IONICS
·
2023
·
IF 2.8
Li Wei,Zhao Yi,Zhang Chunyan,Kang Juanxue,Tang Qinyuan,Liu Yongfei,Yang Lin,Yuan Shutang
The production of hydrogen peroxide (H 2 O 2 ) by 2-electron oxygen reduction reaction (ORR) in acidic electrolytes is a promising alternative to the existing anthraquinone process. However, the development of cost-effective catalysts with high activity for H 2 O 2 electrosynthesis remains a great challenge. Here, we report a cobalt-nitrogen-carbon catalyst in which cobalt single atoms are supported on carbon black (Co-N-CB) for the electrosynthesis of H 2 O 2 in an acid medium. The prepared Co-N-CB shows high activity for O 2 reduction into H 2 O 2 with an average selectivity of 80.6% over a wide potential range of 0.1–0.7 V vs. RHE in 0.1 M HClO 4 electrolytes. We found that (i) the Co single atoms are the active sites of 2-electron ORR; (ii) a catalyst for efficient H 2 O 2 production by O 2 reduction should achieve a good balance between high ORR activity and H 2 O 2 selectivity. Using Co-N-CB as a cathodic catalyst, the electrochemical device could electrosynthesize H 2 O 2 directly from H 2 and O 2 with a high productivity of 291.0 mol kg cat −1 h −1 . Our work provides a flexible way to prepare affordable catalysts for efficient H 2 O 2 electrosynthesis.
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ANALYTICAL SCIENCES
·
2023
·
IF 1.6
Yang Yu Meng,Yan Yuan,Zhou Jia Ying,Huang Cheng Zhi,Zhen Shu Jun,Zhan Lei
Real-time monitoring of hypochlorous acid (HClO) in biological systems is of great significance for exploring and regulating its pathological functions because abnormal production of HClO is closely related with many diseases, such as atherosclerosis, rheumatoid arthritis, and cancer. Herein, we developed a reliable fluorescent Fe-doped carbon dots (Fe-CDs) for the sensitive and selective detection of biological HClO using ferrocenecarboxylic acid and m -phenylenediamine as precursors through a one-step solvothermal procedure. The Fe-CDs exhibited excellent a wide HClO detection range from 20 nmol/L to 1000 nmol/L with corresponding limits of detection at 7.8 nmol/L. The sensing mechanism is based on the chemical oxidation of the hydroxyl groups on the surface of Fe-CDs by HClO. In addition, Fe-CDs also displayed high photoluminescence yield, excitation-independence emission, as well as good biocompatibility, enabling the successful imaging of endogenous and exogenous HClO in HeLa cells. These results revealed that Fe-CDs holds great promise as a robust fluorescent probe for investigating HClO-mediated biological events. Graphical abstract
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Nanoscale Research Letters
·
2017
·Vol. 12
·期 1
·1-13
·
IF 2.833
Dong Xiaoting,Niu Yawei,Ding Yi,Wang Yuemin,Zhao Jialan,Leng Wei,Qin Linghao
Nano erythrocyte ghosts have recently been used as drug carriers of water-soluble APIs due to inherit biological characteristics of good compatibility, low toxicity, and small side-effect. In this study, we developed a novel drug delivery system based on nano erythrocyte ghosts (STS-Nano-RBCs) to transport Sodium Tanshinone IIA sulfonate (STS) for intravenous use in rat. STS-Nano-RBCs were prepared by hypotonic lysis and by extrusion methods, and its biological properties were investigated compared with STS injection. The results revealed that STS-Nano-RBCs have narrow particle size distribution, good drug loading efficiency, and good stability within 21 days. Compared with STS injection, STS-Nano-RBCs extended the drug release time in vitro and in vivo with better repairing effect on oxidative stress-impaired endothelial cells. These results suggest that the nano erythrocyte ghosts system could be used to deliver STS.
