Drug Delivery and Translational Research
·
2020
·Vol. 11
·期 5
·1969-1982
·
IF 2.664
Zhao Haijun,Chen Mengyuan,Zhao Zhujiang,Zhu Linjia,Yuan Shaofei
Balancing the antitumor activity and systemic toxicity of tripterine still faces a big challenge due to the narrow therapeutic window. To address this issue, we report a microemulsion system based on tripterine, brucea oil, and glycyrrhizin, and dual modified with both transferrin and cell-penetrating peptide SA-R 6 H 4 (Tf/SA-R 6 H 4 -TBG-MEs) for combinational and tumor-targeted cancer therapy. Such a microemulsion exhibited a spherical shape with a size of ~50 nm and a mildly-negative charge. The half-maximal inhibitory concentration (IC 50 ) of Tf/SA-R 6 H 4 -TBG-MEs against ovarian cancer SKOV3 cells was 0.27 ± 0.43 μg tripterine/mL, which was 5.85 times lower than that of free tripterine. The cellular uptake of tripterine after treatment with Tf/SA-R 6 H 4 -TBG-MEs was 1.56 times higher than that of TBG-MEs (non-modified microemulsion). In pharmacokinetics studies, the area under the curve of Tf/SA-R 6 H 4 -TBG-MEs increased by 1.97 times compared with that of the physical mixture group. The tumoral accumulation of tripterine was significantly improved in Tf/SA-R 6 H 4 -TBG-MEs group than TBG-MEs-treated group. In antitumor efficacy in vivo, Tf/SA-R 6 H 4 -TBG-MEs exhibited the strongest inhibition of tumor growth and the longest survival period among all the groups, which is associated with the rational combination, microemulsion system, and dual modification with tumor-targeted ligands. Importantly, Tf/SA-R 6 H 4 -TBG-MEs significantly reduced the toxicity of tripterine against the liver and kidney. Our design provides a new approach for efficient and safe ovarian cancer therapy based on a multicomponent combination.
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高影响因子
Nano Convergence
·
2020
·Vol. 7
·期 1
·1-7
·
IF 2.919
Deng Yu-Hao,Yang Zhen-Qian,Ma Ren-Min
Modern electronic and photonic devices rely on single-crystalline thin film semiconductors for high performance and reproducibility. The emerging halide perovskites have extraordinary electronic and photonic properties and can be synthesized via low cost solution-based methods. They have been used in a variety of devices with performance approaching or over the devices based on conventional materials. However, their solution based growth method is intrinsically challenge to grow large scale single-crystalline thin film due to the random nucleation and isotropous growth of the crystal. Here, we report the growth of centimeter-scale perovskite single-crystalline thin films by controlling the nucleation density and growth rate of the crystal under a spatially confined growth condition. The hydrophobic treatment on substrates inhibits nucleation and accelerates the growth of single-crystalline thin film, providing enough space for initial nucleus growing up quickly without touching each other. Single-crystalline perovskite thin-film with an aspect ratio of 1000 (1 cm in side length, 10 μm in thickness) has been successfully grown. The low trap density and the high mobility of the as-grown thin film show a high crystallinity. The photodetector based on the perovskite thin film has achieved a gain ~ 10 4 , benefitting from the short transit time of the carries due to the high mobility and thin thickness of the active layer. Our work opens up a new route to grow large scale perovskite single-crystalline thin films, providing a platform to develop high- performance devices.
