Nano Research
·
2023
·Vol. 16
·期 7
·8961-8969
·
IF 9.9
Cheng Lu,Wu Fengxia,Tian Yu,Lv Xiali,Li Fenghua,Xu Guobao,Hsu Hsien-Yi,Zhang Yongjun,Niu Wenxin
Plasmonic catalysis is emerging as a dynamic field in heterogeneous catalysis and holds great promise for the efficient utilization of solar energy. Central to the development of plasmonic catalysis is the design of efficient plasmonic nanocatalysts. In this report, plasmonic gap nanostructures (PGNs) on the basis of Au@poly(o-phenylenediamine) (POPD)@Pd sandwich nanostructures are synthesized as plasmonic nanocatalysts by an in-situ reduction synthetic strategy, which allows for the precise engineering of the POPD gap size between plasmonic Au and catalytic Pd components. The introduction of conducting POPD nanogap in PGNs not only effectively enhances their light harvesting capability, but also provides an effective charge transfer channel for harnessing the photogenerated hot charge carriers. In this respect, distinct gap-dependent performances in plasmon-enhanced electrocatalysis of ethanol oxidation reactions (EOR) are demonstrated with the PGN nanocatalysts and over 2.5 folds of enhancement can be achieved. A volcano plot is derived to describe the relationship between the catalytic activities and gap size of the PGN nanocatalysts, which is well explained by the interplay of their light harvesting and charge transport capabilities. These results highlight the importance of gap engineering in PGNs for plasmonic catalysis and offer the promise of developing efficient plasmonic nanocatalysts for other heterogeneous catalytic reactions.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Li Zheng,Zhu Yabo,Zeng Haowen,Wang Chong,Xu Chen,Wang Qiang,Wang Huimin,Li Shiyou,Chen Jitang,Xiao Chen,Yang Xiangliang,Li Zifu
Nanomedicine has been developed for cancer therapy over several decades, while rapid clearance from blood circulation by reticuloendothelial system (RES) severely limits nanomedicine antitumour efficacy. We design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES. Stiff nanogels are injected preferentially to abrogate uptake capacity of macrophages and temporarily block RES, relying on inhibition of clathrin and prolonged liver retention. Afterwards, soft nanogels deliver doxorubicin (DOX) with excellent efficiency, reflected in high tumour accumulation, deep tumour penetration and outstanding antitumour efficacy. In this work, we combine the advantage of stiff nanogels in RES-blockade with the superiority of soft nanogels in drug delivery leads to the optimum tumour inhibition effect, which is defined as mechano-boosting antitumour strategy. Clinical implications of stiffness-dependent RES-blockade are also confirmed by promoting antitumour efficacy of commercialized nanomedicines, such as Doxil and Abraxane.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-20
·
IF 10.2
Huang Yufen,Kou Qinjie,Su Yanrong,Lu Lu,Li Xisheng,Jiang Haiye,Gui Rong,Huang Rong,Nie Xinmin,Li Jian
Strategies to overcome toxicity and drug resistance caused by chemotherapeutic drugs for targeted therapy against hepatocellular carcinoma (HCC) are urgently needed. Previous studies revealed that high oxidored-nitro domain-containing protein 1(NOR1) expression in HCC was associated with cisplatin (DDP) resistance. Herein, a novel dual-targeting nanocarrier system AR-NADR was generated for the treatment of DDP resistance in HCC. The core of the nanocarrier system is the metal–organic frameworks (MOF) modified with nuclear location sequence (NLS), which loading with DDP and NOR1 shRNA (R). The shell is an A54 peptide inserted into the erythrocyte membrane (AR). Our results show that AR-NADR efficiently internalized by tumor cells due to its specific binding to the A54 receptors that are abundantly expressed on the surface of HCC cells and NLS peptide-mediated nuclear entry. Additionally, DDP is more likely to be released due to the degradation of Ag-MOF in the acidic tumor microenvironment. Moreover, by acting as a vector for gene delivery, AR-NADR effectively inhibits tumor drug resistance by suppressing the expression of NOR1, which induces intracellular DDP accumulation and makes cells sensitive to DDP. Finally, the anti-HCC efficacy and mechanisms of AR-NADR were systematically elucidated by a HepG2/DDP cell model as well as a tumor model. Therefore, AR-NADR constitutes a key strategy to achieve excellent gene silencing and antitumor efficacy, which provides effective gene therapy and precise treatment strategies for cisplatin resistance in HCC. Graphical Abstract
