ULTRASONICS SONOCHEMISTRY
·
2019
·
IF 7.279
L.L. Dong,Y.C. Ding,W.T. Huo,W. Zhang,J.W. Lu,L.H. Jin,Y.Q. Zhao,G.H. Wu,Y.S. Zhang
Recently, graphene decorated with various inorganic nanoparticles, such as Pt, Au, Ag, TiO 2 and Fe 3 O 4 , among which Ag nanocomposites are good candidates for electronics, optics, electrochemistry and catalysis. However, preparation techniques for Ag nanoparticles/carbon matrix hybrids require tedious multi-step processes often involving toxic reducing agents/high temperatures which is not viable for scalable production. Here, a facile, one step and eco-friendly chemical co-reduction route was utilized to synthesis of a new nanocomposites by Ag nanoparticle anchored on reduced graphene oxide (rGO) at ambient temperature and combined first principles theoretical analyze their interfacial adsorption behavior, is reported. In this way, graphene oxide (GO) and Ag + simultaneously reduced by thiourea dioxide (TD) without using any additional reduced reactants. Results indicated that GO was successfully reduced to rGO and well-dispersed Ag nanoparticles with sizes of 6–7 nm, anchored on the surface of rGO sheets. Reduction mechanism was attributed to the synergistic effect of its hydrolysis products in aqueous media. The experiment and theoretical calculation results obtained demonstrate this method to be applicable to the synthesis of other metals on rGO sheets in order to improve wettability and interfacial bonding between rGO and metal and may possibly find various forthcoming medicinal, industrial and technological applications.
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高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2020
·Vol. 20
·期 4
·2079-2086
·
IF 1.134
Hu Xiangna,Bian XingZhong,Yu Shaozhou,Dan Kun
A magnetic Fe3O4@SiO2@Ag@COOH nanoparticle (NPs)/Au film was fabricated as an effective surface-enhanced Raman scattering (SERS) substrate through a combination of a solvothermal reaction, the Stöber method and an in-situ reaction. The superparamagnetic
property of Fe3O4@SiO2@Ag and the decoration with –COOH groups allow efficient enrichment and capture of thiabendazole molecules. A large quantity of sub-10 nm gaps emerge when Ag NPs are decorated on the surface of the SiO2 shell, offering
a dramatic electromagnetic field enhancement induced by localized surface plasmon resonance (LSPR). Finite-difference time-domain (FDTD) simulations show that strong near-field enhancement around the gap areas between the Ag NPs and Au film occurs, which is caused by the coupling between the
LSPR of the Ag NPs and surface plasmon polaritons (SPPs) of the Au film. Due to the superparamagnetic property and high electromagnetic field enhancement, the Fe3O4@SiO2@Ag@COOH NPs/Au film as a SERS substrate can detect 1 μg/L thiabendazole in solution,
showing great potential for SERS detection of environmental pollutants.
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DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 19
·8867-8875
·
IF 4.197
Yu Chen,Qihua Wang,Tingmei Wang
We demonstrate the fabrication of yolk–shell catalysts consisting of a single M (M = Ag, Au) nanoparticle encapsulated within a hollow mesoporous organosilica shell via an organosilane-assisted strategy. The advantages of our method lie in its good controllability of the void space as well as the thickness of the mesoporous shell. The M@CTAB/SiO2 synthesized through a modified Stöber method can transform to yolk–shell structures after adding (3-aminopropyl)trimethoxysilane (APTMS)/TEOS or (3-aminopropyl)triethoxysilane (APTES)/TEOS into the synthetic medium. We give unambiguous evidence that the middle CTAB/SiO2 layer transforms into a less dense APTMS-rich organic–inorganic layer which was selectively removed in alkaline aqueous solution, while the amino-functionalized hybrid shells remain intact. Moreover, we discuss the role of alkylamino groups in the shell in the transformation from Ag@SiO2 nanorattles to hollow structures when impregnating the as-synthesized Ag@SiO2 nanorattles in HAuCl4 aqueous solution. The nanorattles also exhibit high catalytic activity for the catalytic reduction of p-nitrophenol.
