ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yaqing Yang,Simin Wei,Jialin Wang,Junjie Li,Jinlu Tang,Albert Aryee Aaron,Qiyong Cai,Ningning Wang,Zhaohui Li
Nitrite (NO 2 − ) is extensively found in the daily dietary environment. However, consuming too much NO 2 − can pose serious health risks. Thus, we designed a NO 2 − -activated ratiometric upconversion luminescence (UCL) nanosensor which could realize NO 2 − detection via the inner filter effect (IFE) between NO 2 − -sensitive carbon dots (CDs) and upconversion nanoparticles (UCNPs). Due to the exceptional optical properties of UCNPs and the remarkable selectivity of CDs, the UCL nanosensor exhibited a good response to NO 2 − . By taking advantage of NIR excitation and ratiometric detection signal, the UCL nanosensor could eliminate the autofluorescence thereby increasing the detection accuracy effectively. Additionally, the UCL nanosensor proved successful in detecting NO 2 − quantitatively in actual samples. The UCL nanosensor provides a simple as well as sensitive sensing strategy for NO 2 − detection and analysis, which is anticipated to extend the utilization of upconversion detection in food safety.
研究领域:
食品安全
·
光学检测
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2023
·Vol. 25
·期 40
·5730-5739
·
IF 3.1
Ying Chen,Xuegang Zheng,Meijuan Liu,Haobo Lin,Shusheng Pan,Weiwei Xing,Zhiyu Liu,Dekang Xu,Hao Lin
In previous studies, LiErF4 mostly served as a dipolar-coupled antiferromagnet and was less commonly used as a luminescent material to study the luminescence performance. Therefore, there are few research reports on the luminescent properties of LiErF4 materials at this stage. In this work, the LiErF4:Ce,Yb,Y@LiYbF4:Tm@LiYF4 core/shell/shell upconversion nanoparticles (UCNPs) and the relevant derivative samples were successfully prepared by coprecipitation method. The LiErF4:Ce,Yb,Y@LiYbF4:Tm@LiYF4 UCNPs exhibit a prominent emission peak at 792 nm and several weak emission peaks in the visible light region under irradiation at 980 nm. Here, the cross relaxation between Ce3+ and Er3+ in the core can effectively reduce unwanted visible light emissions (4S3/2 + 2F5/2 → 4F9/2 + 2F7/2, 4F9/2 + 2F5/2 → 4I9/2 + 2F7/2, 4I9/2 + 2F5/2 → 4I11/2 + 2F7/2, 4I11/2 + 2F5/2 → 4I13/2 + 2F7/2). The Yb3+ ions not only work as an energy transfer medium promoting energy transfer, but also as an energy harvester effectively absorbing excitation energy, which can improve energy utilization and promote first near-infrared (NIR-I) emission. The intensity of NIR-I and the ratio of NIR-I to visible light are increased due to the cross relaxation between Ce3+ and Er3+ and the energy migration among Yb3+. The UCNPs emitting strong NIR-I light are advisable for biological imaging.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2022
·Vol. 32
·期 4
·1289-1297
·
IF 2.525
Yu Dezhong,Zha Zhonghui,Tang Sheng,Qiu Yuan,Liu Dong
Upconversion nanoparticles (UCNPs) have achieved considerable success in protein sensing in vitro. And aptamer is one of the most frequently used biomolecules to modify the nanoparticles for protein assay. However, the complicated process of modifying UCNPs with DNA and the susceptibility of the phosphate groups of DNA backbone to adsorb on the surface of UCNPs have limited their practical applications. To overcome these limitations, a modification-free fluorescent biosensor based on polydopamine-coated upconversion nanoparticles (UCNPs@PDA) is proposed. It consists of UCNPs@PDA and CEA aptamer-functionalized AuNPs (AuNPs-CEA aptamer). The CEA aptamer on AuNPs can be adsorbed onto the surface of UCNPs@PDA due to the interactions of π–π stacking and hydrogen bonding, triggering the process of fluorescence resonance energy transfer (FRET) from UCNPs@PDA to AuNPs-CEA aptamer. In the presence of CEA, the AuNPs-CEA aptamer departs from UCNPs@PDA due to the stronger affinity of CEA with its aptamer. Therefore, the recovery of upconversion fluorescence can sensitively quantify the concentration of CEA. This biosensor provides a linear range from 0.1 to 100 ng/mL for CEA with a LOD of 0.031 ng/mL in an aqueous solution. In spiked human serum samples, the same linear range is acquired with a slightly higher LOD of 0.055 ng/mL, demonstrating the great potential of the biosensor in practical application.
