Journal of Environmental Sciences
·
2026
·
IF 6.5
Huilin Yu,Aijun Gui,Zhenkun Zhang,Juan Xu,Xueqian Wu,Menghui Lin,Haiying Cai,Junhui Zhang
● FLU induces cardiotoxicity in zebrafish at embryonic and adult stages. ● FLU-induced cardiac injury is driven by oxidative stress and mitochondrial dysfunction. ● FLU suppresses mitochondrial complex genes and oxidative phosphorylation. ● FLU disrupts glycolysis and TCA cycle metabolism in the heart. ● FLU shows strong binding affinity to multiple zebrafish SDH subunits. Fluxapyroxad (FLU), a widely detected succinate dehydrogenase inhibitor fungicide, poses potential cardiotoxic risks to aquatic organisms. In this study, we explored the cardiotoxic mechanisms of FLU in zebrafish at both embryonic and adult stages. Embryonic FLU exposure caused significant cardiac structural and functional abnormalities, accompanied by increased reactive oxygen species, elevated malondialdehyde, reduced glutathione, and heightened apoptosis. Ultrastructural analysis revealed mitochondrial vacuolization, matrix rarefaction, and myofibril disorganization. Mitochondrial respiration, including basal respiration, ATP production, and maximal respiration, was significantly suppressed. In adult zebrafish, FLU led to atrial enlargement, ventricular wall thickening, reduced blood flow, and additional mitochondrial damage. Transcriptomic data showed marked downregulation of mitochondrial complex subunit genes and disruptions in oxidative phosphorylation and reactive oxygen species pathways. Metabolomic analysis demonstrated significant alterations in glycolytic and tricarboxylic acid cycle metabolites, reflecting impaired cardiac energy metabolism. Molecular docking further demonstrated strong binding of FLU to zebrafish succinate dehydrogenase subunits, supporting direct inhibition at the protein level. Collectively, these findings reveal that FLU induces cardiotoxicity by promoting oxidative stress, disrupting mitochondrial function, and impairing energy metabolism. This study offers mechanistic insight into SDHI fungicide toxicity and supports their ecological risk assessment. Download: Download high-res image (207KB) Download: Download full-size image
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PHYSICAL REVIEW LETTERS
·
2024
·Vol. 132
·期 25
·256503
·
IF 8.1
Kaiwen Chen,Xiangqi Liu,Jiachen Jiao,Muyuan Zou,Chengyu Jiang,Xin Li,Yixuan Luo,Qiong Wu,Ningyuan Zhang,Yanfeng Guo,Lei Shu
A positive muon spin relaxation study of polycrystalline La${}_{3}$Ni${}_{2}$O${}_{6.92}$ under ambient pressure reveals static long range bulk magnetic order consistent with a spin density wave.
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Physical Review Materials
·
2024
·Vol. 8
·期 9
·094202
·
IF 3.1
Jian Yuan,Xianbiao Shi,Hong Du,Wei Xia,Xia Wang,Jinguang Cheng,Baotian Wang,Ruidan Zhong,Shihao Zhang,Yanfeng Guo
The correlation between magnetism and nontrivial topological band structure serves as a unique venue for discovering exotic topological properties. Combining magnetotransport measurements and first-principles calculations, we unveil herein that the hexagonal EuCuP holds a topologically trivial state in the paramagnetic structure, while strong magnetization dependent anisotropic topological states in the spin-polarization structures. Specifically, it hosts a trivial topological state in the in-plane spin-polarization structure, while a Weyl semimetal state in the out-of-plane spin-polarization structure. Our scaling analysis suggests that the intrinsic Berry curvature in the spin-polarization structures can account for the observed large anisotropic anomalous Hall effect. First-principles calculations show that the magnetization and the spin-orbit coupling simultaneously play essential roles for the appearance of the four pairs of Weyl points in the out-of-plane spin-polarization structure. Our work therefore establishes in EuCuP the intimate relation between magnetism and the nontrivial topological states, which would be instructive for future study on this key issue of topological physics.
