ACS Sustainable Chemistry & Engineering
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2019
·
IF 6.97
Chunhe Yu,Xiaohua Jiang,Dongmiao Qin,Guichun Mo,Xiangfei Zheng,Biyang Deng
S,N-Codoped carbon quantum dots (SNCQDs) with a quantum yield (QY) of 23% have been synthesized using lotus root as a carbon source and glutathione (GSH) as a nitrogen and sulfur source. The obtained SNCQDs exhibited many excellent features such as a simple preparation process, high fluorescence QY, satisfactory photostability, superior water solubility, and biocompatibility. The SNCQDs combined with Cu2+ were used as a novel off–on nanoprobe for 6-thioguanine (TG). Initial fluorescence is significantly quenched in this sensing system via electron transfer from SNCQDs to Cu2+. Fluorescence is recovered after adding TG owing to Cu2+–TG complex formation between Cu2+ and TG. A novel off–on fluorescent nanoprobe was presented for highly sensitive determination of TG. Under optimal conditions, the nanoprobe exhibited a wide linearity range of 0.005–80 μmol/L for TG and a detection limit of 1.6 nmol/L. The designed off–on nanoprobe was successfully utilized for detecting TG in plasma and urine of a leukemia patient and imaging of TG in living T24 cells.
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高影响因子
ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 3
·353-360
·
IF 2.049
Sifan XU,Shuqi YE,Yunhui XU,Feifan LIU,Yushun ZHOU,Qian YANG,Hailong PENG,Hua XIONG,Zhong ZHANG
To achieve a rapid, sensitive, and economical method for the detection of ascorbic acid (AA) in the presence of Fe3+, a nitrogen and sulfur co-doped carbon dots (N,S-co-CDs) based fluorescence sensing system was developed. In this work, N,S-co-CDs were successfully synthesized via a one-step microwave-assisted method within 2.5 min using ammonium citrate and L-cysteine as precursors. The fluorescence of N,S-co-CDs was quenched (off ) by Fe3+ through a static-quenching mechanism. Subsequently, the fluorescence was recovered (on) after introducing AA into the quenched system, which was attributed to the reduction effect of AA for Fe3+. Therefore, a switch-on sensor (N,S-co-CDs/Fe3+ system) was developed for AA detection. Under optimal conditions, the limit of detection (LOD) of 2.31 μmol/L for AA was obtained over a linear range from 0 to 150 μmol/L. Furthermore, the proposed sensing method was successfully applied to detect AA in processed fruit juice with satisfactory results. The most important is that the sensor derived from a microwave-assisted method has simple and eco-friendly synthesis processes, is rapid, and has high detection efficiency. Therefore, such a switch-on sensor may be a promising candidate sensor for AA detection in processed fruit samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Jing-Yu Liu,Xiao-Xiao Hou,Zhuo-Yu Li,Shu-Hua Shan,Ming-Chang Chang,Cui-Ping Feng,Yin Wei
The fruiting body of Hericium erinaceus has been used to treat digestive system disorder-related diseases for over 2000 years in China. A novel polysaccharide, HEFP-2b, was obtained from H. erinaceus fruiting bodies. Physical and chemical analysis showed that HEFP-2b consisted of fucose, galactose, glucose, and mannose in molar ratio of 11.81:22.82:44.28:21.09, and that its molecular weight was 3.252 × 10 4 Da. The backbone of HEFP-2b consisted of →6)-linked-α-D-Glc p -(1→ and →4)-β-D-Gal p -(1→ and →3,6) -α-D-Man p linkage, with two side-branching units of (1→ and →6)-β-D-Gal p and (1→ and →4)-α-D-Man p , terminated by Glc and Fuc. The results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell cycle arrest experiments revealed that HEFP-2b considerably inhibited the growth of colon cancer cells (HCT-116) in vitro . The growth inhibitory effects of HEFP-2b correlated with their ability to arrest the cell cycle at the S -phase. Our results will provide valuable information for future studies on HEFP-2b as a novel health-promoting functional food ingredient that can be used for treating colon cancer.