研究领域:
生物医学
·
纳米技术
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2021
·
IF 3.712
Solomon Tiruneh Dibaba,Yao Xie,Wensong Xi,Artur Bednarkiewicz,Wei Ren,Lining Sun
Combining treatment and diagnosis, called theranostics, which is achieved within single nanoparticle is an ultimate goal of many studies. Herein, we developed a new nanotheranostic agent − Nd 3+ -sensitized upconversion nanoparticles core for dual modal imaging (i.e., upconversion luminescence imaging and magnetic resonance imaging) and antimony nanoshell for photothermal therapy (PTT). The core-shell-shell upconversion nanoparticles (NaYF 4 :Yb,Er@NaYF 4 :Yb,Nd@NaGdF 4 :Nd, named as UCNP) were firstly synthesized using thermal decomposition method and then were coated by antimony shell over the surface of UCNP using simple cost and time effective new method. Furthermore, the surface of UCNP@Sb nanostructures was modified with DSPE-PEG in order to enhance the water solubility and biocompatibility. The final nanotheranostic agent, named as UCNP@Sb-PEG, exhibits very low toxicity, good biocompatibility, very good photothermal therapeutic effect, and efficient upconversion luminescence (UCL) imaging of HeLa cells under only one laser (808 nm) irradiation. The antimony shell is quenching the upconversion emission in pristine nanotheranostic agent, but interestingly, the UCL intensity of the agent recovers progressively under 808 nm laser irradiation due to light induced degradability of antimony shell. Besides, high longitudinal relaxivity ( r 1 ) obtained from the experiment approves excellent potential of the nanotheranostic agent for T 1 -weighted magnetic resonance imaging application.
研究领域:
纳米医学
·
生物材料
·
肿瘤学
✓ 已验证
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Chen Xiaojiao,Yang Zhiying,Chen Qiong,Zhang Youyu
Accurate blood glucose determination is essential to the clinical diagnosis and management of diabetes. This work establishes an inner filter effect (IFE) strategy between upconversion nanoparticles (UCNPs) and quinone-imine complex for glucose monitoring in human serum simply and efficiently. In this system, the enzyme glucose oxidase (GOx) catalyzes the reaction of glucose into hydrogen peroxide (H2O2) and gluconic acid when compulsion by oxygen. In the presence of horseradish peroxidase (HRP), the produced H2O2 can catalytically oxidize phenol and 4-amino antipyrine (4-AAP) to generate quinone-imine products. The purple-colored quinone-imine complex effectively absorbed the fluorescence of NaYF4:Yb3+, Er3+ UCNPs, leading to the strong fluorescence quenching of UCNPs through IFE. Thus, a new approach was established for glucose monitoring by determining the fluorescence intensity. Under the optimal condition, this approach shows better linearity to glucose from 2–240 μmol/L with a low detection limit at 1.0 μmol/L. Owing to the excellent fluorescence property and background-free interference of the UCNPs, the biosensor was applied for glucose measurements in human serum and got a satisfactory result. Furthermore, this sensitive and selective biosensor revealed great potential for the quantitative analysis of blood glucose or different kinds of H2O2-involved biomolecules for the application of clinical diagnosis.
