Journal of Bionic Engineering
·
2020
·Vol. 17
·期 5
·1019-1028
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IF 2.222
Dong Sanbao,Li Mingzhong,Liu Chenwei,Zhang Jie,Chen Gang
In this paper, we fabricate a biomimetic superhydrophobic coating on an X90 pipeline steel substrate by electrodeposition of copper, hydrothermal treatment to form a copper oxide layer, and subsequent surface modification with Stearic Acid (SA). The coating exhibits static contact angles of water of 160° ± 3.1° in the air and 170.7° ± 2.5° in cyclopentane, indicating the strongly water-repelling nature of the coating. The morphologies of the cyclopentane hydrate formed on steel substrates with and without the superhydrophobic coating are investigated. The results show that the hydrate particle on the coating exhibits spherical morphology and herein the interfacial contact area and adhesion force to the solid surface can be essentially reduced. The adhesion force reduction may be resulted by the decrease in the contact area between the hydrate and the solid surface.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 28
·期 1
·1052-1060
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IF 3.056
Sun Xu,Xu Li,Jiang Weina,Xuan Yan,Lu Wen,Li Zhong,Yang Shilong,Gu Zhenzhen
In the present study, a magnetic adsorbent, rhein-coated magnetic Fe 3 O 4 nanoparticle (RMNP), for Pb 2+ and Mg 2+ had been developed, and adsorption mechanism was studied via low-field NMR. RMNP was characterized by TEM, FTIR, and XRD. RMNP could adsorb and remove Pb 2+ and Mg 2+ from water and was successfully applied to remove Pb 2+ and Mg 2+ from wastewater, with satisfactory recovery rates and high adsorption capacities. The calculated maximum adsorption capacity for Mg 2+ and Pb 2+ was approximately 69.3 and 64.9 mg g −1 of RMNP, respectively, which was better than some results reported. Low-field NMR results showed that Pb 2+ or Mg 2+ enhanced the T 2 relaxation time of RMNP, which suggested that RMNP selectively coordinated with Pb 2+ or Mg 2+ and led to the aggregation of RMNP, furthermore removal of Pb 2+ or Mg 2+ from water. The standard curves for △T 2 -cation concentration exhibited good line correlation. The linear ranges were from 4.2 × 10 −6 to 2.0 × 10 −4 mol L −1 for Pb 2+ and from 5.0 × 10 −6 mol L −1 to 1.0 × 10 −4 mol L −1 for Mg 2+ , respectively. The limits of detection were 1.4 × 10 −6 mol L −1 for Pb 2+ and 2.1 × 10 −6 mol L −1 for Mg 2+ , respectively. In short, low-field NMR could clearly display the interaction between RMNP and Pb 2+ or Mg 2+ , even be used to detect Pb 2+ or Mg 2+ in suitable condition. Besides, this method could be expanded to study the interaction between other magnetic adsorbents and analytes.
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JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 32
·15405-15414
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IF 3.553
Wang Yige,Gao Bo,Wang Qian,Li Xiaohui,Su Zhi,Chang Aimin
The aim of this paper is to present a novel negative temperature coefficient (NTC) thermistor based on A 2 Zr 2 O 7 (A = Nd, Sm, Gd, Yb) zirconate ceramics with pyrochlore-type structure for high-temperature application. The zirconate ceramics were synthesized via a solid-state reaction method where rare-earth oxides and ZrO 2 were used as starting materials. The physical structures were characterized by X-ray diffraction, scanning electron microscopy, and Raman spectroscopy. It was confirmed that Nd 2 Zr 2 O 7 and Sm 2 Zr 2 O 7 are pyrochlore phases, while Yb 2 Zr 2 O 7 and Gd 2 Zr 2 O 7 are defect fluorite phases. The electrical property investigated by using resistance–temperature measurements demonstrated that the prepared A 2 Zr 2 O 7 zirconate ceramics exhibit a typical characteristic of NTC over a wide temperature range between 673 and 1273 K. Particularly, A 2 Zr 2 O 7 , in addition to having high activation energy to ensure better sensitivity, can still maintain higher resistivity under high-temperature environments. Furthermore, the resistivity of A 2 Zr 2 O 7 is almost independent of the change in oxygen partial pressure. These properties are superior to the classical spinel-type or perovskite-type NTC thermistor, providing valuable information to explore new NTC thermistor for high-temperature applications.
