BMC Pregnancy and Childbirth
·
2023
·Vol. 23
·期 1
·1-10
·
IF 3.1
Ding Ailing,Wan Huimin,Peng Juan,Wang Huizi,Zhu Shaodan,Dong Xudong
Background Hypertensive disorders complicating pregnancy (HDCP) and gestational diabetes mellitus (GDM) can affect the placental barrier function to varying degrees. However, current studies show that the transfer and distribution characteristics of trace elements in the maternal-fetal system are still unclear. This study investigated the effect of the placental barrier on the transfer of trace elements from mother to fetus and its relationship with HDCP and GDM. Methods A case-control method was used in this study. 140 pairs of samples were collected; 60 were from healthy pregnant women, and 80 were from patients with pregnancy complications. The contents of trace elements in paired samples were determined by inductively coupled plasma–mass spectrometry (ICP-MS). SPSS software was used to analyze the differences in trace element levels in matched samples of each group. The correlations were analyzed based on Pearson’s correlation factor (r). Results The distribution characteristics of Fe content in the pathological group (HDCP group and GDM group) were the same as those in the normal group (umbilical cord blood > maternal blood > placenta), but there was no significant difference in the iron content in maternal blood and cord blood of pathological group. The distribution characteristics of Mn content in the pathological group (placenta > umbilical cord blood > maternal blood) were changed compared with those in the normal group (placenta > maternal blood > umbilical cord blood). In addition, the placental Cr content and cord blood Cr and Ni content of the pathological group were higher than those of the normal group. HDCP placental Cr and GDM placental Fe levels were significantly correlated with the Apgar score. Conclusions The transfer of Fe and Mn and the placental barrier function of Cr and Ni in the maternal-fetal system of HDCP and GDM are significantly altered, which directly or indirectly increases the maternal and fetal health risk.
✓ 已验证
DOI
PubMed
高影响因子
JOM
·
2023
·
IF 2.6
Zhu Yanshaozuo,Shen Xixun,Chen Qian,Xu Qunjie
A silicate and phosphate composite passive film on zinc was prepared from a composite passivation solution containing zinc dihydrogen phosphate and sodium metasilicate. The morphology, composition, valence and functional groups of the passive film with different passivation times were analyzed through field-emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy, X-ray photoelectron spectroscopy and infrared spectroscopy to understand its evolution process. The passive film exhibits a cyclic film-forming process with a periodic ratio of silicate and phosphate, which is caused by the periodic changes in the alkalization degree of the interface between the electrode and the solution. Such periodic film-forming process promotes the passive film growth and makes the passive film uniform and dense. Electrochemical analysis, immersion tests and copper sulfate spotting tests illuminate that the composite passive film is more corrosion-resistant than the pure silicate passive film. This composite passivation film exhibits a uniform corrosion behavior with gradually expanding micropores due to the effective inhibition of inward diffusion and permeation of chloride ions by the dense film structure of cyclic growth, which avoids the pinhole corrosion and improves the protection of the passivation film.