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MACROMOLECULES
·
2026
·Vol. 59
·期 17
·9719-9726
·
IF 5.7
Wang Zefan,Zeng Jiale,Cheng Lin,Yu Wei,Zhang Chunbo,Men Yongfeng
Compared to natural rubber (NR), petroleum-derived synthetic rubbers (SR) generally exhibit greater structural diversity and thermal stability. However, due to the lack of nonrubber components such as phospholipids and proteins, the mechanical properties of SR, such as strength and toughness, are far inferior to those of NR. It is reasonable to assume that the mechanical properties of rubbers are largely governed by chain networks. The coexistence of physical entanglements and chemical cross-links makes it difficult to distinguish their respective contributions. We elucidate the influence of physical entanglement using a series of model mixtures consisting of ultrahigh-molecular-weight (UHMW) uncross-linked rubber with its chemically identical unentangled oligomers. The concentration of physical entanglement can be quantitatively controlled and determined by rheological measurements. Uniaxial tensile results reveal that an intense entanglement network limits the maximum draw ratio of rubber, while slightly reducing the entanglement concentration could promote its elongation behavior. Due to the lack of stress transmitters, mixtures with a higher amount of oligomer fraction become brittle and soft. Combined with true stress–strain curve analysis, in situ synchrotron wide-angle X-ray scattering results provide conclusive evidence that the stretching-induced crystallization is delayed at higher strains with decreasing UHMW polymer content, and the onset critical strain ε c is inversely proportional to the entanglement concentration. Our observations are believed to provide new perspectives and understanding for designing rubbers with high-performance mechanical properties.
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Ning Li,Minzhi Dai,Qingduo Wang,Shuhua Ma,Ye Sun,Bingye Chen,Ruihuan Duan,Zijian Wang,Alex V. Trukhanov,Changjian Li,Zheng Liu,Xin Luo,Xiaoxu Zhao
Layered Indium phosphorus trichalcogenides (In 4/3 P 2 X 6 ) have received significant attention due to their ordered indium vacancies and stacking-dependent properties, enabling applications in electronics, catalysis, and energy storage. However, the vacancy-governed stacking polytypes and atomic structures in In 4/3 P 2 X 6 remain elusive. Moreover, the facile reconstruction of the indium vacancies upon external stimulus makes their direct visualization challenging. Here, a low-dose aberration-corrected scanning transmission electron microscopy (STEM), four-dimensional STEM (4D-STEM) techniques, and density functional theory (DFT) are employed to systematically explore the atomic structure of In 4/3 P 2 X 6 and the magnetic properties of doped In 4/3 P 2 X 6 . The indium vacancies with glide-reflection symmetric ordering in In 4/3 P 2 X 6 are resolved at the atomic scale, driving armchair-type interlayer gliding with an unconventional step in In 4/3 P 2 Se 6 and zigzag-type gliding in In 4/3 P 2 S 6 , yielding ABC and nearly-ABC stacking polytypes, respectively. DFT calculations reveal that both gliding modes are energetically favorable, with their distinctions arising from the ligand-modulated interlayer charge distributions. Besides, filling the indium vacancies with magnetic dopants induces tunable magnetic ordering in In 4/3 P 2 X 6 , and also drives a structural transition to an MPX 3 -like phase and a non-magnetic paramagnetic (PM)−FM transition. This study sheds light on vacancy-governed structure in In 4/3 P 2 X 6 and highlights it as an excellent matrix for designing novel functional 2D magnets via doping engineering.
