Frontiers in Chemistry
·
2018
·
IF 4.155
Pang Juan,Gao Ziyu,Zhang Long,Wang Huiming,Hu Xiaohong
Azobenzene, a photo switcher, has attracted increasing interest due to its structural response to photo stimulus in the field of information science and chemical sensing in the recent decades. However, limited water solubility and cytotoxicity restrained their applications in the biomedical field. In research, HA-AZO has been designed as a water soluble photo switcher in biomedical application. Synthesized HA-AZO had good water-solubility and a stable π-π* transition absorbance peak trans-isomer. With exposure to UV, transformation from trans-isomer to cis-isomer of HA-AZO could be realized according to UV spectra. Reversely, trans-isomer could be gradually recovered from cis-isomer in the dark. Simultaneously, quick response and slow recovery could be detected in the process of structural change. Moreover, repeated illumination was further used to detect the antifatigue property of HA-AZO, which showed no sign of fatigue during 20 circles. The influence of pH value on UV spectrum for HA-AZO was investigated in the work. Importantly, in acid solution, HA-AZO no longer showed any photoresponsive property. Additionally, the status of HA-AZO under the effect of UV light was investigated by DLS results and TEM image. Finally, in vitro cytotoxicity evaluations were performed to show the effects of photoresponsive macromolecule on cells.
研究领域:
生物材料学
·
生物医药工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 43
·期 1
·121-129
·
IF 3.201
Dandan Guo,Nadeem Muhammad,Chaoyan Lou,Dan Shou,Yan Zhu
Recently, the growing abuse of glyphosate herbicides in agricultural production has caused widespread accumulation of glyphosate in the environment, which is threatening the health or life of human beings and animals. To solve this problem, novel dendrimer grafted adsorbents were proposed for the rapid and efficient removal of glyphosate from water samples. These adsorbents were synthesized by grafting poly(amidoamine) dendrimers (PAMAM) onto poly(styrene-divinyl benzene-glycidylmethacrylate) beads. The morphological structure and chemical composition of the adsorbents were investigated by SEM, the BET method, FTIR spectroscopy, XPS and elemental analysis. Batch adsorption experiments were performed in glyphosate standard solutions with different pH, temperatures, and initial concentrations. Under the optimized conditions, adsorption equilibrium was attained rapidly within 5 min. Experimental data were correlated well with the pseudo-second-order model and the Langmuir model. The effect of temperature was also discussed by the thermodynamic parameters. Unlike other glyphosate adsorbents, their adsorption capabilities could be easily controlled by varying the generation of PAMAM dendrimer used. In addition, regeneration experiments showed that the adsorbents exhibited good reproducibility. When applied in the purification of contaminated drinking water, the removal efficiency of the adsorbents could be more than 95%.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Wei Qin,Xue Han,Junwei Wang,Xie Wang,Jianli Zhang
To design some excellent extractants for the separation of Zr(Ⅳ) and Hf(Ⅳ), a novel set of polyamidoamine dendrimers peripherally modified with salicylaldehyde (Abbreviated as PAMAM-SA) have been synthesized. UV-vis absorption and fluorescent spectrometry were used to study the selectivity of G.1.0, G2.0, G3.0 and G4.0 PAMAM-SA on Zr(Ⅳ) and Hf(Ⅳ) compared with other metal ions, and their extraction/separation performance on Zr(Ⅳ) and Hf(Ⅳ) was also investigated under different pH solutions. The results show that these dendrimers have superior selectivity on Zr(Ⅳ) and Hf(Ⅳ) as compared with Ca 2+ , Mg 2+ , Fe 3+ and Ni 2+ ions. The binding stoichiometry of G1.0, G2.0, G3.0 and G4.0 PAMAM-SA dendrimers with Zr(Ⅳ) is 1:4, 1:8, 1:10, 1:16 molar ratio determined by fluorescent titration respectively and the molar ratio of these dendrimers with hafnium is similar to that of zirconium. Both of the maximum extraction efficiency (EE%) on Zr(Ⅳ) and the separation coefficient (β Zr/Hf ) are following the order of G2.0-PAMAM-SA > G1.0-PAMAM-SA > G3.0-PAMAM-SA > G4.0-PAMAM-SA, and the maximum EE% on Zr(Ⅳ) is up to 98.9% and furthermore the β Zr/Hf is 1.52 for G2.0-PAMAM-SA at lower acid concentration compared with the reported extractants. The favorable higher EE% and β Zr/Hf indicate that G2.0-PAMAM-SA may be potentially employed as a highly selective and efficient extractant to enhance separating zirconium from hafnium.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xiaoqi Liu,Yanyun Zhang,Yan Liu,Ting'an Zhang