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IEEE SENSORS JOURNAL
·
2023
·Vol. 23
·期 4
·3475-3484
·
IF 4.3
Jiawen Yin,Wei Chen,Wanlei Gao,Xin Zhang,Bo Tang,Qinghui Jin
Considering the indispensable of pH for tap water, a pH sensor with the characteristics of an implantable, long-term stable, and long lifetime is urgently needed for on-line and in situ pH monitoring in tap water, but this is always a challenging issue. In this article, a competitive integrated electrochemical pH sensor is developed and batch manufactured via micro-electro-mechanical system (MEMS). A dense and ultrasensitive IrOx electrode is obtained for almost 1.5 times Nernst response (−82.88 mV/pH), after preparation process optimization. A Si-Si3N4-KCl agar gel-polydimethylsiloxane (PDMS) multilayer structured Ag/AgCl electrode is designed and proven to be a long lifetime (>40 days) and be stable. By integrating with the IrOx film and solid-state Ag/AgCl electrode on a mini chip and verifying the effectiveness of the as-fabricated sensor by pH detection, the miniature pH sensor demonstrates wide detection range (1.8–12), stirring sensitivity, desirable linearity ( ${R}^{2}=0.999$ ), ideal repeatability and good resistance to other interference substances. Particularly, by employing the mass-production technique, favorable response consistency (relative standard deviation (RSD) < 2%) is witnessed, offering the opportunity to mass-produce the proposed sensor in the future. What’s more, the sensor still kept 91.7% sensitivity when compared to the sensitivity obtained at its initial state, after continuously operating for 32 days. Undoubtedly, the sensitive, durable, miniaturized, and mass-produced pH sensor proposed in this article is a competitive device to implant into the water pipeline for pH in situ online monitoring.
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2021
·
IF 3.995
Wei Tian,Yaqin Rong,Dali Li,Jin Tian,Naiming Lin,Zhongde Wang
The contamination of water by heavy metal ions can easily cause serious environmental problems and damage to the human body hands down. Using zeolitic imidazolate framework-67 (ZIF-67) as a sacrificial template, polyhedral CoS hollow nanocages (HNC) were successfully synthesized by self-template approach as adsorbents for heavy metal ions removal. The CoS HNCs suggested good chemical stability and extremely efficient heavy metal ions removal of Ag + , Cd 2+ , Cu 2+ , Pb 2+ and Zn 2+ , which can be ranked in the order of Ni 2+ ≪ Zn 2+ , Cd 2+ < Pb 2+ , Cu 2+ , Ag + . The saturation adsorption for Ag + reached 2147.944 mg g −1 and exhibited high distribution coefficients (K d ) > 107 mL g −1 . The CoS HNCs can rapidly reduce the Ag + concentration from ppm level to trace level of 1 ppb. It has been proved that the rapid and selective adsorption was achieved via the hierarchical pore structure of the CoS HNCs can better disperse these metal vacancies with super affinity and the S 2− , reduce the mass transfer distance and accelerate mass transfer. It is expected that such a CoS HNCs could be a promising alternative to conventional materials for the adsorption of heavy metal ions.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Clement Yaw Effah,Longlong Tan,Qimeng Zhang,Xinyu Li,Lijun Miao,Xiaolei Zhou,Lihua Ding,Yongjun Wu
Pseudomonas aeruginosa ( PA ) is an opportunistic pathogen that is widely distributed in soil, water, air, food, animal, and human body surfaces, and is also one of the main pathogens of iatrogenic infections which can cause various infections in people with weakened immune systems. The rapid detection of PA in varied environmental and clinical samples is important for hospital infection control, clinical diagnosis, and food and environmental safety monitoring. In this study, we constructed an efficient separation and enrichment surface-enhanced Raman scattering (SERS) platform based on a dual recognition strategy, and supplemented it with a machine learning nonlinear regression model to achieve rapid, highly sensitive, accurate, and specific detection of PA. By combining the SERS platform with support vector machine learning regression model, a detection limit of 15 CFU/mL with a liner range of 50 to 10 8 cells/mL was achieved. The highly sensitive dual-identification tag-type SERS quantitative analysis system established in this study has the advantages of wide detection range, low detection limit, good specificity, high accuracy and short detection time, thereby providing a method for the prevention and clinical diagnosis of PA infection-related diseases as well as food and environmental safety monitoring.
