PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
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2019
·Vol. 377
·期 2150
·
IF 3.093
Bharat Bhushan
Water contamination is one of the major environmental and natural resource concerns in the twenty-first century. Oil contamination can occur during operation of machinery, oil exploration and transportation, and due to operating environment. Oil spills occasionally occur during oil exploration and transportation. Water contamination with various chemicals is a major concern with growing population and unsafe industrial practices of waste disposal. Commonly used oil–water separation techniques are either time consuming, energy intensive and/or environmentally unfriendly. Bioinspired superhydrophobic/superoleophobic and superoleophobic/superhydrophilic surfaces have been developed which are sustainable and environmentally friendly. Bioinspired oil–water separation techniques can be used to remove oil contaminants from both immiscible oil–water mixtures and oil–water emulsions. Coated porous surfaces with an affinity to water and repellency to oil and vice versa are commonly used. The former combination of affinity to water and repellency to oil is preferred to avoid oil contamination of the porous substrate. Oil–water emulsions require porous materials with a fine pore size. Recommended porous materials include steel mesh and cotton fabric for immiscible oil–water mixtures and cotton for oil–water emulsions. A review of various approaches is presented in this paper.
This article is part of the theme issue ‘Bioinspired materials and surfaces for green science and technology (part 2)’.
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ACS Applied Materials & Interfaces
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2019
·
IF 8.456
Pengfei Wei,Wei Jing,Zuoying Yuan,Yiqian Huang,Binbin Guan,Wenxin Zhang,Xu Zhang,Jianping Mao,Qing Cai,Dafu Chen,Xiaoping Yang
Biomaterials that have capacities to simultaneously induce bone regeneration and kill bacteria are in demand because bone defects face risks of severe infection in clinical therapy. To meet the demand, multifunctional biodegradable microspheres are fabricated, which contain vancomycin to provide antibacterial activity and strontium-doped apatite to provide osteocompatibility. Moreover, the strontium component shows activity in promoting angiogenesis, which further favors osteogenesis. For producing the microspheres, vancomycin is loaded into mesoporous silica and embedded in polylactide-based microspheres via the double emulsion technique and the strontium-doped apatite is deposited onto the microspheres via biomineralization in strontium-containing simulated body fluid. Sustained release behaviors of both vancomycin and Sr2+ ions are achieved. The microspheres exhibit strong antibacterial effect against Staphylococcus aureus, while demonstrating excellent cell/tissue compatibility. Studies of differentiation confirm that the introduction of strontium element strengthens the angiogenic and osteogenic expressions of mesenchymal stromal cells. Subcutaneous injection of the microspheres into rabbit’s back confirms their effectiveness in inducing neovascularization and ectopic osteogenesis. Finally, an infected rabbit femoral condyle defect model is created with S. aureus infection and the multifunctional microspheres are injected, which display significant antibacterial activity in vivo and achieve efficient new bone formation in comparison with biomineralized microspheres without vancomycin loading. The vancomycin- and strontium-loaded microspheres, being biomineralized, injectable, and biodegradable, are attractive because of their flexibility in integrating multiple functions into one design, whose potentials in treating infected bone defects are highly expected.
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Biomaterials Science
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2018
·Vol. 7
·期 1
·272-286
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IF 5.831
Peng-Fei Wei,Zuo-Ying Yuan,Wei Jing,Bin-Bin Guan,Zi-Hao Liu,Xu Zhang,Jian-Ping Mao,Da-Fu Chen,Qing Cai,Xiao-Ping Yang
Treatment of infected bone defects still remains a formidable clinical challenge, and the design of bone implants with both anti-bacterial activity and -osteogenesis effects is nowadays regarded as a powerful strategy for infection control and bone healing. In the present study, bioresorbable porous-structured microspheres were fabricated from an amphiphilic block copolymer composed of poly(L-lactide) and poly(ethyl glycol) blocks. After being surface coated with mussel-inspired polydopamine, the microspheres were loaded with nanosilver via the reduction of silver nitrate and apatite via biomineralization in sequence. At optimized loading amounts, the nanosilver-loaded microspheres showed no unfavorable effects on the proliferation and differentiation of bone marrow mesenchymal stem cells despite preserving strong antibacterial activity in in vitro evaluations. For the critical-sized defects (ϕ = 8 mm) in the rat cranium that was pre-infected with Staphylococcus aureus, the filling of the dual-purpose microspheres demonstrated an effective way to kill bacteria in vivo, and in the meantime, it promoted new bone formation efficiently alongside the degradation of microspheres. Thus, the results suggested that bioresorbable microspheres with both osteoconductive and antibacterial activities were a good choice for treating infected bone defects.
