CATALYSIS LETTERS
·
2024
·
IF 2.3
Xu Pengfei,Ma Haiming,Shen Wenjuan,Quan Fengjiao,Li Jianfen,He Yun
Ammonia (NH 3 ) can be used as a fertilizer, a chemical or a new generation of fuel and has important agricultural and industrial value. Electrochemical NO 3 – -to-NH 3 (NITRR) can realize the conversion of waste into treasure and waste resources, which is a promising method for ammonia synthesis. However, the process of NITRR is very complicated, resulting in product diversification and poor selectivity. In this work, an iron modified cerium oxide in rod form (Fe/CeO 2 -rod) catalysts was designed and used for the NITRR. The Fe/CeO 2 -rod catalyst showed excellent activity, and achieves high Faradaic efficiency (FE 95%) and NH 3 yield rate (4.04 mg h –1 cm –2 ) in 0.1 M KOH electrolyte at – 0.52 V versus reversible hydrogen electrode. Furthermore, this catalyst exhibits a negligible activity decay during continuous electrolysis for 25 h. Further experiments provide the important role of Fe, which promote the formation of hydrogen radicals (H*). This study may provide new pathways to improve the activity of inexpensive catalysts for NITRR. Graphical Abstract
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Nature Synthesis
·
2024
·
IF 0
Huang Da-Shuai,Qiu Xiao-Feng,Huang Jia-Run,Mao Min,Liu Lingmei,Han Yu,Zhao Zhen-Hua,Liao Pei-Qin,Chen Xiao-Ming
The synthesis of urea by the electrochemical co-reduction of CO 2 and nitrate is a crucial and challenging task. Catalysts typically suffer from either low Faradaic efficiency (FE) or inadequate current density, leading to a restricted yield rate of urea. Here we report ultrasmall γ-Fe 2 O 3 nanoparticles (<2 nm) encapsulated in the pores of a conductive (40 S cm −1 ) metal–organic framework Ni-HITP (HITP = 2,3,6,7,10,11-hexaaminotriphenylene), resulting in a composite material, γ-Fe 2 O 3 @Ni-HITP. Under neutral conditions, γ-Fe 2 O 3 @Ni-HITP exhibited a state-of-art electrocatalytic performance for urea synthesis through the co-reduction of CO 2 and nitrate in CO 2 -saturated 1 M KHCO 3 and 0.1 M KNO 3 aqueous solutions, achieving a FE urea of 67.2(6)%, a current density of −90 mA cm −2 and an high yield rate of \(20.4(2)\,{\mathrm{g}}\,{\mathrm{h}}^{-1}\,{\mathrm{g}}_{\mathrm{cat}}^{-1}\) (7.7(1) mg h −1 cm −2 ), which is about five times higher than the rates of previously reported catalysts. No degradation was observed over 150 h of continuous operation at such a high yield rate. Enlarging the electrode area by 125 times yielded about 1.05(4) g of high-purity urea over 8 h. A mechanistic study revealed that Fe(III) ions in the γ-Fe 2 O 3 nanoparticles exhibit high activity, generating the key intermediates *NH 2 and *COOH. Furthermore, pairs of adjacent Fe(III) ions in the γ-Fe 2 O 3 nanoparticles can act as highly active catalytic sites for catalysing the C–N coupling between *NH 2 and *COOH, resulting in the formation of the subsequent key intermediate *CONH 2 , thereby contributing to the exceptionally high performance of γ-Fe 2 O 3 @Ni-HITP for urea production.