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CATALYSIS LETTERS
·
2022
·Vol. 153
·期 8
·2331-2340
·
IF 2.936
Qi Wei,Luo Kexin,Su Qing,Sun Xiaoman,Li Xiaodong,Liu Ziqian,Wu Qiaolin
Covalent organic frameworks (COFs) with precise designable structures are becoming popular semiconductor materials for photocatalytic applications. In this study, a hydrazone-linked COFs ( TFPT-ODH ) material was constructed from the reversible polycondensation of 2,4,6-tris(4-formylphenyl)-1,3,5-triazine with oxalohydrazide. Thanks to the bottom-up strategy, the as-prepared TFPT-ODH exhibited satisfactory crystallinity, high thermal and chemical stability. The benefit of the combined effects of narrow band gap and efficient separation of photogenerated carriers, the photofunctional TFPT-ODH further demonstrated outstanding photocatalytic activity, stability, and recyclability in the photocatalytic cyclization reactions of 2-isocyanodiaryl compounds with phenylhydrazine. The photocatalytic mechanism for the photocyclization approach to phenylphenanthridines was proposed based on experimental data and spectrum techniques. Our work also demonstrates application in developing COFs-based photocatalysts for the photocatalytic cyclization of bioactive PAHs derivatives. Graphical abstract
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CHROMATOGRAPHIA
·
2023
·Vol. 86
·期 5
·387-399
·
IF 1.7
Li Qianjin,Wang Tingting,Hou Yadan,Wang Dan,Xiong Shuqing,Wei Chenhong,Cao Qianyong,Wang Fenying
Boronate affinity materials have been widely studied in separation science, chemical sensing, drug delivery and nanomedicine due to their unique recognition mechanism towards cis -diol-containing biomolecules ( cis -diols). In this paper, a new phenylboronic acid (PBA)-functionalized silica particle was prepared by one-pot synthetic strategy based on a PBA-coupled silane reagent, which was synthesized using 1,3,5-benzenetricarboxaldehyde as a spacer arm to covalently link 3-aminophenylboronic acid and 3-aminopropyltriethoxysiliane. Such PBA-functionalized silica particles displayed wrinkle shape with large surface area of 192 m 2 g −1 , resulting in its high binding capacities of 480 µmol g −1 for catechol and 63 µmol g −1 for adenosine. Moreover, the PBA-functionalized silica particles could rapidly extract the cis -diols in 10 min with a high binding recovery of 83–92%, much higher than its control polymers (1 ~ 47%). In addition to the good extraction performances, the PBA-functionalized silica particles also exhibited fluorescence responses to the cis -diols using two different excitation lights at 300 nm and 470 nm, giving emission lights at 379 nm and 631 nm, respectively, whose fluorescence-responsive mechanism was preliminarily studied. In summary, the developed boronate affinity silica particles can be used not only for the solid-phase extraction of cis -diols, but also to report the recognition events through the fluorescence signals, providing an idea to develop multi-functional boronate affinity materials for simultaneous enrichment and detection of cis -diols in biological samples.
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CELLULOSE
·
2023
·Vol. 30
·期 12
·7939-7953
·
IF 5.7
Ren Hui,Mo Wenxuan,Li Bo
As a kind of chemical additives, surfactants are widely used in the processes of papermaking, which played roles of wetting, dispersing, emulsifying etc. to adjust and maintain the product performance. However, there are few reports about the effect of surfactants on fiber properties, especially during paper recycling. This work investigated the effects of three types of surfactants on the cellulosic fibers and paper properties during five-time recycling. Properties of recycled paper with five times were presented as the index of papermaking potential. The results showed that cetyl trimethyl ammonium bromide (CTAB), a cationic surfactant, had an obvious negative effect on paper properties. For continuous surfactant supplements, the burst, tearing, and tensile index decreased by 50.2%, 41.6%, and 43.6%, respectively. Sodium dodecyl benzene sulfonate (SDBS), an anionic surfactant, had a significant positive effect on fibers’ WRV and inhibited the fibers’ hornification to some extent. However, it had a negative effect on paper properties by affecting the bonding between the fibers. Triton X-100 (TX-100), a nonionic surfactant, improved paper properties according to the papermaking potential. For adding surfactant only once, the burst, tearing, and tensile index increased by 15.0%, 8.59%, and 7.2%, respectively. For these three types of surfactants, TX-100 was generally more beneficial for fiber and paper. This paper revealed the effects of surfactants on the fiber and paper properties and perfected the theory of surfactants applied for fiber and paper in papermaking.