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International Journal of Nanomedicine
·
2026
·
IF 8.7
Jing Zhang,Xiaoqiang Kong,Xiangping Wu,Dongyun Tao,Xiang Li,Huimin Cheng
Introduction Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor prognosis, and Fusobacterium nucleatum (Fn) colonization further aggravates tumor progression, immunosuppression and therapeutic resistance. Conventional monotherapies are limited by insufficient tumor targeting, rapid drug clearance and failure to reverse immune suppression. Here, we fabricated cRGD-modified nanoparticles (Ag@GQDs/QUE-siP-c-L) for co-delivery of AgNPs, quercetin (QUE) and PD-L1 siRNA (siP).Methods The morphology, particle size, surface metal elements, drug content and QUE entrapment efficiency of Ag@GQDs/QUE-siP-c-L were obtained using particle size analysis, SEM, inductively coupled plasma-optical emission spectrometry (ICP-OES) and HPLC. We further detected cellular uptake, in vitro drug release, cytotoxicity, intracellular reactive oxygen species level, PD-L1 gene silencing efficiency and in vitro anti-Fn activity. Pharmacokinetics and tissue distribution of Ag and QUE were analyzed by ICP-OES and LC-MS/MS, and in vivo antitumor efficacy and biosafety were tested in Fn-colonized orthotopic 4T1 tumor mice.Results Ag@GQDs/QUE-siP-c-L exhibited uniform spherical morphology (195.87± 15.96 nm) with high encapsulation of QUE. cRGD modification enhanced Ag/QUE cellular uptake in 4T1 cells, with pH-responsive release accelerated under tumor acidic conditions. The nanoparticles exhibited selective tumor cytotoxicity, induced oxidative stress, downregulated PD-L1 mRNA, and exerted potent anti-Fn activity in vitro. Pharmacokinetics revealed increased AUC0-t and reduced clearance compared with free drugs, and cRGD modification promoted tumor accumulation and retention of drugs. In vivo preliminary experiments proved the Ag@GQDs/QUE-siP-c-L formulation suppressed tumor growth with a tumor inhibition rate of 45%, and effectively modulated the tumor immune microenvironment: it increased tumor-infiltrating CD3⁺CD4⁺ T cells, reduced PD-L1⁺CD11c⁺ dendritic cells, and decreased the proportions of immunosuppressive Tregs and MDSCs. Hematoxylin-eosin staining and serum liver-kidney biochemistry confirmed no obvious systemic toxicity.Conclusion Ag@GQDs/QUE-siP-c-L serves as a multimodal nanoplatform for Fn-associated TNBC with combined in vitro antibacterial, gene silencing and in vivo antitumor immunomodulatory effects, showing great potential for future translational research.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·632
·
IF 5.4
Wang Xinxin,Sun Weijia,Zhang Jiale,Zhang Yuting,Wang Xiaoli,Zhou Nandi
Carcinoembryonic antigen (CEA) is a pivotal broad-spectrum tumor marker, yet its accurate quantification in early-stage cancer remains challenging due to the limited sensitivity and operational complexity of conventional immunoassays. We report a signal-on fluorescent probe that synergistically integrates the fluorescence resonance energy transfer (FRET) quenching capability of Au@Ag NPs with enzyme-free catalytic hairpin assembly (CHA) amplification for ultrasensitive detection of CEA. In this design, a Cy3-labeled hairpin DNA (H1) is anchored onto Au@Ag NPs to construct Au@Ag-H1 NPs, where the fluorophore is efficiently quenched. In the presence of CEA, the target specifically displaces a complementary DNA (cDNA) trigger from its aptamer duplex, initiating a CHA cascade reaction that repeatedly opens H1, spatially separates Cy3 from the nanoparticle surface, and restores the fluorescence emission. This strategy endows the probe with both an ultralow background signal and exponential signal amplification. Under optimized conditions, the proposed probe exhibited a wide linear range from 0.1 to 50 ng·mL − 1 with a limit of detection as low as 67.2 pg·mL − 1 , alongside excellent selectivity, reproducibility, and stability. Its practical utility was further validated through successful application in spiked human serum and clinical samples from cancer patients. Collectively, this approach provides a simple, rapid, and highly sensitive platform for CEA quantification, holding considerable promise for early cancer screening and diagnostics. Graphical abstract