研究领域:
生物传感
·
医学诊断
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Optical Materials
·
2024
·
IF 0
Jiaxin Li,Yujiao Zhang,Pengli Wang,Dan Xiao,Cuisong Zhou
Alloyed upconversion nanoparticles (aUCNPs, NaYbF4:10% Er@NaYF4) with high Yb3+ doping were designed to brighten luminescence, exploring multicolor patterns of information encryption. The luminescence intensity of aUCNPs was 2.3 times higher than that of common doped UCNPs reported (dUCNPs, NaYF4:20% Yb, 2% Er@NaYF4). Furthermore, because of the high Yb3+ doping (90%), both green and red emissions of aUCNPs were enhanced, ∼4.2 and ∼17.2 times stronger than that of NaYF4:20% Yb, 10% Er@NaYF4, respectively. The reasons for the aUCNPs having a brightened luminescence were explored by synthesizing four UCNPs with different structures and comparing their luminescence. These are attributed to their unique features: (1) a larger absorption cross section for accumulating energy, (2) more efficient energy transfer between Yb3+ and Er3+, and (3) their inert shell inhibiting surface quenching. Eventually, three colors including yellow, orange, and red were obtained by combining aUCNPs and neutral red (NR) taking advantage of the inner filter effect (IFE), and aUCNPs were thus successfully applied in information encryption with multicolor patterns.
研究领域:
材料科学
·
光学
·
信息安全
✓ 已验证
DOI
JOURNAL OF LUMINESCENCE
·
2025
·
IF 3.6
Zhuoyue Li,Zhenlong Cheng,Maoxiu Huang,Qingkai Chen,Yuanli Liu,Zhiyi He,Jun Ou
In this paper, highly fluorescent, structurally homogeneous, and small-sized NaYF 4 upconversion nanoparticles were synthesized via the hydrothermal method, Yb/Ho/Mn co-doping altered the local symmetry of the crystals, slightly deforming their structure and enhancing the fluorescence intensity of the nanocrystals. The strong green light emission from the synthesized samples was mechanistically explained by energy transfer upconversion combined with excited state absorption process involving Yb-Mn dimers. The highest fluorescence intensity was observed with 15 mol% Mn 2+ , which increased the fluorescence intensity by a factor of approximately 10.88 compared to the undoped sample. Furthermore, this work explored the optical temperature-sensing properties of these upconversion fluorescent nanocrystals for non-contact temperature measurement, leveraging thermal and non-thermal coupling mechanisms. It provided a promising strategy for developing high-performance optical temperature sensors using other transition metal-doped lanthanide materials.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
BIOPHYSICAL CHEMISTRY
·
2025
·
IF 2.2
Changqiu Ma,Anqi Han,Daheng Jiang,Qiuyan Wang,Linghui Zeng,Lixin Zhu,Mingya Yang,Xiaoliang Xu
Photodynamic therapy utilizes photosensitizer to generate reactive oxygen species (ROS) under irradiation of light for anticancer. However, due to the strong absorption of visible light by tissues and organs, photodynamic therapy meets challenges in deep tissues. Herein, we propose an upconversion-driven photodynamic therapy combined with chemodynamic therapy based on UCNP@SiO 2 @Fe 3 O 4 @MC540. Upon the excitation of 980 nm laser, the visible emission of upconversion nanoparticles activates MC540 to produce ROS, which is enhanced by Fe 3 O 4 through magnetic field modulation. Subsequently, Fe 3 O 4 degrades under acidic conditions to produce ·OH via Fenton-reaction for chemodynamic therapy. The in vitro and in vivo experiments indicate that the two-step cooperative strategy exhibits significant anticancer efficacy. Besides, Finite Difference Time Domain (FDTD) simulation reveals that the enhancement stems from surface electric field and light absorption. It offers a deeper understanding of phototherapeutic process.