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高影响因子
IONICS
·
2020
·Vol. 26
·期 11
·5481-5489
·
IF 2.394
Wang Jing,Li Yufan,Deng Xianmei,Yan Lei,Shi Zhiqiang
In this work, polyacrylonitrile/sulfonated poly(ether ether ketone) (PAN/SPEEK) composite fiber membrane as separator for lithium-sulfur battery was first prepared by electrospinning. In order to reduce the shuttle effect, multilayered polyelectrolyte complexes (CS/CNTs) n as surface modification agents were prepared by alternating deposition of oppositely charged hydroxylated multi-walled carbon nanotubes (MWCNTs-COOH) and chitosan (CS) via the layer-by-layer method. The as-prepared fiber multilayered complex separator (FMCS) was finally treated by heating at 120 °C to form cross-linked network for better thermal stability. FMCS possessed much higher porosity than that of the commercial PP separator (44%). As expected, the assembled membranes remained intact even at 150 °C, while PP separator shrunk severely. Compared with PP, PAN/SPEEK/(CS/MWNTs-COOH) 10 showed the discharge capacity of 956.9 mAh/g at 0.1 C and maintained 463 mAh/g after 100 cycles with the capacity retention rate of 48.4% which is higher than that of the commercial PP separator. Thus, this work can provide a simple method for modifying separator for long-life lithium-sulfur battery.
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JOURNAL OF POLYMER RESEARCH
·
2020
·Vol. 27
·期 8
·1-11
·
IF 2.426
Fu Congcong,Ding Lan,Yin Jialin,Tian Shasha,Ma Lan,Zhang Qi,Qin Fei,Cao Lili,Deng Kuilin
In this investigation, we described a facile preparation of temperature/photo dual sensitive polymers (PGABs) by Ugi four-component polymerization (Ugi-4CP) at room temperature in “one-pot” method using glutaraldehyde, 4 -amido-azobenzene, t -butyl isocyanide and carboxyl-end-capped polyethylene glycols (S-PEG) as monomers. PGABs were found to be reversibly sensitive to the temperature in salt solution, and their lower critical solution temperatures (LCST) can be tuned to the range of 17.2–68.4 °C by changing the structure of PGABs, sort and concentration of salt. The configuration transition of PGABs between cis -form and trans -form was reversibly induced by the alternating radiation at 365 and 254 nm. The rate and conversion of isomerization showed a remarkable dependence on the chemical structure of PGAB. By the photosensitivity, the LCST of PGAB-800 is further regulated in 1.0 °C change because of the hydrophilicity difference of cis - trans -azobenzene moiety. Through the combination of the thermosensitivity and photosensitivity, the particles of PGABs with nano/μm dimension were successfully controlled by the light radiation and temperature change.
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Plasmonics
·
2020
·Vol. 15
·期 6
·2061-2069
·
IF 2.335
Xu Runxiang,Yan Luting,Zhu Yanyun,Yin Lan,Song Xiaodong
Triangular Ag nanoplates have been synthesized via the seed-mediated method, which has good morphology and can be reproduced stably. The wavelength of local surface plasmon resonance (LSPR) can be easily controlled in the range of 500–900 nm. When triangular Ag nanoplates were applied to surface-enhanced Raman scattering (SERS) based on suspension aggregates and solid aggregates, the detection limit of rhodamine 6G (R6G) were greatly increased to 3.125 × 10 −7 M and 10 −11 M, respectively, and there was an excellent linear relationship between the intensity of Raman peak and the concentration of R6G. In addition, when the excitation light was tuned to the LSPR wavelength, the surface plasmon resonance will be excited to the maximum extent, and the enhanced electromagnetic field will maximize the Raman scattering. Furthermore, some progress has been made in the optimization of SERS by compounding graphene hydrogels in solid aggregates and adding mercapto polyethylene glycol in suspension aggregates.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2020
·Vol. 28
·期 10
·2702-2709
·
IF 2.572
Yu Xianglin,Cheng Kai,Xiang Yu,Mei Hua,Wang Jiapei,Li Junbo
A superabsorbent resin (SAR) with good degradability was prepared with acrylic acid (AA), acrylamide (AM), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), organic montmorillonite (OMMT) and titanium dioxide (TiO 2 ) through inverse suspension polymerization, using potassium persulfate (KPS) as initiator and N,N-methylenebisacrylamide (MBA) as crosslinker. The structure and micrographs of the SAR were fully characterized with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD). Meanwhile, the effects of major factors such as initiator, crosslinker, OMMT and TiO 2 contents and the oil–water ratio on liquid absorbency were investigated, which reached 769.3 g/g in distilled water and 91.1 g/g in 0.9wt% NaCl solution, respectively. The equilibrium degradation performances were evaluated under the optimum conditions by the mass loss of the SAR in the soil and under the ultraviolet light, which reached 32.3wt% after 120 days and 83.9wt% after 40 h, respectively. The introduction of OMMT promoted the photodegradability obviously. The maximum photodgradation of PAA/TiO 2 SAR reached 74.3wt% after 60 h, which was lower than the PAA/OMMT/TiO 2 SAR. The degradable SAR has an encouraging potential for agricultural and forestry applications.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2020
