MOLECULAR NEUROBIOLOGY
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2025
·
IF 4.3
Chen Xue,Zhou Xing-Yue,Lan Cai,Fu Hai-Jun,Li Zhi-Chao,Chen Meng-Yi,Wen Yong-Ping,Yu Lu,Qin Da-Lian,Wu An-Guo,Wu Jian-Ming,Zhou Xiao-Gang
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by pathological protein aggregation and oxidative stress, leading to progressive neurodegeneration. Enhancing autophagy, the primary intracellular pathway for clearing misfolded proteins, represents a promising therapeutic strategy. In this study, we identify Araloside A (ARA), a triterpenoid saponin derived from Aralia elata , as a potent autophagy inducer that alleviates AD- and PD-related pathology. In neuronal cell models, ARA promotes autophagosome formation, increases LC3-II and Beclin-1 levels, and decreases P62, indicating enhanced autophagic activity. Mechanistic investigations reveal that ARA directly binds to Raf, MEK, and ERK proteins and activates autophagy in a Raf/MEK/ERK-dependent manner. This activation facilitates the clearance of APP, total Tau, phosphorylated Tau, and α-synuclein, thereby reducing cytotoxicity. Furthermore, in transgenic Caenorhabditis elegans models of AD and PD, ARA treatment alleviates protein aggregation and behavioral deficits via ERK-dependent autophagy. Together, these findings identify ARA as a natural compound that enhances autophagic clearance of neurotoxic aggregates via Raf/MEK/ERK pathway activation, offering promising therapeutic insights for neurodegenerative proteinopathies.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiaoqing Li,Min Zuo,Ziwei Lan,Fengling Jiang,Dickon H. L. Ng,Jia Li
C/OVs-Ni-Cu-LDHs@MnO2 tubular micromotors with enzyme-like activity and abundant oxygen vacancies (OVs) were synthesized hydrothermally using kapok as a biotemplate. MnO2 acted as the micromotor’s “driving engine”, catalyzing the generation of H2O2 bubbles to provide driving force for the motor, enabling efficient motion (144.45 ± 3.97 μm/s in 5% H2O2). The micromotors also exhibited enzyme-like activity, oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) via reactive radicals. A sensor for the colorimetric detection of GLY (lowest detection limit 0.63 μM) was developed by utilizing the enzyme inhibition induced by Cu2+-glyphosate (N-(phosphonomethyl)glycine, GLY) chelation. Meanwhile, the micromotor catalyzes H2O2 and activates peroxymonosulfate (PMS), efficiently generating hydroxyl radicals (•OH), superoxide radicals (O2•–), and single-linear oxygen (1O2). Under the synergistic effect of self-driven propulsion and efficient catalysis, achieving 93.71% GLY degradation in 40 min. This study provides an intelligent strategy for developing dynamic sensors with dual functions of simultaneous detection and degradation of GLY.
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APPLIED ENERGY
·
2025
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IF 11
Xianda Sun,Baibin Ma,Jinxu Hao,Zirui Wu,Yi Li,Hao Liu,Yuandong Yang,Xiaohan Ren
The ammonia crossover that poisons the conventional cathode catalysts and damages the cell performance and efficiency is one of the paramount bottlenecks limiting the development of direct ammonia fuel cells (DAFCs). Synthetizing the ammonia tolerance catalysts has been proven to be an effective avenue to solve the above-mentioned problems, however, the mass and charge transports within the anti-ammonia poisoning electrodes has not been fully elucidated. Herein, an alkaline DAFC with anti-ammonia poisoning Fe-N-C cathode is reported, and the main effort is expended on investigating the impact of mass and charge transports on cell performance, internal resistance, and operating stability. The alkaline DAFC exhibits a thermodynamic efficiency as high as 88.6 %, higher than that of hydrogen-based fuel cells. The preliminary experimental results indicate that the performance of DAFC with anti-ammonia poisoning Fe-N-C cathode is higher than that of conventional Pt/C cathode under the same catalyst loading. The impressive open-circuit voltage of 0.74 V and peak power density of 107 mW cm −2 are obtained under atmospheric pressure and 80 °C, which is primarily ascribed to both the anti-ammonia poisoning of Fe-N-C catalyst and the facilitated mass and charge transports. Furthermore, the voltage curve of DAFC is quite stable during the constant-current discharging at 100 mA cm −2 for 10-h, demonstrating the good durability of DAFC with anti-ammonia poisoning Fe-N-C cathode.