Scientific Reports
·
2024
·Vol. 14
·期 1
·1-18
·
IF 3.8
Zhang Jing,Xin Hongmei,Wang Wuji,Li Yanyi,Wu Riga,Wei Lisi,Su Si,Wang Xiaohong,Wang Xiujuan,Wang Xiaojuan,Li Li,Hu Rilebagen
Lactoferrin is a natural multifunctional glycoprotein with potential antidepressant-like effects. However, the mechanism of its antidepressant effect has not been explored from the perspective of gut flora metabolism. Therefore, we employed both 16S rDNA gene sequencing and LC–MS metabolomics analysis to investigate the regulatory effects and mechanisms of lactoferrin in a rat model of depression. After one week of acclimatization, twenty-four 7-week-old male Sprague–Dawley rats were randomly and equally assigned into three groups: the control group, the model group, and the lactoferrin intervention group. The control group rats were housed under standard conditions, while the rats in the model and lactoferrin intervention groups were individually housed and exposed to chronic unpredictable mild stress for 44 days simultaneously. The lactoferrin intervention group was provided with water containing 2% lactoferrin (2 g/100 ml). Behavioural tests were conducted at week 7. Upon completion of the behavioral tests, the rats were anesthetized with isoflurane, humanely euthanized using a rat guillotine, and tissue samples were collected for further experiments. The results indicated that lactoferrin intervention led to an increase in sucrose solution consumption, horizontal movement distance, number of cross platforms, and residence time in the target quadrant. Additionally, it resulted in an increase in jejunal tight junction protein ZO-1 expression and a suppression of serum expression of inflammatory factors, Lipopolysaccharide and Diamine oxidase. In summary, lactoferrin can regulate the metabolic disorder of intestinal flora, reduce intestinal permeability, and further regulate the metabolic balance of hippocampal tissues through the microbiota-gut-brain axis. This process ultimately alleviates the depression-like behavior in rats.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qianqian Yu,Xiaohan Sun,Meiying Wu,Zejun Pan,Jing Chen,Zhaolin Yang,Xin Li,Yudong Li,Dexiu Min,Xiaodong Li,Chengyu Wang
With the advancement of technology, the production of domestic sewage and industrial wastewater containing dyes are increasing steadily. In the evolutionary process of catalytic reduction wastewater, recyclability and homogenization are still puzzles. Herein, a wood-derived cellulose catalytic system with hierarchical pore structure was proposed based on chlorite-alkali method for efficient catalytic reduction on 4-nitrophenol (4-NP). The chlorite-alkali hydrolysis process played a significant role in enhancing channel connectivity and hydrophilicity of balsa (BS, O. pyramidale ) when removing lignin and hemicellulose. The results of cumulative complete intrusion and extrusion showed that the porosity of BS increased from 76.07 % to 92.58 % after removing components. A universal in-situ constructed tactic of PdNPs supported on a dehemicellulose BS (DHBS) without external reducing agent. Additionally, the superhydrophilic hierarchical porous wood-derived cellulose structure had a synergistic effect with plasmonic enhancement of PdNPs on the catalytic reduction of 4-NP, resulting in reducing 4-NP rapidly, which achieving a reduction efficiency of 90 % in the 90 s with the rate constant of 1.51 min −1 . The approach addressed the issue of low catalytic metal particle load and hider catalytic activity resulting from the limited thickness and porosity, and has a good application prospect in wastewater treatment.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Ruling Tang,You Luo,Yasmina Sultanbawa,Yongguang Huang
ALRP3 is a rapidly fermentable pectin, while USRP2 is a slowly fermentable one. • Repeated dosing with either pectin was conducive to SCFA production. • ALRP3 preferentially enriched butyrate-producing bacteria. • USRP2 specifically promoted Bifidobacterium and Phocaeicola . This study investigated how gut microbiota responds to repeated interventions with two structurally distinct pectic polysaccharides (ALRP3 and USRP2) isolated from red raspberries and how structural variations influence fermentation outcomes. The low-molecular-weight and less branched ALRP3 was rapidly fermentable, while high-molecular-weight and more branched USRP2 was slowly fermentable. Both pectic polysaccharides modulated gut microbiota and promoted SCFA levels, and these effects were significantly influenced by polysaccharide