FOOD RESEARCH INTERNATIONAL
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2026
·
IF 8.8
Yaning Nie,Ting Xia,Yihong Fu,Yixie Chen,Jun Wang,Nannan Zhang,Shuxia Huang,Junhong Yu,Min Wang
Dark beer melanoidin (BM) exhibited colloidal properties and negative charge. • Glycosidic, peptide and non-covalent bonds were broken after chemical treatment. • Structure and bioactivity of BM were relatively stable during in vitro digestion. • The levels of polyphenolics and SCFAs were increased during colonic fermentation. • Phloroglucinol was the main phenolic compound during colonic fermentation. Melanoidins are brown macromolecular products of Maillard reaction formed through thermal processing, which provide unique flavor and bioactive function of food. This study aims to reveal the changes of structure and bioactive characteristics in beer melanoidin-rich fraction (BM) during different chemical treatments and in vitro digestion and fermentation. The results showed that BM had colloidal properties with 24.21–99.28 nm and negative charge, which mainly contained carbohydrates. In addition, microscopic morphology showed surface cracks after acid treatment, blocky particles after alkali treatment, and some porous small particles after salt treatment. These might be caused by the disruption of polysaccharide, protein, and the skeleton structure through spectra. Moreover, during simulated in vitro digestion stage, Mw of BM was slightly decreased, which might be due to the breakage of glycosidic bonds. Microscopic morphology presented a relatively complete block structure. However, the contents of total phenolics and flavonoids and the production of short-chain fatty acids were significantly increased during colonic fermentation process. Phloroglucinol was the main phenolic compound and its content also increased during colonic fermentation. Collectively, the results indicated that BM had relative stability during the digestion stage, and released bioactive compounds during colonic fermentation. These findings suggest that BM, as a novel colloidal prebiotic, possesses potential role in intestinal health. Download: Download high-res image (164KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Liu Yang,Baoshan He,Ming Lu,Zhengyong Liang,Yao Liu,Wenjie Ren,Yiwei Xu
The core–shell FeNPs@Pt shows excellent catalytic activity and stability. • Selective detection via thiol–Michael addition without enzymes or aptamers. • The color development is rapid and convenient, taking only 150 s to complete. • The suppression–recovery mechanism amplifies the signal and enhances sensitivity. In this study, we propose an innovative Acrylamide (AA) detection platform based on platinum-coated magnetic iron nanoparticles (FeNPs@Pt). The introduction of a platinum shell not only preserves the intrinsic catalytic properties of FeNPs but also significantly enhances their structural stability and catalytic activity. Compared with traditional antibody–aptamer-based detection methods, this platform employs a thiol–Michael addition reaction combined with a nanocatalyst-mediated cascade colorimetric process. This approach overcomes key limitations of antibody–aptamer technologies, such as high cost and operational complexity, enabling rapid and low-cost detection of AA. The mechanism involves a specific Michael addition reaction between AA and 2,2′-(ethylenedioxy)diethanethiol (EDT), which mitigates the inhibitory effect of EDT on the catalytic activity of FeNPs@Pt. Subsequently, the addition of 3,3′-dimethylbenzidine (TMB) triggers a colorimetric reaction within 150 s, rendering the result visible to the naked eye. This sensing platform exhibits a linear response over the range of 1–200 μM, with a detection limit as low as 0.63 μM. Notably, the FeNPs@Pt–EDT–TMB-based colorimetric detection platform not only provides an efficient and low-cost method for acrylamide detection but also offers an innovative solution for on-site food safety monitoring, demonstrating significant application potential. Download: Download high-res image (108KB) Download: Download full-size image
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OPTICAL MATERIALS
·
2026
·
IF 4.3
Dewei Ma,Xiaoyang Qin,Chengdong Wu
Lead-free copper-based halides have attracted significant attention for optoelectronic applications due to their excellent photophysical properties, good stability, and environmental friendliness. However, current synthesis methods for copper-based halide nanocrystals either require high-temperature inert protection or rely on insulating long-chain ligands, limiting their practical applications. In this study, we report a facile one-pot room-temperature synthesis of Cs 3 Cu 2 X 5 (X = Cl, Br) and CsCu 2 I 3 nanocrystals using an anti-solvent method. Short-chain propionic acid (PA) is introduced as a surface passivation ligand, significantly enhancing photoluminescence through defect passivation. The PA-coated Cs 3 Cu 2 Cl 5 nanocrystals exhibit good resistance to ethanol but poor stability in water. To improve thermal stability, PMMA encapsulation is employed, with the composite film retaining ∼90% of initial PL intensity at 80∼90 °C and two-thirds at 150 °C. Time-resolved PL decay measurements confirm that both PA coating and PMMA encapsulation prolong the exciton lifetime. This work provides a green and effective strategy for the synthesis and surface engineering of copper-based halide nanocrystals for environmentally friendly optoelectronic applications.