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-9
·
IF 4.6
Zhang Lijun,Liu Chuhe,Yin Liufang,Huang Cheng,Fan Shengjie
Hepatic fibrosis is a late stage process of many chronic liver diseases. Blocking the fibrosis process will be beneficial to the treatment and recovery of the diseases. Mangiferin has many pharmacological activities. Recently, it has been reported that mangiferin may relieve tissue fibrosis, including renal, myocardial, pulmonary fibrosis via anti-inflammatory and anti-oxidative effects in animal models. Here, we investigate the effects of mangiferin on CCl4-induced liver fibrosis and the underlying mechanism in mice. Thirty-two male C57BL/6 mice were randomly divided into 4 groups (n = 8 in each group), injected with carbon tetrachloride (10% CCl4) for 8 weeks, and oral administrated with mangiferin (50 mg/kg or 100 mg/kg) from the fifth week. The serum levels of ALT, AST were analyzed to evaluate liver function. H&E, Masson’s trichrome and Sirius red staining were used to assess liver morphology and the degree of liver fibrosis. Quantitative RT-PCR and Western blot were used to assay the gene expression and protein levels. The results showed that mangiferin alleviated the serum levels of AST, ALT, ALP, TBA and TBIL, reduced liver lesions, prevented hepatic parenchymal necrosis, and ameliorated collagen accumulation in the liver of CCl4-treated mice. Meanwhile, mangiferin inhibited the expression of inflammatory genes IL-6 and IL-1β, fibrogenic genes α-SMA, TGF-β and MMP-2 and bile acid metabolism genes ABCB4, ABCB11, SULT2A1 in the liver of CCl4-treated mice. Furthermore, mangiferin reduced collagen accumulation and HSCs activation, inhibited the p-IκB and p-p65 protein levels. Our results suggest that mangiferin could alleviate liver fibrosis in CCl4-treated mice through inhibiting NF-κB signaling, and mango consuming may have beneficial effects to hepatic fibrosis.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 12
·5319-5333
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IF 4.5
Wang Yun,Tan Hongjie,Sang Lexian,Xie Yunying,Jia Fuchao,Zhou Tong,Yin Guangchao,Sun Fazhe,Wang Xiaomei
An optimized acetone gas sensor based on Ti 3 C 2 / α -Fe 2 O 3 (TF) composite materials was synthesized using microwave and etching methods. The structures, morphology and composition of the TF composites were characterized via XRD, XPS, SEM and TEM. The crystal of α -Fe 2 O 3 porous nanorods is hexagonal, and the α -Fe 2 O 3 nanoclusters formed from α -Fe 2 O 3 nanorods were adhered adequately on the lamellar Ti 3 C 2 MXene in the TF composite. The specific surface area and surface defects of the TF composites increased compared with pure α -Fe 2 O 3 nanocluster material, thus exposing a large number of gas adsorption sites. Furthermore, the excellent electrical conductivity and high free charges transfer ability of Ti 3 C 2 MXene provided more electrons for the gas-sensitive reaction and enhanced the transmission capacity of gas-sensitive reaction electrical signal, respectively. The Schottky barriers were formed at the interface of α -Fe 2 O 3 and Ti 3 C 2 MXene increasing the resistance of TF gas sensor in air, which is beneficial to the response of TF gas sensor. So, the gas-sensitive performance of TF gas sensor to acetone was greatly improved. The response of TF gas sensor to 100 ppm acetone was up to 23.38, which was nearly 2.3 times higher than pure α -Fe 2 O 3 gas sensor. The lower detection limit of TF gas sensor could be as low as 1 ppm. In addition, the TF gas sensor had excellent selectivity, long-term repeatability and stability for acetone.