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Journal of Analysis and Testing
·
2023
·
IF 4.7
Chai Shuiqin,Chi Yuting,Sun Wanlin,Pei Xinyu,Pei Shuchen,Sun Chengyu,Luo Kang,Yao Bo
Silicon quantum dots (SiQDs) with high water-soluble and favorable photostability were prepared by a one-step hydrothermal method. The average diameter of SiQDs was 2.02 nm characterized by transmission electron microscope. It was to be noted that the as-prepared SiQDs showed effective antibacterial activity, which was attributed to electrostatic interaction and the generation of reactive oxygen species. The minimum inhibitory concentration of SiQDs against Escherichia coli and Staphylococcus aureus was 0.45 mg/mL and 0.38 mg/mL, respectively. Besides, based on the static quenching effect-induced fluorescence quenching mechanism, the SiQDs exhibited high sensitivity and selectivity for detecting tetracyclines (TC). A good linear relationship was obtained between the fluorescence intensity of SiQDs and the concentration of tetracycline (TC) in the range of 0–0.08 μmol/L ( R 2 = 0.9993) with a detection limit of 0.0176 μmol/L. Furthermore, the TC content in the honey samples was determined using the SiQDs. All the results suggest that the as-prepared SiQDs can be a potential fluorescent probe for application in antibacterial and analysis.
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JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 9
·1-9
·
IF 2.8
Wang Linlin,Wang Zhipeng,Qu Minjie,Zhou Guangyuan
There has been a broad demand for materials with high thermal stability and low dielectric constant in the field of microelectronic devices and communication technology. In this paper, a novel fluorinated poly(aryl ether) (FPAE) was prepared by S N 2 nucleophilic polycondensation. FPAE was demonstrated to possess a favorable dielectric constant of 2.68 at 1 MHz and its dielectric relaxation behavior at various temperatures and frequencies was analyzed. The resin performed excellent thermal stability and heat resistance, with a 5% mass loss temperature of 514 °C and a glass transition temperature of 260 °C. FPAE exhibits high solubility in N, N-dimethyl-formamide, acetone, ethyl acetate and other solvents. Excellent solubility gives FPAE good film formation and processability. The tensile strength and tensile modulus of FPAE were 67.0 MPa and 2.1 GPa, displaying decent mechanical properties. Attributed to the characteristics of the fluorine atoms, FPAE demonstrated a certain hydrophobicity with a water contact angle of 97.9°, as well as satisfactory water absorption (0.17%) and a low surface energy of 21.71 J/mm 2 . These data indicate that FPAE is expected to be used as low-dielectric material in microelectronics and communication technology.
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ANALYTICAL SCIENCES
·
2023
·Vol. 39
·期 12
·1939-1946
·
IF 1.6
Xiang Jian Jun,Yuan Li Juan,Liao Qie Gen,Zhang Da Wen,Luo Lin Guang
Azo-linked covalent organic polymers (ACOPs) were synthesized by a simple azo reaction, with 2,2ʹ-bis(trifluoromethyl)benzidine and 1,3,5-trihydroxybenzene as the monomers. The preparation process was mild, green, and environmental-friendly, avoiding the use of high temperature, metal catalysis, and harmful organic reagent. The obtained ACOPs were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, powder X-ray diffraction, and Brunauer–Emmett–Teller. With the prepared ACOPs as adsorbent, a method of pipette tip solid-phase extraction–liquid chromatography–tandem mass spectrometry detection (PTSPE–LC–MS/MS) was proposed for the analysis of target sedatives in animal tissues. Furthermore, the parameters for the extraction of five sedatives, including the amount of adsorbent, pH value, ion strength, elution solvent and volume, were investigated. Under the optimized conditions, the linear dynamic range was found from 0.1 to 10.0 μg kg −1 , and the limits of detection were ranged from 0.02 to 0.1 μg kg −1 . The method was assessed by the analysis of target sedatives in animal tissues, and the recoveries for the spiked pork muscle and pork liver samples were 84–102% and 83–101%, respectively. The results show that the developed method of PTSPE–LC–MS/MS with ACOPs as adsorbent is efficient for the analysis of trace sedatives in animal tissues. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 31
·12724-12735
·
IF 4.5
Zhang Changhai,Wang Hairui,Zhang Tiandong,Zhang Yue,Zhang Yongquan,Tang Chao
Polymer dielectric materials are attracting wide focus in electronics, but their low energy density limits miniaturization and intelligent application. In recent years, the sandwich-structured has offered an ideal way to enhance the energy storage performance of polymer materials. In this work, the symmetrically sandwich composite dielectrics were prepared, containing an outer layer of poly (vinylidene fluoride-trifluoro ethylene chlorofluoride)@titanium dioxide (P (VDF-TrFE-CFE)@TiO 2 ) and an inner layer of poly (methyl methacrylate)@magnesium oxide (PMMA@MgO). The sandwich structure can combine the advantages of the excellent breakdown strength of PMMA and the superior polarization strength of P (VDF-TrFE-CFE). Moreover, TiO 2 with a high dielectric constant further improves the polarization strength, and the insulation performance enhances by MgO with a large band gap. The experimental results show that 0.5–1–0.5 sandwich composite dielectric has the most excellent breakdown strength of 633.8 kV/mm, and a discharge energy density of 17.16 J/cm 3 with an efficiency of 70.1%. This work offers experimental guidance for the development of outstanding energy storage performance of polymer dielectric capacitors.
