CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Mengke Li,Zhiguo He,Hui Zhong,Wei Sun,Liang Hu,Mengqi Luo
A novel ternary composite catalyst (FeOOH/Fe 2 O 3 /(Fe 0.67 Mn 0.33 )OOH ) directly prepared from electrolytic manganese residue was applied for terpineol degradation in this study. The reaction system could remove 76.8% of chemical oxygen demand (COD) from simulated water containing terpineol (100 mg/L), while the degradation process could be accelerated under alkaline condition (84.6% at pH 9.0). The degradation performances of Fe 2 O 3 , FeOOH and (Fe 0.67 Mn 0.33 )OOH indicated that the in-situ formed (Fe 0.67 Mn 0.33 )OOH riched in oxygen vacancies (O V ) could promote the PMS activation activity of catalyst mainly ascribed by enhancing interfacial electron transfer . The · OH was the primary active radical, the production of which was favored by the metal−OH. This ternary composite catalyst had anti-jamming ability toward most common ions. Further, this system also displayed an outstanding degradation ability for actual mineral processing wastewater (93.2% COD removal). The developed system expanded the horizon for the high-value utilization of metallurgical slag and the treatment of refractory organic pollutants in mineral processing wastewater.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2020
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IF 16.683
Qi Sun,Ting Cheng,Zhirong Liu,Limin Qi
BiVO 4 is one of the most promising photoanode materials for photoelectrochemical (PEC) water splitting, but it usually suffers from severe charge recombination. In this work, cobalt silicate (Co-Sil) was decorated on a nanoporous BiVO 4 photoanode as a novel cocatalyst by photoelectrophoretic deposition that integrated photoelectrochemical oxidation and electrophoretic deposition. The resultant BiVO 4 /Co-Sil photoanode reached a photocurrent density of 5.0 mA/cm 2 at 1.23 V RHE , around 3-fold enhancement compared with the pristine BiVO 4 photoanode. Detailed PEC measurements combined with density functional theory calculations revealed that the excellent performance of the Co-Sil cocatalyst could be attributed to the electron transfer from Co-Sil to BiVO 4 , the reduced overpotential of the OOH* formation, and the photoelectrochemical oxidation of Co(II). Furthermore, a high photostability was achieved for the BiVO 4 /Co-Sil photoanode by dissolving NaVO 3 in the electrolyte. This work may provide new insights on the rational design and effective fabrication of promising cocatalysts for solar water splitting.
研究领域:
材料科学
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光化学
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电化学
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可再生能源
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Jie Wu,Yuanyuan Zhang,Bin Zhang,Siwei Li,Ping Xu
Development of low-cost, efficient, and durable electrocatalysts for the oxygen evolution reaction (OER) is crucial for multiple energy conversions and storage devices. Herein, Zn-doped CoS2 nanoarrays supported on carbon cloth, Co(Zn)S2/CC, are fabricated through a facile sulfidization of CoZn metal–organic frameworks. This precatalyst, Co(Zn)S2/CC, with a well-defined nanoarray structure affords excellent OER catalytic activity (η = 248 mV at 10 mA/cm2) and long-term durability in 1 M KOH. X-ray photoelectron and in situ Raman spectroscopic studies indicate that Co(Zn)S2 undergoes surface reconstruction with the generation of Co(Zn)OOH adsorbed with SO42– at the surface during the OER process. The Zn dopant is calculated to impact on the electronic structure of Co species and further the adsorption of intermediates. This work not only provides a novel method for the synthesis of bimetallic sulfides but also gives insights into the doping effect on the OER performance of transition metal sulfides.
研究领域:
电化学
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材料科学
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能量转换与存储
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2025
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IF 6.9
Duo Xu,Chenchangxiang Wang,Xiaochen Hu,Qiming Sun,Weigao Zhong,Qiangli lv,Haoran Guo,Hua Wang,Zhouhang Li,Kongzhai Li,Zhishan Li
The oxygen evolution reaction (OER) plays a crucial role in hydrogen production, but its potential is limited by the lack of scalable and stable electrocatalysts for industrial applications. In this study, we developed a repeated impregnation-drying co-precipitation (RIP) method to prepare CoFe-based OER electrocatalysts. We found that the optimized FeCo(OOH) x -5/NF catalyst achieves an overpotential of 340 mV at 500 mA cm −2 , significantly outperforming catalysts prepared via hydrothermal or chemical bath deposition methods. The RIP method accelerates the co-precipitation rate of metal ions and helps repair defects between the catalytic layer and the nickel foam substrate, promoting the three-dimensional growth of the catalyst layer. Notably, the entire reaction occurs in air, and the solution can be reused, ensuring the optimal utilization of all ions. Additionally, the FeCo(OOH) x -5/NF catalyst was scaled up to 6000 cm 2 to assess the feasibility of roll-to-roll industrial production. In practical alkaline water electrolysis, electrolyzers equipped with FeCo(OOH) x -5&RANEY Nickel catalysts demonstrated excellent performance, achieving 500 mA cm −2 at 1.75 V in 6.0 M KOH. This work provides valuable insights into the design of efficient alkaline OER electrocatalysts, such as FeCo(OOH) x /NF, for promising industrial applications.