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ACS Applied Energy Materials
·
2018
·
IF 0
Kai Yang,Lei Zhong,Yudi Mo,Rui Wen,Min Xiao,Dongmei Han,Shuanjin Wang,Yuezhong Meng
Lithium sulfur battery is highly appealing for energy storage because of its high theoretical capacity and energy density. Nevertheless, as one of the pivotal problems, the shuttling of soluble polysulfide intermediates hinders its practical application. In this work, we employ an electronic conductive carbon material and a lithium ion conductive block polymer (lithium sulfonated poly(styrene-ethylene-butylene-styrene), Li+-SSEBS) to fabricate a functional separator by a simple coating method. The functional coating on the PP separator exhibits excellent electronic conductivity for reactivating the active materials, good lithium ion conductivity for facilitating lithium ion transport, and great ionic selectivity for the suppressing polysulfide shuttle. With this separator, the battery shows a high initial discharge capacity of 1066 mAh g–1 and excellent capacity retention of 762.7 mAh g–1 after 350 cycles at 0.5 C. It also exhibits excellent rate performance with a high capacity of 750 mAh g–1 at 2 C and good recovery capability. Furthermore, a correction strategy has been adopted to investigate the anti-self-discharge behavior of Li–S battery, which is more reasonable and precise than reported method. The results demonstrate that the SEBS-based functional separator can endow the enhanced electrochemical performance and anti-self-charge capability of Li–S battery.
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Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 22
·10433-10440
·
IF 9.931
Yiping Hu,Feng Li,Yu Long,Haidong Yang,Lili Gao,Xuefeng Long,Haiguo Hu,Na Xu,Jun Jin,Jiantai Ma
Searching for highly efficient, stable and non-noble metal electrocatalysts for the hydrogen/oxygen evolution reaction (HER/OER) is crucial to renewable-energy conversion systems. Cobalt phosphosulfide (CoPS) is regarded as a promising electrocatalyst for the HER in acid solution. Nonetheless, there are no studies of its HER and OER activity in basic solution. Herein, we engineer a novel and highly efficient water splitting electrocatalyst of ultrafine CoPS nanoparticles (NPs) encapsulated in N, P, and S tri-doped porous carbon (CoPS@NPS-C) through metal–organic frameworks (MOFs) and commercial carbon black (XC-72) as precursors. The abundant and evenly distributed metals of MOFs form ultrafine CoPS NPs, and the rich N organic ligands of MOFs and XC-72 are shaped into the NPS-C to protect CoPS NPs leading to long-term stability in water-splitting applications. Meanwhile, the strong interaction between CoPS and NPS-C in this special structure not only ensures the high activity of the HER in acid solution and the OER in alkaline solution, but also maintains good HER performance in alkaline solution. The results display that the novel structure electrocatalyst of CoPS@NPS-C has great potential in water-splitting applications.
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POLYMER
·
2014
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IF 3.766
Binshuang Wu,Yutao Xu,Zhiyang Bu,Linbo Wu,Bo-Geng Li,Philippe Dubois
To synthesize high quality (co)polyesters derived from 2,5-furandicarboxylic acid (FA), an acetic acid refluxing/pH-swing method was proposed to purify FA. 2-Carboxyl furfural and other impurities were removed completely from FA with this method. Using highly purified FA, biobased polyester poly(butylene furnadicarboxylate) (PBF) and aliphatic-aromatic copolyesters poly(butylene adipate-co-butylene 2,5-furandicarboxy-late)s (PBAFs) were synthesized via melt (co)polycondensation. The (co)polyesters were characterized with GPC , FTIR, 1 H NMR, DSC and TGA , and their tensile mechanical properties were also assessed. The copolyesters possess random chain structure, monomer feed ratio-controlled copolymer composition and excellent thermal stability ( T d,5% > 340 °C) in full composition range. Both BA-rich and BF-rich PBAFs are crystalline polymers . The crystallizability decreases with composition, up to nearly amorphous at moderate ϕ BF (40–60%). PBAFs with ϕ BF no more than 50% exhibit obvious high-elastic deformation and rebound resilience, and possess tensile properties ( E 18–160 MPa, σ b 9–17 MPa, ε b 370–910%) comparable to poly(butylene adipate). PBAFs with higher ϕ BF behave like nonrigid plastics with low tensile moduli (42–110 MPa), moderate strength (30–42 MPa) and high elongation at break (310–470%). In comparison, PBF is a strong and tough thermoplastic having balanced mechanical properties, namely, much higher tensile modulus (1.9 GPa) and strength (56 MPa) and high elongation at break (260%). It seems necessary and effective to use highly purified FA for synthesizing high performance FA-derived (co)polyesters.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2014
