JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 4
·146
·
IF 3.5
Li Wenjing,Ma Haihong,Yang Pingfeng,Zhou Zhengfa,Xu Weibing,Ren Fengmei
With the advancement of the semiconductor industry, UV-induced adhesion- reducing adhesives have found widespread application in the manufacturing and processing of wafers. In this paper, a terminal hydroxyl dimer acid-glycidyl methacrylate (DA-GMA) trimer, which is named as DG, was first synthesized by dimer acid (DA) and glycidyl methacrylate (GMA). Subsequently, a bio-based polyurethane UV adhesion-reducing adhesives, which is noted as DGI-UV, was prepared using DG, isophorone diisocyanate (IPDI), cis-2-butene-1,4-diol and photoinitiators, respectively. The correct structure of DG was confirmed via Fourier Transform Infrared Spectroscopy (FT-IR) and Nuclear Magnetic Resonance Hydrogen Spectroscopy (¹H NMR). The effects of NCO/OH molar ratio, the content of cis-2-butene-1,4-diol and photoinitiator (type and content) on the performance of DGI-UV were analyzed. The results indicated that the optimal comprehensive performance of DGI-UV was achieved when the NCO/OH molar ratio was 1.3, the content of cis-2-butene-1,4-diol was 10 wt% of DG, and diphenyl (2,4,6- trimethylphenylformyl) phosphorus oxide (TPO) was selected as the photoinitiator at a content of 3 wt% of the total amount of DA and GMA. Under the optimized conditions, the 180° peel strength of DGI-UV decreased from 25.90 N/25 mm before UV irradiation to 0.25 N/25 mm after UV irradiation. Laser confocal 3D measurement microscope images revealed that the surface roughness of the adhesive film increased from 0.04 to 1.28 after UV irradiation. The bio-based polyurethane adhesion- reducing adhesives developed in this study offers both enhanced initial tack and superior peel performance, providing an eco-friendly and efficient new material option for ultra-thin wafer temporary bonding applications.
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ANIMAL REPRODUCTION SCIENCE
·
2026
·
IF 2.6
Mengting Huang,Aixia Li,Rongjiang Ma,Yi Gao,Yuxuan Jia,Xiangyu Shen,Minghong Xie,Liang Yang,Kangsen Shen,Zheng Ao,Yiyu Zhang,Xiang Chen,Ting Gong
Male infertility is increasingly linked to impaired spermatogenesis, with emerging evidence implicating the umami taste receptor T1R1/T1R3 in male reproductive regulation. This study explored its role in regulating autophagy during spermatogenesis in Xiang pigs. Immunofluorescence confirmed T1R1/T1R3 co-localization in spermatogenic cells. Knockdown of TAS1R3 by RNAi triggered robust autophagy, characterized by increased autophagosomes, mitochondrial swelling, a significant accumulation of 2 C (diploid, spermatogonia) cells (increasing by ~21%), a corresponding reduction 4 C (tetraploid, spermatocytes) cells (decreasing by ~11%), a marked upregulation of Beclin 1 protein (by ~8.0-fold) and the LC3-II/LC3-I ratio (by ~2.9-fold), downregulation of mTOR , and suppression of key spermatogenic genes ( POU5F1 , SYCP3 , STRA8 ). Conversely, the receptors activation by its natural ligand L-glutamate (L-Glu) suppressed autophagy, reducing Beclin 1 levels and the LC3-II/LC3-I ratio to approximately 0.7-fold of the control. This activation improved cellular function, upregulated mTOR, increased 1 C (haploid, spermatids) cell populations, and downregulated STRA8 . Under H₂O₂-induced autophagy, L-Glu restored T1R3 expression, thereby reversing excessive autophagy and calcium overload, and rescuing the expression of autophagy-related ( BECN1 , mTOR ) and spermatogenesis-related genes ( SYCP3 , STRA8 ). In vivo experiments, dietary supplementation with 0.5% L-Glu significantly increased seminiferous tubule diameter and epithelium thickness in Xiang pig testes, upregulating T1R1 and the autophagy substrate p62/SQSTM1. In conclusion, T1R1/T1R3 regulates spermatogenesis by modulating autophagy. Activation by L-Glu mitigates autophagic damage and promotes spermatogenesis, offering a novel strategy for enhancing male fertility by targeting T1R1/T1R3.
