO 2 diffusion. Furthermore, the Ca24Al1Zr0.3 adsorbent exhibited superior carbonation reaction kinetics during long-term cyclic operation.
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Toxics
·
2024
·Vol. 12
·期 4
·288
·
IF 3.9
Kun Zhou,Miaomiao Tang,Wei Zhang,Yanling Chen,Yusheng Guan,Rui Huang,Jiawei Duan,Zibo Liu,Xiaoming Ji,Yingtong Jiang,Yanhui Hu,Xiaoling Zhang,Jingjing Zhou,Minjian Chen
The increasing use of molybdate has raised concerns about its potential toxicity in humans. However, the potential toxicity of molybdate under the current level of human exposure remains largely unknown. Endogenous metabolic alterations that are caused in humans by environmental exposure to pollutants are associated with the occurrence and progression of many diseases. This study exposed eight-week-old male C57 mice to sodium molybdate at doses relevant to humans (0.01 and 1 mg/kg/day) for eight weeks. Inductively coupled plasma mass spectrometry (ICP-MS) and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS) were utilized to assess changes in urine element levels and serum metabolites in mice, respectively. A total of 838 subjects from the NHANES 2017–2018 population database were also included in our study to verify the associations between molybdenum and cadmium found in mice. Analysis of the metabolome in mice revealed that four metabolites in blood serum exhibited significant changes, including 5-aminolevulinic acid, glycolic acid, l-acetylcarnitine, and 2,3-dihydroxypropyl octanoate. Analysis of the elementome revealed a significant increase in urine levels of cadmium after molybdate exposure in mice. Notably, molybdenum also showed a positive correlation with cadmium in humans from the NHANES database. Further analysis identified a positive correlation between cadmium and 2,3-dihydroxypropyl octanoate in mice. In conclusion, these findings suggest that molybdate exposure disrupted amino acid and lipid metabolism, which may be partially mediated by molybdate-altered cadmium levels. The integration of elementome and metabolome data provides sensitive information on molybdate-induced metabolic disorders and associated toxicities at levels relevant to human exposure.
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Coatings
·
2025
·Vol. 15
·期 3
·267
·
IF 2.8
Junyu Liu,Hansheng Li,Wencan Cui,Shihua Sang,Liang Guan,Chen Zhao
This study focuses on the preparation of a highly active surface-enhanced Raman spectroscopy (SERS) substrate, where Ag nanoparticles synthesized by the Lee–Meisel method are loaded onto the surface of GO@PVP nanoparticles through classical electrostatic attraction. The substrate was characterized by SEM and XPS analysis. The SERS-active substrate was utilized for the detection of phenanthrene in aqueous solutions, achieving a detection limit of 10−8g/L (5.6 × 10−11mol/L). In comparison to conventional Raman spectroscopy, this method exhibits a significant reduction in the detection limit and holds promise for trace polycyclic aromatic hydrocarbons (PAHs) monitoring in environmental samples.
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American Journal of Translational Research
·
2021
·
IF 4.06
Shaochang Wu,Guidong Zhu,Dajin Zhou,Hongtao Xu,Longyou Zhao
Objective: This study was designed to demonstrate the accuracy of ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in detecting serum concentration of anti-schizophrenic drugs in patients with mental illness. Methods: The study participants were 186 schizophrenia patients treated in our hospital. Serum concentrations of anti-schizophrenic drugs in Chinese patients with mental illness were evaluated according to the reference intervals of drug therapy recommended in the guidelines. Results: Five drugs, namely Aripiprazole (ARI), Amisulpride (AMI), Olanzapine (OLA), Paliperidone (PAL) and Ziprasidone (ZIP) all showed good linearity within the linear range. The within-day precision of the above five drugs was all between 1.3%-8.9% and the inter-day precision was between 1.8%-7.6%, with within-day and inter-day relative standard deviations (RSDs) less than 15.00% and accuracy ranging from 87.00% to 106.73%. However, AMI had a mean blood concentration of 436.31±241.05 ng/mL (median concentration: 379.34 ng/mL), which was significantly higher than the reference range (100-320 ng/mL) recommended in the guidelines. Good recovery rates (86.21%-99.77%) were obtained after the samples were stored at room temperature for 24 h, at 4°C for 48h and at -20°C for half a year. Conclusions: Given that UPLC-MS/MS renders more accurate results in detecting the concentration of psychotropic drugs, it can be applied clinically to detect the concentration of therapeutic drugs in patients with mental illness.