·Vol. 104
·期 15
·6767-6777
·
IF 3.53
Yan Zhiyu,Wu Xiangli,Zhao Mengran,Zhang Jinxia
High temperature is a major threat to Pleurotus ostreatus cultivation. In this study, a potential mechanism by which P. ostreatus mycelia growth is inhibited under heat stress was explored. Lactate, as a microbial fermentation product, was found unexpectedly in the mycelia of P. ostreatus under heat stress, and the time-dependent accumulation and corresponding inhibitory effect of lactate on mycelial growth was further confirmed. The addition of a glycolysis inhibitor, 2 -deoxy- d -glucose (2DG), reduced the lactate content in mycelia and slightly restored mycelial growth under high-temperature conditions, which indicated the accumulation of lactate can be inhibited by glycolysis inhibition. Further data revealed mitochondrial dysfunction under high-temperature conditions, with evidence of decreased oxygen consumption and adenosine triphosphate (ATP) synthesis and increased reactive oxygen species (ROS). The removal of ROS with ascorbic acid decreased the lactate content, and mycelial growth recovered to a certain extent, indicating lactate accumulation could be affected by the mitochondrial ROS. Moreover, metabolic data showed that glycolysis and the tricarboxylic acid cycle were enhanced. This study reported the accumulation of lactate in P. ostreatus mycelia under heat stress and the inhibitory effect of lactate on the growth of mycelia, which might provide further insights into the stress response mechanism of edible fungi. Key Points • Lactate can accumulate in Pleurotus ostreatus mycelia under heat stress and inhibit its growth. • The accumulation of lactate may be due to the acceleration of glycolysis and the dysfunction of mitochondria of P. ostreatus mycelia under high-temperature stress. • The glycolysis and tricarboxylic acid cycle of P. ostreatus mycelia were accelerated under high-temperature stress.
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高影响因子
CELLULOSE
·
2020
·Vol. 27
·期 12
·7127-7138
·
IF 4.21
Liu Hanbin,Yang Xiaohan,Wang Jiaxi,Meng Qingjun,Qian Liwei,Wu Haiwei,Duan Chao,Li Zhijian,Zhou Hongwei
Abstract Separation of dyes and proteins from water remains a significant challenge. Common absorbents without recyclability might bring secondary pollutions, which may be avoided by developing stimuli-responsive smart absorbents. Here in this work, a CO 2 -responsive polymer poly(2-(dimethylamino) ethyl methacrylate) was grafted from cellulose fibers (Cell-g-PDEA). The chemical structure and surface morphology were confirmed with nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray powder diffraction and scanning electron microscope. The CO 2 -sensitivity was demonstrated by monitoring the pH, surface Zeta potential and dispersed appearance under stimulus of CO 2 . Furthermore, the modified cellulose fibers were packed into a syringe to construct a smart separation column that reversibly captured and released anionic dyes and proteins from water under gas stimulus. Comparing with traditional pH or temperature responsive materials, the CO 2 -responsive cellulose fibers take the advantages on energy-saving, good reversibility and moderate running conditions, thus might find applications in smart separations, clinical diagnose and therapies. Graphic abstract
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JOM
·
2020
·Vol. 72
·期 9
·3195-3203
·
IF 2.054
Xie Boyi,Yang Tianzu,Liu Weifeng,Zhang Duchao,Chen Lin
The treatment of spent lead paste is essential for the recycling of spent lead-acid batteries. In this study, we propose a facile route for the recovery of lead from spent lead paste by pre-desulfurization followed by low-temperature reduction smelting. The effects of two desulfurization methods, i.e., high-pressure and normal-pressure processes, on the desulfurization efficiency of spent lead paste were compared. The high-pressure process was found to be more effective than the normal-pressure process; 99.1% of sulfur was removed under the high pressure conditions with NaOH excess of 1.1 at 150°C for 30 min. Moreover, a part of PbO 2 reacted with PbO to form Pb 3 O 4 . Afterwards, the desulfurized residue, mainly consisting of Pb 3 O 4 and PbO 2 , was directly used in low-temperature reduction smelting, and the optimum smelting conditions were determined to be: starch/Pb-residue mass ratio = 1/6.3; Na 2 O/Pb-residue mass ratio = 1/15; B 2 O 3 /Pb-residue mass ratio = 1/7.5; smelting temperature 700°C; and smelting duration 90 min. The lead recovery under the optimum conditions was as high as 93%. Scanning electron microscope images of the smelting slag showed that the smelting slag mainly consisted of PbO x and Na 2 O.