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Zhiguo Li,Qiang Li,Jinpeng Cao,Xiaoge Wang,Xiang Xu,Jochi Tseng,Peixi Zhang,Jinxia Deng,Kun Lin,Tianyou Zhai,Xianran Xing
2D Janus structures break the mirror symmetry, thereby leading to the emergence of novel properties. Anion-ordered Janus structures hold potential for developing large spontaneous polarization ferroelectrics. However, van der Waals disordered alloys are generally more thermodynamically stable; anion-ordered Janus structures can only be realized in certain monolayer transition metal dichalcogenides so far. The polarization in these materials cannot be reversed; therefore, the realization of anion order triggered ferroelectricity remains a challenge. Here, we report that S/Se ordering induces Janus ferroelectricity in SnS 0.6 Se 0.4 nanobelts with a high Curie temperature of approximately 600 K. The second-harmonic generation of SnS 0.6 Se 0.4 nanobelts is approximately 300 times more intense than that of SnS nanobelts. The switchable spontaneous polarization of SnS 0.6 Se 0.4 nanobelts was confirmed by piezoelectric force microscopy, representing the first realization of anion-ordered Janus ferroelectricity. This anion ordering induces a structural phase transition from the non-ferroelectric Pnma to the ferroelectric phase Pm. Our work has realized a periodically anion-ordered Janus structure with ferroelectricity in van der Waals materials and provided a candidate material for novel non-volatile memory devices and optoelectronic applications.
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MOLECULES
·
2026
·Vol. 31
·期 7
·1092
·
IF 5.1
Jiaxing Zhang,Wen Wang,Zubiyan Yibula,Xin Peng,Rongxin Su,Wei Qi
Natural anthraquinones possess a wide range of biological activities, including antibacterial, antiviral, antitumor, and antioxidant effects. However, studies on their ability to inhibit amyloid protein aggregation remain relatively limited. In this study, we used insulin as a model protein to investigate the anti-amyloidogenic potential of several natural anthraquinones. Specifically, the inhibitory mechanisms of five anthraquinones (emodin, anthraflavin, aloe-emodin, alizarin, and purpurin) on insulin amyloid fibrillation were explored in both dilute and crowded environments (PEG 2000 and PEG 4000). Multidisciplinary analytical results demonstrated that all five anthraquinones could effectively inhibit insulin amyloid fibrillation in both dilute and crowded environments. Simultaneously, crowded agents themselves also exhibited inhibitory effects on insulin amyloid aggregation. However, the inhibitory efficacy of anthraquinones was weaker in crowded environments than in dilute solutions, indicating that although crowded agents themselves suppressed insulin aggregation, they may interfere with the regulatory roles of anthraquinones on insulin aggregation behavior. Interestingly, purpurin showed stronger inhibitory activity in crowded environments compared to dilute solutions. Furthermore, fluorescence spectral analysis suggested that the quenching mechanism of insulin by all these anthraquinones was identified as static quenching mode. Molecular simulation studies revealed that anthraquinones could bind to the aggregation-prone regions of insulin via hydrogen bonding and hydrophobic interactions, thereby inhibiting insulin amyloid aggregation. Notably, the inhibitory capacity of these compounds was correlated with their structural features and the binding affinities to insulin. Collectively, this study explored the anti-amyloid activity of anthraquinones, which held significant research value for the development of potential therapeutic agents for amyloid-associated proteinopathies.
