查找使用阿拉丁产品的科研文献

Folium crataegi boosts skin regeneration for burn injury in rats through multiple ways

Zhihong Deng,Lifeng Zhao,Xiuxue Li,Chang-Yun Wang,Yue Zhou,Mengfei Li,Yingfei Li,Xianjun Fu

Appropriate topical dressings for burn treatments are important to accelerate skin wound recovery and prevent external infections. This study aimed to evaluate the effect and investigate the mechanism of folium crataegi ( Crataegus pinnatifida Bge. ) for the treatment of burn wounds, as well as to compare the therapeutic effects of aqueous extracts ( HLW ) and alcoholic extracts ( HLE ) from folium crataegi . The results demonstrated that both HLW and HLE groups exhibited a higher wound contraction rate than the silver sulfadiazine ( SSD ) ointment group. Moreover, HLW showed more significant wound repair effects than HLE . HLW significantly increased levels of EGF and FGF-2 in wound tissue, as well as TGF-β1 , VEGF , CAT and IL-10 in serum. Folium crataegi extract, especially aqueous extracts, exerted good anti-inflammatory, anti-oxidant and anti-bacterial effects by upregulating the expression of lag3 , txn1 and slpi , respectively. Folium crataegi extract significantly inhibits the expression of npas2 , a key gene in the circadian rhythm pathway. In conclusion, this research illustrated that the folium crataegi extract, especially aqueous extracts, had better therapeutic effects on skin burns through multiple ways, possibly including a novel mechanism related to circadian rhythm pathway. These findings suggest that folium crataegi could be a valuable source of compounds for enhancing skin regeneration through multiple ways.

Thermally responsive flexible self-luminous binary fatty alcohol eutectic-based reversible thermochromic passive energy-saving eucalyptus wood aerogel composites

Ruiqian Tao,Nianrong Feng,Jiahua Li,Bochen Li,Yugui Lv,Kenan Li,Dongying Hu

The development of flexible self-luminous reversible thermochromic passive energy-saving composites (TPCMs) is self-challenge due to the defects of easy leakage, non-visibility, solid phase rigidity, and weak light absorption . So, the emerging TPCMs were cleverly constructed using wood aerogel as support skeleton and different mass ratios of natural latex/long afterglow components as flexible and self-luminescent matrix based on optimal binary fatty alcohol eutectic (C 14 C 20 ). Among them, C 14 C 20 R-TEW-1R and C 14 C 20 G-TEW-0.35 P stand out with suitable phase transition temperatures (28.8 °C and 29.7 °C), high latent heat values (100.5 J g −1 and 119.4 J g −1 ), and low supercooling (0.7 °C and 0 °C). Induced by phase change, they change from rigid to flexible, from red/green to milky white, and can absorb light to achieve self-luminescence in the dark (orange red and blue-green) and enhanced photothermal efficiency. Beyond the traditional thermal/light stability and excellent anti-leakage performance, TPCMs realizes the combination of temperature sensitivity/control and self-luminous, providing broad application prospects in home automation, passive energy-saving in buildings, luminescent response switches, and other fields.

Efficient removal of ginkgolic acids from Ginkgo biloba leaves crude extract by using hydrophobic deep eutectic solvents

Qihui Dong,Jun Cao,Rong Wu,Tingting Shi,Wen Zhang,Fuliang Cao,Guibin Wang,Erzheng Su

Extract of Ginkgo biloba leaves (EGb) is a widely used phytotherapy drug, while ginkgolic acids (GAs) are considered as potentially hazardous constituents in EGb. In this work, a liquid-liquid microextraction method for removing ginkgolic acids from Ginkgo biloba leaves crude extract using hydrophobic deep eutectic solvent (DES) was reported. After screening and designing, a ternary hydrophobic DES composed of l -menthol, 1-hexanol and lauric acid at a molar ratio of 1:0.8:0.2, named as MHL, gave the highest removal rate of GAs. The removal conditions were optimized based on the removal rate of GAs, and the optimal conditions were 27.5 % (v/v) of ethanol solution used as the aqueous phase for dissolving the Ginkgo biloba leaves crude extract, 180 μL of the hydrophobic DES, removal temperature of 40 °C, and removal time of 24 min, respectively. Under these conditions, the removal rate of GAs in the model EGb solution reached 74.35 ± 1.56 %. Only one step removal could reduce the GAs content in the real Ginkgo biloba leaves crude extract to 4.02 μg/g (below 5.00 mg/kg). Scaling up the removal operation volume by 100 times, the removal rate of GAs did not decrease, but even improved. The retention rates of total flavonoids and ginkgolides always kept at high levels. This work provides the basic for further considering hydrophobic DESs as green media for efficiently removing the GAs in the standardized EGb production.