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npj Science of Food
·
2026
·
IF 9.7
Shi Yuxuan,Sun Jiayi,Chen Lin,Xu Shuang,Guo Shasha,Xu Anan,Ye Qun,Wang Yuefei,Xu Ping
While black tea’s oxidized polyphenols hold potential for gut health, the specific protective mechanisms of its ethanol-soluble fraction (BES), particularly regarding host-microbiota interactions, remain poorly defined. This study elucidated the dual mechanisms through which BES ameliorates dextran sulfate sodium (DSS)-induced colitis in mice. By integrating network pharmacology, molecular docking/dynamics simulations, RT-qPCR, and Western blot analysis, we identified the PI3K/AKT signaling axis as a potential host target. Our findings suggest that key flavonoid constituents stably bind to critical nodes, potentially downregulating the expression and activation of pathway components. Concurrently, 16S rRNA sequencing and metabolomics revealed that BES reshaped gut microbiota by suppressing Akkermansia and enriching SCFA producers such as Lactobacillus , restoring fecal SCFA levels. Fecal microbiota transplantation confirmed that BES-modulated microbiota alone transferred protection. Thus, BES acts concertedly through direct PI3K/AKT inhibition and indirect microbiota-SCFA modulation, providing a mechanistic basis for targeted use of black tea fractions in intestinal inflammation.
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ACS Nano
·
2026
·Vol. 20
·期 34
·23716-23728
·
IF 17.3
Zeng Qing,Tamtaji Mohsen,Zhou Rui,Zhou Tao,Guo Zhengxiao,Chen GuanHua,Tse Edmund C. M.
Electrocatalytic oxidation of glycerol toward high-value
C3 products
on Pd-based catalysts presents a promising strategy for upgrading
and converting glycerol. However, C3 intermediates often adsorb too
tightly on Pd-based catalyst surfaces during glycerol oxidation, leading
to C–C bond cleavage. Herein, cubic-shaped PdBi nanoparticles
with tunable Ni doping levels are successfully synthesized through
a one-step solvothermal method. Owing to the downshift of d-band center
originating from the introduction of Bi and Ni as well as the cubic
shape, the PdBiNi ternary nanocubes (NCs) exhibit excellent electrocatalytic
performance for the glycerol oxidation reaction (GOR). Specifically,
Pd 83 Bi 12 Ni 5 NCs with the lowest d-band
center exhibit a specific activity of 61.12 mA cm geo –2 and a mass activity of 5.34 A mg Pd –1 . Notably, the Faradaic efficiency (FE) toward C3
products exceeds 97%. In situ Fourier transform infrared spectroscopy
and density functional theory calculations show that key C3 intermediates
are easily desorbed from the catalyst surface, thereby suppressing
C–C bond cleavage and thus preventing overoxidation into low-value
products. In addition, Pd 83 Bi 12 Ni 5 NCs possess long-term durability over the course of 16 cycles (1
h/cycle) with an FE for C3 products between 92.5% and 97.6% upon scale-up
deployment in a flow electrolyzer, validating its feasibility in practical
operations.