·Vol. 173
·期 8
·2042-2053
·
IF 1.687
He Yu-Cai,Yang Zhen-Xing,Zhang Dan-Ping,Tao Zhi-Cheng,Chen Chao,Chen Yi-Tong,Guo Fei,Xu Jian-He,Huang Lei,Chen Rui-Jie,Ma Xiao-Feng
The reductase (PgCR) from recombinant Escherichia coli CCZU-Y10 displayed high reductase activity and excellent stereoselectivity for the reduction of ethyl 4-chloro-3-oxobutanoate (COBE) into ethyl ( S )-4-chloro-3-hydroxybutanoate (( S )-CHBE). To efficiently synthesize ( S )-CHBE (>99 % enantiomeric excess (ee)), the highly stereoselective bioreduction of COBE into ( S )-CHBE with the whole cells of E. coli CCZU-Y10 was successfully demonstrated in a dibutyl phthalate-water biphasic system. The appropriate ratio of the organic phase to water phase was 1:1 ( v / v ). The optimum reaction temperature, reaction pH, cosubstrate, NAD + , and cell dosage of the biotransformation of 100 mM COBE in this biphasic system were 30 °C, 7.0, mannitol (2.5 mmol/mmol COBE), 0.1 μmol/(mmol COBE), and 0.1 g (wet weight)/mL, respectively. Moreover, COBE at a high concentration of (1,000 mM) could be asymmetrically reduced to ( S )-CHBE in a high yield (99.0 %) and high enantiometric excess value (>99 % ee). Significantly, E. coli CCZU-Y10 shows high potential in the industrial production of ( S )-CHBE (>99 % ee).
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高影响因子
ACS Applied Materials & Interfaces
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2017
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IF 7.504
Yinghua Liu,Wenxiu Duan,Wei Song,Juanjuan Liu,Cuiling Ren,Jiang Wu,Dan Liu,Hongli Chen
Colorimetric and fluorescent dual mode detection methods have gained much attention in recent years; however, it is still desirable to develop new colorimetric and fluorescent dual mode nanosensors with more simple preparation procedures, low cost, and excellent biocompatibility. Herein, a colorimetric and fluorescent nanosensor based on B, N, S-co-doped carbon dots (BNS-CDs) was synthesized by one-step hydrothermal treatment of 2,5-diaminobenzenesulfonic acid and 4-aminophenylboronic acid hydrochloride. Using this nanosensor, a highly sensitive assay of Fe3+ in the range of 0.3–546 μM with a detection limit of 90 nM was provided by quenching the red emission fluorescence. It is more attractive that Fe3+ can also be visualized by this nanosensor via evident color changes of the solution (from red to blue) under sunlight without the aid of an ultraviolet (UV) lamp. Furthermore, the designed nanosensor can be applied for efficient detection of intracellular Fe3+ with excellent biocompatibility and cellular imaging capability, and it holds great promise in biomedical applications.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Shengwen Liu,Xian Zhang,Guozhong Wang,Yunxia Zhang,Haimin Zhang
Developing bifunctional oxygen electrocatalysts with superior catalytic activities of oxygen reduction reaction (ORR) and oxygen revolution reaction (OER) is crucial to their practical energy storage and conversion applications. In this work, we report the fabrication of Co/CoxSy@S,N-codoped porous carbon structures with various morphologies, specific surface areas, and pore structures, derived from controllably grown Co-based metal–organic frameworks with S- and N-containing organic ligands (thiophene-2,5-dicarboxylate, Tdc; and 4,4′-bipyridine, bpy) utilizing solvent effect (e.g., water and methanol) under room temperature and hydrothermal conditions. The results demonstrate that Co/CoxSy@S,N-codoped carbon fibers fabricated at a pyrolytic temperature of 800 °C (Co/CoxSy@SNCF-800) from Co-MOFs fibers fabricated in methanol under hydrothermal conditions as electrocatalysts exhibit superior bifunctional ORR and OER activities in alkaline media, endowing them as air cathodic catalysts in rechargeable zinc–air batteries with high power density and good durability.