structure, dosing cycles, and their interaction. During fed-batch fermentation, the substrates were initially added at 0 h and subsequently supplemented at 12, 24, and 36 h, resulting in four substrate additions in total. Following repeated supplementation, the fecal microbiota gradually formed new stable community structures, and SCFAs steadily accumulated, with both pectic polysaccharides reaching the peak total SCFA production after the third supplementation. They enriched similar beneficial bacteria but also induced distinct flora. ALRP3 specifically boosted butyrate-producing bacteria and butyrate production, while USRP2 enriched specific Bifidobacterium strains. These results support the targeted design of pectic polysaccharide-based microbiota regulation strategies. Download: Download high-res image (206KB) Download: Download full-size image
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Materials Today Nano
·
2026
·
IF 7.6
Yu Xiao,Yuheng Wang,Jingjing Zheng,Song Gao,Haojie Li,Yingyuan Zhao,Xiubo Xie,Chuanxin Hou,Wei Du
Fabricating electromagnetic coupling carbon-based aerogels with tightly bound and uniformly distributed components is a proven strategy for improving electromagnetic wave absorption (EWA) performance. Herein, highly ordered porous cobalt/cobalt (II) oxide/carbon (Co/CoO/C) aerogels were successfully fabricated via ice-templated freeze casting coupled with one-step carbonization, relying on the complexation reaction between cobalt ions and chitosan. The optimal sample, Co/CoO/C-1.0, achieves a minimum reflection loss (RL m ᵢ n ) of −58.15 dB and an effective absorption bandwidth (EAB) of 6.48 GHz at a thickness of 2.2 mm. Additionally, the aerogel exhibits excellent radar stealth performance (with a significant reduction in radar cross-section, RCS) and thermal insulation properties. Gradient structural design effectively extends the effective absorption bandwidth (EAB) to 11.23 GHz. Mechanism analysis reveals that the outstanding EWA performance of these aerogels stems from the synergistic effect of diverse attenuation pathways, including multiple scattering, dipole polarization, interfacial polarization, conduction loss and magnetic resonance. The regulation of cobalt content effectively achieves an optimal balance between impedance matching and electromagnetic loss. This multifunctional Co/CoO/C aerogel integrating EWA, radar stealth and thermal insulation capabilities possess great application prospects under complex service conditions and provide critical guidance for the rational design of carbon-based EWA absorbers. The highly ordered porous electromagnetic coupling Co/CoO/C aerogel was synthesized. The optimized aerogel achieves a minimum reflection loss (RL m ᵢ n ) of −58.15 dB and an effective absorption bandwidth (EAB) of 6.48 GHz at a thickness of 2.2 mm. The gradient multilayer structural design effectively broadens the effective absorption bandwidth (EAB) to 11.23 GHz. Download: Download high-res image (393KB) Download: Download full-size image
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 3.5
Shoukang Xiao,Ze Qin,Junying Chen,Liyu Chen,Kui Shen
A novel strategy is developed to heterogenize homogeneous cocatalysts. • Optimal nanoreactors are highly active and size-selective for CO 2 fixation. • The catalytic mechanism of CO 2 cycloaddition over OM@x-m-UiO-66/PBr is revealed. The cycloaddition of CO 2 with epoxides represents a promising strategy for mitigating CO 2 emissions. However, most heterogeneous catalytic systems still rely on homogeneous halogen-based cocatalysts to achieve desirable activities, which significantly complicates subsequent product purification and separation. Herein, we report a facile strategy to heterogenize homogeneous Br-based cocatalysts by encapsulating them into within stable UiO-66-based core–shell nanoreactors for efficient CO 2 fixation. Specifically, ordered mesoporous Ce-based UiO-66 (OM-UiO-66) was first synthesized via a soft-template method. The homogeneous Br-based cocatalyst was then adsorbed into the mesopores of OM-UiO-66, followed by epitaxial growth of a microporous Ce-based UiO-66 shell with controllable thickness to complete the encapsulation, thereby yielding a size-selective nanoreactor that possesses both 0.6 nm sieving channels and 10 nm reaction channels. Importantly, the synergistic interactions among the high concentration of the cocatalyst confined in the mesopores, the abundant Lewis acidic Ce sites on the pore walls, the mesoporous microenvironment that facilitates