研究领域:
化学工程
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材料科学
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电化学
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产品关联
DOI
高影响因子
Journal of Water Process Engineering
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2024
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IF 6.3
Yang Li,Shuijing Wang,Hengming Huang,Jiahui Kou,Chunhua Lu,Zhongzi Xu,Jinhua Ye
Faster OH − transfer for efficient adsorption on catalysis is key to accelerating the oxygen evolution reaction (OER). The diffusion of OH − in electrolyte mainly involves two mechanism which is dependent on the water coordination number (CN): Grotthuss diffusion (4 CN) and vehicular diffusion (5 CN). The Grotthuss diffusion is much faster but the vehicular diffusion of OH − is predominant in the electrolyte. Herein, negatively charged kaolin, which are simply dispersed in the electrolyte, are utilized to provide surface electrostatic attraction to H 2 O and repulsion to OH − to reduce the OH − CN from 5 to 4 for rapid Grotthuss diffusion. This contributes to the accelerated OH − adsorption which facilitates the charge transfer, the formation and the deprotonation of *OOH leading to enhanced OER performance. The OH − CN recovery from 4 to 5 is proved quite slow after leaving the kaolin surface, breaking the limitation that kaolin must be on the catalyst surface. This strategy exhibits universality for various electrocatalysts with reduced overpotential by 10–246 mV at 10 mA cm −2 . We provide a clean, simple and low-cost way to promote the industrial development of alkaline water electrolysis.
研究领域:
电化学
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材料科学
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催化
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能量转换
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产品关联
DOI
高影响因子
EES Catalysis
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2025
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IF 8.1
Jie Yang,Lifang Chen,Xuya Zhu,Wenwen Shi,Mengxue Huang,Chang Liu,Ruimin Ding,Lin Gan,Xi Yin
H2O2 -related electrochemical reactions, including two-electron oxygen reduction reaction (2e-ORR), H2O2 oxidation reaction (HPOR), and H2O2 reduction reaction (HPRR), have received significant attention for the electrosynthesis H2O2 and energy storage. Understanding the complex structure-activity relationships among 2e-ORR/ HPOR/HPRR and their connections is crucial for further developing highly efficient catalysts and working systems. Herein, we unveil these intricacies by employing model Co-N-C catalysts with well-defined active site configuration (Co-N4-pyrrolic and Co-N4- pyridinic ) in a combined experimental and computational approach. We report the higher 2e-ORR/HPOR but lower HPRR activity of CoN4-pyrrolic site than the CoN4-pyridinic site based on their reaction free energy landscapes remodeled considering the chemisorption steps of O2 and H2O2 . The results reveal that the binding free energy of *OOH (ΔG*OOH ) can only be utilized as a reliable descriptor for 2e-ORR/HPOR activity, but not indicative of HPRR activity, regardless of the scaling relationship of the common reaction intermediates ( *OOH or *OH). The HPRR activity of CoN 4 sites strongly depends on the H2O2 adsorption strength and configuration. These findings provide valuable insights into the design of catalysts for H2O2 -related electrochemical energy conversion and storage systems.
研究领域:
电化学
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催化
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材料科学
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能量转换与存储
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计算化学
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产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
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2024
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IF 8.1
Shiqi Zhang,Ying Cheng,Zhiyuan Ni,Xuefei Lei,Biao Wang,Xuanwen Liu,Rui Guo
Reasonably designing and constructing transition metal based compounds with controllable composition and structure is a promising option for obtaining economically efficient oxygen evolution reaction (OER) electrocatalysts. This paper presents a one-pot self-templated epitaxial growth, phase transition and self-dissolution strategy for constructing hollow nanoboxes/solid nanocubes of CoFe bimetallic Prussian blue analogues (PBAs). The CoFe mixed phosphide with a porous hollow nanoboxes structure obtained after subsequent phosphating heat treatment exhibite enhanced OER electrocatalytic activity in alkaline media, exhibiting a low overpotential of 230 mV and a Tafel slope of 35.5 dec −1 at 10 mA cm −2 , as well as excellent stability for 48 h. The excellent OER activity of CoP-FeP nanoboxes (CoP-FeP NBs) can be attributed to the combination effect between their composition and structure. Structurally, the exquisite porous hollow nanoboxes structure greatly expands the surface area, reduces ion diffusion pathways, and reduces charge transfer resistance. Compositionally, the inner transition metal phosphide exhibits good conductivity and undergoes surface reconstruction during OER, forming high valence Co(Fe)OOH active substances in situ. The strong interface coupling effect of CoOOH/FeOOH optimizes the electronic structure. This work presents a facile and efficient strategy for the construction of PBAs hollow structural materials and the exploitation of low-cost and efficient electrocatalysts.