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Scientific Reports
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2020
·Vol. 10
·期 1
·14092-14092
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IF 3.998
Yang Chen,Juan Ni,Yun Gao,Jinghui Zhang,Xuesong Liu,Yong Chen,Zhongjian Chen,Yongjiang Wu
Colorectal cancer (CRC) is a common malignancy occurring in the digestive system. Despite progress in surgery and therapy options, CRC is still a considerable cause of cancer mortality worldwide. In this study, a colon cancer patient-derived xenograft model was established to evaluate the antitumor activity of Shikonin. The protective effect underlying Shikonin was determined through assessing serum levels of liver enzymes (ALT, AST) and kidney functions (BuN, Scr) in PDX mice. Proteomics and metabolomics profiles were integrated to provide a systematic perspective in dynamic changes of proteins and global endogenous metabolites as well as their perturbed pathways. A total of 456 differently expressed proteins (DEPs), 32 differently expressed metabolites (DEMs) in tumor tissue, and 20 DEMs in mice serum were identified. The perturbation of arginine biosynthesis, purine metabolism, and biosynthesis of amino acids may mainly account for therapeutic mechanism of Shikonin. Furthermore, the expression of mRNAs participating in arginine biosynthesis (CPS1, OTC, Arg1) and do novo purine synthesis (GART, PAICS, ATIC) were validated through RT-qPCR. Our study provides new insights into the drug therapeutic strategies and a better understanding of antitumor mechanisms that might be valuable for further studies on Shikonin in the clinical treatment of colorectal cancer.
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CELLULOSE
·
2020
·Vol. 27
·期 15
·8923-8935
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IF 4.21
Sun Longfei,Wang Fei,Jiang Jingjing,Liu Hangcheng,Du Binglei,Li Mingze,Liu Yixin,Li Minghua
Sodium alginate (SA), as the eco-friendly and human-safe biomass material not only can achieve effective dispersion of graphene nanoplatelets (GnPs), but also improve the interaction between GnPs and cellulose macromolecules. Based on this, a flexible and wearable GnPs/cellulose strain sensor with a special 2 × 2 double rib knitted fabric structure (KFGS) was prepared by a simple dip-coating method that could be used on a large scale. The KFGS exhibited dual sensing performance with high sensitivity (25.32 kPa −1 at 3 kPa pressure, gauge factor 32.62 at 25% tensile strain), stretchability (ε > 25%) and dynamic stability (signal drift < 6% after 300 cycles). Its potential application prospects were also predicted by the monitoring of human movement and physical parameters through a wireless Bluetooth connection.
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MACROMOLECULAR RESEARCH
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2020
·Vol. 28
·期 11
·1032-1039
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IF 2.047
Xu Chang-An,Lu Mangeng,Wu Kun,Shi Jun
Polyurethane (PU) elastomer has been widely used in many fields. In this work, polyurethane/polysiloxane elastomers are synthesized by one-step polymerization using polyether and polyester polyols. The properties of polytetramethylene ether glycol (PTMG) and polycarbonate (PCDL) on polyurethane/polysiloxane elastomers are characterized by various test methods. The results show that PTMG is superior to PCDL in heat resistance and hydrophobicity to polyurethane/polysiloxane elastomers. The heat resistance index of PTMGPU is as high as 154 °C, and its contact angle has reached 115.2°. In addition, the surface of PTMGPU contains more silicone. This may be because the chain structure of PTMG is conducive to the migration of siloxane to the surface, and then a Si-O-Si protective layer is formed, thereby improving the heat resistance and hydrophobicity of the surface of PTMGPU. PCDLPU shows good mechanical properties, which may be related to the stronger chain structure of PCDL. This provides a theoretical basis for the future application of polyurethane/polysiloxane materials.