the enrichment of CO 2 and epoxide substrates, and the judiciously controlled thickness of the microporous shell collectively impart the as-prepared nanoreactor with high catalytic activity, excellent recyclability, and remarkable substrate size selectivity for the cycloaddition of CO 2 with epoxides under ambient conditions. This work not only develops a novel strategy for the efficient fixation of CO 2 via the heterogenization of homogeneous catalysts with a novel MOF-based core–shell architecture, but also provides a compelling paradigm for the heterogenization of other homogeneous catalysts. The heterogenization of homogeneous Br-based cocatalysts is realized by encapsulating them into a new kind of stable UiO-66-based core–shell nanoreactors for efficient and size-selective CO 2 cycloaddition with epoxides under ambient conditions. Download: Download high-res image (370KB) Download: Download full-size image
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Advanced Materials Technologies
·
2026
·
IF 6
Yanghuan Mao,Zhuoyun Liu,Chun Wang,Yuxin Peng,Aijia Ren,Cairong Liu,Muxi Ai,Tianhong Zhu,Pengfei Lian,Wu Bin Ying,Zhe Yu
Flexible hybrid electronics (FHEs) have widespread potential applications in wearable sensing, in particular for practical monitoring of human pulses. However, FHEs suffer from insufficient conformation with complex and dynamic skin surfaces. Resulting motion artifacts severely limit the long-term reliability of pulse monitoring under various exercise conditions. This underscores the importance of developing system-level mechanical stretchability. Herein, we propose a technical route to fabricate intrinsically stretchable hybrid electronics via liquid metals (LMs) patterning. Taking advantage of the selective wettability and microoxidation of LMs, a semicured polymer is used as a soft transfer medium to achieve high-fidelity LMs patterning at a device yield of 96.3%, with the resolution of 100 µm. Importantly, this method can be scaled up through compatibility with mature roll-to-roll flexible circuit printing technology. Our method enables the fabrication of stretchable FHEs, which can form a conformal interface with the skin and undergo adaptive deformation during motion (sitting, walking, and running), allowing real-time accurate acquisition of pulse signals by photoplethysmographic sensing. Our work provides a robust technical pathway for advancing FHE systems and boosts the development of wearable pulse monitors.
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Surfaces and Interfaces
·
2026
·
IF 6
Xiaolong Yao,Weihong Zhang,Zhengyang Feng,Meiqin Qu,Chun Wang,Longchun Zhong,Dengchao Liu,Wei Wang,Guotao Xiao,Qingwei Bu,Yingxue Sun,Gang Li,Xinyue Liang,Le Wang,Xiaoming Wei
COF-V rapidly adsorbs 2,4-DCP, CAP and DCF-Na within 30 min. • Maximum capacities of 665.54–773.65 mg∙g −1 were achieved. • Ternary mixtures exhibit a non-additive synergistic compensation effect. • Imine sites and hierarchical pores enable stable, reusable adsorption. Efficient capture of structurally diverse chlorinated organic compounds (COCs) from mixed aqueous matrices requires adsorbents that combine accessible porosity with chemically differentiated binding environments. Here, we report an imine-linked covalent organic framework, COF-V, that integrates a conjugated pore surface, imine-rich polar sites and hierarchical micro-/mesoporosity, with a Brunauer-Emmett-Teller surface area of 752.73 m 2 ∙g −1 and dominant pore sizes of 1.92 and 3.78 nm. COF-V rapidly adsorbed 2,4-dichlorophenol (2,4-DCP), chloramphenicol (CAP) and diclofenac sodium (DCF-Na), reaching equilibrium within 30 min and exhibiting Langmuir capacities of 680.84, 773.65 and 665.54 mg∙g −1 at 293 K, respectively. In binary mixtures, competition depended strongly on molecular size and functional-group complementarity. In the ternary system, however, the observed adsorption-retention ratios of 77.15 %, 94.66 % and 83.43 % exceeded those predicted from independent superposition of the corresponding binary inhibition effects, giving compensation coefficients of 1.021, 1.014 and 1.072. This non-additive synergistic compensation arises from complementary occupation of confined and wider pore domains and differentiated use of aromatic and polar binding sites, rather than from adsorption exceeding the corresponding single-solute capacities. X-ray photoelectron spectroscopy and density functional theory calculations reveal a cooperative mechanism involving pore confinement, π-π and n-π interactions, hydrophobic association, hydrogen and halogen bonding, and speciation-dependent electrostatics. COF-V preserved its characteristic framework structure after acid and alkali exposure and retained cycle stability factors above 0.85 after five regeneration cycles. These results identify pore-molecule complementarity and spatially differentiated interfacial interactions as design principles for mitigating competitive adsorption in multicomponent aqueous systems. Download: Download high-res image (230KB) Download: Download full-size image