✓ 已验证
产品关联
DOI
高影响因子
Communications Biology
·
2023
·Vol. 6
·期 1
·1-16
·
IF 5.9
Liu Shaojun,Li Dongyu,Yu Tingting,Zhu Jingtan,Semyachkina-Glushkovskaya Oxana,Zhu Dan
The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new alternative methods of treating diabetes-related dysfunction of microglia is urgently needed. Here, we evaluate the effects of transcranial photobiomodulation (tPBM) on microglial function in diabetic mice and investigate its mechanism. We find tPBM treatment effectively improves insulin therapy on microglial morphology and reactivity. We also show that tPBM stimulates brain drainage system through activation of meningeal lymphatics, which contributes to the removal of inflammatory factor, and increase of microglial purinergic receptor P2RY12. Besides, the energy expenditure and locomotor activity of diabetic mice are also improved by tPBM. Our results demonstrate that tPBM can be an efficient, non-invasive method for the treatment of microglial dysfunction caused by diabetes, and also has the potential to prevent diabetic physiological disorders.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2023
·Vol. 30
·期 9
·1705-1715
·
IF 4.8
Zhou Guotao,Wang Yilin,Qi Tiangui,Zhou Qiusheng,Liu Guihua,Peng Zhihong,Li Xiaobin
Goethitic bauxite is a widely used raw material in the alumina industry. It is an essential prerequisite to clarify the effect of Ti- and Si-containing minerals on goethite transformation in the Bayer digestion process, which could efficiently utilize the Fe- and Al-containing minerals present in goethitic bauxite. In this work, the interactions between anatase or kaolinite with goethite during various Bayer digestion processes were investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The results showed that anatase and kaolinite hindered the transformation of goethite. Anatase exerted more significant effects than kaolinite due to the dense sodium titanate layer on the goethite surface after reacting with the sodium aluminate solution. Adding the reductant hydrazine hydrate could eliminate the retarding effect by inducing the transformation of goethite into magnetite. In this process, titanium was embedded into the magnetite lattice to form Ti-containing magnetite. Furthermore, the weakening of the interaction between magnetite and sodium aluminosilicate hydrate reduced the influence of kaolinite. As a validation of the above results, the reductive Bayer method resulted in the transformation of goethite into goethitic bauxite with 98.87% relative alumina digestion rate. The obtained red mud with 72.99wt% Fe 2 O 3 could be further utilized in the steel industry. This work provides a clear understanding of the transformative effects of Ti- and Si-containing minerals on iron mineral transformation and aids the comprehensive use of iron and aluminum in goethitic bauxite subjected to the reductive Bayer method.
✓ 已验证
产品关联
DOI
高影响因子
Nano Research
·
2023
·
IF 9.9
Li Hanbo,Meng Dejing,Zhang Chenqi,Ji Yinglu,Gao Xinshuang,Hu Zhijian,Wu Xiaochun
Herein, a new strategy is proposed for achieving dynamic chiral controls in self-assembly systems of plasmonic nanorods based on temperature-modulation. Via enlarging Au{100} side facets of Au nanorod (AuNR) building block and changing surface ligand from often-used cetyltrimethylammonium bromide (CTAB) to cetylpyridinium chloride (CPC), inversion of chiroptical signal in side-by-side (SS) oligomers is realized. Under the guide of chiral cysteine (Cys), Au{100} side facet-linked SS rods twist in the opposite direction compared with Au{110} side facet-linked counterparts. At high CPC concentration, by controlling the incubation temperature of chiral Cys, the dominant twist mode can be regulated. Finite-difference time-domain (FDTD) simulations indicate the key role of the twisting dihedral angle of the oligomers in driving chiral signal inversion. At low CPC concentration, a temperature-sensitive chiral switching is observed owing to the conformation change of the CPC ligand layer. The temperature-modulated chiral responses are based on the interactions of chiral molecules, achiral surface ligands, and exposed facets of the building block. The rich dynamic tunability of chiroptical responses of plasmonic assemblies may find applications in stimulus-responsive nanodevices.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Hu Changjiang,Jiang Zhiwen,Wu Qunyan,Cao Shuiyan,Li Qiuhao,Chen Chong,Yuan Liyong,Wang Yunlong,Yang Wenyun,Yang Jinbo,Peng Jing,Shi Weiqun,Zhai Maolin,Mostafavi Mehran,Ma Jun