Chitosan bead grafted by third-generation dendrimers (CB-G3) with a diameter of 1.40 mm was synthesized to investigate their performance in recovering Ag(I), Cu(II), and Pb(II) ions in aqueous media. The prepared adsorbents were characterized by XRD, FT-IR, elemental analysis, TGA , and SEM, and the effects of pH, contact time, concentration, and temperature were examined. The results showed that the adsorbents were successfully fabricated. The optimum pH value was 5, and the increased generation number contributed to adsorption capacity improvement, indicating that electrostatic interactions between amine groups and metal ions are the governing mechanism of adsorption by the CB-G3. The kinetics, isotherms, and thermodynamics of Ag(I), Cu(II), and Pb(II) adsorption onto the CB-G3 were investigated. The adsorption processes can be described using pseudo-second-order kinetic and Langmuir models. The maximum monolayer adsorption capacities were 105.62, 88.82, and 97.87 mg·g −1 for Ag(I), Cu(II), and Pb(II) at 30 °C within 210 min, respectively. Electrostatic interactions and hydrogen bonds are the main mechanisms between metal ions and N atoms. Therefore, the CB-G3 is a promising candidate for Ag(I), Cu(II), and Pb(II) adsorption owing to its splendid ability in easy separation, good adsorptivity, and reusability for efficiently adsorbing Ag(I), Cu(II), and Pb(II) ions.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BioNanoScience
·
2025
·Vol. 15
·期 3
·1-17
·
IF 3.2
Lu Tianwen,Dai Yixuan,Shi Yue,Wang Xiaojun,Hong Yinan,Pan Hong,Wu Zhansheng
Laccase is a kind of green biocatalyst which is widely distributed in nature. However, the application of free laccase was greatly limited due to the poor stability and low utilization. In order to prepare a carrier with abundant immobilized sites, This study designed a novel magnetic dendrimers (MPG-x) as an excellent carrier for immobilizing laccase. Fe 3 O 4 was used as the core, and the desired MPG-x was obtained by modifying the surface of Fe 3 O 4 with hyperbranched polyaminoamide (PAMAM) dendrimers. Due to its controllable generation number, this carrier can provide a relatively abundant number of surface binding sites for laccase immobilization. Then the immobilized laccase MPG-2@GA-Lac and MPG-2@Cu 2+ -Lac were prepared by glutaraldehyde crosslinking and copper chelating adsorption, respectively. The results showed that the loading of MPG-2@GA-Lac and MPG-2@Cu 2+ -Lac reached 48.9 mg/g and 50.6 mg/g respectively, and MPG-2@GA-Lac and MPG-2@Cu 2+ -Lac retained 74.4% and 108.1% of the initial free laccase activity, respectively. In addition, the two immobilized laccase showed better pH stability, temperature stability, thermal stability and storage stability than free laccase. The activation of Cu 2+ in the active center of laccase made MPG-2@Cu 2+ -Lac exhibit better stability. Methyl orange (MO) removal experiments showed that MPG-2@Cu 2+ -Lac exhibited higher MO removal efficiency (82.56%) over a wider pH and temperature range than MPG-2@GA-Lac (72.19%), and MPG-2@Cu 2+ -Lac maintained a MO removal efficiency of 66.18% after 6 cycles of operation. This study is expected to further expand the application of laccase in the degradation of dye wastewater.
研究领域:
环境科学
·
生物技术
·
纳米技术
·
酶工程
·
废水处理
✓ 已验证
产品关联
DOI
高影响因子
Cell Reports Physical Science
·
2021
·
IF 0
Lin Qiao,Qing Dai,Huamin Zhang,Xianfeng Li
Summary Turing patterns and reaction-diffusion models are of great significance in biological and chemical fields. However, Turing-shape materials together with their application are rarely investigated, since at present Turing patterns are typically formed by the reaction of small molecules in a viscous system. Herein, a facile route to fabricate membrane materials with macro-scale Turing patterns is proposed. Macromolecules, rather than small molecules, are chosen as reactants to generate chemical Turing patterns, which makes it easy to freeze and construct Turing-shape materials. The formation mechanism and influence factors of Turing patterns are discussed in detail via experimental investigation and numerical simulation. Turing-shape membranes are successfully applied to electrochemical energy storage and exhibit good performance benefiting from the rich surface area.