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MEASUREMENT
·
2026
·
IF 6.1
Qi-Zhi Cai,Jia-Qi Wang,Ben Li,Na-Na Du,Hua-Long Du,He-Yun Zhang,Jia-Jun Diao,Qi Wang
A PbF 2 -assisted dielectric modulation strategy was proposed for enhancing SPR response in U-shaped fiber sensors. • The PbF 2 layer achieved a 1.97-fold enhancement in local electric-field intensity through interfacial dielectric modulation. • The experimentally fabricated coating showed excellent agreement with the optimized 70 nm design predicted by FEM simulations. • The proposed sensor achieved an average RI sensitivity of 8483.58 nm/RIU over 1.3381–1.3778. • A maximum sensitivity of 14195.32 nm/RIU and an experimental FOM of 40.42 RIU −1 were obtained. To improve the sensitivity of fiber-optic SPR sensors, a lead fluoride (PbF 2 ) sensitizing layer was introduced into a U-shaped fiber SPR configuration as a fluoride-based dielectric modulation layer. The proposed sensor was designed using a U-bent multimode fiber integrated with a PbF 2 -modified layer and was evaluated by FEM simulation and experimental testing. In the FEM simulation, the local electric field near the sensing interface became stronger after adding the PbF 2 -containing layer, with a peak intensity about 1.97 times higher than that of the pure-Au structure. The stronger electric field is mainly associated with the change in the effective dielectric environment and the redistribution of the evanescent field at the Au/analyte interface after introducing the PbF 2 -containing layer. The wide band gap and optical transparency of PbF 2 also make it suitable as a low-loss dielectric sensitizing layer. In the simulation, a PbF 2 thickness of 70 nm gave the best overall response. Experimentally, the sensor showed an average RI sensitivity of 8483.58 nm/RIU over the RI range of 1.3381–1.3778. For comparison, the pure-Au U-shaped sensor had a sensitivity of 4207.54 nm/RIU, corresponding to a 2.02-fold improvement after PbF 2 modification. In the high-RI range of 1.3669–1.3778, the sensitivity reached 14,195.32 nm/RIU, which was 3.37 times higher than that of the pure-Au sensor. The sensor also showed good stability under the tested conditions, with a thermal drift coefficient of 0.4867 nm/°C from 30 °C to 60 °C and an average sensitivity RSD of 0.6181% in repeated RI measurements. The PbF 2 -containing layer therefore improves the RI response of the U-shaped fiber SPR sensor through interfacial dielectric modulation.
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POLYMER
·
2026
·
IF 5.1
Shang Peng,Zhaonan Wang,Ding Huang,Kangjie Zhou,Yong Liu,Fan Cheng,Hai Liu
Cellulose nanofiber (CNF) aerogels are promising sustainable porous materials, but their mechanically weak sheet-like networks and intrinsic flammability limit practical deployment under demanding conditions. Herein, we report a minimal-polymer interfacial densification strategy that uses only approximately 2 wt% aramid nanofibers (ANFs) to reinforce and fire-protect CNF aerogels. Through an in situ sol–gel–coating process, the ANF sol is converted into a compact interfacial coating on CNF sheets, yielding a hierarchical ANF–CNF–ANF sandwich skeleton that stabilizes weak inter-sheet junctions while preserving the ultralight porous structure. This optimized skeleton endows the aerogel with a compressive strength of 219 kPa and a modulus of 618 kPa, corresponding to 2.6- and 15-fold improvements over pristine CNF aerogel, respectively, while maintaining a low thermal conductivity of 37.1 mW m −1 K −1 . The ANF-modified aerogel also exhibits self-extinguishing behavior, an increased limiting oxygen index, and reduced heat and smoke release, demonstrating improved fire resistance. This study provides a facile minimal-polymer interfacial engineering route for developing mechanically robust, fire-safe, and thermally insulating bio-based aerogels.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Wang Yi-Wei,Zhang Jing-Hua,Liu Ming,Liu Ya-Dong,Ji Sheng-Xiang