The efficient use of renewable X/γ-rays or accelerated electrons for chemical transformation of CO 2 and water to fuels holds promise for a carbon-neutral economy; however, such processes are challenging to implement and require the assistance of catalysts capable of sensitizing secondary electron scattering and providing active metal sites to bind intermediates. Here we show atomic Cu-Ni dual-metal sites embedded in a metal-organic framework enable efficient and selective CH 3 OH production (~98%) over multiple irradiated cycles. The usage of practical electron-beam irradiation (200 keV; 40 kGy min −1 ) with a cost-effective hydroxyl radical scavenger promotes CH 3 OH production rate to 0.27 mmol g −1 min −1 . Moreover, time-resolved experiments with calculations reveal the direct generation of CO 2 •‒ radical anions via aqueous electrons attachment occurred on nanosecond timescale, and cascade hydrogenation steps. Our study highlights a radiolytic route to produce CH 3 OH with CO 2 feedstock and introduces a desirable atomic structure to improve performance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RARE METALS
·
2023
·
IF 8.8
Zhou Hou-Wang,Zhao Cong,Zhao Ze-Yu,Jiang Jun-Chen,Jin Hui-Le,Wang Shun,Pan Shuang,Xu Min-Yi,Chen Yi-Huang,Jin Hai-Ming
Hydrogel-based triboelectric nanogenerator (TENG) has a promising applied prospect in wearable electronic devices. However, its low performance, poor stability, insufficient recyclability and inferior self-healing seriously hinder its development. Herein, we report a robust route to a liquid metal (LM)/polyvinyl alcohol (PVA) hydrogel-based TENG (LP-TENG). Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel, the as-prepared LP-TENG exhibited comprehensive advantages of adaptability, biocompatibility, outstanding electrical performance, superior stability, recyclability and diverse applications, which were unattainable by traditional systems. Concretely, the LP-TENG delivered appealing open circuit voltage of 250 V, short circuit current of 4 μA and transferred charge of 120 nC with high stability, outperforming most advanced TENG systems. The LP-TENG was successfully employed for versatile applications with multifunctionality, including human motion detection, handwriting recognition, energy collection, message transmission and human–machine interaction. This work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics, flexible skin and smart robots. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Liu Yongli,Chen Letian,Su Xiaoyan,Wang Li,Jiao Ya,Zhou Penghui,Li Bin,Duan Ruijuan,Zhu Guifen
Mercury ion (Hg 2+ ) is a highly toxic and ubiquitous pollutant, whose effective detection has aroused widespread concern. A novel ratiometric fluorescent sensor has been designed to rapidly and efficiently detect Hg 2+ based on blue/red carbon dots (CDs) with environmental friendliness. This sensor was well characterized via TEM, FTIR, XPS, UV–vis, and zeta potential analysis and displayed excellent fluorescence properties and stability. The fluorescence of blue CDs at 447 nm was significantly quenched with the addition of Hg 2+ resulted from the static quenching, whereas that of red CDs at 650 nm remained invariable. A sensitive method for Hg 2+ determination was constructed in the range of 0.05–7.0 nmol mL −1 with optimal conditions, and the detection limit was down to 0.028 nmol mL −1 . Meanwhile, compared to other 17 metal ions, the ratiometric fluorescent sensor exhibited high selectivity for Hg 2+ . Furthermore, satisfied recoveries had also been obtained for measuring trace Hg 2+ in practical environmental samples. This developed ratiometric fluorescent sensor provided a reliable, environmental-friendly, rapid, and efficient platform for the detection of Hg 2+ in environmental applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Zhang Fenghua,Li Zhong,Wang Xun
Inorganic nanowires-based organogel, a class of emerging organogel with convenient preparation, recyclability, and excellent mechanical properties, is in its infancy. Solidifying and functionalizing nanowires-based organogels by designing the gelator structure remains challenging. Here, we fabricate Ca 2 -P 2 W 16 and Ca 2 -P 2 W 15 M nanowires utilizing highly charged [Ca 2 P 2 W 16 O 60 ] 10 − and [Ca 2 P 2 W 15 MO 60 ] 14 − /13 − cluster units, respectively, which are then employed for preparing organogels. The mechanical performance and stability of prepared organogels are improved due to the enhanced interactions between nanowires and locked organic molecules. Compressive stress and tensile stress of Ca 2 -P 2 W 16 nanowires-based organogel reach 34.5 and 29.0 kPa, respectively. The critical gel concentration of Ca 2 -P 2 W 16 nanowires is as low as 0.28%. Single-molecule force spectroscopy confirms that the connections between cluster units and linkers can regulate the flexibility of nanowires. Furthermore, the incorporation of fluorophores into the organogels adds fluorescence properties. This work reveals the relationships between the microstructures of inorganic gelators and the properties of organogels, guiding the synthesis of high-performance and functional organogels.