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ENVIRONMENTAL POLLUTION
·
2026
·
IF 7.2
Xianlang Liu,Han Xiao,Zhipeng Liao,Xuyang Zhang,Weixin Zhang,Qiang Luo,Guiyou Tian
Dicofol (DCF), a widely used organochlorine pesticide, is classified as a persistent organic pollutant (POP). However, its toxicological profile and the underlying mechanisms of action in vertebrates remain poorly understood. In this study, exposure of zebrafish ( Danio rerio ) to sublethal concentrations of DCF led to notable behavioral abnormalities in both larvae and adults, effects that were accompanied by increased apoptosis in brain tissues. Additionally, molecular docking analysis identified the α3-subunit containing Na + /K + -ATPase (ATP1A3A) as a potential target of DCF; this finding was corroborated by significant inhibition of Na + /K + -ATPase activity observed in brain tissue samples upon DCF treatment. Further investigation demonstrated elevated intracerebral calcium levels, enhanced oxidative stress, downregulation of chaperones involved in protein folding, increased protein ubiquitylation, and accumulation of phosphorylated microtubule-associated tau protein in the brains of DCF-treated adults. Transcriptomic profiling corroborated these findings, revealing activation of apoptotic pathways, dysregulation of calcium homeostasis, impairment of ROS clearance, and aberrant expression of genes related to neuronal function. In summary, our findings demonstrate that DCF exposure induces toxicity in zebrafish by disrupting multiple signaling cascades, culminating in neuronal apoptosis and neurotoxicity. These findings underscore the potential ecological risks and human health implications associated with DCF exposure. Environmental implication Exposure to the persistent organic pollutant dicofol (DCF) induces neurotoxicity in zebrafish by disrupting multiple signaling cascades. Such disruption triggers calcium dysregulation, oxidative stress, protein misfolding, phosphorylated tau protein accumulation, and neuronal apoptosis, which are hallmarks of neurodegeneration. Given the evolutionary conservation of these toxicity mechanisms across vertebrates, DCF may pose potential ecological risks to other aquatic species, suggesting that DCF contamination in water sources could represent an unrecognized environmental risk factor for human neurological health. These findings warrant regulatory attention to this legacy pesticide.
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JOURNAL OF LUMINESCENCE
·
2026
·
IF 3.8
Yuanjian Huang,Heng Yu,Zhanghai Tian,Ruirui Cui,Zijiang Luo,Xiang Guo
To construct high-performance green fluorescent media suitable for non-contact optical temperature measurement and information anti-counterfeiting, excellent fluorescence thermal stability phosphors are required. In this paper, CaLa 1- x GaO 4 : x Er 3+ phosphors were synthesized using a high-temperature solid-state method. When excited at 378 nm, the optimized CaLaGaO 4 :2%Er 3+ sample yielded efficient downshifting luminescence, with prominent green bands centered at 523 and 552 nm originating from the 2 H 11/2 → 4 I 15/2 and 4 S 3/2 → 4 I 15/2 transitions, respectively. Weak red emission near 669 nm, attributed to the 4 F 9/2 → 4 I 15/2 transition, was also observed. Leveraging fluorescence intensity ratio methodology based on thermally coupled energy levels ( 2 H 11/2 and 4 S 3/2 ) for non-contact optical temperature measurements, the system yielded a maximal relative sensitivity of 1.97% K −1 at 298 K, while the absolute sensitivity reached 0.89% K −1 at 473 K, highlighting its superior thermal sensing properties. Moreover, the refined luminescent powders were blended with polyvinyl alcohol (PVA) to formulate a security printing medium. This ink remains colorless under ambient illumination; however, upon exposure to 365 nm ultraviolet radiation, it distinctly exposes concealed alphanumeric characters and designs. Consequently, this system exhibits significant applicability within the domain of optical information encryption and forgery prevention. The synergistic combination of efficient downshifting luminescence and high temperature measurement sensitivity establishes the potential of synthesized CaLaGaO 4 :Er 3+ phosphors as a multifunctional platform for luminescence sensing.