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JOURNAL OF NON-CRYSTALLINE SOLIDS
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2018
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IF 2.488
Shasha Wang,Yuelong Xu,Meifang Yan,Lihui Zhang,Zhenfa Liu
Porous carbon xerogels were successfully fabricated by carbonization of resorcinol-formaldehyde-phloroglucinol gels in the presence of surfactants . The effect of non-ionic, cationic, anionic and zwitterionic surfactants on the porous structure of carbon xerogels was investigated. Micropore structural carbon xerogels were obtained when a cationic surfactant was used. The result of surface tension test showed the non-ionic surfactant Tween 60 gave the lowest surface tension. Thermal conductivity experiments revealed the carbon xerogels in this work possessed low thermal conductivity and are suitable as thermal insulation materials. The pore size directly determined the thermal conductivity of carbon xerogels, and the thermal conductivity decreased with pore size. Among the obtained samples, the one using hexamethylenetetramine (HTM) exhibited the highest CO 2 adsorption capacity (2.89 mmol g −1 ) and adsorption selectivity as a result of the high microporosity (88.0%). Therefore, HTM-CA was identified as a promising material for CO 2 adsorption.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 136
·期 46
·48237
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IF 2.188
Feng Gao,Yifang Mi,Xinlei Wu,Jun Yao,Qi Qi,Zhihai Cao
Stimuli-responsive polymeric nanogels hold great potential in biological applications. In this work, thermoresponsive polymeric nanogels were conveniently prepared through inverse miniemulsion polymerization of two monomers with a good biocompatibility, N -vinylcaprolactam and 2-methoxyethyl acrylate. A macromolecular crosslinker, poly(ethylene glycol) dimethacrylate (PEGDMA), was used to achieve a better thermoresponsiveness, compared with low-molecular-weight crosslinkers. The prepared poly( N -vinylcaprolactam- co -2-methoxyethyl acrylate) (poly(NVCL- co -MEA)) nanogels could be well redispersed in aqueous systems, displaying a reversible thermoresponsive transition behavior. The influences of the synthesis parameters including the emulsifier content, PEGDMA content, and monomer composition on the particle properties of poly(NVCL- co -MEA) nanogels both in inverse emulsions and in aqueous dispersions were systematically investigated. Furthermore, the impacts of the monomer composition and PEGDMA content on the thermoresponsiveness of poly(NVCL- co -MEA) nanogels were also studied. Promisingly, the introduction of MEA monomeric units to the copolymer chains only slightly reduced the thermoresponsiveness of poly(NVCL- co -MEA) nanogels. This feature allows to improve the biocompatibility of polymeric nanogels by using MEA as the comonomer without need to compromise the thermoresponsiveness of nanogels. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 48237.
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JOURNAL OF MATERIALS RESEARCH
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2013
·Vol. 28
·期 19
·2666-2676
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IF 1.713
Yang Wenming,Cao Yang,Xu Xiaoling,Zhou Zhiping,Liu Lukuan,Xu Wanzhen
The indole molecularly imprinted polymer (indole-MIP) was synthesized by atom transfer radical emulsion polymerization (ATREP). The novel adsorbent was used to adsorb indole from fuel oil. The indole-MIP had a high selectivity to indole, and the mass transfer limitations were overcome. The property and morphology of indole-MIP were described by a series of characterization methods. A great specific area and more pores of indole-MIP were shown. The static adsorption experiments display that equilibrium adsorption capacity of indole-MIP was 34.488 mg/g. The adsorption process was spontaneous by thermodynamic analysis, and a dense mass of indole was adsorbed onto indole-MIP at a proper low temperature (298 K). Pseudo-second-order kinetic model was more fitted with experimental data. Both Langmuir and Freundlich isotherm models were obeyed by adsorption isotherm test. The selective and competitive performances of indole-MIP were favorable, and the regeneration capacity was appreciable.