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RARE METALS
·
2024
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IF 9.6
Zhou Xiao-He,Mo Min-Hua,Chen Zi-Wei,Liu Wen-Jing,Zhang Yan-Li,Pathak Janak L.,Wang Li-Jing,Liu Chang,Shao Long-Quan,Chen Liang-Jiao
Promotion of angiogenesis is crucial for bone tissue repair, and the poor activity of angiogenic cells and growth factors is the main problem in angiogenesis. New proangiogenic nanomaterials are urgently needed to be a promising strategy for this issue. Nb promotes bone formation and fracture healing, possibly by increasing vascular endothelial growth factor (VEGF) production. Nanoniobium particles (nNb) may promote angiogenesis. However, the effect of nNb on angiogenesis is unclear, limiting its application. This study confirmed that nNb significantly promoted angiogenesis. nNb increased and Ras-related C3 botulinum toxin substrate (Rac) family small guanosine triphosphatase (GTPase) 1 (Rac1) expression, inducing F-actin aggregation at the front edge of cells and the formation of pseudopodia to mediate cell migration, further promoting angiogenesis. We discovered that cyclin-dependent kinase-like 5 (CDKL5) is a new signaling molecule that activates Rac1. V-ets erythroblastosis virus E26 oncogene homolog (ETS) domain-containing protein (ELK1), regulating CDKL5 and Rac1, plays an upstream regulatory role. When ELK1 was inhibited, CDKL5 and Rac1 levels were decreased. ELK1, CDKL5 or Rac1 are effective regulatory targets of angiogenesis. Inhibiting expression of ELK1, CDKL5 or Rac1 decreased angiogenesis. Thus, nNb has good angiogenic effects. The ELK1-CDKL5-Rac1 signaling pathway regulates the migration of endothelial cells to promote angiogenesis. nNb can be used in bone tissue engineering as a new nanomaterial, and it will promote the development of a new strategy for tissue engineering. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 11
·1-8
·
IF 2.8
Liu Juan,Liu Bing,Song Kai Xin
The effects of cold sintering assisted two-step sintering on the structural evolution and microwave dielectric properties of Al 2 O 3 ceramics are systematically investigated in this work. XRD analysis reveals that the crystal structure remains stable throughout the cold sintering and following high-temperature sintering processes. Rietveld refinement confirms the trigonal Al 2 O 3 configuration and the absence of impurities. Increasing cold sintering pressure results in improved relative density, reaching over 94% after post-sintering at 1575 °C. Additionally, the sintering temperature of Al 2 O 3 ceramics via cold-sintering assisted two-step sintering route is 100 °C lower than that via direct conventional sintering. The microwave dielectric properties, including ε r and Qf , exhibit enhancements with increasing cold sintering pressure and post-sintering temperature. The measured ε r closely aligns with the theoretical value, indicating a successful densification. Qf achieves its peak of 100,220 GHz at 1575 °C under 375 MPa, nearly 2 times higher than the value obtained at 125 MPa (53,280 GHz). The optimal microwave dielectric properties ( ε r = 9.67, Qf = 100,220 GHz, and τ f = − 54.5 ppm/°C) are achieved at a cold sintering pressure of 375 MPa and post sintering temperature of 1575 °C.
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Lipids in Health and Disease
·
2024
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IF 3.9
Xue Ran,Ying-jie Wang,Shi-gang Li,Chi-bing Dai
Background/aims Research has indicated that treatment with rosuvastatin can improve liver pathology in metabolic-associated fatty liver disease (MAFLD) patients and that treatment with Bifidobacterium can improve MAFLD. Therefore, the effects of Bifidobacterium , rosuvastatin , and their combination on related indices in a rat model of diet-induced MAFLD need to be investigated. Methods Forty rats were divided into five groups: the normal diet group (N), high-fat diet (HFD) model group (M), HFD + probiotic group (P), HFD + statin group (S), and HFD + probiotic + statin group (P-S). To establish the MAFLD model, the rats in Groups M, P, S, and P-S were fed a HFD for 8 weeks. The treatments included saline in Group N and either Bifidobacterium , rosuvastatin , or their combination in Groups P, S, and P-S by intragastrical gavage. After 4 weeks of intervention, the rats were euthanized, and samples were harvested to analyze gastrointestinal motility and liver function, pathological changes, inflammatory cytokine production, and the expression of proteins in key signaling pathways. Results HFD feeding significantly increased the body weight, liver index, and insulin resistance (IR) index of the rats, indicating that the MAFLD model was successfully induced. Bifidobacterium reduced the liver of MAFLD rats, while Bifidobacterium with Rosuvastatin decreased the liver index, IR index, and levels of aspartate aminotransferase and alanine aminotransferase in MAFLD rats. The MAFLD model showed altered expression of proteins in signaling pathways that regulate inflammation, increased production of inflammatory cytokines, an elevated MAFLD activity score (MAS), and pathological changes in the liver. The MAFLD model also showed reduced relative counts of intestinal neurons and enteric glial cells (EGCs), altered secretion of gastrointestinal hormones, and slowed gastrointestinal emptying. Bifidobacterium , rosuvastatin , or their combination inhibited these various changes. HFD feeding changed the rats’ gut microbiota, and the tested treatments inhibited these changes. These results suggest that the gastrointestinal motility disorder and abnormal liver function in MAFLD rats may be related to a reduction in Escherichia-Shigella bacteria and an increase in Asticcacaulis bacteria in the gut microbiota and that the improvement in liver function induced by Bifidobacterium plus rosuvastatin may be related to increases in Sphingomonas and Odoribacter bacteria and a decrease in Turicibacter bacteria in the gut microbiota. Conclusions The combined use of Bifidobacterium and rosuvastatin could better regulate the gut microbiota of MAFLD model rats, promote gastrointestinal emptying, and improve liver pathology and function than single treatment with Bifidobacterium or rosuvastatin . This provides a better strategy for the treatment of MAFLD.