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APPLIED AND ENVIRONMENTAL MICROBIOLOGY
·
2024
·
IF 3.9
Chao-Fan Yin,Yong Nie,Tao Li,Ning-Yi Zhou
Many Acinetobacter species can grow on n-alkanes of varying lengths (≤C40). AlmA, a unique flavoprotein in these Acinetobacter strains, is the only enzyme proven to be required for the degradation of long-chain (LC) n-alkanes, including C32 and C36 alkanes. Although it is commonly presumed to be a terminal hydroxylase, its role in n-alkane degradation remains elusive. In this study, we conducted physiological, biochemical, and bioinformatics analyses of AlmA to determine its role in n-alkane degradation by Acinetobacter baylyi ADP1. Consistent with previous reports, gene deletion analysis showed that almA was vital for the degradation of LC n-alkanes (C26–C36). Additionally, enzymatic analysis revealed that AlmA catalyzed the conversion of aliphatic 2-ketones (C10–C16) to their corresponding esters, but it did not conduct n-alkane hydroxylation under the same conditions, thus suggesting that AlmA in strain ADP1 possesses Baeyer–Villiger monooxygenase (BVMO) activity. These results were further confirmed by bioinformatics analysis, which revealed that AlmA was closer to functionally identified BVMOs than to hydroxylases. Altogether, the results of our study suggest that LC n-alkane degradation by strain ADP1 possibly follows a novel subterminal oxidation pathway that is distinct from the terminal oxidation pathway followed for short-chain n-alkane degradation. Furthermore, our findings suggest that AlmA catalyzes the third reaction in the LC n-alkane degradation pathway.
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MARINE BIOTECHNOLOGY
·
2025
·Vol. 27
·期 1
·1-16
·
IF 2.8
Bai Ying,Yang Gan,Liu Tongde,Chen Fuyan,Xia Junhong
During wintering, red tilapia may develop variable black spots on their bodies, significantly reducing their market value. Understanding the mechanisms driving this phenomenon is essential for molecular improvements in body color. In this study, we investigated chromatin accessibility landscapes in the eyes of red tilapia with two distinct phenotypes (normal pure red and black spot) under wintering stress using ATAC-seq and RNA-seq analyses. We observed that approximately 32.7% of chromatin accessibility peaks were located in promoter regions, followed by intergenic regions (32.4%) and intronic regions (26.7%). One thousand two hundred twenty-nine differentially accessible regions (DARs) and 1448 differentially expressed genes (DEGs) were identified between the RS and DS groups. Notably, DEGs associated with melanin synthesis, including tyrp1 , tyr , tyrp1b , pmela , slc24a5 , and mlph , were significantly upregulated in the DS group, which aligns with the observed 1.85-fold increase in melanin content, compared to the RS group. 92 DEGs were associated with significant changes in chromatin accessibility between groups ( R 2 = 0.8059; p < 0.0001), indicating potential regulatory relationships. Interestingly, 23.92% of the DARs were located on the chromosome 3. Specifically, a 2.5-fold difference in average peak height on LG3: 11,215,273–11,217,225 were observed between DS and RS tilapia. In the region, transcription factors including HSF1 and HSF2 were identified as key regulators of chromatin structure and gene expression under wintering stress. Our findings reveal that dynamic chromatin accessibility in the eyes of red tilapia facilitates adaptation to wintering stress by regulating visual signaling, melanin production, and downstream pigmentation.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Huadong Fu,Rui Chen,Yong Xie,Zheng Wei,Yan Qin,Zhixiong Huang