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JOURNAL OF POROUS MATERIALS
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2020
·Vol. 27
·期 6
·1755-1763
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IF 2.183
Yang Jie,Dai Jiangdong,He Jinsong,Wang Lulu,Xie Atian,Yan Yongsheng
The formation of high-quality hierarchically porous N-doped carbons with multi-scale pores, high specific surface area and large pore volume generally suffers from multistep complicated procedures. It still remains a great challenge to develop facile and effective approaches. Here, a novel three-in-one strategy (synergistic self-templating, self-activation and in-situ N-doping) was designed to fabricate hierarchically porous N-doped carbons (HPNCs) directly, via a one-pot carbonization using ethylenediaminetetraacetic acid tripotassium salt dehydrate (EDTA-3K) as the sole starting material. The as-obtained HPNCs exhibited 3D porous architecture, very high BET surface areas (e.g., 2787 m 2 g −1 ), rich porosity and good nitrogen doping amounts, resulting in good CO 2 capture capacity (e.g., 5.80 mmol g −1 , at 273 K and 1.0 bar), and tetracycline adsorption ability (e.g., 1092 mg g −1 ). This discovery can provide a new concept for simply fabricating well-defined and unique functional porous carbons for various applications, such as sensor, energy storage and conversion, adsorption, separation, catalysis, bio-medicine, environmental protection.
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CELLULOSE
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2020
·Vol. 27
·期 15
·8695-8708
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IF 4.21
Zhang Hui,Liu Yan,Cui Sisi,Zhou Yifa,Hu Junli,Ma Jiangang,Liu Yichun
Abstract Electrospun cellulose nanofibers are promising biomaterials but are suffering from the use of unfavorable organic solvents during the electrospinning process. In this manuscript, we used the periodate oxidation—adipic acid dihydrazide crosslinking strategy to fabricate electrospun cellulose nanofibers. Periodate oxidation of cellulose generated water soluble aldehyde cellulose, which thus allowed for the electrospinning in aqueous solution and avoided the use of unfavorable organic solvents. The following crosslinking with adipic acid dihydrazide made the nanofibers water resistant. The results show that the prepared cellulose nanofiber mats show moderate wet mechanical strength around 1 MPa, are able to absorb water equal to 30 times of their own weight, can degrade gradually by hydrolysis, and are cytocompatible. These cellulose nanofibers are expected to find applications in biomedical fields such as wound healing and tissue regeneration. Graphic abstract
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AAPS PHARMSCITECH
·
2020
·Vol. 21
·期 6
·1-13
·
IF 2.401
Tian Chunling,Liu Liu,Xia Mengqiu,Chu Xiao-qin
This study aimed to evaluate the effects of two different structural alcohol permeation enhancers (menthol and propylene glycol) on the internal structure and in vitro properties of the dual drug–loaded lyotropic liquid crystalline (LLC) gels. The LLC gels were prepared and characterized by polarized light microscopy, small-angle X-ray scattering, differential scanning calorimetry, attenuated total reflectance-Fourier transform infrared spectrum, and rheology. Based on the results, the inner structure of the gels was Q II mesophase and exhibited a pseudoplastic fluid behavior. The level of internal order in the LLC mesophase would be affected by introduced 2 wt% menthol (MEN) and propylene glycol (PG). The in vitro release experiment showed that the release behavior of sinomenine hydrochloride (SH) and cinnamaldehyde (CA) from the LLC system was dominated by Fickian diffusion ( n < 0.43). MEN and PG had the opposite effects on the release of hydrophilic SH, while the MEN and PG both increased the release of lipophilic drug CA . Furthermore, in vitro permeation studies indicated that MEN and PG could both improve the skin permeability of SH and CA, and MEN displayed more pronounced enhancement. All the samples showed no skin irritation on the normal rat skin. Collectively, in our research, monoterpenoid MEN exhibited a better penetration-promoting effect than straight-chain fatty alcohol PG on the dual drug–loaded LLC system.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-13