研究领域:
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Syed Jalil Shah,Wenyuan Li,Ying Tang,Yang Hu,Shanliang Jiang,Hui He,Ruimeng Wang,Zhongxing Zhao,Zhenxia Zhao
Fabrication of broad-spectrum response photocatalysts in a controllable manner that can efficiently utilize solar light as much as possible remains a top priority target yet a challenging task. In this work, a facile approach of synchronous bottom-up growth was employed to construct UCNP/NMIL(Ti) nanohybrids via NH 2 -BDC (NH 2 -MIL-125-ligand) linkage between upconversion NaYbF 4 :Tm 3+ nanoparticles (~13-nm) and NH 2 -MIL-125. The ligand sharing integration strategy generated abundant oxygen vacancies and coordinatively-unsaturated-metal sites, efficiently enhanced light absorption, energy-transfer upconversion (UC-PL), photo-induced e - / h + generation, and their separation (CV, EIS, Photocurrent-density). Consequently, UCNP/NMIL(Ti) exhibited excellent acetaldehyde photodegradation activity, with 12.5–77.0-folds higher rate constants ( k a ) than those of state-of-the-art photocatalysts under visible light and high humidity. Furthermore, the photocatalytic activity of UCNP/NMIL(Ti) only declined from 96.0% to 92.5% after five cycling-runs, demonstrating its remarkable photo-catalytic stability. Considering these attributes, the current strategy provides an avenue to synthesize efficient UCNPs/MOF composites for widespread usage in a variety of commercial applications.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Shen Zhang,Shuhua Li,Dong Li,Jizhong Wu,Tianhui Jiao,Jie Wei,Xiaomei Chen,Qingmin Chen,Quansheng Chen
Contamination of aquatic products with sulfonamide antibiotics poses a threat to consumer health and can lead to the emergence of drug-resistant bacteria. Common methods to detect such compounds are slow and require expensive instruments. We developed a sensitive sulfadiazine (SDZ) detection method based on the photoinduced electron transfer between UCNPs and Cu 2+ . The surface-modified upconversion nanoparticles bind to Cu 2+ by electrostatic adsorption, causing fluorescence quenching . The quenched fluorescence was subsequently recovered by the addition of imidazole and SDZ to the detection system, which formed a complex with Cu 2+ . The sensor showed excellent linearity over a wide concentration range (0.05–1000 ng/mL), had a low limit of detection (0.04 ng/mL), was selective, and was not affected by common substances present in aquatic media. This indicates that the sensor has great potential for application in the detection of SDZ residues in aquatic products.
研究领域:
分析化学
·
食品安全
·
生物传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
STAR Protocols
·
2024
·
IF 1.3
Ruipeng Wang,Jingxuan Guo,Hanlu Yao,Xuekai Luo,Yixiang Deng,Yuhang Tian,Yan Zhang,Shangbang Gao
Summary In deep tissue, optogenetics faces limitations with visible light. Here, we present a protocol for near-infrared (NIR) optogenetics manipulation of neurons and motor behavior in Caenorhabditis elegans using emissive upconversion nanoparticles (UCNPs). We describe steps for synthesizing and modifying UCNPs. We then detail procedures for regulating neurons using these UCNPs in the model organism C. elegans . Using NIR light allows for superior tissue penetration to manipulate neuronal activities and locomotion behavior. For complete details on the use and execution of this protocol, please refer to Guo et al., 1 Ao et al., 2 and Zhang et al. 3
研究领域:
神经科学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Yang Yu,Sai Xu,Yuefeng Gao,Muhan Jiang,Jinsu Zhang,Xiangping Li,Xizhen Zhang,Baojiu Chen
The development of upconversion nanoparticles based logic systems, especially integrated logic systems is still a challenge until now. In this work, an upconversion nanocomposite system is developed and studied for the sensing abilities toward hydrion, hydroxyl ions , metal ions and anions (S 2 − , I − ) by taking the advantages of turn-on and turn-off upconversion fluorescence switching response. Triggering by different kinds of ions, the upconversion system can act as a fluorescence switch due to the specific recognition abilities of Rhodamine 6G functionalized PEI for specific ions and the energy transfer process from upconversion nanoparticles to recognition molecules. Based on these results, multiple molecular logic gates , including single-input logic operation (YES, NOT), double-inputs logic operation (OR, AND, NOR, INHIBIT) and multiple-input integrative logic operation (INHIBIT+OR) are developed by employing hydrion, hydroxyl ions, metal ions and anions as inputs and the changes in the upconversion fluorescence intensity as output. The multiple logic operations are of great significance for the applications in biomedicine and molecular calculation.
研究领域:
生物医学
·
纳米技术
·
化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）