Synthesis, characterization and properties of novel nonionic hydrocarbon/fluorocarbon hybrid surfactants containing a short fluoroalkyl chain

Yutang Zhou,Yichao Shen,Liangjie Shi,Yong Jin,Shuangquan Lai,Yujia Tang

Nanostructured metallic FeNi2S4 with reconstruction to generate FeNi-based oxide as a highly-efficient oxygen evolution electrocatalyst

Jun Jiang,Ying-Jie Zhang,Xiao-Jiao Zhu,Shu Lu,Lu-Lu Long,Jie-Jie Chen

FeNi-based nanomaterials with bimetallic alloying effect deliver a great promise as an efficient electrocatalyst for oxygen evolution reaction (OER). However, the reconstruction to generate in-situ catalytically FeNi-based oxides or hydroxides during OER process and high electrical conductivity demand foster the great pursuit of the rational design of FeNi-based OER electrocatalyst a big challenge. Herein, we design and fabricate a nanostructured metallic FeNi 2 S 4 as a highly efficient OER electrocatalyst. This catalyst exhibits an overpotential of (250 mV) and a Tafel slope (62 mV dec −1 ), that outperforms the benchmark of commercial RuO 2 . The experimental results demonstrate that the alloying effect and the superior electrical conductivity , endow it a great electrocatalytic performance. Such a nanostructured metallic OER electrocatalyst shows a great promise in water splitting.

Research on combined-pour point depressant of methacrylate-acrylamide copolymers and ethylene-vinyl acetate copolymers for diesel fuel

Hualin Lin,Suya Yin,Baoting Su,Yuan Xue,Sheng Han

The combined-pour point depressants (PPDs) have shown potential for the improvement of the cold flow properties of diesel. In this study, free radical polymerization was used to polymerize methacrylate (RMC) and acrylamide (AM) in different molar ratios (1:1, 3:1, 6:1, 9:1, 12:1, 15:1). Methacrylate-acrylamide copolymers (RMC-AM) were synthesized and analyzed through Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ( 1 H NMR), and thermogravimetric analysis (TGA) to characterize the copolymers. Through exploring the effect of different chain lengths and different monomer molar ratios on the solid point (SP) and cold filter-plugging point (CFPP) of diesel, C 14 MC-AM (9:1) showed relatively good performance (ΔSP = 25 °C, ΔCFPP = 10 °C). Then, ethylene–vinyl acetate copolymer (EVA) materials with different VA content were introduced in this study. Diesel treated with 1000 ppm of EVA-2 (VA = 28%) showed relatively good performance (ΔSP = 18 °C, ΔCFPP = 10 °C). C 14 MC-AM (9:1) was mixed with EVA −2 in different ratios (1:0, 4:1, 2:1, 1:1, 1:2, 1:4, and 0:1, namely, PPDC-1 ~ 7) to produce synergy and improve the cold flow properties of diesel. The ΔSP and ΔCFPP of diesel fuel treated with only 500 ppm PPDC-5 can reach 28 °C and 23 °C, respectively. In addition, the crystallization behavior and crystal morphology of the treated diesel fuel were discussed through differential scanning calorimeter, polarized optical microscope and rheological analysis. The results showed that the combined-PPD made the wax crystals dissolve in the diesel system. The wax crystals became more uniform and denser under the action of AM polar groups.