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Yulian Tang,Wenxin Gou,Xue Lv,Xuemei Zhou,Junkai Hao,Chengjie Sun,Tao Sun,Lei Hu,Zhengquan Yan
Conveniently and efficiently monitoring I − and Hg 2+ in agricultural products or drinking beverages for the protection of human health is currently a great challenge. With this aim, a Ag-Pt bimetal quantum-dot nanozyme boosted by bioactive folic acid (FA@Ag-Pt QDs) was first developed for multichannel monitoring of I − and Hg 2+ in this work using a two-step liquid-phase reduction method. Not only did the present FA@Ag-Pt QDs possess superior peroxidase-like activity with Michaelis constant ( K m ) and maximal reaction rate ( V max ) of 0.01 mM/2.95 × 10 −8 M·s −1 and 1.15 mM/3.88 × 10 −8 M·s −1 , respectively, trace Hg 2+ or I − could exclusively alter their enzyme-mimic performance with obvious color changes from blue to colorless or dark blue. I − could also strengthen the inherent fluorescence property of FA@Ag-Pt QDs. When applied for visual monitoring of I − and Hg 2+ in real beverages or iodine-containing agricultural products, the detection recoveries were 93.9 %–105.3 % and 96.8–104.3 % with low detection limits of 6.56 × 10 −8 mol/L and 4.00 × 10 −10 mol/L (S/N = 3), respectively. The recovery and detection limit for fluorescent detection of I − were 95.8 %–104.1 % and 1.75 × 10 −8 mol/L (S/N = 3), respectively. The mechanisms driving the improved peroxidase-like activity of FA@Ag-Pt QDs and their selective monitoring of Hg 2+ and I − were illustrated in detail. The proposed FA@Ag-Pt QDs will act as an efficient sensor for the practical multichannel monitoring of Hg 2+ and I − , with superior catalytic signal amplification.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Hui Lu,Xiaoran Li,Feng Li,Xiuquan Xu,Rong Zhao,Chenyi Xiong,Qing Hu,Zhuoqing Miao,Miao Tian
Photocatalytic technique has been widely accepted as a promising and effective candidate for eliminating antibiotic and pathogen pollutants in aquatic environment. Herein, a novel O, K co-doped g-C 3 N 4 photocatalyst embedded with single-atom Ag (denoted as Ag/OKCN) was successfully constructed to achieve the enhanced photocatalytic degradation and disinfection efficiency under visible light irradiation. The optimal Ag/OKCN-6 could eliminate 80.4 % of tetracycline (TC) within 60 min with a rate constant of 0.0259 min −1 , which was 4.98 times of pristine g-C 3 N 4 . Meanwhile, Ag/OKCN-6 could also completely inactivate>7-log CFU·mL −1 of Escherichia coli ( E. coli ) by efficient disruption of cell membranes. The synergistic effect of O, K co-doping and single-atom Ag embedding contributed to an extended light response, preeminent separation and transfer of photoexcited charges, prolonged carrier lifetime as well as ameliorative hydrophilicity, which was conducive to the excellent photocatalytic performance. Radical trapping and electron spin resonance (ESR) experiments validated that superoxide radicals ( • O 2 − ) were crucially responsible for the superior photocatalytic activity. This work provides a facile route to construct multi-strategy modified g-C 3 N 4 -related photocatalysts for efficiently eliminating aquatic environmental pollutants.