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高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-11
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IF 3.8
Yu Weiwei,Ai Ting,Sun Weizhe,Yang Shuo,Mao Yufeng,Tan JiangLin,Yu Feng,Yin Chen,Jiang Qin,Yu Chengye,Chen Shiling
In this study, MnFe 2 O 4 microspheres were synthesized to activate potassium persulfate complex salt (Oxone) for the degradation of 17β-estradiol (17β-E2) in aqueous solutions. The characteristic of MnFe 2 O 4 was detected by XRD, XPS and SEM-EDS. The experimental results indicated that the degradation of 17β-E2 followed pseudo-first-order kinetics. At 25 °C, 17β-E2 concentration of 0.5 mg/L, MnFe 2 O 4 dosage of 100 mg/L, Oxone dosage of 0.5 mmol/L, and initial pH value of 6.5, the decomposition efficiency of 17β-E2 reached 82.9% after 30 min of reaction. Additionally, free radical quenching experiments and electron paramagnetic resonance analysis demonstrated that SO 4 − • and •OH participated in the reaction process of the whole reaction system, with SO 4 − • being the main reactive oxygen species (ROS). The activation mechanism of the MnFe 2 O 4 /Oxone/17β-E2 system is proposed as follows: MnFe 2 O 4 initially reacts with O 2 and H 2 O in solution to generate active Fe 3+ -OH and Mn 2+ -OH species. Subsequently, Fe 3+ -OH and Mn 2+ -OH react with Oxone in a heterogeneous phase activation process, producing highly reactive free radicals. After four cycles of MnFe 2 O 4 material, the removal rate of 17β-E2 decreased by 24.1%.
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ACTA PHARMACOLOGICA SINICA
·
2025
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IF 8.4
Guo Qing,Gan Jun,Wang En-ze,Wei Yu-ming,Xu Jie,Xu Yun,Zhang Fei-fei,Cui Meng,Jia Meng-xing,Kong Ming-jian,Tang Qiong-yao,Zhang Zhe
Patients suffering epilepsy caused by the gain-of-function mutants of the hKCNT1 potassium channels are drug refractory. In this study, we cloned a novel human KCNT1B channel isoform using the brain cDNA library and conducted patch-clamp and molecular docking analyses to characterize the pharmacological properties of the hKCNT1B channel using thirteen drugs. Among cinchona alkaloids, we found that hydroquinine exerted the strongest blocking effect on the hKCNT1B channel, especially the F313L mutant. In addition, we confirmed the antitussive drug tipepidine was also a potent inhibitor of the hKCNT1B channel. Subsequently, we proved that these two drugs produced an excellent therapeutic effect on the epileptic model of KCNT1 Y777H mutant male mice; thus, both could be ready-to-use anti-epileptic drugs. On the other hand, we demonstrated that the activation of the KCNT1 channel by loxapine and clozapine was through interacting with pore domain residues to reverse the run-down of the KCNT1 channel. Taken together, our results provide new insights into the mechanism of the modulators in regulating the KCNT1 channel activity as well as important candidates for clinical tests in the treatment of KCNT1 mutant-associated epilepsy.