研究领域:
材料科学
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电化学
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纳米技术
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催化
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Jiayi Zhang,Chi Ma,Haifeng Zhang,Haibing Wang,Siya Wang,Xueting Ren,Licheng Zhang,Menghuan Li,Zhong Luo,Xiang Cui
Mitochondrial dysfunction of nucleus pulposus cells (NPCs) drives IDD. • An injectable liposome-anchored ECM-mimetic hydrogel (ILH) is developed. • ILH repairs NPC mitochondria via SIRT1-AMPK-PGC-1α activation and ROS scavenging. • ILH reverses NPC senescence to restore disc structure and function. Mitochondrial dysfunction is a key driver of nucleus pulposus cell (NPC) senescence with crucial roles in orchestrating intervertebral disc (IVD) degeneration. However, the development of effective therapies is limited by the complex IVD structure and mitochondrial pathology. Here, an injectable liposome-anchored extracellular matrix (ECM)-mimetic hydrogel (ILH) was engineered for treating IVD degeneration via restoring mitochondrial biogenesis in senescent NPCs. Specifically, nicotinamide mononucleotide (NMN)-loaded liposomes were functionalized with the mitochondria-targeting peptide SS31 (MTLs) and incorporated together with Vitamin K 2 (VK 2 ) into an injectable hyaluronic acid-gelatin hydrogel crosslinked via dynamic Schiff base and boronate ester bonds. ILHs provide immediate mechanical support to degenerative IVDs while enabling on-demand release of encapsulated MTLs and VK 2 within the nucleus pulposus (NP). MTLs facilitates mitochondrial targeted-NMN delivery to replenish intracellular NAD + levels and activate SIRT1 signaling in senescent NPCs, thereby promoting AMPK-dependent mitochondrial biogenesis and suppressing the p53-associated senescence programs. On the other hand, SS31 alleviates cardiolipin peroxidation and preserves mitochondrial cristae integrity, while VK 2 activates the antioxidative Nrf2/HO-1 pathway to further improve mitochondrial quality control. Collectively, these coordinated effects enable comprehensive mitochondrial repair while further maintaining their structural and functional integrity in senescent NPCs, providing a promising therapeutic strategy for clinical treatment of IVD degeneration.
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DOI
高影响因子
Research
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2026
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IF 12.9
Jian-Xuan Sun,Ye An,Si-Han Zhang,Jin-Zhou Xu,Abudureyimu Maimaiti,Jing-Yu Xu,Yi-Fan Huang,Yu-Xuan yang,Mei-Cheng Liu,Shao-Gang wang,Qi-Dong Xia
Precision theranostics for castration-resistant prostate cancer remain a major challenge because of tumor heterogeneity, drug toxicity, and resistance to conventional therapies. Here, we report a multifunctional theranostic nanoplatform that integrates multimodal imaging guidance, dual-targeted delivery, photothermal therapy, and immune activation for the precision treatment of prostate cancer. By encapsulating aggregation-induced emission luminogens and magnetic nanoparticles, this system achieves superior second near-infrared fluorescence and magnetic resonance imaging fusion for deep-tissue visualization. The dual-targeting strategy, which integrates magnetic navigation with simultaneous engagement of six-transmembrane epithelial antigen of the prostate 1 and prostate specific membrane antigen (PSMA), effectively addresses tumor heterogeneity by enabling externally guided and biologically specific delivery to both PSMA+ and PSMA− prostate cancer cells. Upon targeted delivery, the synergistic combination of photothermal therapy and chemotherapy achieves potent tumor growth inhibition, activates CD8+ T cells and macrophages to promote robust antitumor immune responses, and elicits durable immunological memory to prevent tumor recurrence. In vitro and in vivo studies demonstrate superior tumor targeting specificity, enhanced imaging contrast, and minimal off-target toxicity. This study provides novel insights into the construction of a multifunctional theranostic nanoplatform in precision oncology, with promising translational potential for clinical management of castration-resistant prostate cancer.