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IF 10.435
Zhang Gutian,Cheng Wenting,Du Lin,Xu Chuanjun,Li Jinlong
Background Phototherapy is a promising strategy for cancer therapy by reactive oxygen species (ROS) of photodynamic therapy (PDT) and hyperthermia of photothermal therapy (PTT). However, the therapeutic efficacy was restricted by tumor hypoxia and thermal resistance of increased expression of heat shock protein (Hsp). In this study, we developed albumin nanoparticles to combine hypoxia relief and heat shock protein inhibition to overcome these limitations for phototherapy enhancement. Results Near-infrared photosensitizer (IR780) and gambogic acid (GA, Hsp90 inhibitor) were encapsulated into albumin nanoparticles via hydrophobic interaction, which was further deposited MnO 2 on the surface to form IGM nanoparticles. Both in vitro and in vivo studies demonstrated that IGM could catalyze overexpress of hydrogen peroxide to relive hypoxic tumor microenvironment. With near infrared irradiation, the ROS generation was significantly increase for PDT enhancement. In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. As a result, IGM could achieve better antitumor efficacy with enhanced PDT and PTT. Conclusion This study develops a facile approach to co-deliver IR780 and GA with self-assembled albumin nanoparticles, which could relive hypoxia and suppress Hsp for clinical application of cancer phototherapy.
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BIOLOGICAL TRACE ELEMENT RESEARCH
·
2021
·Vol. 199
·期 10
·3728-3736
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IF 3.738
Han Gaochao,Tan Zhuangsheng,Jing Haiming,Ning Junyu,Li Zinan,Gao Shan,Li Guojun
Due to the wide application of rare-earth elements (REEs) in the last decades, lanthanum has increasingly entered the environment and has gradually accumulated in the human body through the food chain. Lanthanum is worth paying attention in terms of food safety. Although the genotoxicity of lanthanum has been studied in vitro, data on its DNA damage in vivo rodent are limited, moreover, which have also presented some controversy. This study aimed to conduct an in vivo rodent alkaline comet assay, and as a companion test to the lanthanum nitrate carcinogenicity test. We conducted an oral gavage experiment for 180 days (26 weeks) to test for the persistence of DNA damage of long-term low-dose accumulation of lanthanum nitrate (12.5, 25, and 50 mg/kg body weight), in F1 hybrid C57-ras transgenic mice (CB6F1) by using alkaline comet assay in the blood and liver. The comet assay revealed that all the tested concentrations of lanthanum nitrate did not induce DNA damage in any of the tissues investigated, whereas DNA damage was induced in the positive control group. These results could indicate that lanthanum nitrate can accumulate in tissues and organs of the mice after exposure, and does not possess DNA damage in C57-ras transgenic mice after repeated treatments at oral doses up to 50 mg/kg·BW for 26 weeks; also, it did not cause pathological changes in the liver of the mice.
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JOM
·
2020
·Vol. 72
·期 12
·4505-4513
·
IF 2.054
Hai Yun,Wang Shuonan,Liu Hao,Lv Guocheng,Mei Lefu,Liao Libing
Although transition-metal sulfides have emerged recently as a type of promising candidate to serve as lithium-ion battery anodes, the chemical synthesis of transition metal-sulfide materials usually involves a complex operation process and is time-consuming. The natural transition metal-sulfide minerals are potential materials for lithium-ion battery electrodes because of their abundant reserves and cost savings of the synthesis process. The synthesis of nanosized transition metal-sulfide-based materials from natural bulk minerals remains challenging. In our work, we demonstrate that a composite of ~ 10–50-nm ZnS nanoparticles that are anchored on reduced graphene-oxide nanosheets can be synthesized by using bulk natural sphalerite in a simple, rapid and pollution-free microwave shock method. As anode electrode, this composite exhibited a high reversible specific capacity (~ 611 mAh g −1 at 0.1 C), good rate performance and good cycling stability. This work provides a route for the high-value utilization of natural minerals.
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