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NEUROLOGICAL RESEARCH
·
2026
·
IF 1.9
Liang Chen,Shuai Tan,Jianwei Wang,Xiang Shi,Zhou Zhang,Jinjiang He,Haixing Wang
Background Acute spinal cord injury (SCI) results in irreversible neurological deficits. We hypothesized that local transplantation of bone marrow mesenchymal stem cells (BMSCs) combined with erythropoietin (EPO) would inhibit glial scarring and accelerate functional recovery.Objective To quantify the therapeutic efficacy and underlying mechanisms of BMSCs+EPO versus BMSCs alone in a rat model of acute SCI.Methods Forty SD rats (T10 Allen 60 g·cm impact) were randomized to sham, SCI, SCI+BMSCs, or SCI+BMSCs+EPO (n = 10). BMSCs (5 μL, 2 × 105 cells μL−1) were micro-injected into the lesion epicenter at 1 h post-injury; EPO (5 000 IU kg−1) was given intraperitoneally 1 h after surgery. BBB scores were obtained at 1 d, 2 w and 4 w. Western blot, qPCR, histopathology, immunohistochemistry, ELISA, and in vitro cell viability/CCK-8 assays were performed.Results At 4 weeks, BBB scores in the BMSCs+EPO group reached 12.7 ± 1.5, representing a 54% increase over the BMSCs-alone group (8.3 ± 0.7, p = 0.003) and a 179% increase over the SCI group (4.6 ± 0.6, p < 0.001). Combination therapy significantly reduced glial fibrillary acidic protein (GFAP) and vimentin expression, decreased pro-inflammatory cytokines (IL-1β, TNF-α) and chondroitin-sulfate proteoglycans, while elevating BDNF, GDNF and IGF-1 levels. Histological cavitation was reduced by 42% versus BMSCs alone. In vitro, EPO rescued LPS-induced BMSC death, suppressed astrocyte over-proliferation, and promoted PC12 neurite outgrowth via enhanced BDNF/GDNF secretion.Conclusion BMSCs+EPO exerts synergistic neuroprotective effects, achieving superior locomotor recovery compared with BMSCs monotherapy, and represents a promising adjuvant strategy for acute SCI.
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Journal of Aquatic Food Product Technology
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2026
·
IF 1.2
Hanbing Xiao,Huijuan Wang,Can Zhao,Zhijie Zheng,Xiaoqiang He,Yingting Zhao,Yuting Tian
This study examined the effects of different impregnation methods and solutions on texture of soft-pack (retort) canned abalone. Results showed that room temperature and pressure immersion, with either pure water or sodium alginate, did not significantly affect abalone meat hardness. Ultrasonic immersion caused myofibril rupture, leading to a looser structure. Combining sodium alginate with ultrasonic immersion decreased hardness. Vacuum immersion utilized negative pressure to create larger voids, accelerating sodium alginate absorption and enhancing water retention, achieving tenderization without lipid oxidation. Overall, sodium alginate and vacuum impregnation proved most effective for improving abalone texture.
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HISTOLOGY AND HISTOPATHOLOGY
·
2026
·
IF 2.2
Min Zhang,Yue Chen,Lü Ren,Jinzhi Xia,Lu Tao,Jianguo Hu,Jing Li,Xiaofeng Zhang,Zhijun Geng,Yueyue Wang,Xue Song
Objective: To enhance the quality and efficiency of paraffin-embedded pathological section preparation, this study aims to investigate the potential benefits of utilizing the ultrasound oscillation flotation method (UOFM) for section spreading. Methods: Specimens of various tissue types were processed using both the conventional and UOFM for section spreading. The presence of wrinkles or damage during this process was assessed through HE staining, with the number of wrinkles being quantified. The optimal frequency and power density for section spreading were determined by evaluating the qualified rate of sections at various frequencies and power densities, and the average time required for section spreading was compared between the two methods. Results: The results showed that pathological sections of various tissue types rarely showed paraffin dissolution and section breaking after the UOFM. HE staining also revealed that the group exhibited significantly reduced wrinkling and a more intact tissue structure compared with the conventional method group ( p <0.05). Statistical analysis further indicated that the highest rate of section qualification was achieved when employing a frequency of 33 kHz with a power density of 60% or a frequency of 40 kHz with a power density of 75% ( p <0.05). Additionally, the mean duration of section spreading in the group utilizing the UOFM was significantly reduced ( p <0.05). Conclusions: The UOFM effectively maintains the structural integrity of paraffin pathological sections, significantly enhancing the quality of sections and optimizing section preparation efficiency.