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高影响因子
ACS Omega
·
2022
·
IF 4.132
Xueqin Wang,Anjiang Lu,Zhongchen Bai,Tianwen Xu
A highly sensitive multilayer interlaced silver (Ag) nanosheet (MISN) film was prepared on a PPy@PEDOT:PSS film via an electrodeposition method for surface-enhanced Raman scattering (SERS) applications. After the PPy@PEDOT:PSS film was pretreated with ascorbic acid solution, many sparse Ag nanoparticles (NPs) could be directly reduced on the surface of the PPy@PEDOT:PSS film in AgNO3 solution. Then, the MISN film was directionally grown along the surface of sparse Ag NPs by using an electrochemical galvanostatic method to form a Ag/PPy@PEDOT:PSS film for a SERS substrate. The results indicated that with the increase in electrodeposition time, the density of Ag nanosheets was also increased for boosting the SERS effect. Accordingly, owing to the directional growth of Ag NPs, the increase in the length–width ratio of single Ag nanosheets would further promote the SERS signal of the substrate. Moreover, the maximum enhancement factor of the SERS substrate could reach to 12,478, and the minimum limit of detection of melamine solution was down to 5.42 ng/mL. The SERS sensitivity of the Ag nanosheet film reached 100.65. This method of preparing the SERS substrate provides a novel and robust strategy for the low-cost and high-sensitivity detection in biomedicine, drugs, and food.
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高影响因子
Pharmaceutics
·
2021
·Vol. 13
·期 9
·1518
·
IF 6.321
Mengting Duan,Wei Fan,Bing Fan
Mesoporous calcium-silicate nanoparticles (MCSNs) are excellent biomaterials for controlled drug delivery and mineralization induction. In this study, MCSNs were loaded with low-dose silver ion (Ag+) and Triton X-100 (TX-100) as the M-AgTX to achieve both enhanced antibacterial properties and low cytotoxicity for dentin disinfection. The physicochemical property, biocompatibility, infiltration ability into dentinal tubules, anti-bacterial ability against both planktonicEnterococcusfaecalis(E. faecalis) and its biofilm on dentin, effects on dentin microhardness and in vitro mineralization property were systematically investigated. Results confirmed that the MCSNs and M-AgTX nanoparticles showed typical morphology of mesoporous materials and exhibited sustained release of chemicals with an alkaline pH value over time. M-AgTX also exhibited excellent biocompatibility on MC3T3-E1 cells and could eliminate 100% planktonicE. faecalisafter 48-h treatment. On dentin slices, it could enter dentinal tubules by ultrasonic activation and inhibit the growth ofE. faecalison dentin. M-AgTX could completely inactive 28-dayE. faecalisbiofilm. TEM confirmed the destruction of cell membrane integrity and Ag+infiltration into bacteria by M-AgTX. Besides, dentin slices medicated with M-AgTX nanoparticles displayed an increased microhardness. After being immersed in SBF for 7 days, apatite crystals could be observed on the surface of the material tablets. M-AgTX could be developed into a new multifunctional intra-canal medication or bone defect filling material for infected bone defects due to its sustained release profile, low cytotoxicity, infiltration ability, enhanced anti-bacterial and mineralization features.Keywords:mesoporous;nanoparticle;Enterococcus faecalis;silver;Triton X-100;root canal disinfection
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高影响因子
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