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JOURNAL OF POLYMER RESEARCH
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2023
·Vol. 30
·期 3
·1-17
·
IF 2.8
Chen Dongming,Li Ziwei,Li Dacheng,Li Shanrong,Mo Jing,Zheng Zijian,Lu Shaorong
In this study, a new type of compatibilizer, benzamide-grafted polyethylene polyamine (PEPA) containing solvent chain (PDABA-g-PEPA-O) was prepared from PEPA, 3,5-diaminobenzoic acid (DABA) and Oleoyl chloride (OC) and used to modify sisal microcrystalline cellulose (MCC). The natural rubber (NR) was filled with the modified MCC to prepare composites. The compatibilization effect of the prepared compatibilizer on the NR/MCC/PEPA-g-PDABA-O composites was investigated and its compatibilization mechanism was analyzed by molecular dynamics simulation (MD). The results show that adding 3wt% (calculated by MCC mass) PDABA-g-PEPA-O can improve the interfacial interaction between NR and MCC. The highest tensile strength of the NR composites was 25.319 MPa when 2.5phr MCC and 3wt% of PDABA-g-PEPA-O were added and is improved by 13.07% compared with that of NR/2.5phr MCC composites. In addition, the MD results showed that the amide and amine groups in the molecular structure of PDABA-g-PEPA-O formed a strong hydrogen bond and a strong van der Waals interaction with the hydroxyl groups of cellulose and PDABA-g-PEPA-O exhibited good compatibility with NR, which achieved the purpose of compatibilization. Moreover, the properties of tensile, deformation and shear resistance of the composites were enhanced with the addition of PDABA-g-PEPA-O in molecular simulation. The MD results provided a basis for the molecular design and preparation of compatibilizers and understanding their compatibilization mechanism in the polymer composites at a molecular level.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 7
·1-13
·
IF 2.8
Hu Qi,Teng Yuancheng,Zhao Xiaofeng,Zhou Fei,Arslanov Temirlan,Dai Bo
Zn 1− x Ni x ZrTa 2 O 8 ( x = 0.02, 0.04, 0.06, 0.08, 0.10, 0.12) microwave dielectric ceramics were synthesized by traditional solid-state method. The effect of introducing Ni–O bonds to replace part of Zn–O bonds on the ceramic lattice and microwave dielectric properties was systematically studied. An appropriate amount of Ni 2+ substitution improves the microscopic morphology of crystal, including the grain size, number of pores, number of grain boundaries, and the grain uniformity, giving rise to an increase in the compactness of ceramics and, thereby enhancing the microwave dielectric properties. The Raman analysis prove that the introduction of Ni 2+ is beneficial to enhance the vibrational peak intensity of the oxygen octahedron and effectively improve the Q × f value. However, the introduction of excessive Ni 2+ will lead to the decrease of lattice oxygen and the increase of adsorbed oxygen, and the crystal will become relatively active and unstable, and the microwave performance will decrease. In addition, the substitution of Ni 2+ can also effectively control the resonance temperature coefficient, which is beneficial to improve the τ f value. As a result, Zn 0.94 Ni 0.06 ZrTa 2 O 8 exhibits excellent microwave dielectric properties: ε r = 32.15, Q × f = 15,7500 GHz, τ f = − 33.1 ppm/°C, presenting as a potential candidate for low-loss microwave dielectric materials.