Gastric floating pill enhances the bioavailability and drug efficacy of dihydromyricetin in vivo

Hao Liu,Chenyun Gan,Houyin Shi,Kunyan Qu,Liuyang Jing,Muhe Lu,Benyu Su,Huayang Yu,Hang Yuan,Jingjing Chen,Ruirui Zhang,Weiling Zeng

Dihydromyricetin (DHM) is a natural flavonol compound that has shown significant pharmacological activities such as anti-atherosclerosis, anti-diabetes, anti-oxidation, and anti-inflammation, but its clinical application has been hindered by its poor stability and rapid metabolism that reduced its bioavailability in vivo . Since DHM is more stable under acidic conditions, selective and sustained absorption of DHM in the stomach via gastric floating drug carriers provide an attractive way to settle the problems. Previously, we reported a gastric floating tablet for DHM that demonstrated improved stability and bioavailability of the drug. However, the application of this drug carrier was still constrained by low drug content percentage, and short floating and drug releasing durations. Besides, the influences of dosage forms on the drug efficacy of DHM in vivo were not yet clear. In this study, gastric floating pill as a novel sustained-release dosage form for DHM (DHM-GFP) was developed using combined techniques of extrusion molding and freeze drying . The physicochemical properties of DHM-GFP could well meet the pharmacopoeial requirements for pills. Our data indicated that DHM-GFP had significantly higher drug content percentage, improved floating ability and more sustained drug release than the previously reported DHM tablet, and is promising to become a once-a-day dosing preparation. More importantly, this novel dosage form resulted in notably prolonged residence time, improved bioavailability, and enhanced anti-inflammatory effect of DHM in vivo , indicating its great potential to translate this natural compound into clinical application.

Waterproof Phase Change Material with a Facilely Incorporated Cellulose Nanocrystal/Poly(N-isopropylacrylamide) Network for All-Weather Outdoor Thermal Energy Storage

Ling Zhou,Xue-feng Tao,Li-sheng Tang,Ming-Bo Yang,Wei Yang

The incorporation of porous supporting materials to prepare shape-stable phase change materials (PCMs) is of great interest in recent years. However, extensive reported composite PCMs are shape-stable in the air atmosphere but neglected in the water environment. To develop shape-stable and waterproof PCMs is important for their outdoor applications but challenging. Herein, we report a novel cellulose nanocrystal/poly(N-isopropylacrylamide) (CNC/PNIPAM) gel-supported hexadecanol (H-anol) PCM with good thermal storage properties and excellent shape stability in both air and water environments. The CNC/PNIPAM hydrogel is prepared through an ultraviolet-induced C═C cross-linking reaction, and its physical structure and mechanical properties are well characterized. H-anol is then directly immerged into the CNC/PNIPAM alcogel by a facile and low-cost solvent-exchange strategy. The mechanism of the solvent-exchange strategy has been established. Because of the temperature-sensitive hydrophilic/hydrophobic transform behavior of the CNC/PNIPAM network, the CNC/PNIPAM/H-anol PCM displays excellent shape stability in a water environment by forming a dense hydrophobic surface, providing it with great potential in all-weather thermal energy storage applications.

Click-Chemistry Approach toward Antibacterial and Degradable Hybrid Hydrogels Based on Octa-Betaine Ester Polyhedral Oligomeric Silsesquioxane

Jin Han,Qinyue Chen,Yupeng Shen,Zhixiong Liu,Xiaoyu Hao,Mingqiang Zhong,Zhengping Zhao,Michael R. Bockstaller

An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol–ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed excellent flexibility as well as torsion resistance. Antibacterial efficacy of hydrogels (and degradation products) was evaluated using Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Efficacy was found to increase with the concentration of cetyl chloroacetate (CCA) in the hydrogel network, reaching 93% and 99% for Escherichia coli and Staphylococcus aureus, respectively. Degradation of hydrogels was observed in weak alkali conditions (pH = 8) and at physiological conditions (pH = 7.4). The degradation time of the hydrogels could be finely tuned by variation of the CCA content in the hydrogel and environmental stimulus. The tunable degradation behavior under physiological conditions combined with high antibacterial efficacy could render the presented materials interesting for tissue engineering applications.