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Zhongyou Jiang,Shanshan Dong,Dingying He,Jiazheng Yang,Suqing Dai,Shuaitao Peng,Suhua Chen
Bonded nitrogen of lone pair electrons gives a chance for carbon-based substrates to complex with and consequently electrochemically analyze heavy metals, e.g., cadmium(II) (Cd(II)). However, the carbon atom bonded with nitrogen atom present positively charged and could electrostatically hinder Cd(II) adsorption, leading to a limited electroanalytical sensitivity. In this study, we adopted a sequential iron occupying and nitric acid etching strategy to elongate C–N bond in graphitic carbon nitride (CN), which could weaken the energy barrier for Cd(II) adsorption. Material characterizations show the iron occupying and nitric acid etching strategy successfully elongated C–N bond without damaging the skeletal structure of CN and significantly enhanced Cd(II) adsorption capacity. Experiments combined with first principle calculations verified the efficient and sensitive binding of Cd(II) with nitrogen in the elongated C–N. As a result, in comparison with pristine CN, the C–N elongated material (marked as EtCN–Fe 0.3 ) possessed a much higher sensitivity (22.34 vs. 16.92 μA ppb −1 cm −2 ) and a dramatically lower limit of detection (LOD) (0.29 vs. 2.22 ppb). The sensor demonstrates a broad linear range (1−500 ppb), exceptional reproducibility (relative standard deviation = 1.4 %), and long-term stability (only 1.1 % of sensitivity loss over 10 days). EtCN–Fe 0.3 electrode even showed high recovery rates (98.2−102.4 %) in various real waters, which were in agreement with Inductively coupled plasma-mass spectrometry (ICP-MS)/Atomic absorption spectrophotometry (AAS) methods. This study provides a facile strategy to activate carbon materials to electrochemically detect trace heavy metals with precision and cost-effectiveness.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Xiao Dai,Xianhong Zhu,Shiyu Li,Ze Wu,Chenyang Zhao,Xun Gao,Longshan Zhao
Some illegal businesses often add antibiotics such as sulfonamides to expand the functional range of lipstick. However, the abuse of antibiotics will lead to serious adverse reactions and increase the drug resistance of bacteria. To ensure the safety of lipstick, it is necessary to monitor the antibiotic content, which urgently needs to develop an efficient and highly sensitive analytical method. In this study, a magnetic solid-phase extraction (MSPE) method was developed using a composite adsorbent based on carboxylated multi-walled carbon nanotubes (c-MMWCNT) and carbon dots (CDs) for sample pretreatment. A magnetic dispersive solid-phase extraction coupled with high-performance liquid chromatography method was established using silanized serine‑modified carbon dots (Sil-Ser-OCDs) as the sorbent for the determination of sulfapyridine (SPY) and sulfamethazine (SMT). Key extraction parameters including adsorbent dosage, extraction time, and pH were optimized using response surface methodology. The optimal extraction conditions were determined to be an adsorbent dosage of 72 mg, extraction time of 4.5 min, and pH 6.0. Under the optimal conditions, the recoveries of SPY and SMT were in the range of 88.0%-93.4%, and the RSD values of intra-day and inter-day precision were under 4.2% and 5.4%, respectively, indicating that the approach has excellent accuracy and precision.