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2026
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IF 11
Jiarong Liang,Si Wang,Zhonghui Ma,Fei Kuang,Xiangkun Li,Zhilong Gong,Jinzhu Su,Zhiyi Wang
Combining efficient photocatalytic activity with precise targeting is crucial for covalent organic framework (COF)-based nanomedicines to remodel the immunosuppressive microenvironment and sensitize “cold” tumors to immunotherapy. Herein, we constructed two isomorphic frameworks featuring distinct electronic topologies: a zwitterionic squaric acid (SA) COF with inherent electrostatic asymmetry, and a charge-neutral terephthaldehyde (TA) COF. The spatial divergence of ion centers in SA COF triggers intense molecular-level ionic displacement polarization, creating a robust internal electric field. Such unique field-effect regulation accelerates photogenerated charge separation for efficient superoxide anion production, enhances intersystem crossing for singlet oxygen generation, and promotes nonradiative energy relaxation for high-performance photothermal conversion under dual-wavelength irradiation. After PEGylation and iRGD modification, the formulated SA@PEG-iRGD exhibits excellent physiological stability and active deep tumor penetration. With near-infrared absorption, it enables high-contrast photoacoustic imaging for guided dual-wavelength (660/808 nm) phototherapy. This spatiotemporally controlled therapeutic cascade triggers lethal ferroptosis and precise photothermal ablation, potently activating immunogenic cell death. Combined with aPD-L1 therapy, it eliminates primary tumors, produces abscopal effects, and establishes immune memory against recurrence and metastasis. This study highlights the value of electronic structure engineering in COF-based precision nanomedicine.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
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2025
·
IF 6.8
Xiaojuan Hu,Xingwen Cheng,Liqiang Shao,Lan Yang,Gongning Chen,Zhangwei Yan,Mengdie Yu,Yehui Kang,Xiaozhou Mou,Xianghong Yang,Yu Cai
Acute kidney injury (AKI) causes renal tubular damage, driven primarily by mitochondrial dysfunction and reactive oxygen species (ROS)-mediated oxidative stress, leading to a cellular energy crisis. The physiological architecture of the kidney hampers targeted drug delivery, rendering metabolic restoration a therapeutic challenge. To address this, we developed a second near-infrared (NIR-II) light-driven, bioenergetic nanoplatform (UCTR) that leverages upconversion nanoparticle (UCNPs)-enhanced photosynthesis for energy replenishment and mitochondrial repair in AKI. The UCTR consists of thylakoid membrane (TM)-encapsulated UCNPs cloaked with activated renal tubular epithelial cell membranes (RECM), enabling targeted accumulation in injured tubules. The UCNPs convert deep-tissue-penetrating NIR-II light into visible wavelengths, activating photosynthetic adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH) synthesis within the TM component under irradiation. This exogenous bioenergetic supply mitigates hypoxia-induced mitochondrial energy deficits, while the AMPK/PGC-1α pathway is simultaneously activated to restore the mitochondrial membrane potential. Moreover, UCTR synergizes the antioxidative and anti-inflammatory effects of plantain, accelerating tubular repair.
研究领域:
生物医学工程
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纳米医学
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肾脏病学
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分子生物学
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转化医学
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氧化应激
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能量代谢
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
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2024
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IF 14.7
Xiaoyu Wu,Zijun Bai,Hui Wang,Hanqing Wang,Dahai Hou,Yunzhu Xu,Guanqun Wo,Haibo Cheng,Dongdong Sun,Weiwei Tao
Copper-based nanomaterials demonstrate promising potential in cancer therapy. Cu + efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione, initiating chemical dynamic therapy (CDT) and ferroptosis. Cuproptosis, a newly identified cell death modality that represents a great prospect in cancer therapy, is activated. However, active homeostatic systems rigorously keep copper levels within cells exceptionally low, which hinders the application of cooper nanomaterials-based therapy. Herein, a novel strategy of CRISPR-Cas9 RNP nanocarrier to deliver cuprous ions and suppress the expression of copper transporter protein ATP7A for maintaining a high level of copper in cytoplasmic fluid is developed. The Cu 2 O and organosilica shell would degrade under the high level of glutathione and weak acidic environment, further releasing RNP and Cu + . The liberated Cu + triggered a Fenton-like reaction for CDT and partially transformed to Cu 2+ , consuming intracellular GSH and initiating cuproptosis and ferroptosis efficiently. Meanwhile, the release of RNP effectively reduced the expression of copper transporter ATP7A, subsequently increasing the accumulation of cooper and enhancing the efficacy of CDT, cuproptosis, and ferroptosis. Such tumor microenvironment responsive multimodal nanoplatform opens an ingenious avenue for colorectal cancer therapy based on gene editing enhanced synergistic cuproptosis/CDT/ferroptosis.
研究领域:
生物技术
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纳米技术
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肿瘤学
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基因编辑
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）