ACS Nano
·
2024
·
IF 15.8
Kexin Lv,Mengmeng Hou,Yufang Kou,Hongyue Yu,Mengli Liu,Tiancong Zhao,Jiacheng Shen,Xirui Huang,Jie Zhang,Mohamed F. Mady,Ahmed A. Elzatahry,Xiaomin Li,Dongyuan Zhao
Thanks to their excellent photoelectric characteristics to generate cytotoxic reactive oxygen species (ROS) under the light-activation process, TiO2 nanomaterials have shown significant potential in photodynamic therapy (PDT) for solid tumors. Nevertheless, the limited penetration depth of TiO2-based photosensitizers and excitation sources (UV/visible light) for PDT remains a formidable challenge when confronted with complex tumor microenvironments (TMEs). Here, we present a H2O2-driven black TiO2 mesoporous nanomotor with near-infrared (NIR) light absorption capability and autonomous navigation ability, which effectively enhances solid tumor penetration in NIR light-triggered PDT. The nanomotor was rationally designed and fabricated based on the Janus mesoporous nanostructure, which consists of a NIR light-responsive black TiO2 nanosphere and an enzyme-modified periodic mesoporous organosilica (PMO) nanorod that wraps around the TiO2 nanosphere. The overexpressed H2O2 can drive the nanomotor in the TME under catalysis of catalase in the PMO domain. By precisely controlling the ratio of TiO2 and PMO compartments in the Janus nanostructure, TiO2&PMO nanomotors can achieve optimal self-propulsive directionality and velocity, enhancing cellular uptake and facilitating deep tumor penetration. Additionally, by the decomposition of endogenous H2O2 within solid tumors, these nanomotors can continuously supply oxygen to enable highly efficient ROS production under the NIR photocatalysis of black TiO2, leading to intensified PDT effects and effective tumor inhibition.
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高影响因子
RSC Advances
·
2024
·Vol. 14
·期 53
·39779
·
IF 3.9
Hongshuang Qin,Huaying Niu,Yanxiang Guo,Xiaoting Wang,Tao Liu,Chuanqi Zhao
Photodynamic therapy (PDT) has emerged as an effective way to deal with drug-resistant bacterial infections. Especially, blue light (BL) mediated PDT (BL-PDT) presents unique advantages in the treatments of skin infection due to the strong light absorption of superficial skin, weak penetration of BL and little damage to deep tissues. However, the photosensitizers used for BL-PDT are very limited, and the ongoing development of novel BL photosensitizers is indispensable. Porphyrins are good sources for developing efficient photosensitizers. Herein, for developing more effective BL photosensitizers, five porphyrin derivatives that can be excited by BL [5,10,15,20-tetraphenylporphyrin (TPP), 5,10,15,20-tetrakis(4-bromophenyl)porphyrin (TBPP), 5,10,15,20-tetrakis(4-chlorophenyl)porphyrin (TCPP), 5,10,15,20-tetrakis(4-fluorophenyl)porphyrin (TFPP), 5,10,15,20-tetrakis(4-iodophenyl)porphyrin (TIPP)] are subjected to the investigation of PDT against MRSA (methicillin resistant Staphylococcus aureus ). The results reveal that TBPP-mediated BL-PDT shows outstanding bactericidal effects. Mechanism studies show that TBPP + BL can induce reactive oxygen species (ROS) up-regulated in MRSA, rupture cell membrane, inhibit ATP (adenosine triphosphate) production and virulence factor expression. Furthermore, TBPP + BL effectively eliminates MRSA form biofilms, inhibits biofilm formation and disintegrates mature biofilms. More importantly, TBPP-PDT significantly accelerate mouse skin wound healing in a biofilm infection model. Our work offers new insights into the development of novel BL photosensitizers. Photodynamic therapy mediated by 5,10,15,20-tetrakis(4-bromophenyl)porphyrin (TBPP) effectively eliminates drug-resistant Staphylococcus aureus , inhibits biofilm formation and accelerates wound healing in a mouse model.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yuan Jing,Fandi Meng,Fuhui Wang,Li Liu