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Cancer Communications
·
2026
·
IF 28.4
Nianke Zang,Jinfeng Gan,Ye Chen,Zheng Huang,Chichu Xie,Junlong Dang,Changyuan Huang,Linjie Yang,Xuelian Chen,Guangli Rong,Jianbo Sun,Yiming Shao,Julie Wang,Guangying Qi,Yu Liu,Song Guo Zheng
Background: T-LAK cell-originated protein kinase (TOPK), a serine/threonine kinase, is aberrantly overexpressed in human tumors and promotes malignant proliferation. Melanoma is a highly immunogenic tumor in which CD8+ T cell-mediated cytotoxicity is usually less effective in tumor control and responsive to immune checkpoint blockade. It is unclear whether the expression and functional characterization of TOPK within the immune cells affect the tumor microenvironment (TME) in patients with melanoma. This study aims to elucidate the expression pattern and immunoregulatory function of TOPK in CD8+ T lymphocytes during antitumor responses. Methods: Public single-cell RNA-sequencing (scRNA-seq) dataset analysis and flow cytometry assessed TOPK in tumor-infiltrating CD8+ T cells from patients with melanoma. Genetic deletion and pharmacological inhibition of TOPK using HI-TOPK-032 tested T cell-mediated melanoma control. Flow cytometry and tumor cell coculture killing assays measured effector release and target-cell apoptosis. Mechanistic analyses included assessment of interferon regulatory factor 5 (IRF5) expression, together with combination therapy using a programmed cell death protein 1 (PD-1)-blocking antibody in vivo. scRNA-seq of tumor-infiltrating lymphocytes (TILs) from Topkfl/fl and Cd8CreTopkfl/fl mice was also performed to define TOPK-dependent immune programs within the melanoma TME. Results: Single-cell transcriptomes identified a TOPK+ subset of tumor-infiltrating CD8+ T cells in melanoma, which was higher than that in normal lymph nodes (LNs), and exhibited suppressed cytotoxic and cytokine programs. CD8+ T cell-specific Topk deletion increased granzyme B (GzmB), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) secretion and improved tumor control. TOPK-deficient CD8+ T cells showed elevated activation-associated signaling pathways and immune effector gene expression. In murine TIL scRNA-seq, Cd8CreTopkfl/fl tumors exhibited increased effector and activation programs, reduced exhaustion and dysfunction programs, and enhanced immune crosstalk in the TME. Mechanistically, TOPK suppressed IRF5 expression and HI-TOPK-032 restored CD8+ T cell cytotoxicity in vitro and, with anti-PD-1, further inhibited tumor growth and increased intratumoral cytokine production. In human CD8+ T cells, enforced TOPK expression impaired cytotoxicity and cytokine secretion, reversed by IRF5 coexpression. Conclusions: These findings establish TOPK as the immune checkpoint limiting CD8+ T cell functionality in tumors and indicate the potential of TOPK inhibition as a strategy to augment T cell-based immunotherapies.
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BIOMASS & BIOENERGY
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2026
·
IF 7
Ge-liang Xie,Yu Luo,Kai-cheng Xia,Sheng-ren Li,Lujiang Xu,Zhen Fang
Aromatic amines, particularly aniline derivatives, serve as pivotal intermediates in the manufacture of dyes, pharmaceuticals, and polymers. However, their conventional synthesis remains heavily reliant on fossil feedstocks and frequently employs toxic reagents. The valorization of lignin presents a promising, renewable pathway to these valuable compounds, yet the reactivity of lignin-derived phenols varies markedly depending on their functional group substituents. Herein, a pronounced "promotion-inhibition dichotomy" is reported. Alkyl substituents substantially enhance reactivity-achieving a 44.3 mol% yield of aromatic amines from 4-propylphenol, representing a 34.7% increase over phenol. Conversely, methoxy groups exert a strong inhibitory effect in limiting the yield of aromatic amines from 4-propylguaiacol to only 11.0 mol%. Furthermore, Mo-Ga/HZSM-5 catalyst employed under NH 3 -H 2 atmosphere effectively doubled the yield of aromatic amines to 25.9 mol%. A sequential hydrodeoxygenation-amination strategy is further devised, boosting the yield to 34.1 mol%. Notably, by integrating this two-step strategy with a lignin-first biorefining approach, a 16.6 mol% of aromatic amines (based on lignin) could be achieved from birch. This study elucidates key reactivity principles in lignin valorization and demonstrates an integrated strategy that advances the sustainable production of aromatic amines from renewable biomass.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 33
·17791-17803
·
IF 3.9
Wang Qingguo,Li Liang,Yang Shuangqiao
Postconsumer recycled polyethylene (rPE) is commonly
downcycled
because degradation and mixed waste histories compromise its mechanical
reliability, creep resistance, and functional performance. Here, we