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JOURNAL OF MOLECULAR HISTOLOGY
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2025
·Vol. 56
·期 2
·1-15
·
IF 2.2
Hou Huailong,Qiu Zhengjun,Che Jingyi,Li Yanping,Sun Jingxuan,Zhang Weiwei,Ma Jinjie,Zhang Shuang,Li Mengdi,Niu Yumei,He Lina
Dental pulp stem cells (DPSCs), a subset of tooth-derived mesenchymal stem cells (MSCs), demonstrate significant promise in clinical stem cell therapy. However, prolonged in vitro expansion commonly results in compromised stemness, limiting therapeutic efficacy. Thus, maintaining the stemness of DPSCs during expansion and culture is a key challenge for regenerative medicine. In the current study, the impact of simulated microgravity (SMG) on DPSC stemness was investigated using the three-dimensional clinostat Cellspace-3D. After SMG treatment for 3 days, DPSCs demonstrated markedly enhanced replicative activity, proliferation efficiency, self-renewal capacity, and effective inhibition of the senescence process. Under specific differentiation induction conditions, DPSCs in the SMG group exhibited superior osteogenic, adipogenic, chondrogenic, and neural differentiation potentials. Additionally, DPSCs exhibited higher expression levels of the MSC surface markers Stro-1 and CD146 and stemness maintenance-related genes Oct4, Nanog, and Sox2 in the SMG group compared to those from the normal gravity (NG) group. To elucidate the potential molecular mechanisms by which SMG influences the stemness of DPSCs, transcriptome sequencing of total RNA was performed, and identified that differentially expressed genes (DEGs) are closely associated with the MAPK signaling pathway. Further verification experiments demonstrated that the MAPK/ERK signaling pathway was activated in the SMG group. In conclusion, SMG effectively maintains the stemness of DPSCs cultivated in vitro, and its mechanism of action may be associated with the activation of the MAPK/ERK signaling pathway.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
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IF 3.8
Guo Mengyue,Ke Tongwei,Zhang Huiru,Zhang Jing,Qin Jia’an,Ruan Haonan,Tian Jiao,He Chunjiao,Luo Yawen,Qin Xuhua,Luo Jiaoyang,Yang Meihua
Thiamethoxam is one of the top three neonicotinoids found in the environment and in food. The widespread use of thiamethoxam in medicinal and edible herbs threatens their safe use. Therefore, it is particularly important to develop a rapid and simple approach to detect thiamethoxam residues in herbal medicines. In this study, colloidal carbon-based immunochromatographic strip (CNP-ICS) and colloidal gold-based immunochromatographic test strip (GNP-ICS) methods were respectively developed for the determination of thiamethoxam . The cutoff value of CNP-ICS was 0.1 ng mL −1 , which is six times more sensitive than that of the GNP-ICS method (0.6 ng mL −1 ). The CNP-ICS method was applied to detect thiamethoxam in medicinal and edible Lonicerae Japonicae Flos (LJF) for the first time, with a limit of detection of 10 ng g −1 . The detection results of thiamethoxam in 26 batches of LJF samples by the CNP-ICS were consistent with those of the LC–MS/MS method. High residue levels (10.16–530.40 ng g −1 ) and high detection rates (69.23%) of thiamethoxam in LJF were observed. The CNP-ICS prepared in this study has the merits of low cost, simple preparation, non-toxicity, and high sensitivity, which can be utilized for rapid field screening of thiamethoxam residues in complex matrices such as herbal medicines. Graphical
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-19
·
IF 14.7
Yang Mei,Chen Tingting,Chen Xin,Pan Hongxian,Zhao Guoli,Chen Zhongxing,Zhao Nan,Ye Qianfang,Chen Ming,Zhang Shenrong,Gao Rongrong,Meek Keith M.,Hayes Sally,Ma Xiaowei,Li Xin,Wu Yue,Zhang Yiming,Kong Na,Tao Wei,Zhou Xingtao,Huang Jinhai