The slippery liquid-infused porous surfaces (SLIPS) have recently attracted significant interest in marine antifouling and corrosion protection. Nevertheless, the insufficient durability and corrosion resistance of SLIPS considerably affect their application potential. In this work, a preparation strategy for ultradurable slippery organic coating was proposed to combat biofouling and corrosion. Digital light processing (DLP) was first employed to fabricate organic protective coatings with gradient porous structures to improve the stability and durability of the SLIPS. The structure with a smaller pore size in the upper segment relative to the basal area was designed to concurrently enhance the lubricant’s storage and retention capabilities. The antifouling experiment demonstrated excellent antifouling performance, with a bacterial colonization of merely 2.08% after immersion in a Pseudomonas aeruginosa solution for 28 days. The antialgae assessment demonstrated that the surface antifouling efficacy of the gradient SLIPS coating was enhanced by 99.75% after a 10-day immersion period. The EIS results indicated that the SLIPS coating with a gradient porous structure exhibited remarkable corrosion resistance, as evidenced by a |Z|0.01 Hz value of 2.93 × 1010 Ω·cm2 after 60 days of immersion. The gradient porous structure effectively resolves the intrinsic dilemma between the storage and depletion of lubricant, which greatly improves the stability and durability of the SLIPS coating. The ultradurable slippery organic coating with facile preparation and controllable structure exhibits exceptional long-term antifouling and anticorrosion properties, thereby making it highly promising for potential application.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Linshuang Liu,Haipeng Song,Shiqi Zhao,Huan Zhang,Peng Chen,Jingjing Wu,Feifei Jia,Shaoxian Song
Based on the strong activation activity and affinity of Co and MoS 2 for peroxymonosulfate (PMS), respectively, in this study, a CoS 2 /MoS 2 @chitosan (CoS 2 /MoS 2 @CS) gel with favorable photo responsive behavior was synthetically synthesized for more potent degradation of tetracycline (TC). It was found that CoS 2 /MoS 2 @CS had excellent catalytic active for the degradation of TC under visible light irradiation. The presence of CoS 2 /MoS 2 interfacial structure improve the electron transfer ability of the MoS 2 interface, and the degradation rate of TC was increased from 0.0106 min −1 to 0.0463 min −1 , with a high degradation rate of 97.4 %. CoS 2 /MoS 2 can effectively degrade TC within 5 cycles, demonstrating superior cycling stability. In addition, the system degraded different organic pollutants (tetracycline (TC), tetracycline hydrochloride (TCH), crystal violet (CV), and methylene blue (MB)) with a degradation rate higher than 96 %, which supports the ability of the CoS 2 /MoS 2 @CS-PMS system to degrade various chemical contaminants. Quenching analysis indicates that SO 4 •− is the primary reactive chemical free radical for the degradation of TC in the CoS 2 /MoS 2 @CS-PMS system. It provides an approach of combining the synergistic action of Co (II) and photogenerated carriers for more efficient activation of PMS that some inspirations of heterojunction catalysts for AOP applications.
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JOURNAL OF MOLECULAR LIQUIDS
·
2025
·
IF 5.2
Jiahao Song,Hao Wu,Kaihu Zhang,Ruirui Liu,Yunfan Yang,Xinyue Zhang,Ahmed Elsherif,Ning Ma,Alaa S. Abd-El-Aziz
Ionic liquids (ILs) have been widely used as flexible sensors due to their tunable properties, low vapor pressure, and high electrical conductivity. ILs containing sulfonium cations have exhibited low melting points, high conductivity, and excellent stability comparable to imidazolium-based ILs, rendering them promising candidates for low-temperature sensing applications. Nevertheless, the unique properties of functionalized sulfonium-based ILs pose challenges for their synthesis using conventional methods, thereby limiting their widespread utilization. In this study, we propose an efficient approach for the preparation of functionalized sulfonium-based ILs and, for the first time, obtain ILs capable of ultraviolet (UV) light sensing at −10 °C. The synthesized ILs maintain their liquid state over a broad temperature range (−30 °C to 150 °C) and exhibit sensitive responses to UV light under complex environments, including low and high temperatures, as well as underwater, demonstrating great potential for their applications as flexible sensors.