report an integrated upcycling strategy that combines dynamic covalent
cross-linking, solid-state shear milling (S 3 M), and solid-state
stretching to convert rPE into reprocessable, creep-resistant, high-strength,
and thermally conductive composites. Dynamic cross-linking reduced
the maximum creep strain at 80 ° C from 1.66% for rPE to 0.50%
for the optimized cross-linked sample. After adding 5 wt % graphite
nanosheets and applying a 3-fold stretching ratio, the optimized composite
achieved a tensile strength of 108.7 MPa and an in-plane thermal conductivity
of 2.55 W/(m·K), approximately 4.2 and 6.1 times higher than
the corresponding rPE-derived controls. The dynamic network enabled
remolding with high property retention, while the oriented graphite/polyethylene
structure improved resistance to photo-oxidative aging. This scalable
route provides a practical approach for producing durable functional
materials from recycled polyolefins.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhongxin Dong,Yanchao Yang,Dianfu Ren,Yanwei Xiao,Di Wu,Liangliang Pei,Yunhe Xing,Han Feng,Shengdao Wang,Guibin Wang
Closed-loop recycling of PAEK composites via dynamic imination strategy. • Intractable PAEK is converted into a soluble amorphous intermediate. • Continuous fibers are non-destructively recovered with >95% strength retention. • The amorphous intermediate can regenerate into PAEK resin. • Recycled matrix retains pristine thermomechanical performance over multiple cycles. The recycling of high-performance fiber-reinforced PAEK composites is hindered by a paradox: the chemical inertness and crystallinity that provide exceptional stability also make their deconstruction extremely difficult, while conventional harsh methods irreversibly degrade both fibers and resin matrix. Herein, we report a targeted structural reconstruction strategy that enables the mild amorphization and closed-loop recovery of high-value composite components. With PEEK as a model, ZnCl 2 is utilized to catalyze the targeted imination of carbonyl groups. As verified by rigorous density functional theory (DFT) calculations, this specific coordination significantly reduces the kinetic activation barrier, enabling the disruption of the dense crystalline structure under extraordinarily mild conditions. Crucially, this crystalline-to-amorphous transition fundamentally overcomes mass transfer limitations, enabling the non-destructive extraction of continuous reinforcing fibers while retaining >95% of their pristine mechanical properties. After fiber separation, acid-catalyzed hydrolysis triggers structural reconstruction of the PEEK molecular backbone, largely restoring its original semi-crystalline morphology and key thermomechanical properties. This versatile recycling platform exhibits broad applicability across PAEK-based materials with diverse molecular architectures and maintains stable performance over three consecutive recycling cycles. This work provides a promising strategy with potential for further process development of high-performance PAEK composites.
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Acta Biomaterialia
·
2026
·
IF 10.4
Xi Zeng,Nana Gong,Guangyu Zhang,Yanhong Lu,Mingdong Cheng,Xiaohan Fan,Yujie Wang,Anwei Huang,Chi Hu,Jing Wang,Jing Zhang,Ming Zeng,Ziyi Yu
Diabetic chronic wounds remain difficult to treat because hypoxia and insufficient regenerative signaling persist. Although live biotherapeutics offer a promising route to local oxygenation therapy, current methods largely support a single microbial function rather than coordinate microbial oxygenation with regenerative cues. Here, we report a hydrogel living therapeutic material in which a crosslinked hyaluronic acid matrix coordinates a living metabolic module of Synechococcus elongatus with a regenerative module of platelet-rich plasma (PRP). The matrix enables injectability and rapid gelation while supporting microbial metabolic activity and modulating the local retention and release of PRP-derived growth factors. The resulting material sustains oxygen generation and preserves the viability of the living module. Particularly, it reduces intracellular ROS accumulation, promotes fibroblast migration, and enhances endothelial tube formation in vitro. In diabetic wounds, it accelerates wound closure and improves re-epithelialization, collagen remodeling, and angiogenesis. Transcriptomic analysis further reveals coordinated regulation of stimulus-response, immune-related, and cytokine- and chemokine-associated pathways. This work establishes a living therapeutic material framework for integrating microbial oxygenation with regenerative signaling for pathological wound microenvironment remodeling. Statement of significance Diabetic wounds are difficult to heal because damaged tissues often lack both oxygen and regenerative signals. Current living wound therapies