Keratoconus, a disorder characterized by corneal thinning and weakening, results in vision loss. Corneal crosslinking (CXL) can halt the progression of keratoconus. The development of accelerated corneal crosslinking (A-CXL) protocols to shorten the treatment time has been hampered by the rapid depletion of stromal oxygen when higher UVA intensities are used, resulting in a reduced cross-linking effect. It is therefore imperative to develop better methods to increase the oxygen concentration within the corneal stroma during the A-CXL process. Photocatalytic oxygen-generating nanomaterials are promising candidates to solve the hypoxia problem during A-CXL. Biocompatible graphitic carbon nitride (g-C 3 N 4 ) quantum dots (QDs)-based oxygen self-sufficient platforms including g-C 3 N 4 QDs and riboflavin/g-C 3 N 4 QDs composites (RF@g-C 3 N 4 QDs) have been developed in this study. Both display excellent photocatalytic oxygen generation ability, high reactive oxygen species (ROS) yield, and excellent biosafety. More importantly, the A-CXL effect of the g-C 3 N 4 QDs or RF@g-C 3 N 4 QDs composite on male New Zealand white rabbits is better than that of the riboflavin 5’-phosphate sodium (RF) A-CXL protocol under the same conditions, indicating excellent strengthening of the cornea after A-CXL treatments. These lead us to suggest the potential application of g-C 3 N 4 QDs in A-CXL for corneal ectasias and other corneal diseases.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-15
·
IF 3.8
Yue Jiayuan,Zheng Qi,Ding Shushu,Yin Yujian,Zhang Xiaodan,Wang Liyun,Gu Yipeng,Li Jiejia,Zhang Yuhan,Shi Yurou,Dong Yuetan,Zhu Qing,Duo Huixiao
In this study, the removal effect of a new MOF-on MOF adsorbent based on Cu–Co bimetallic organic frameworks on tetracycline antibiotics (TCs) in water system was studied. The adsorbent (Cu-MOF@Co-MOF) were synthesized by solvothermal and self-assembly method at different concentrations of Co 2+ /Cu 2+ . The characterization results of SEM, XRD, XPS, FTIR and BET indicated that the MOF-on MOF structure of Cu-MOF@Co-MOF exhibited the best recombination and physicochemical properties when the molar ratio of Co 2+ : Cu 2+ is 5:1. In addition, the Cu-MOF@Co-MOF have a high specific surface area and bimetallic clusters, which can achieve multi-target synergistic adsorption of TCs. Based on above advantages, Cu-MOF@Co-MOF provided a strong affinity and could efficiently adsorb more than 80% of pollutants in just 5 to 15 min using only 10 mg of the adsorbent. The adsorption capacity of tetracycline and doxycycline was 434.78 and 476.19 mg/g, respectively, showing satisfactory adsorption performance. The fitting results of the experimental data were more consistent with the Langmuir isotherm model and pseudo-second-order kinetic model, indicating that the adsorption process of TC and DOX occurred at the homogeneous adsorption site and was mainly controlled by chemisorption. Thermodynamic experiments showed that Cu-MOF@Co-MOF was thermodynamically advantageous for the removal of TCs, and the whole process was spontaneous. The excellent adsorption capacity and rapid adsorption kinetics indicate the prepared MOF-on MOF adsorbent can adsorb TCs economically and quickly, and have satisfactory application prospects for removing TCs in practical environments. The results of the study pave a new way for preparing novel MOFs-based water treatment materials with great potential for efficient removal.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Zhang Zhen,Xing Zhenyu,Luo Xianglin,Cheng Chong,Liu Xikui
Dual-atom catalysts featuring synergetic dinuclear active sites, have the potential of breaking the linear scaling relationship of the well-established single-atom catalysts for oxygen reduction reaction; however, the design of dual-atom catalysts with rationalized local microenvironment for high activity and selectivity remains a great challenge. Here we design a bisalphen ladder polymer with well-defined densely populated binuclear cobalt sites on Ketjenblack substrates. The strong electron coupling effect between the fully-conjugated ladder structure and carbon substrates enhances the electron transfer between the cobalt center and oxygen intermediates, inducing the low-to-high spin transition for the 3 d electron of Co(II). In situ techniques and theoretical calculations reveal the dynamic evolution of Co 2 N 4 O 2 active sites and reaction intermediates. In alkaline conditions, the catalyst exhibits impressive oxygen reduction reaction activity featuring an onset potential of 1.10 V and a half-wave potential of 1.00 V, insignificant decay after 30,000 cycles, pushing the overpotential boundaries of ORR electrocatalysis to a low level. This work provides a platform for designing efficient dual-atom catalysts with well-defined coordination and electronic structures in energy conversion technologies.
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