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BIOMATERIALS
·
2019
·
IF 10.273
Hong Cheng,Jing-Hao Fan,Lin-Ping Zhao,Gui-Ling Fan,Rong-Rong Zheng,Xiao-Zhong Qiu,Xi-Yong Yu,Shi-Ying Li,Xian-Zheng Zhang
Targeted delivery of the drug to its therapeutically active site with low immunogenicity and system toxicity is critical for optimal tumor therapy. In this paper, exosomes as naturally-derived nano-sized membrane vesicles are engineered by chimeric peptide for plasma membrane and nucleus targeted photosensitizer delivery and synergistic photodynamic therapy (PDT). Importantly, a dual-stage light strategy is adopted for precise PDT by selectively and sequentially destroying the plasma membrane and nucleus of tumor cells. Briefly, plasma membrane-targeted PDT of chimeric peptide engineered exosomes (ChiP-Exo) could directly disrupt the membrane integrity and cause cell death to some extent. More interestingly, the photochemical internalization (PCI) and lysosomal escape triggered by the first-stage light significantly improve the cytosolic delivery of ChiP-Exo, which could enhance its nuclear delivery due to the presence of nuclear localization signals (NLS) peptide. Upon the second-stage light irradiation, the intranuclear ChiP-Exo would activate reactive oxygen species (ROS) in situ to disrupt nuclei for robust and synergistic PDT. Based on exosomes, this dual-stage light guided subcellular dual-targeted PDT strategy exhibits a greatly enhanced therapeutic effect on the inhibition of tumor growth with minimized system toxicity, which also provides a new insight for the development of individualized biomedicine for precise tumor therapy.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 31
·期 10
·2007188
·
IF 16.836
Hao Miao,Runqing Shen,Wenhai Zhang,Zaifu Lin,Hao Wang,Likun Yang,Xiang-Yang Liu,Naibo Lin
Silk fibroin (SF) has attracted great interest in bone tissue engineering due to its extraordinary characteristics in terms of mechanical properties, biocompatibility, and biodegradability. SF scaffolds are assembled by biocompatible polydopamine nanoparticles at mesoscopic scale, which endows the scaffolds with a near-infrared (NIR) light response for the treatment of bone tumors. The functionalized SF scaffold not only enhances the significant structure and performance of native SF scaffold for bone treatment and reconstruction, such as primary and mesoscopic structure, multi-level pores, and biodegradation, as well as biocompatibility but also have excellent photothermal effect leading a significant cytotoxicity to MG63 cancer cells after NIR laser irradiation. Moreover, the penetration of NIR light in tissue is improved using an optical fiber, which demonstrates the obtained scaffolds’ great potential in the application of photothermal therapy.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jinxing Yu,Peiyi Yan,Feng Chen,Shu Jin,Xiaoxiang Xu,Jun Qian
Semiconductor-based photocatalytic techniques provide a durable and environmentally benign route to disinfect microbes. However, their disinfection activities are often limited by inadequate use of photocarriers (e − and h + ), particularly for narrow bandgap semiconductors. Here, we directly grow narrow bandgap semiconductor MgIn 2 S 4 onto In 2 O 3 to fabricate MgIn 2 S 4 @In 2 O 3 hierarchical tubular heterostructures. Using the model microbes Escherichia coli bacteria, we demonstrate that MgIn 2 S 4 @In 2 O 3 can achieve an exceptionally high antimicrobial activity (7 log reduction in viable cells count for 30 min illumination) although MgIn 2 S 4 and In 2 O 3 alone are almost inactive. Owing to the intimate contact between MgIn 2 S 4 and In 2 O 3 , MgIn 2 S 4 @In 2 O 3 enables efficient photocarrier separation which supports continuous production of copious reactive species ( i.e. h + and O 2 − ) for disinfection. Numerical simulation indicates that photocarriers are spatially well-separated in MgIn 2 S 4 @In 2 O 3 due to the type-II heterojunction formed. These findings signify the possibility to achieve high antimicrobial activity from otherwise almost inactive semiconductors by properly constructing the heterogeneous interfaces.
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BIOMATERIALS
·
2019
·
IF 10.273
Zhang Yuan,Bailong Tao,Ye He,Caiyun Mu,Genhua Liu,Jixi Zhang,Qiang Liao,Peng Liu,Kaiyong Cai
Biofilm formation is a main challenge in treatment of bone-implant-associated infections, resulting in tolerance to immune system and antibiotics. However, smart non-surgical or non-invasive treatment methods of combating established biofilm on an implant have been less reported. Herein, a therapeutic system consisting of mesoporous polydopamine nanoparticles (MPDA) to combat biofilm is reported for the first time. We develop a synergistic photothermal/photodynamic therapy (PTT/PDT) strategy aiming for biofilms eradication on titanium (Ti) implant, which is integrated with MPDA loading with photosensitizer Indocyanine Green (ICG) by π-π stacking. Specifically, MPDA is functionalized with RGD peptide to endow the modified Ti sample (Ti-M/I/RGD) with good cytocompatibility. More importantly, Ti-M/I/RGD implant remarkably kills Staphylococcus aureus ( S. aureus ) biofilm with an efficiency of 95.4% in vivo upon near infrared (NIR). After biofilm eradication, implant still displays great performance regarding osteogenesis and osseointegration . Overall, this study provides a PTT/PDT strtategy for the development of antibacterial Ti implants for potential orthpediac application.