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Journal of Physical Chemistry Letters
·
2026
·
IF 4.5
Ziyu Liu,Xin Wen,Chenqi Yi,Zongsong Gan
Crystallization of covalent organic frameworks (COFs) is fundamentally limited by the high activation energies and slow bond-exchange dynamics of imine linkages, rendering solvothermal synthesis intrinsically sluggish (hours to days) and difficult to control. Here, we report a nonequilibrium crystallization strategy in which a 473 nm continuous-wave laser creates a confined photothermal microreactor at the solid–liquid interface. Gaussian focusing generates microsecond local hotspots and steep temperature gradients, producing instantaneous supersaturation in the focal region and driving dynamic covalent exchange into an ultrafast, far-from-equilibrium regime. As a result, COF-300 nucleates and grows in situ within seconds, without catalysts and with submicrometer spatial confinement. Laser power and exposure provide real-time, deterministic control over nucleation and crystal growth, enabling the on-demand, in situ integration of COF microcrystals. Moreover, the highly localized photothermal pathway allows direct laser writing of ordered COF microstructures without transfer or postprocessing. This work establishes an accessible nonequilibrium synthesis route for dynamic covalent materials and offers a generalizable strategy for rapid, programmable crystallization toward integrated photonic architectures.
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Journal of the American Chemical Society
·
2025
·
IF 15.6
Jiawei Guo,Qiaoyu Zhang,Yang Shen,Fangyuan Cheng,Moli Sang,Xuan Wang,Yunjun Pan,Mingyu Liu,Hao-Bing Yu,Bo Hu,Sheng Wang,Liangzhen Zheng,Ce Geng,Chaofan Yang,Lianzhong Luo,Gang Zhang,Lei Du,Yuanning Li,Wei Zhang,Yandong Zhang,Binju Wang,Shengying Li,Xingwang Zhang
Thiolactomycin (1), which features a unique γ-thiolactone ring, is a promising antibiotic candidate that specifically targets bacterial type II fatty acid synthase. Despite extensive studies on its pharmacological activities, modes of action, and chemical synthesis, the enzymatic processes responsible for forming the activity-determining γ-thiolactone ring have remained largely unknown. Here, we resolve this problem by revealing that the condensation and heterocyclization (Cy) domain of the nonribosomal peptide synthetase (NRPS) TlnC (TlnCCy), along with the cytochrome P450 enzyme TlnA, cooperatively enable the γ-thiolactone assembly. TlnCCy mediates an unusual sulfurtransfer reaction to sulfurate the polyketide intermediate, generating a thiocarboxylate intermediate. Subsequently, TlnA acts as a γ-thiolactone synthase, converting the linear thiocarboxylate intermediate into 1 via a distal radical-based cyclization mechanism. These findings not only expand the functional and catalytic repertoires of NRPS Cy domains and P450 enzymes but also highlight a special enzymatic strategy for γ-thiolactone biosynthesis in nature.
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WASTE MANAGEMENT
·
2025
·
IF 7.1
Fangfang Lou,Jun Wang,Jingyuan Sima,Jiahui Lei,Chenxi Zhu,Qunxing Huang
Domestic landfills function as both significant sinks and sources of microplastics (MPs). Inadequate management and re-excavation of landfill mineralized refuse can lead to the release of these emerging contaminants into the surrounding environment, resulting in secondary pollution. Therefore, systematic risk assessments of MPs in landfills are crucial for understanding their environmental impact and informing mitigation strategies. This research investigated three landfills in economically diverse regions of Southeast China, including two sanitary landfills and one informal dump site. A uniform sampling and analytical approach, including solvent extraction and pyrolysis–gas chromatography-mass spectrometry (Py-GC/MS), was applied to quantify mixed MPs of polyethylene (PE), polypropylene (PP), and polystyrene (PS) across 68 mineralized refuse samples. The average MPs concentrations in the three landfills ranged from 0.44 to 1.56 g/ (kg mineralized refuse by mass), and 0.105 to 0.397 g/ (m 3 mineralized refuse by volume). Sanitary landfills contained higher MPs levels due to prolonged degradation under harsh landfill conditions. However, despite its older landfill age, the dump site exhibited lower MPs concentrations but a higher diffusion threat due to the lack of effective preventive measures. This research demonstrated that MPs contamination risk was also driven by landfill age and regional economic status. These findings provide a quantitative basis for assessing MPs pollution in landfills and emphasize the need for targeted strategies to mitigate MPs release into the environment.
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