mainly focus on microbial oxygen production, but they rarely coordinate oxygen supply with growth-factor-mediated tissue repair. This study develops an injectable living hydrogel that combines photosynthetic Synechococcus elongatus with platelet-rich plasma in a hyaluronic acid matrix. The material continuously generates oxygen, retains and releases regenerative factors, reduces oxidative stress, and promotes cell migration, angiogenesis, collagen remodeling, and wound closure. By integrating metabolic oxygenation with regenerative signaling, this work provides a strategy for remodeling pathological wound microenvironments and designing living therapeutic materials for chronic tissue repair. Download: Download high-res image (320KB) Download: Download full-size image
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Polymers
·
2026
·Vol. 18
·期 17
·2106
·
IF 5.8
Yi Mao,Zhao Ke,Ying Ma,Hui Li,Zexu Hu
Phenolphthalein poly (aryl ether ketone) (PEK-C) is highly compatible with epoxy resin, which is applied in epoxy resin-based composites to improve their strength. Solution spinning and electrospinning techniques are often used to produce PEK-C fibers, but these techniques pollute the environment and are not productive. To address the above challenges, melt spinning may be employed, but due to the high degree of molecular chain entanglement and poor melt fluidity of PEK-C, melt spinning remains difficult. Herein, this study presents the continuous melt spinning of PEK-C fibers through rheology modulation and melt strength enhancement. A series of PEK-C samples with different molecular weights were prepared by adjusting the molar ratio of monomers. The influence of molecular weights on rheological properties was investigated via capillary rheology tests. PEK-C with molecular weight (2.01 × 104g/mol) was chosen, and the optimal spinning temperature was determined to be 370 °C. The as-polymerized PEK-C powder was compounded into pellets; subsequently, the PEK-C pellets with enhanced melt strength were continuously processed into fiber through melt spinning. The obtained PEK-C fibers possess high tensile strength (0.56 cN/dtex) and breaking strength (1.06 cN/dtex). The mechanical properties and molecular chain orientation of PEK-C fibers were also optimized by spinning process parameters. This work presents continuous melt spinning of PEK-C fibers via rheology modulation and melt strength enhancement, which resolve the environmental and low productivity issues.
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Journal of Water Process Engineering
·
2026
·
IF 6.6
Lixun Fan,Yonggang Zhao,Mingli Ye,Hongyun Niu,Yaqi Cai
NH₂-MIL(Fe) is grafted onto amino-functionalized NH₂-PS resin to gain micro-nanoscale adsorbent. • SMX adsorption is favorable at pH 5.2–8.0 with an adsorption capacity of 250.61 mg·g −1 . • Hydrogen bonding and electrostatic attraction are the driving forces for SMX adsorption. • The Fe(III) centers in MOF endow NH₂-PS@NH₂-MIL(Fe) Fenton-like catalytic activity. Sulfonamide antibiotics (SAs) are ubiquitous in the aquatic environment and difficult to remove using conventional wastewater treatment processes. Adsorption and Fenton-like oxidation are efficient techniques for the elimination of SAs from water. In this study, a novel hierarchical micro-nano structural adsorbent was synthesized by grafting Fe-based MOFs (NH 2 -MIL(Fe)) onto amino-functionalized polystyrene-divinylbenzene resin (NH 2 -PS). The physicochemical properties and structural features of the composite (NH 2 -PS@NH 2 -MIL(Fe)) were systematically characterized by SEM, EDS, XRD, FTIR, BET and XPS, confirming the successful immobilization of NH 2 -MIL(Fe) on the PS surface and the presence of abundant active sites. The adsorption behavior of sulfamethoxazole (SMX) on NH 2 -PS@NH 2 -MIL(Fe) was evaluated under various conditions, including pH, adsorbent dosage, and coexisting anions. The adsorption process followed the pseudo-second-order kinetic model and Langmuir isotherm model, indicating a monolayer sorption with a maximum capacity of 250.6 mg·g −1 at pH 5.2 and thermodynamic analyses revealed that the adsorption was spontaneous and exothermic. Based on FTIR, XRD and XPS analyses, electrostatic attraction, hydrogen bonding, π–π stacking, and metal–ligand coordination/Lewis acid-base interaction collectively governed the adsorption of SMX. Furthermore, the Fe(III) centers endowed NH 2 -PS@NH 2 -MIL(Fe) Fenton-like catalytic activity. With the addition of H 2 O 2 , over 95% of SMX was eliminated rapidly from water in a wide pH range. Based on the dual functions, this material can efficiently remove SMX from surface water samples. These results highlight the great potential of NH 2 -PS@NH 2 -MIL(Fe) for efficient removal of sulfonamide antibiotics. Download: Download high-res image (319KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）