Influence of maleic anhydride-co-methyl benzyl acrylate copolymers modified with long-chain fatty amine and long-chain fatty alcohol on the cold flow properties of diesel fuel

Fengfei Chen,Jinbao Liu,Taishun Yang,Suya Yin,Baoting Su,Maiying Xie,Bin Dai,Sheng Han,Yuan Xue

Precipitation of n-alkanes at low temperatures is the main factor that affects the cold flow properties of diesel fuel. In order to improve the clod flow properties of diesel fuel, maleic anhydride-methyl benzyl acrylate copolymer (MA-MB) were synthesized and modified with long-chain fatty amine and long-chain fatty alcohol (RNH 2 and ROH, R = C 14 , C 16 , C 18 ) to obtain a series of aminated copolymers R 1 MA-MB (R 1  = N 14 , N 16 , N 18 ) and esterified copolymers R 2 MA-MB (R 2  = C 14 , C 16 , C 18 ). These copolymers were characterized by gel permeation chromatography (GPC), Fourier transform infrared (FTIR) spectroscopy, and proton nuclear magnetic resonance ( 1 H NMR), and the oil affinity and oil solubility were studied by the static contact angle. The influences of them used as pour point depressants (PPDs) on the cold flow properties of diesel fuel were investigated. Results indicate that the esterified copolymers exhibit a better depression effect in depressing the solid point (SP) and cold filter plugging point (CFPP) than that of aminated copolymers. Among that, C 14 MA-MB exhibited the most considerable reduction on the SP and CFPP by 24 and 8 °C at 500 ppm addition, respectively. In addition, the depression mechanism was explored by differential scanning calorimetry, rheological analysis and polarizing optical microscopy. The analysis shows that C 14 MA-MB changed the crystal behaviors by modifying the crystal growth direction, restraining the crystal accumulation, and retarding the formation of large crystals, thus enhancing the cold flow properties of diesel fuel. Therefore, the synthesized copolymers are the highly effective PPDs of diesel fuels.

Hierarchically Porous PVA Aerogel for Leakage-Proof Phase Change Materials with Superior Energy Storage Capacity

Li Yang,Jie Yang,Li-Sheng Tang,Chang-Ping Feng,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang

Organic phase change materials (PCMs) have been widely used in the thermal energy storage field, but melt leakage above the phase change temperature has greatly hindered their practical applications. Herein, poly(vinyl alcohol) (PVA) aerogels with hierarchically porous structure are fabricated and introduced into phase change matrices to obtain novel leakage-proof composite PCMs (CPCMs). The thermal storage efficiency of the working substance in the CPCMs reaches as high as 95.6%, maintaining a tremendously high energy storage density. More importantly, the CPCMs exhibit prominent shape stability when heated at 80 °C, higher than the phase change temperature, for 60 h. Finally, the leakage-proof CPCMs exhibit great application potential in the thermal management of electronic devices.

Regioselective magnetization in semiconducting nanorods

Zhuang Tao-Tao,Li Yi,Gao Xiaoqing,Wei Mingyang,García de Arquer F. Pelayo,Todorović Petar,Tian Jie,Li Gongpu,Zhang Chong,Li Xiyan,Dong Liang,Song Yonghong,Lu Yang,Yang Xuekang,Zhang Libing,Fan Fengjia,Kelley Shana O.,Yu Shu-Hong,Tang Zhiyong,Sargent Edward H.

Chirality—the property of an object wherein it is distinguishable from its mirror image—is of widespread interest in chemistry and biology 1 , 2 , 3 , 4 , 5 , 6 . Regioselective magnetization of one-dimensional semiconductors enables anisotropic magnetism at room temperature, as well as the manipulation of spin polarization—the properties essential for spintronics and quantum computing technology 7 . To enable oriented magneto-optical functionalities, the growth of magnetic units has to be achieved at targeted locations on a parent nanorod. However, this challenge is yet to be addressed in the case of materials with a large lattice mismatch. Here, we report the regioselective magnetization of nanorods independent of lattice mismatch via buffer intermediate catalytic layers that modify interfacial energetics and promote regioselective growth of otherwise incompatible materials. Using this strategy, we combine materials with distinct lattices, chemical compositions and magnetic properties, that is, a magnetic component (Fe 3 O 4 ) and a series of semiconducting nanorods absorbing across the ultraviolet and visible spectrum at specific locations. The resulting heteronanorods exhibit optical activity as induced by the location-specific magnetic field. The regioselective magnetization strategy presented here enables a path to designing optically active nanomaterials for chirality and spintronics.