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Foods
·
2026
·Vol. 15
·期 17
·3085
·
IF 6
Xiao Yang,Song Xu,Ying Tong,Jichu Luo,Xixing Fang,Jiaxing Du,Changyuan Zhou,Guangnian Hu,Bao Yang,Qisong Zhang
(1) Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with gut microbiota dysbiosis and metabolic perturbations. Although Liubao tea (LBT) has gastroprotective benefits, the precise mechanisms by which LBT extract (LBTE) alleviates UC by orchestrating microbial and metabolic homeostasis remain poorly understood. (2) Methods: A DSS-induced UC mouse model was used to evaluate LBTE efficacy. Serum pharmacochemistry, untargeted metabolomics, 16S rRNA sequencing, and targeted SCFA metabolomics were integrated to characterize absorbable active constituents, metabolic shifts, and gut microbiota landscapes. SCFA- and arachidonic acid metabolism-related targets were validated by RT-qPCR and Western blotting. PGF models and FMT were used to assess the causal role of gut microbiota in LBTE-mediated efficacy. (3) Results: LBTE preserved colon length and mucosal integrity while reducing IL-6, TNF-α, IL-1β, and oxidative stress. It enriched SCFA-producing genera and increased colonic butyric and valeric acids, activating GPR41/GPR109A signaling, upregulating ZO-1 and occludin, and strengthening the intestinal barrier. LBTE also downregulated PTGS2 and ALOX5, restored PTGS1 and CYP3A11, and inhibited NF-κB signaling. These effects were weakened in PGF mice but reproduced by FMT from LBTE-treated donors, confirming microbiota-dependent protection. (4) Conclusions: LBTE may serve as a complementary strategy for UC prevention and management.
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ACS Sensors
·
2026
·
IF 10.9
Peng Xu,Yanlei Guo,Xin Lv,Shuting Wei,Dan Yang,Renquan Guan,Yuxin Wang,Yingmin Teng,Aiceng Li,Huaqiao Tan,Zhongling Lang,Zheng Lou,Lili Wang,Zhao Zhao
The necessity for high-efficiency, low-power room-temperature (RT) ammonia (NH3) sensors is particularly acute in environmental monitoring, industrial safety, and medical diagnostics. However, conventional chemiresistive sensors frequently require elevated temperatures to initiate reactions, leading to high energy consumption and potential safety risks. Inspired by plant photosynthesis, this paper successfully designs a ternary S-scheme heterojunction for a photo-activated RT NH3 sensor. The design effectively mimics the efficient charge transfer process in photosynthesis, thereby significantly promoting the separation and migration of photogenerated carriers and enhancing the sensing performance. Experimental results demonstrate exceptional performance under illumination: a high response value of 1679% (representing a 20-fold improvement over the dark state), rapid response and recovery times of 2.1 s and 1.9 s, respectively, along with outstanding selectivity, excellent stability, and a detection limit as low as 17 ppb. This work demonstrates a novel, efficient RT photo-activated NH3 sensor and provides innovative insights into designing biomimetic, smart gas-sensing materials and devices.
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Food Bioscience
·
2026
·
IF 6.2
Xin Zhang,Zhitong Wang,Yijia Hu,Mengjie Yang,Jingyu Hao,Xiuzhen Jia,Wen Zhao,Xuebo Liu,Zhigang Liu,Yanhui Lu
Environmental stressors and probiotics modulate gut microbiota, regulating intestinal barrier function and immune homeostasis. As a potential functional food ingredient, probiotics exhibit various health-promoting properties, including the alleviation of gastrointestinal disorders. This study investigated the exacerbating effects of chronic unpredictable mild stress (CUMS) on dextran sulfate sodium (DSS)-induced colitis and the protective efficacy of Lacticaseibacillus paracasei subsp. paracasei K56 (K56) against this stress-aggravated inflammation. CUMS exposure activated the hypothalamic–pituitary–adrenal (HPA) axis and increased corticosterone levels. Compared with the DSS group, the CUMS + DSS group exhibited higher levels of disease activity index (DAI), histopathological damage, CSF1 expression, and pro-inflammatory cytokines. In mice with CUMS-exacerbated colitis, K56 pretreatment (10 9 CFU/d for 5 weeks) significantly attenuated body weight loss, colon shortening, and DAI. K56 concurrently restored Claudin-1 and Mucin-2 (MUC2) expression, elevated goblet cell counts, and reinforced intestinal barrier integrity. Additionally, K56 reduced pathogenic bacteria and enriched short-chain fatty acid (SCFA)-producing taxa, which increased fecal propionate and butyrate production. K56 also balanced T helper 17 (Th17) and regulatory T (Treg) cells in the colonic lamina propria. Our results indicate that K56 alleviates stress-exacerbated colitis through the microbiota/SCFA/immune axis, supporting its potential as a functional probiotic intervention for managing stress-aggravated intestinal inflammation.