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Chinese Journal of Integrative Medicine
·
2023
·
IF 2.9
Gu Jiao-jiao,Wei Ya-ru,Ma Ku,Wang Xiao-qi,Gao Huai-lin
Objective To investigate the effects of Tongxinluo (TXL) on thromboangiitis obliterans (TAO) and the underlying mechanisms. Methods Ninety male C57/BL6J mice were randomly divided into 6 groups according to a random number table: the sham group, TAO model group, Compound Danshen Tablet (CDT) group, and the high-, medium-, and low-dose TXL groups. All mice except the sham group were injected with sodium laurate (0.1 mL, 5 mg/mL) in the femoral artery to establish TAO mouse model. After modeling, mice in the sham and TAO model groups were intragastrically administered 0.5% (w/v) sodium carboxymethylcellulose, mice in the CDT group were intragastrically administered 0.52 g/kg CDT, and mice in the TXL-H, TXL-M, and TXL-L groups were intragastrically administered 1.5, 0.75, and 0.38 g/kg TXL, respectively. After 4 weeks of gavage, the recovery of blood flow in the lower limbs of mice was detected by Laser Doppler Imaging. The pathological changes and thrombosis of the femoral artery were observed by morphological examination. The expressions of tumor necrosis factor α (TNF-α) and inducible nitric oxide synthase (iNOS) in the femoral artery wall were detected by HE staining. Levels of thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-keto-PGF1α), endothelin-1 (ET-1), interleukin (IL)-1β and IL-6 were measured using enzyme-linked immunosorbent assay (ELISA). Levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) were detected by a fully automated biochemical analyzer. Results TXL promoted the restoration of blood flow in the lower limbs, reduced the area of thrombosis in the femoral artery, and alleviated the pathological changes in the femoral artery wall. Moreover, the levels of TXB2, ET-1, IL-6, IL-1β, TNF-α and iNOS were significantly lower in the TXL groups compared with the model group ( P <0.05 or P <0.01), while the level of 6-keto-PGF1α was significantly higher ( P <0.01). In addition, APTT, PT, and TT were significantly prolonged in TXL groups compared with the model group ( P <0.05 or P <0.01), and FIB levels were significantly decreased compared with the model group ( P <0.01). Conclusions TXL had a protective effect on TAO mice, and the mechanism may involve inhibition of thrombosis and inflammatory responses. TXL may be a potential drug for the treatment of TAO.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 4
·1-9
·
IF 5.7
Su Zhanying,Zhang Li,Yu Ying,Lin Bixia,Wang Yumin,Guo Manli,Cao Yujuan
An electrochemical strategy based on bimetallic nanozyme in collaboration with toehold-mediated DNA replacement effect is proposed for the sensitive determination of miRNA-21. The AuPt nanoparticles (AuPt NPs) are prepared as a catalytic beacon; it shows favorable peroxidase properties with a Michaelis contant ( K m ) of 0.072 mM for H 2 O 2 , which is capable of catalyzing H 2 O 2 to induce an intense redox reaction, and causing a measurable electrochemical signal. To further enhance the strength of the signal response, a novel toehold-mediated DNA replacement strategy is employed. DNA strands with specific sequences are modified on electrodes and AuPt NPs, respectively. In the presence of miRNA-21, a cyclic substitution effect is subsequently activated via a specific toehold sequence and leads to a large accumulation of AuPt NPs on the electrodes. Subsequently, a strong signal depending on the amount of miRNA-21 is obtained after adding a small amount of H 2 O 2 . The analytical range of this determination method is from 0.1 pM to 1.0 nM, and the LOD is 84.1 fM. The spike recoveries for serum samples are 95.0 to 102.4% and the RSD values are 3.7 to 5.8%. The results suggests a promising application of the established method in clinical testing and disease diagnosis. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 22
·63109-63120
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IF 5.8
Yu Le,Wang Zhuang,Wang De-Gao
Layered double hydroxide (LDH) nanomaterials are utilized extensively in numerous fields because of their distinctive structural properties. It is critical to understand the environmental behavior and toxicological effects of LDHs to address potential concerns caused by their release into the environment. In this work, the toxicological effects of two typical LDHs (Mg-Al-LDH and Zn-Al-LDH) on freshwater green algae ( Scenedesmus obliquus ) and the main affecting factors were examined. The Zn-Al-LDH exhibited a stronger growth inhibition toxicity than the Mg-Al-LDH in terms of median effect concentration. This toxicity difference was connected to the stability of particle dispersion in water and the metallic composition of LDHs. The contribution of the dissolved metal ions to the overall toxicity of the LDHs was lower than that of their particulate forms. Moreover, the joint toxic action of different dissolved metal ions in each LDH belonged to additive effects. The Mg-Al-LDH induced a stronger oxidative stress effect in algal cells than the Zn-Al-LDH, and mitochondrion was the main site of LDH-induced production of reactive oxygen species. Scanning electron microscope observation indicated that both LDHs caused severe damage to the algal cell surface. At environmentally relevant concentrations, the LDHs exhibited joint toxic actions with two co-occurring contaminants (oxytetracycline and nano-titanium dioxide) on S. obliquus in an additive manner mainly. These findings emphasize the impacts of the intrinsic nature of LDHs, the aqueous stability of LDHs, and other environmental contaminants on their ecotoxicological effects.