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高影响因子
DALTON TRANSACTIONS
·
2017
·Vol. 46
·期 48
·16885-16894
·
IF 4.029
Yan-Ru Chen,Qin Wang,Xue Bai,Zhen Yan,Yunkun Ning,Feng He,Zhijian Wu,Jun Zhang
The rational design of non-noble materials as low-cost, highly efficient, and durable catalysts to improve the oxygen reduction reaction is extremely urgent and challenging. The oxygen reduction reaction is a kinetically sluggish process that greatly affects the energy conversion efficiency. In this paper, novel hierarchical heteroatoms-co-doped Fe2M/graphene (M = P, N) nanocomposites were developed by a facile strategy, including hydrothermal and subsequent calcination methods. The thermal treatment of an ionic liquid and thiourea not only supplied heteroatom sources but also promoted the formation of iron phosphide and iron nitride and enhanced their catalytic performances. The electrochemical results indicated that the as-obtained hybrid catalysts manifested enhanced electrocatalytic activity toward the oxygen reduction reaction owing to the strong synergistic effects. The high content of heteroatoms distributed on the surface and interface of the hybrids and the density functional theory calculations suggested that Fe–N–C, Fe–P–C, and Fe–S–C multiple active surface sites were formed at the hybrids interfaces. Moreover, these results demonstrated that heteroatom-doped catalysts could effectively form a charge-transfer channel and thus modify the charge distribution in the hybrids interfaces. The as-prepared heteroatoms-doped Fe2M/graphene hybrids would be developed into highly efficient catalysts as ideal alternatives for noble metal catalysts in practical applications.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Yong Wang,Shikai Xue,Yuhao Liao,Haiyan Wang,Qiujun Lu,Ningli Tang,Fuyou Du
In this study, Ag/Bi 2 O 3 /Bi 5 O 7 I with s-scheme heterostructures were successfully synthesized in situ by nano-silver modification of CUA-17 and halogenated hydrolysis.The growth rate of Bi 2 O 3 crystals was effectively controlled by adjusting the doping amount of Ag, resulting in the formation of a facet-coupling heterojunctions . Through the investigation of the microstructure and compositional of catalysts, it has been confirmed that an intimate facet coupling between the Bi 2 O 3 (120) facet and the Bi 5 O 7 I (312) facet, which provides robust support for charge transfer. Under visible light irradiation, the AgBOI.3 heterojunction photocatalyst exhibited an outstanding degradation rate of 98.2% for Bisphenol A (BPA) with excellent stability. Further characterization using optical, electrochemical, impedance spectroscopy, and electron spin resonance techniques revealed significantly enhanced efficiency in photogenerated charge separation and transfer, and confirming the s-scheme structure of the photocatalyst. Density functional theory calculations was employed to elucidate the mechanism of BPA degradation and the degradation pathway of BPA was investigated by LC-MS. Finally, the toxicity of the degradation intermediates was evaluated using T.E.S.T software.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-21
·
IF 10.6
Yu Jiang,Gao Yidan,Liu Fei,Zhang Yuyu,Li Jianda,Ding Luogang,Ren Sufang,Yang Jie,Jiao Jian,Feng Gong,Chen Zhi,Sun Wenbo,Wu Jiaqiang
Background Animal and human health are seriously threatened by bacterial infections, which can lead to bacteremia and extremely high rates of morbidity and mortality. Recently, there have been reports indicating the involvement of exosomal circular RNAs (circRNAs) in a range of human disorders and tumor types. However, the role of exosomal circRNAs in bacterial infection remains elusive. Methods We extracted and identified exosomes from the culture medium of PIEC cells infected with or without Glaesserella parasuis . RNA sequencing analysis was performed on the exosomes to screen and identify circRNAs (circHIF1α) associated with Glaesserella parasuis infection. PIEC cells were infected with Staphylococcus aureus or Streptococcus suis 2 to further determine whether exosome-derived circHIF1α was the crucial circHIF1α associated with bacterial infections. The transmission process of exosomes and their circHIF1α between cells was clarified via exosome tracing and co-culture assay. Moreover, the mechanism of circHIF1α being packaged into exosomes was explored, and the effects of exosomes and their circHIF1α on cell proliferation, DNA damage and cell cycle were analyzed. In addition, the binding mode and site of interacting proteins with circHIF1α were further determined. In vivo and in vitro, the role of exosomes and their circHIF1α in host resistance to bacterial infection was confirmed. Results We first discovered a new circHIF1α that was very stable and detectable, encapsulated into exosomes by hnRNPA2B1, and whose expression in exosomes of bacterially infected PIEC cells significantly decreased. Additionally, exosomal circHIF1α reduced bacterial infection both in vitro and in vivo and suppressed the growth of reception cells. Mechanistically, the circHIF1α interacted with the KH domain of IGF2BP3 in an m6A-modified manner, which mediated DNA damage to arrest the cells at the G1/S phase through the interaction between the regulator of Chromosome Condensation 2 (RCC2) and γ-H2AX protein. Exosomal circHIF1α is a unique therapeutic target for bacterial infection since this work highlights its critical function in fighting bacterial infection.
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高影响因子
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