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ACS Omega
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2024
·
IF 3.7
Yang Xie,Peng Li,Dong Fu,Fan Yang,Xin Sui,Bo Huang,Jiaying Liu,Jialong Chi
Cannabidiol (CBD) has demonstrated its potential to enhance depression treatment through various biological pathways. However, the application potential of CBD is significantly impeded by its polymorphic nature, limited water solubility, and hepatic first-pass metabolism. To improve chemical stability and water solubility, nanostructured lipid carriers loaded with CBD (CBD-NLCs) were developed using a hot-melt emulsification method and optimized by response surface methodology (RSM). The process parameters were optimized using a four-factor and three-level Box–Behnken experimental design consisting of 29 experiments. The CBD-NLCs were formulated and characterized, demonstrating desirable properties, including a mean particle size of 54.33 nm, a PDI value of 0.118, a zeta potential of −29.7 mV, and an impressive encapsulation efficiency rate of 87.58%. The nanoparticles were found to possess an approximately spherical shape, as revealed by scanning and transmission electron microscopy. The stability studies have demonstrated that CBD-NLCs effectively mitigated the photodegradation of CBD and exhibited a stable behavior for 42 days when stored. The CBD-NLCs displayed a biphasic release profile characterized by an initial burst release (over 50% of CBD released within 20 min) followed by a subsequent gradual and sustained release, aligned with first-order kinetics and Fickian diffusion. These findings demonstrate the potential suitability of this formulation as a carrier for CBD in food fortification and pharmaceutical applications.
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JOURNAL OF POLYMER RESEARCH
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2024
·Vol. 31
·期 10
·1-12
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IF 2.6
Che Junwen,Zhang Hong,Zeng Jiexiang,Jiang Jianyu,Bai Zijian,Wang Yan,Zhang Fankai
To achieve effective temperature-regulated modification of spray-bonded cotton for superior thermal management capabilities, a dual-network phase transition microspheres (PCP) was developed through a one-step process using emulsion polymerization. This innovative approach incorporated eutectic polyethylene glycol (PEG) as the phase change component, chemically cross-linked polyacrylamide (PAM) as the first network, and ionically cross-linked calcium alginate (CA) as the second network. The PCP, which contains PEG solid-loaded in the dual network, was utilized as a modifier for the post-treatment of spray-bonded cotton using a coating technique. Key findings reveal that the effectively immobilization of PEG has been, without any abserved chemical reactions between PEG and PAM/CA. Additionally, PEG maintained its crystalline properties when combined with PAM/CA. The PCP exhibited a distinct morphology with smooth, spherical particles averaging round 5 μm in diameter. The optimized PCP sample exhibits a melting onset temperature of 37.20 °C, a melting enthalpy of 92.59 J·g −1 , and impressive heat resistance. The resulting temperature-regulated spray-bonded cotton (TRSBC) displayed intelligent temperature control characteristics with a melting onset at 37.65 °C and a latent heat of 32.08 J·g −1 . Compared to untreated spray-bonded cotton (USBC), TRSBC exhibited a notable delay effect in both heating and cooling processes, resulting in a temperature differential of 23.5 °C during heating and 16.3 °C during cooling, underscoring its superior temperature control capabilities. Research indicates that TRSBC possesses significant potential in thermal management applications, encompassing clothing, high-tech textiles, and temperature-regulating sandwich panels, thereby presenting considerable opportunities for commercial ventures. Graphical Abstract
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Qilin Guo,Qingchao Wang,Yiyong Pan,Boyuan Kang,Wenlong Xu,Xinxin Zhao,Yuxin Wang,Chenhao Li,Hongyu Ba,Shuang Chen,Huie Liu
Due to its high porosity, large specific surface area, and strong photothermal conversion performance, graphene aerogel has unique advantages in the field of pollution treatment, especially in the field of recovering highly viscous oils. However, for the treatment of highly viscous oils, the high adsorption capacity and high adsorption rate of graphene aerogel often cannot be combined, which is one of the important reasons limiting its development in this field. A double-step templating strategy for graphene aerogels preparation was used in this work, i.e., Pickering emulsion soft templating and unidirectional freeze casting. Specifically, the dense Pickering emulsion droplets can be stabilized in a short period of time, so that they can be cured quickly. After that, graphene aerogels (DGA-0.8-25) with dual pore structure were prepared by unidirectional freeze casting technology to further form aligned pores based on the pores formed by the Pickering emulsion droplet soft template. The dense presence of Pickering emulsion droplets gives DGA-0.8-25 an ultra-high porosity (96.8 %), which can adsorb 184.53 times its own mass of crude oil. Due to the unidirectional pore structure, the adsorption rate of DGA-0.8-25 on crude oil is as high as 8.39 g·g −1 ·min −1 , which realizes dual improvement of the adsorption capacity and rate of graphene aerogel on crude oil and shows a good application prospect in the treatment of high viscosity crude oil. In addition, DGA-0.8-25 has unique advantages in the field of oil–water separation, with a separation efficiency of 99.04 % for water-in-oil emulsions and 97.63 % for oil-in-water emulsions. When repeated used in photothermal adsorption of highly viscous oil, DGA-0.8-25 can still maintain more than 90.61 % of its initial adsorption capacity after ten cycles of use-regeneration. Because of its unique advantages such as high efficiency and low cost, DGA shows promising in its future large-scale use.