Element-hybrid phenolic aerogel composites are often utilized as lightweight thermal protection materials for aerospace craft. Zr-phenolic (Zr-PR) aerogels have been extensively studied due to their exceptional high-temperature resistance. However, the phase transformation of ZrO2, the pyrolysis product of Zr-PR, caused the volume changes and internal stresses, greatly limiting the application of Zr-PR. In this work, a small amount of nano-Y2O3 particles was directly doped into the Zr-PR aerogel composites to form the nanoscale mosaic structure. This aerogel composite exhibited properties of low density (0.51 g/cm3) and low thermal conductivity (<0.151 W/(m K)); moreover, it showed a significant improvement in oxidative ablation resistance with a 33% reduction in the linear ablation rate. The research indicated that the doping of nano-Y2O3 effectively addressed the adverse effects associated with ZrO2 phase transformation by in situ rapidly forming (<60s) the dense yttria-stabilized zirconia (YSZ) thermal barrier layer on the ablation surface, which significantly delayed the thermal-oxidative ablation of the composites. Additionally, the pyrolytic carbon (PyC) on the ablation surface can form abundant multilayered graphene structures due to the catalytic graphitization effect produced by the solid-solution reaction of YSZ, which further enhanced the oxidation resistance. This work provides a simple and efficient approach to improve the ablation performance of Zr-PR aerogel composites, broadening their application in extreme thermal environments.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Hua Zhang,Linlin Xu,Yue Tian,Anxin Jiao,Ming Chen
Optical anticounterfeiting labels based on surface-enhanced Raman scattering (SERS) with enriched molecular “fingerprint” information is not only related to the enhanced sensitive detection but also strongly dependent on excellent long-time stability of nano-platforms. By virtue of in-situ overgrowth of highly dense and close-packed Ag nanoparticles (NPs) on Ti 3 C 2 T x nanosheets, herein, we prepared an extraordinary SERS active nano-substrates with exceptional long-term stability for achieving ultrastable anticounterfeiting tags. The obtained Ag@Ti 3 C 2 T x exhibit a significantly SERS activity with a detection limit of methylene blue (MB) molecules as low at 10 -16 M, approaching 0.1 femtomole (fM) ultra-trace level. More importantly, since nearly all active Ag NPs were completely encapsulated in the 2D supports, the unparalleled stability of the resultant Ag@Ti 3 C 2 T x can be undoubtedly verified by immersing them into H 2 O 2 oxidative solution, which is obviously better than that of bare Ag NPs. Then, the hybrid Ag@Ti 3 C 2 T x were subsequently incorporated into polydimethylsiloxane (PDMS) to obtain transparent flexible Ag@Ti 3 C 2 T x @PDMS, giving rise to the ultra-sensitive SERS imaging-based steganographic information. Interestingly, the ultrastable anticounterfeiting capability of the smart SERS nano-platforms is further highlighted by keeping them even after for 400 days storage. The present work holds a great potential for propelling robust SERS-based steganography in many practical real-world scenarios.
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Molecular Medicine Reports
·
2019
·Vol. 20
·期 1
·332-340
·
IF 1.851
Lina Liu,Jing Yan,Fei Ge,Xiangtao Xu,Jun Lu,Huilian Shi,Shuihong Li,Yue Zhao,Changzheng Zhang
Saikosaponin‑D (SSD), which is the main bioactive component in the traditional Chinese medicine Chai Hu (Bupleurum falcatum L), possesses estrogen‑like properties and is widely used in treating estrogen‑related neurological disorders. The current study aimed to investigate the protective effects of SSD on the fear memory deficit in ovariectomized (OVX) rats and the potential underlying mechanism. SSD treatment significantly prolonged freezing time in OVX rats in a manner similar to that of estradiol (E2), whereas this effect was markedly suppressed by co‑administration of ICI182780, a non‑selective estrogen receptor (ER) inhibitor. The expression of ERα in the hippocampus of OVX rats was significantly elevated by SSD; however, Erβ expression and E2 synthesis were not markedly affected by SSD treatment. Collectively, this study demonstrated that SSD‑mediated fear memory improvement in OVX rats may be attributed not to E2 levels or ERβ activity, but to ERα activation in the hippocampus.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Zou Meina,Chen Yanrong,Zheng Zongji,Sheng Shuyue,Jia Yijie,Wang Xiangyu,Ren Shijing,Yang Yanling,Li Xiaomin,Dong Wenhui,Guan Meiping,Zhang Qian,Xue Yaoming