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INVESTIGATIONAL NEW DRUGS
·
2023
·Vol. 41
·期 5
·664-676
·
IF 3.4
Pan Mingzhu,Liu Yali,Sang Tian,Xie Jiajun,Lin Huishu,Wei Jianpeng,Shao Shuai,Zheng Yanying,Zhang Juan
Liposomal doxorubicin exhibits stronger drug accumulation at the tumor site due to the Enhanced Permeability and Retention (EPR) effect. However, the prognosis for the patient is poor due to this drug’s lack of targeting and tumor metastasis during treatment. Vascular epidermal growth factor receptor (VEGFR2) plays an important role in angiogenesis and cancer metastasis. To enhance antitumor efficacy of PEGylated liposomal doxorubicin, we constructed a VEGFR2-targeted and doxorubicin-loaded immunoliposome (Lipo-DOX-C00) by conjugating a VEGFR2-specific, single chain antibody fragment to DSPE-PEG2000-MAL, and then we inserted the antibody-conjugated polymer into liposomal doxorubicin (Lipo-DOX). The immunoliposome was formed uniformly with high affinity for VEGFR2. In vitro, Lipo-DOX-C00 enhanced doxorubicin internalization into LLC and 4T1 cells compared with non-conjugated, liposomal doxorubicin. In vivo, Lipo-DOX-C00 delivered DOX to tumor tissues effectively, which exhibited an improved antitumor and anti-metastasis efficacy in both LLC subcutaneous tumor models and 4T1 tumor models. In addition, the combined therapy of a VEGFR2–MICA bispecific antibody (JZC01) and Lipo-DOX-C00 achieved enhanced inhibition of cancer growth and metastasis due to activation of the immune system. Our study provides a promising approach to clinical application of liposomal doxorubicin.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-13
·
IF 16.6
Li Huixin,Xu Yanpeng,Wang Yang,Cui Yihao,Lin Jiake,Zhou Yuemin,Tang Shuling,Zhang Ying,Hao Haibin,Nie Zihao,Wang Xiaoyu,Tang Ruikang
Material-based tactics have attracted extensive attention in driving the functional evolution of organisms. In aiming to design steerable bioartificial organisms to scavenge pathogenic waterborne viruses, we engineer Paramecium caudatum (Para), single-celled microorganisms, with a semiartificial and specific virus-scavenging organelle (VSO). Fe 3 O 4 magnetic nanoparticles modified with a virus-capture antibody (MNPs@Ab) are integrated into the vacuoles of Para during feeding to produce VSOs, which persist inside Para without impairing their swimming ability. Compared with natural Para, which has no capture specificity and shows inefficient inactivation, the VSO-engineered Para (E-Para) specifically gathers waterborne viruses and confines them inside the VSOs, where the captured viruses are completely deactivated because the peroxidase-like nano-Fe 3 O 4 produces virus-killing hydroxyl radicals (•OH) within acidic environment of VSO. After treatment, magnetized E-Para is readily recycled and reused, avoiding further contamination. Materials-based artificial organelles convert natural Para into a living virus scavenger, facilitating waterborne virus clearance without extra energy consumption.
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危险品化学品经营许可证（带存储）