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Heliyon
·
2024
·
IF 3.4
Onyinyechi Lydia Ugorji,Ikechukwu Virgilius Onyishi,Amarauche Chukwu,Anthony Amaechi Attama
5-flourouracil (5-FU) is typically modulated with leucovorin (LEU) in clinical practice to improve clinical efficacy and patient survival rates. However, this combination has undesirable side effects and makes 5-FU more toxic. Hence, integrating a vesicular system (proniosomes) with another delivery vehicle may improve drug targeting, while resolving the aforementioned drawbacks. This study aimed to engineer 5-FU/LEU proniosomes for possible delivery to the colon. The modified slurry approach was used to create drug-loaded proniosomes (150 mg/9 g of carrier) using both water-soluble (dextrin (DEX) and lactose (LAC)) and insoluble (Neusilin FH 2 (NEU)) carriers. The powdered formulations were filled into Eudragit S100 (10 %)-coated capsules or Eudragit FS 30D capsules for enteric- or colon-specific delivery. In vitro evaluations (flow properties, powder X-ray diffractometry (XRD) analysis, particle size analysis, entrapment efficiency, drug release, scanning electron microscopy (SEM), polydispersity index, Fourier transform infrared spectroscopy (FTIR), and stability studies) were performed on the formulations. An in vitro cytotoxicity test [real-time cell assay (RTCA)] against HCT-116 colon cancer cell lines was performed using the optimized formulation. In vitro evaluations showed that the nanoparticles had good physicochemical properties. RTCA studies showed sustained cell death with the formulations compared to the pure drug and placebo. The sequential drug release of the colon-targeted capsules containing 5-FU and LEU- loaded proniosomes showed negligible drug release in SGF (pH 1.2) and phosphate buffer solution (pH 6.8) (approximately 11 %) but profound drug release (>80 %) at pH 7.4. Drug-loaded proniosomes engineered for colon targeting (Eudragit S100 (10 %) capsules or Eudragit FS 30D capsules) showed good colon-specific targeting and favorable in vitro cytotoxicity profiles.
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Food Bioscience
·
2024
·
IF 4.8
Xiaoqiang Zou,Mudassar Hussain,Imad Khan,Yanxi Wang,Bangzhi Jiang,Lei Zheng,Yuechao Pan,Jijie Hu,Azqa Ashraf
Medium- and long-chain structured lipids (MLSLs) rich in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were synthesized by acidolysis of fish oil (Omax 1812, a mixture of sardine and anchovy oils) with caprylic acid (CA) using a lipase bio-imprinted with fatty acids as a catalyst. A bio-imprinted lipase for the acidolysis reaction was first prepared under optimal conditions, and its activity was 1.43 times higher than that of the non-bioimprinted. The bio-imprinted lipase was used as a catalyst to produce such MLSLs, and the reaction conditions were optimized. Under the optimal conditions, equilibrium was achieved in 8 h, and the total and the sn -1, 3 CA contents in the obtained product were 28.72% and 42.26%. Additionally, the total and the sn -2 DHA contents were 14.23% and 21.10%, respectively, and the total and the sn -2 EPA contents were 16.43% and 10.14%, respectively. These obtained MLSLs, rich in sn -1, 3 CA, and sn -2 DHA, EPA can deliver significant health benefits.
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Processes
·
2024
·Vol. 12
·期 1
·202
·
IF 2.8
Wanping Zhang,Xuefang Shi,Shilian Zheng
The goal of this research was to study the factors influencing the in vitro transdermal penetration of nicotinamide and to establish an evaluation method for the in vitro transdermal absorption of nicotinamide. The permeability of nicotinamide was investigated with Franz diffusion cell in vitro transcutaneous assays, and the effect of the receiving solution composition, receiving solution pH, skin type, diffusion cell temperature, active ingredient concentration, supply quantity, and product dosage form on its permeation was investigated separately by high-performance liquid chromatography. The best assay for the transdermal absorption of nicotinamide was established—there was a better transdermal absorption performance, more stable system, better applicability, and better reproducibility when the receiving solution was PBS (phosphate-buffered saline) solution, the pH was 7.4, the membrane was pig ear skin, the temperature was 37 °C, the concentration of nicotinamide was 3%, and the dose of the test substance was 2 g. In the three cosmetic dosage forms of toning lotion, milk lotion, and gel, the permeability of milk lotion was the highest, followed by toning lotion and gel.
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