High-salt intake leads to kidney damage and even limits the effectiveness of drugs. However, it is unclear whether excessive intake of salt affects renal tubular energy metabolism and the efficacy of dapagliflozin on renal function in diabetic kidney disease (DKD). In this study, we enrolled 350 DKD patients and examined the correlation between sodium level and renal function, and analyzed influencing factors. The results demonstrated that patients with macroalbuminuria have higher 24 h urinary sodium levels. After establishment of type 2 diabetes mellitus model, the animals received a high-salt diet or normal-salt diet. In the presence of high-salt diet, the renal fibrosis was aggravated with fatty acid metabolism dysregulation. Furthermore, Na+/K+-ATPase expression was up-regulated in the renal tubules of diabetic mice, while the fatty acid metabolism was improved by inhibiting Na+/K+-ATPase of renal tubular epithelial cells. Of note, the administration with dapagliflozin improved renal fibrosis and enhanced fatty acid metabolism. But high salt weakened the above-mentioned renal protective effects of dapagliflozin in DKD. Similar results were recapitulated in vitro after incubating proximal tubular epithelial cells in high-glucose and high-salt medium. In conclusion, our results indicate that high salt can lead to fatty acid metabolism disorders by increasing Na+/K+-ATPase expression in the renal tubules of DKD. High salt intake diminishes the reno-protective effect of dapagliflozin in DKD.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2021
·
IF 4.219
Long Ma,Yingying Lu,Yaqin Li,Zhizhen Yang,Yu Mao,Yi Wang,Shuli Man
Adenosine, as a naturally occurring nucleoside , plays an important role in human health maintenance. In recent years, many studies have shown that adenosine has the effect of cancer inhibition, and some of its analogs have been successfully marketed as anticancer drugs . This report mainly describes the anti-colon cancer activities and mechanism of a novel halogenated adenosine analog named 5′-bromodeoxyadenosine (5’-BrDA). As a result, 5’-BrDA concentration-dependently inhibited colon cancer cells proliferation , induced autophagy without disruption of lysosomal stability, and promoted autophagy-independently cellular mitochondrial apoptosis by increasing the accumulation of reactive oxygen species . Furthermore, 5’-BrDA inhibited the tumor growth of colon cancer in CT26 inbred mice without affecting the body weight in vivo . Collectively, the above-mentioned mechanisms contributed to the anticancer activity of 5’-BrDA. It is rare to discover novel anticancer adenosine analogs during the past couple of decades. We believe that our work will enrich the understanding of adenosine analogs, also, pave the way for adenosine analogs product based anticancer drug development.
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BIOLOGICAL & PHARMACEUTICAL BULLETIN
·
2015
·Vol. 38
·期 8
·1142-1149
·
IF 1.828
Kexin Wang,Yu Sun,Peng Lin,Jun Song,Ruxing Zhao,Wenjuan Li,Xinguo Hou,Chuan Wang,Lingshu Wang,Ping Zhu,Li Chen
β-Cell insufficiency plays an important role in the development of diabetes. Environmental factors, including lifestyle, play a critical role in β-cell dysfunction. Modern lifestyles affect the inherent circadian clock in central and peripheral organs. Recent studies have demonstrated that the normal intrinsic circadian clock in islets was essential for the viability of β cells and their insulin secretory function. Overall, however, the data are inconclusive. Our study demonstrated that the disrupted circadian rhythm of islets in streptozotocin induced type1 diabetic mice may be associated with impaired β-cell function and glucose intolerance. Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, could partially restore the normal circadian rhythm and activate the 5′ AMP-activated protein kinase (AMPK) signaling pathway. Our study provided evidence demonstrating that Liraglutide might restore β-cell function and protect against the development of diabetes in a mouse model by attenuating the disruption of the intrinsic circadian rhythm in islets and by activating AMPK signaling.
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