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CHEMOSPHERE
·
2024
·
IF 8.1
Yulu Jia,Chengyang Zhang,Hongcen Zheng,Guoyang Zhang,Shujuan Zhang
Indirect photodegradation is an important pathway for the reduction of steroid estrogens in sunlit surface waters. Nevertheless, the kinetics and mechanisms governing the interaction between coexisting carbonyl compounds and estrogens under visible light (Vis) remain unexplored. This study systematically investigates the Vis-induced photodegradation of 17 β -estradiol (E2) in the presence of five specific carbonyl compounds—biacetyl (BD), acetone, glyoxal, pyruvic acid, and benzoquinone . The results demonstrate that, among these compounds, only BD significantly enhanced the photodegradation of E2 under Vis irradiation (λ > 400 nm). The pseudo-first order photodegradation rate constants ( k 1 ) of E2 in the Vis/BD system were 0.025 min −1 and 0.076 min −1 in ultrapure water and river water, respectively. The enhancing effect of BD was found to be pH-dependent, increasing the pH from 3.0 to 11.0 resulted in a 76% reduction in the k 1 value of E2 in the Vis/BD system. Furthermore, the presence of humic acid , NO 3 − , or HCO 3 − led to an increase of more than 35% in the k 1 value of E2, while NO 2 − exerted a pronounced inhibitory effect, resulting in a 92% decrease. Peroxyacetyl and peroxymethyl radicals, derived from BD in a yield ratio of 9, played a crucial role in the degradation of E2. These peroxyl radicals primarily targeted electron-rich hydroxyl sites of E2, initiating hydroxylation and ring-opening reactions that culminated in the formation of acidic byproducts. Notably, toxicity evaluation indicates that these hydroxylated and acidic products exhibited lower toxicity than the parent compound E2. This study highlights the important role of peroxyl radicals in estrogen degradation within aquatic environment, and also helps to design efficient visible light-responsive photo-activators for the treatment of estrogen-contaminated waters.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Minglu Zhang,Qi Yuan,Yanyan Guo,Saijin Song,Dongyu Wang,Junli Zhang,Hao-Yang Mi,Jian Han,Chuntai Liu,Changyu Shen
Planar 1D photonic crystals (1DPhCs), owing to their photonic bandgaps (PBGs) formed by unique structural interference, are widely utilized in light protection applications. Multifunctional coatings that integrate various light management functions are highly desired. In this study, we present the fabrication of dual-PBG 1DPhCs with high reflectance in both the blue and near-infrared (NIR) regions. The 1DPhCs were constructed through the alternating stacking of hollow SiO2 (HS) nanoparticles hybridized with poly(vinyl alcohol) (PVA), referred to as PHS, and TiO2 layers. The 1DPhC with 7 bilayers demonstrated remarkable reflectance of 98.2% and 93.4% in the blue and NIR spectra, respectively, with shielding efficiencies of 93.9% and 85.6%. Compared to bare PC, the temperature was observed to be 10.6 °C lower, achieving a thermal insulation efficiency of 44.8% in the 900 nm near-infrared range. Additionally, spectral fitting using the transfer matrix method (TMM) and optimization of process parameters, including PHS concentration and spin-coating speed, enabled the fabrication of 1DPhCs with tunable optical thickness ratios. The fabricated films demonstrated a smooth surface morphology with flat and uniform interfaces, as well as excellent environmental stability. These features make the 1DPhCs highly promising for applications in light protection and thermal management. This study provides a novel approach for the development of dual-PBG 1DPhCs with enhanced protective capabilities.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2024
·
IF 6.9
Jinyang Liu,Qiqi Liao,Chengcai Li,Xueliang Jiang,Jiuming Li,Wangyong Jin,Guojin Liu,Yuhai Guo,Bin Yu,Hailin Zhu
Being a low-energy, reusable, and environmentally friendly degradation technology, photocatalysis has excellent application prospects in textile dye wastewater degradation. In this study, we combine the advantages of photocatalysis and membrane technology to prepare photocatalytic membranes that immobilize the photocatalyst and alleviate membrane pollution. Dual-precursor graphitic carbon nitride (U6M1) was composited with Bi 12 TiO 20 (BTO) using the annealing method to prepare a novel Δ(Z + II)-type BTO/U6M1 photocatalyst with visible-light response capacity. Subsequently, BTO/U6M1/PES composite photocatalytic membranes were fabricated using the nonsolvent-induced phase separation (NIPS) method, and the photodegradation activity of the composite membranes was executed against rhodamine B (RhB) dye. The results indicated that the composite membrane exhibiting the best photocatalytic performance achieved nearly 100 % degradation of RhB within 120 min. Furthermore, the membrane with optimal photocatalytic performance retained photocatalytic activity for five consecutive dye degradation tests, demonstrating its reusability.
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