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RARE METALS
·
2025
·
IF 11
Luo Qi-Zhi,Huang Jin-Shu,Liu Teng-Yu,Yuan Ji-Li,Belousov Artem S.,Li Sheng-Kun,Yang Song,Li Hu
Photocatalytic selective synthesis of lactic acid (LA) from biomass sugars with a single heterogeneous catalyst is promising but challenging due to the multiple reaction steps involved. Herein, a K-doped C-rich red polymerized carbon nitride (RPCN) photocatalyst with uniform K/C dual sites was constructed by a molten salt template method, which was highly efficient for cascade isomerization dehydration of glucose to LA with > 90% selectivity under visible light and gentle conditions. Control experiments and theoretical calculations expounded that the introduced K/C dual sites could improve the light capture ability and photogenerated charge separation efficiency, while the K species provided sufficient Lewis acid sites (adsorption sites) for the isomerization of glucose to fructose. Meanwhile, the introduced C sites that substitute N atoms could promote electrons to be captured by adsorbed oxygen for selective generation of superoxide radicals, which was highly efficient for the scission of the C3–C4 bond in fructose, exclusively furnishing LA. Importantly, the RPCN photocatalyst was also suitable for the photocatalytic upgrading of various biomass saccharides into LA with high yields of 81.3%–95.3% and could be recycled for five consecutive cycles. The tailored construction of dual sites by localization of space charge lightens an avenue for multi-step conversion of biomass with pronounced selectivity. Graphical abstract
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ku-Ku Hao,Qi-Jin Wang,Sheng-Xiang Wei,Hua-Yang Si,Jing-Wen Hao,Nai-Fu Chen,Nai-Dong Chen,Xiao-Yan Gao,Si-Jie Liao,Shao-Jun Zheng,Man-Man Zhang
A neutral polysaccharide (NDHP-2-1) was isolated from Dendrobium huoshanense C. Z. Tang et S. J. Cheng ( D. huoshanense ). Structure characterization revealed that the weight-average molecular weight of NDHP-2-1 was 20.42 kDa, mainly composed of glucose (95.46 %) and mannose (4.54 %). The backbone of NDHP-2-1 consisted of →6)-α-D-Glc p -(1→, →4)-α-D-Glc p -(1→, and →3,4)-α-D-Glc p -(1→. The T-α-D-Glc p was regarded as the branches attached to the O-4 position of →3,4)-α-D-Glc p -(1 → in the backbone. In vitro experiments indicated that NDHP-2-1 exhibited excellent anti-inflammatory activity. The RAW264.7 cell assay results showed that NDHP-2-1 effectively inhibited the release of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10) from LPS-stimulated macrophages. In general, the newly isolated polysaccharide of NDHP-2-1 exhibited significant anti-inflammatory and immunomodulatory properties, suggesting its potential as an effective natural therapeutic agent for managing inflammatory diseases.
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Molecular Catalysis
·
2024
·
IF 3.9
XiaoNing Gao,YanXiao Zhang,Wei Fu,Hong Zhou,Lu Feng
Conventional hydrolysis of total saponins for the extraction of diosgenin, an essential ingredient in the production of steroid hormones, has caused significant ecological pollution, making efficient and clean extraction methods necessary. Here, UiO-66-NH 2 with defect sites containing Zr-coordinated hydroxide and water groups was synthesized using concentrated HCl as a crystal modulator, which was further treated with trimethylsilyl trifluoromethanesulfonate (Me 3 SiOTf) to afford UiO-66-NH 2 OTf using the oxygen affinity of the Me 3 Si group. The strong Lewis acid UiO-66-NH 2 OTf was used to extract diosgenin from the total saponin, and the extraction temperature, extraction time and amount of addition were optimized using single-factor experiments and the response surface method. In addition, high-resolution mass spectrometry has been used to analyze the resulting compounds, thus suggesting an alcoholysis pathway and an alcoholysis mechanism for the total saponins.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Cai Haopeng,Chen Yangdie,Feng Chaochao,Lin Zhenqin
Aimed to address the poor impedance matching of pure tetra-needle ZnO (T-ZnO) as well as to optimise the structure of the wave-absorbing material, this research focused on constructing a bimetallic Zn/Co-ZIF-coated T-ZnO core–shell structure with T-ZnO as a self-sacrificial template. In this work, T-ZnO@Zn/Co-ZIF composites were synthesized by optimizing shell uniformity via modulating DMF/H 2 O solvent ratios (3:1 to 1:1 v/v) and reaction durations (6/24 h). By further pyrolysis, the formation of hollow structures of the derivatives was investigated and the electromagnetic wave absorption performance of the derived materials were evaluated. Optimal core–shell uniformity was achieved at DMF/H 2 O = 3:1 with 24 h reaction time (DH31-24). Pyrolysis at 800 °C (PDH31-24-800) produced hollow Co/C derivatives with complete ZnO volatilization. This material exhibited superior microwave absorption: minimum RL of − 16.40 dB at 14.00 GHz (3.00 mm thickness) and an effective bandwidth (RL ≤ − 10 dB) of 4.48 GHz (11.12–15.60 GHz).