Invasive fungal infections remain a significant global health threat, and the development of antifungal agents that selectively target fungi remains a critical challenge. This study investigates hyperbranched polylysine (HPL) with tunable molecular weight and charge density as a potential selective antifungal candidate. HPL1, with the lowest molecular weight, showed negligible antimicrobial activities, while HPL3, with the highest molecular weight, exhibited broad-spectrum antimicrobial effects against both bacteria and fungi. Notably, HPL2, the mediate molecular weight, demonstrated selective antifungal activities against clinically relevant Candida species, including C. albicans , C. krusei , C. parapsilosis , C. tropicalis , and C. glabrata . This selectivity is mainly ascribed to its optimal zeta potential and appropriate hydrodynamic size, enabling HPL2 to penetrate through the fungal cell wall while stuck in bacterial cell envelopes. Mechanistic studies revealed that HPL2 initially adheres to the fungal surfaces induced via electrostatic interactions, then passively penetrates the fungal cell wall, disrupts membrane integrity, induces intracellular damage, and ultimately leads to cell death. Furthermore, HPL2 exhibited excellent biocompatibility and in vivo therapy efficacy with minimal disruption to host gut microbiota. These results highlight HPL2 as a promising antifungal agent with potent efficacy and favorable safety, which can be easily synthesized at kilogram scale.
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ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·12080-12097
·
IF 5.2
Wang Yiran,Gao Liwen,Cao Lulu,Zhang Long,Zhang Hejin,Li Junyin,Tong Zhaohui,Wang Keran,Yang Yuechao,Zhang Shugang
In this work, a castor oil-based
polyurethane-based controlled-release
urea modified with dehydroabietic acid-grafted chitosan was prepared,
overcoming the poor hydrophobicity of traditional coatings. Dehydroabietic
acid-grafted chitosan (HNCSDA) was synthesized and incorporated into
castor oil-based polyurethane to fabricate modified coated fertilizers.
The chemical structure, micromorphology, thermal stability, hydrophobicity,
nitrogen release, phytotoxicity and antifungal performance of the
coatings were systematically characterized. HNCSDA improved coating
compactness and continuity, reduced structural defects and formed
an effective diffusion barrier. Increasing the HNCSDA dosage from
0% to 20% increased the hydrophobicity and thermal stability of the
coating; the water contact angle increased from 80.6 ° to 116.7 ° ,
and the release longevity increased by 15.54%. In the absence of maize
phytotoxicity and effectiveness against Botrytis cinerea and Rhizoctonia solani , the modified coatings increase
seedling growth, offering a feasible route to eco-friendly biobased
slow-release antifungal fertilizers for sustainable agriculture.
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LANGMUIR
·
2026
·Vol. 42
·期 30
·22403-22412
·
IF 4.4
Cai Jixiang,Zhao Haiyan,Qin Jiannan,Li Mingfu,Zhang Pingjun,Jiang Liqun
Metal–organic frameworks (MOFs) represent promising
platforms
for enzyme immobilization; however, the interplay between surface
chemical heterogeneity and defect density in dictating adsorption
efficiency remains poorly understood. Herein, we systematically investigated
the immobilization of glucose isomerase (GI) on three UiO-66 variants,
indicating that the acetic acid (AA)-modified UiO-66 (UiO-66-AA) achieved
the highest enzyme loading efficiency of 92.8% and activity recovery
of 84.2%, markedly outperforming both pristine UiO-66 and formic acid-modified
UiO-66 (UiO-66-FA). The resulting UiO-66-AA-GI composite achieved
the highest fructose yield of 37.7% with an excellent selectivity
of 94.8% under optimal conditions and retained stable performance
over five recycling cycles. Comprehensive characterization demonstrates
that acetate modification generates a distinctive chemical mosaic
surface, in which hydrophobic methyl domains and residual carboxyl
groups synergistically enable multimodal adsorption via hydrophobic
interactions, hydrogen bonding, and weak electrostatic forces. This
unique surface chemistry, combined with the largest external surface
area, maximizes GI loading while preserving the catalytic activity.
These findings establish that rationally designed surface chemical
mosaics with complementary interaction modes are critical for achieving
high-efficiency enzyme immobilization in MOF-based biocatalysts.
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