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JOURNAL OF POLYMER RESEARCH
·
2020
·Vol. 27
·期 5
·1-11
·
IF 2.426
Pan Zheng,Lv Yukai,Chen Yulong,Qian Xin
Waterproofing layers play a pivotal role in tunnel engineering and building basements. Magnesium acrylate (CA-Mg 2 ) shot-membrane waterproofing materials- commonly used as a waterproof layer- is a type of hydrogel. Poly(vinyl alcohol) (PVA) solution subjected to freezing/thawing treatment has been added to a CA-Mg 2 monomer, resulting in the formation of a CA-Mg 2 /PVA interpenetrating polymer network (IPN) hydrogel which can produced by a redox initiation system. This new IPN hydrogel contains not only a CA-Mg 2 network formed with Mg 2+ coordination bonds, but also a PVA network created by hydrogen bonding between hydroxyl groups. In comparison to CA-Mg 2 hydrogels, the fracture stress of the CA-Mg 2 /PVA hydrogel increased from 0.45 MPa to 0.72 MPa, elongation from 602% to 854%, and the self-healing efficiency of the IPN hydrogel reached 99.9% over 3 h. A new shot-membrane waterproofing materials based on the CA-Mg 2 /PVA hydrogel was prepared and its fracture stress was 1.44 MPa, and self-healing efficiency 80%, at 3 h. In addition, damage to the hydrogel could be repaired repeatedly.
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高影响因子
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2020
·Vol. 51
·期 4
·1339-1343
·
IF 2.035
Ren Guoxing,Xiao Songwen,Liao Caibin,Xia Longgong,Liu Zhihong
The activity coefficient of CoO in SiO 2 -saturated MnO-SiO 2 slag was measured using metal-slag-gas equilibrium experiments under controlled oxygen potentials (10 −12 to 10 −10 atm) at 1623 K. The solubility of CoO in the slag increased with increasing oxygen potential and cobalt content in the alloy. The activity coefficient of cobalt oxide, γ CoO , referred to solid CoO, can be described as: γ CoO = 1.65 − 0.14 (wt pct CoO), where (wt pct CoO) represents the mass percent of CoO in the slag.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 27
·期 19
·24558-24567
·
IF 3.056
Du Jifu,Dong Zhen,Yang Xin,Zhao Long
Quaternary ammonium salt type cotton linter (QCL) was synthesized by radiation grafting of dimethylaminoethyl methacrylate (DMAEMA) onto cotton linter and subsequent quaternization. Batch and column adsorption experiments were used to evaluate the adsorption behaviors of the QCL for phosphate. The adsorption kinetics of QCL for phosphate were well obeyed pseudo-second-order mode. The adsorption isotherms were well fitted by Langmuir, Temkin, and Dubinin–Radushkevich model. Column experiments showed that the breakthrough curves were dependent on the inlet concentration and flow rate but independent on space velocity. Moreover the QCL can be effectively regenerated for further repeated use at least 10 cycles. And QCL exhibited good selective adsorption for phosphate. Such high adsorption and desorption efficiency of QCL made it employing for phosphate adsorption in practical application.
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高影响因子
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