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 6
·435
·
IF 21.8
Hong Na,Li Nian,Li Zhao,Zhang Shudong,Ali Sarmad,Song Yanping,Liu Cui,Kang Jun,Wang Shihao,Zhang Jin Zhong,Wang Zhenyang
Silicon-carbon composite anodes hold the promise to resolve the irreversible capacity fading of silicon in lithium-ion batteries but face persistent challenges dominated by unstable, physical interfacial contacts. Herein, a laser-directed covalent bonding strategy is developed to construct atomic-scale Si–N–C bridges between silicon suboxide (SiO x ) nanoparticles and a 3D nitrogen-doped graphene framework. Localized photothermal processing of polyimide-urea-SiO x precursors on carbon-coated copper foil enables in situ integration of chemically anchored SiO x within a conductive graphene network. The architecture achieves dual stabilization: (i) strong Si–N–C covalent bonds suppress interfacial cracking, while (ii) hierarchical porosity accommodates strain via elastic deformation. Critically, direct fabrication eliminates slurry-derived defects, ensuring structural integrity and minimized interfacial impedance. The optimized composite anode delivers 1826.4 mAh g -1 at 0.1 A g -1 and retains 91.3% capacity over 1000 cycles at a high current density of 2.0 A g -1 , demonstrating exceptional stability under high-rate operation. Mechanistically, density functional theory (DFT) reveals that Si–N–C bonding lowers lithium-ion (Li⁺) adsorption energy (–6.549 eV) and redistributes interfacial charge density, synergistically accelerating ion transport. This work provides atomic-scale insights into covalent interface design and establishes a scalable laser-processing strategy of composite anodes for durable high-energy-density batteries. Graphical
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Yan Zhang,Xiaowei Chen,Wei Li,Baoyi Wang,Qian Zhang,Zhuo Zhao,Yafei Wang,Ying Guan,Yongjun Zhang
The freezing of the dispersion medium causes a huge deterioration in mechanical performance, conductivity, and optical properties of gel materials, limiting their functionality in low-temperature environments such as outer space, deep sea, and polar areas. Here, a deep eutectic solvent is developed using 2-methyl-1,3-propanediol as a hydrogen bond donor and choline chloride as a hydrogen bond acceptor, achieving remarkably low freezing temperature of −107.7 °C, while also exhibiting transparency, stability, and ionic conductive capabilities across a broad temperature range. Utilizing this solvent as a dispersion medium, microphase-separated eutectogels are prepared via the copolymerization of acrylamide and acrylic acid. Retaining its stretchability, high toughness, and energy dissipation capability at −100 °C, the gel thereby serves as an exceptional materials for impact resistance, vibration damping, and temperature sensing. Finally, the development of 2-methyl-1,3-propanediol based solvent and gel materials is expected to offer a new solution for cryo-science and antifreeze applications.
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CHINESE JOURNAL OF CATALYSIS
·
2025
·
IF 17.7
Xu Lin,Danyang Li,Shiqing Huang,Panpan Sun,Yan Huang,Shitao Wang,Lirong Zheng,Dapeng Cao
The limited activity of atomically-dispersed M-N-C electrocatalysts severely restricts their applicability in the oxygen reduction reaction (ORR) for proton exchange membrane fuel cells (PEMFC). Herein, we design and synthesize Se-doped Fe-N-C hierarchical porous electrocatalyst (FeN 4 /SeC 2 ) by optimizing carbon structure and FeN 4 coordination environment. The FeN 4 /SeC 2 electrocatalyst exhibits outstanding ORR activity in 0.1 mol L –1 HClO 4 , and the resulting PEMFC presents a peak power density of 1.20 W cm –2 in H 2 -O 2 condition at a back pressure of 200 kPa, ranking in the top levels among most reported non-precious metal catalyst-based fuel cells. The lower O 2 transfer resistance of FeN 4 /SeC 2 -based membrane electrode assembly than FeN 4 -based one means faster O 2 transport in triple-phase boundary (TPB), and Density functional theory calculation further reveals that the synergistic catalysis between porous SeC 2 and FeN 4 -OH species can efficiently lower the energy barriers for the rate-determining step of the ORR. In short, the outstanding performance of FeN 4 /SeC 2 in PEMFC is ascribed to the Se-doping, which introduces more defects and larger mesoporosity and therefore facilitates ionomer infiltration and O 2 transfer and charge transfer in TPB. The effective strategy of enhancing mass and charge transfers in TPB is anticipated to be applicable in the construction of highly efficient ORR electrocatalysts.
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危险品化学品经营许可证（带存储）