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AICHE JOURNAL
·
2026
·
IF 4.4
Shaojie Ma,Bangzhu Wang,Weiming Zhai,Xinyu Liu,Linlin Chen,Yanhong Chao,Hongping Li,Huaming Li,Peiwen Wu,Wenshuai Zhu,Chunming Xu
Selective capture of structurally diverse molecules remains a major challenge in chemical separations. Here, we introduce dual-acidic deep eutectic solvents (DESs) in which Lewis acids modulate the Brønsted acidity, creating a synergistic environment for the simultaneous extraction of basic and non-basic nitrogen-containing molecules. Brønsted sites, activated by adjacent Lewis centers, preferentially bind basic heterocycles, while the Lewis sites coordinate with non-basic species, achieving unprecedented extraction efficiencies. Mechanistic studies combining FT-IR spectroscopy, density functional theory, and molecular electrostatic potential analysis reveal that proton transfer, Lewis acid–base coordination, and π–cation interactions collectively govern selective recognition. This dual-acidic design strategy is generalizable across different LA-metal DES compositions and robust against competing chemical species. Our findings demonstrate a rational approach to fine-tune cooperative acid functionalities, establishing a versatile platform for selective molecular capture and separations beyond conventional single-acid systems.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2026
·
IF 4
Min Zhuang,Sheng Ke,Xuanyu Wang,Anqi Wang,Ming Ning,Chris Blanchard,Bing Wang,Zhongkai Zhou,Guohua Zhao
BACKGROUND The coexistence of non-starch polysaccharides and resistant starch (RS) impacts the physiological functions of dietary fiber, especially the availability of dietary fiber with some specific structures (e.g. insoluble dietary fiber, IDF). Therefore, three complexes with different ratios of RS/IDF from tiger nuts were prepared, followed by an investigation of their corresponding physicochemical and structural properties, as well as the regulatory role in gut microbiota. RESULTS The results indicated that the complex with RS/IDF ratio of 5/95 (H-IDF) had the greatest water retention, water swelling and oil retention capacities. All three complexes had a similar amylopectin/amylose ratio, which attenuated the impact on microbial fermentation. However, the complex with RS/IDF ratio of 40/60 (L-IDF) had the greatest potential to promote microbial fermentation demonstrated by severe morphological damage. Furthermore, the fermentation of L-IDF led to the greatest generation of acetate and butyrate, but the lowest generation of isobutyrate. Meanwhile, the fermentation of L-IDF enhanced Prevotella abundance, accompanied by a reduced Firmicutes/Bacteroidetes ratio and pathogenic bacteria in terms of Proteobacteria and Escherichia-Shigella . The increased butyrate levels during 24 h fermentation might be primarily due to the enhanced abundance of Faecalibacterium in the early phases and Bifidobacterium in the later phases. The further analysis of functional prediction consistently supported a significantly up-regulated carbohydrate metabolism and down-regulated amino acid metabolism following L-IDF fermentation. CONCLUSION This study might highlight a new approach for designing complex carbohydrates with targeted intestinal health functions via the regulation of the RS/IDF ratio. © 2026 Society of Chemical Industry.