✓ 已验证
DOI
PubMed
高影响因子
Lipids in Health and Disease
·
2023
·Vol. 22
·期 1
·1-16
·
IF 4.5
Li Hanxiao,Dong Yingyue,Han Chunmiao,Xia Lisha,Zhang Yue,Chen Tongsheng,Wang Huamin,Xu Guoheng
Background Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure of heparin. Regarding the structural and physiological properties of the negatively charged polymers, hexasulfonated suramin, a centuries-old medicine that is still used for treating African trypanosomiasis and onchocerciasis, is assumed to be a heparin-related analog or heparinoid. This investigation aims to elucidate the influence of suramin on the adipogenesis.Methods To assess the influence exerted by suramin on adipogenic differentiation of primary white adipocytes in rats, this exploration was conducted both in vitro and in vivo. Moreover, it was attempted to explore the role played by the sulfonic acid groups present in suramin in mediating this adipogenic process.Results Suramin demonstrated a dose- and time-dependent propensity to stimulate the adipogenic differentiation of rat preadipocytes isolated from the superficial fascia tissue and from adult adipose tissue. This stimulation was concomitant with a notable upregulation in expression levels of pivotal adipogenic factors as the adipocyte differentiation process unfolded. Intraperitoneal injection of suramin into rats slightly increased adipogenesis in the superficial fascia and in the epididymal and inguinal fat depots. PPADS, NF023, and NF449 are suramin analogs respectively containing 2, 6, and 8 sulfonic acid groups, among which the last two moderately promoted lipid droplet formation and adipocyte differentiation. The number and position of sulfonate groups may be related to the adipogenic effect of suramin.Conclusion sSuramin emerges as a noteworthy pharmaceutical agent with the unique capability to significantly induce adipocyte differentiation, thereby fostering adipogenesis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2023
·Vol. 301
·期 12
·1475-1486
·
IF 2.4
Li Yinglu,Zhao Jing,Wang Yurui,Zhao Tianfu,Song Yanan,Liang Fei
Nanoscale metal organic frameworks (NMOFs) have become excellent drug carriers for the treatment of cancer or other diseases, due to the advantages of large surface area, high drug loading, tunable structure and easy functionalization, with potential application in the field of drug delivery. In this paper, UiO-66 NMOF was synthesized using terephthalic acid as organic ligand and zirconium chloride as metal salt, and then biocompatible chitosan (CS) and PEGylated chitosan (CS-g-mPEG)-decorated NMOFs as drug carriers were constructed by surface modification, using 5-FU as the drug model. The structures, size and morphology were characterized by IR, XRD, DLS, SEM and TEM respectively. The results showed that when the concentration was 0.0872 M, the molar ratio was 1:1 and the acetic acid amount was 2.9 mL, the average particle size of NMOFs was 145.60 nm and 171.73 nm, respectively. The drug loading capacity and encapsulation rate could reach 15.7% and 52.8%. The in vitro controlled drug release results indicated that the release rate accelerated with increasing temperature and decreasing initial amount, greatly reduced under acidic conditions, and the coating of CS and CS-g-mPEG on the surface of UiO-66 had the effect of controlling drug release, further improved the bioavailability of 5-FU. The decorated UiO-66 NMOFs show excellent biocompatibility as nanodrug carriers and can avoid rapid degradation under gastric acid, which are more suitable for oral drug delivery.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 9
·1-10
·
IF 2.8
Tian Guangming,Zhao Shuo,Pan Longkai,Yang Dong,Ma Jianhua
Poly(ε-caprolactone) (PCL)-based semi-crystalline polymers are shape memory polymers that have been extensively used in various applications ranging from biological, soft robots and flexible electronic devices. Despite the large number of studies aiming at constructing the well-defined crosslinked polymer networks, detailed investigations in terms of structural factors that influence the thermal-mechanical and shape memory properties are still poorly understand and investigated. In this work, PCL crosslinked networks with different molecular weight of diacrylate PCL macromonoter (M n ) are prepared via base-catalyzed thiol-ene Michael addition. The results indicate that the melting temperature, the crystallization temperature and the crystallinity of the polymer networks exhibit an upward trend with increment of M n . Besides that, the tensile strength and shape memory properties are also correlated with M n . Controlled-strain DMA characterization on shape memory properties show that the cPCL-10000 network exhibits the most remarkable shape fixity and shape recovery ratio, indicative of lowering cross-linking density and chains mobility. In particular, permanent shape reconfiguration can also be achieved by triggering transesterification within the same polymer network, and a possible molecular mechanism responsible for the elasticity-based shape memory effect and plasticity-based permanent shape reconfigurability is proposed and combined to present the 2D-to-3D shape-morphing behaviors.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）