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IONICS
·
2023
·Vol. 29
·期 5
·1721-1729
·
IF 2.8
He Tao,Dai Junjie,Dong Yangtao,Zhu Fangshun,Wang Chao,Zhen Aigang,Cai Yurong
The increasing lithium-ion batteries (LIBs) market causes concerns about environmental issues and the mining of the earth’s metallic minerals. The harmless treatment of the spent LIBs and the effective recovery of scarce metal resources are gradually given high priority worldwide. In this article, p-toluenesulfonic acid-based deep eutectic solvents (DESs) are prepared to leach metal components from spent ternary LIBs. And the ternary LiNi 0.5 Co 0.2 Mn 0.3 O 2 material is regenerated through the co-precipitation method and high-temperature solid phase method. The results show that 97.96% of Li, 99.46% of Ni, 100% of Co, and 100% of Mn can be leached out again under the optimum conditions. The synthesized ternary material possesses an excellent reversible capacity (139.0 mAh·g −1 at 0.5 C) and an adequate long-cycle stability (123.6 mAh·g −1 after 100 cycles). This work provides an efficient and clean approach to recycling spent LIBs and has great potential application in the field of battery sustainability.
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Biomass Conversion and Biorefinery
·
2023
·
IF 4
Aryee Aaron Albert,Xiao Yue,Han Runping,Qu Lingbo
In this study, an adsorbent based on waste peanut husks was synthesized. To facilitate the easy removal and efficiency of these peanut husks, it was first endowed with magnetic properties via the coprecipitation method after which NH 2 -MIL-101 (Fe) was loaded onto the magnetized peanut husks. This magnetic biomass-MOF composite (MPN@NH 2 -MIL-101 (Fe)) was used for the removal of 2,4-dichlorophenoxyacetic acid (2,4-D) and tetracycline (TC) in single and binary systems. MPN@NH 2 -MIL-101 (Fe) was found to be a crystalline magnetic adsorbent with a mesoporous structure with a surface area of 70.5 m 2 g −1 , pH point of zero charge of about 4.05, and possesses oxygen and nitrogen atoms containing functional groups which promoted its interactions with the studied pollutants leading to their uptake. Owing to the nature of these contaminants, the interactions that occurred in these adsorption processes were found to be dominated by both chemisorption and physisorption mechanisms. The monolayer adsorption capacity of MPN@NH 2 -MIL-101 (Fe) towards 2,4-D and TC was found to be 79.2 ± 8.3 and 109 ± 3.76 mg g −1 according to the Langmuir model, respectively. In binary systems, MPN@NH 2 -MIL-101 (Fe) had a higher selectivity towards 2,4-D which could be due to its smaller size in comparison with TC signifying the role of intraparticle diffusion. These excellent features of MPN@NH 2 -MIL-101 (Fe) coupled with its stability in aqueous solution and ease associated with its removal may enhance its prospects as an alternative adsorbent for practical applications. Graphical abstract
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危险品化学品经营许可证（带存储）