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CHEMISTRY & BIODIVERSITY
·
2026
·Vol. 23
·期 3
·e03104
·
IF 2.9
Yingjian Lu,Le Li,Zhuolun Xin,Xiangfei Li
UC is a globally escalating intestinal disorder with limited safe and effective interventions. This study investigated the synergistic therapeutic effects and mechanisms of Lactobacillus johnsonii 46 ( L. johnsonii 46) (a feruloyl esterase-producing strain) and rice bran (LJRB) on DSS-induced UC in C57BL/6J mice. The animal groups were divided into control group (CON), DSS group (MOD), sulfasalazine group (SUL), rice bran group (RBN), L. johnsonii 46 group (LAJ), and LJRB treatment group (RBL). The organ index, disease index, and biochemical indicators of mice were measured, the histopathology of the colon was analyzed. The expression of inflammatory factor, tight junction protein and TLRs/TRAF6/NF-κB signaling pathway genes were detected by Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR). LJRB supplementation exerted superior protective effects compared to single rice bran (RBN) or L. johnsonii 46 (LAJ) intervention: it significantly alleviated DSS-induced weight loss (RBL group: 1.46 ± 0.21 g vs. MOD group: ∼3 g, p < 0.05), restored colon length, and reduced the disease activity index (DAI) by ∼50%. Biochemical and molecular analyses showed LJRB remarkably suppressed serum pro-inflammatory cytokines (IL-1β, TNF-α, IL-6; 40%–60% reduction vs. MOD group) while elevating anti-inflammatory IL-10 (∼35% increase), enhanced colonic antioxidant capacity (reduced MDA by ∼30% and increased SOD, GSH, GSH-Px by 25%–40%), and enriched cecal short-chain fatty acids (SCFAs) with acetic acid (0.99 µmol/g), propionic acid (0.31 µmol/g), and butyric acid (0.21 µmol/g) significantly higher than the MOD group. Mechanistically, LJRB synergistically inhibited the TLRs/TRAF6/NF-κB signaling pathway, as indicated by downregulated mRNA expression of TLR4, MyD88, IKKβ, and NF-κB p65 (30%–50% reduction vs. MOD group) and decreased phosphorylation of IKKβ, IκBα, and NF-κB p65 proteins. Histopathological observations confirmed LJRB preserved colon tissue integrity, reduced goblet cell loss, and alleviated mucosal erosion and edema. Collectively, these findings demonstrate LJRB alleviates UC through multi-targeted mechanisms (anti-inflammation, antioxidation, SCFA production promotion, and nuclear factor kappa-B (NF-κB) pathway inhibition), highlighting its potential as a novel natural dietary supplement for UC prevention and management. Graphical Synergistic protective effects of rice bran combined with Lactobacillus johnsonii 46 on DSS-induced ulcerative colitis in mice: Evaluated by clinical, biochemical, histopathological and molecular biological assays.
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JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Chenqing Zhang,Juan Zhang,Zhiyu Zhang,Jing Yan,Zhuoyue Hou,Shusheng Zhang,Kai Hu
Short-chain fatty acids (SCFAs) are key biomarkers of gut microbiota activity and are implicated in various metabolic, inflammatory, and neurological diseases. This study fabricated a phenothiazine-based hyper-crosslinked polymer (PTZ-HCP) and applied it as a solid-phase microextraction (SPME) fiber coating for the analysis of nine SCFAs in rat feces by gas chromatography with flame ionization detection (GC-FID). The prepared PTZ-HCP was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, N 2 adsorption-desorption measurements, and thermogravimetric analysis. These analyses confirmed its successful synthesis and revealed a porous structure, high specific surface area, and excellent thermal stability. Owing to these structural advantages and the capability for multiple functional groups, the PTZ-HCP coatings demonstrated outstanding extraction efficiency and high adsorption capacity for SCFAs. An SPME/GC-FID method using PTZ-HCP coated fibers were established and validated. The validation results demonstrated significant advantages, including a wide linear range (1.0 × 10 -3 -0.50 μg·mL -1 for 2-methylvaleric acid; 1.0 × 10 -3 -2.0 μg·mL -1 for 4-methylvaleric acid), low LODs (3.0 × 10 -4 μg·mL -1 for 2-methylvaleric acid and 4-methylvaleric acid), and good precision (≤ 9.5%). This work presents a novel SPME coating material that effectively addresses key challenges in the extraction and analysis of SCFAs in rat fecal samples. Moreover, it verifies that Coptis chinensis modulates gut microbiota by altering SCFA levels, thereby offering important insights for research on the pathological mechanisms and treatment of Parkinson’s disease.
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