研究领域:
材料科学
·
化学
·
生物学
✓ 已验证
DOI
RSC Advances
·
2024
·Vol. 14
·期 35
·25507-25515
·
IF 3.9
Song Zhang,Mengjia Fang,Junjun He,Lina Ma,Xiaohe Miao,Peichuang Li,Shirui Yu,Wanhao Cai
The mechanisms of specific ion effects on the properties of amide macromolecules is essential to understanding the evolution of life. Because most biological macromolecules contain both complex hydrophilic and hydrophobic structures, it is challenging to accurately identify the contributions of molecular structure to macroscopic behaviors. Herein, we investigated the influence of specific ion effects on the mechanical behaviors of poly(N-isopropylacrylamide) and neutral polyacrylamide (i.e., PNIPAM and NPAM), through a cross-scale study that includes single-molecule force spectroscopy, molecular dynamics simulation and macro mechanical method. The results indicate that the molecular conformation can be markedly influenced by the hydrophilicity (or hydrophobicity) of both macromolecule chain and ions. An extended chain conformation can be obtained when the side groups and ions are relatively hydrophilic, which can also increase the elasticity of a macromolecule chain and film materials. The relatively hydrophobic components promote the collapse of macromolecule chains and reduce the molecular elasticity. It is believed that the hydrogen bonding intensity between a macromolecule chain and aquated ions controls the chain conformation and the elasticity of molecules and films. This study is not only helpful for understanding the self-assembly mechanism of organisms but also provides a way to associate the molecular properties with the macroscopic performance of materials.
研究领域:
生物物理学
·
材料科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Zhaoyong Gao,Benzhi Ju,Bingtao Tang,Wei Ma,Wenbin Niu,Shufen Zhang
Flocculants are crucial agents in wastewater treatment because they can remove oppositely charged impurities effectively and swiftly. However, flocculation also inevitably causes secondary contamination due to the residual properties, nonreusability, and nondegradability of traditional flocculant molecules. Herein, an ecofriendly starch-based flocculant, i.e., 2,4-bis(dimethylamino)-[1,3,5]-triazine-6-starch, was synthesized via a preactivation-etherification strategy. The large molecular weight property of the flocculant produced by this method enhances the intermolecular hydrophobic association, achieving complete phase separation of all flocculant molecules from water and residue-free flocculation for the first time. Importantly, a large molecular weight tertiary amine starch-based flocculant (LMTS) exhibits a remarkable flocculation capacity of over 1800 mg·g–1 for dye wastewater, which is significantly higher than that of traditional polyacrylamide and polyaluminum chloride flocculants. Furthermore, the LMTS flocculant could be recycled by pH adjustment, and its structural stability ensured sustained reusability. This high-performance residue-free biomass-based flocculant offers a green advance for wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2012
·Vol. 51
·期 3
·708-715
·
IF 3.919
Yong Shen,Yinan Ma,Zhibo Li
We report a highly efficient approach to prepare dendrimers by taking advantage of the orthogonal characteristic of aza-Michael addition and thiol-yne reactions. A fifth generation dendrimer was synthesized within five steps without protection/activation procedures. The reactions proceed under benign conditions without byproducts, and the target products can be easily purified via extraction or precipitation without chromatography. The structure of each generation dendrimer was characterized using NMR spectroscopy, size exclusion chromatography, and mass spectrometry. The obtained dendrimers can have peripheral amine or alkyne groups. We demonstrated that these groups can be used for selective and specific conjugation with various functional groups. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
研究领域:
材料科学
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2020
·Vol. 26
·期 57
·13022-13030
·
IF 4.857
Changren Liu,Ling'e Zhang,Sensen Zhou,Xiaoke Zhang,Wei Wu,Xiqun Jiang
Graphical Reductive response : A dendron-based fluorescence turn-on probe mediated by the Förster resonance energy transfer (FRET) mechanism is synthesized by conjugating one Cy5.5 molecule to the focal of a G3 dendron and eight Black Hole Quencher 3 (BHQ-3) molecules to its periphery through a reductively cleavable disulfide linkage. The fluorescence of the probe can be activated effectively and rapidly in the reductive environment of tumors. Specifically amplifying the emission signals of optical probes in tumors is an effective way to improve the tumor-imaging sensitivity and contrast. In this paper, the first case of dendron-based fluorescence turn-on probes mediated by a Förster resonance energy transfer (FRET) mechanism is reported. Dendrons up to the fourth generation with a hydrophilic oligo(ethylene glycol) scaffold are synthesized by a solid-phase synthesis strategy, and show precise and defect-free chemical structures. To construct the fluorescence turn-on probe, one Cy5.5 molecule is conjugated to the focal of a G3 dendron through a robust linkage and eight Black Hole Quencher 3 (BHQ-3) molecules are conjugated to its periphery through a PEG chain bearing a reductively cleavable disulfide linkage. By in vitro and in vivo experiments, it is demonstrated that the fluorescence of the dendron-based probe can be activated effectively and rapidly in the reductive environments of tumor cells and tissues, and the probe thus exhibits amplified tumor signals and weak normal tissue signals. Compared with the reported nanoscale turn-on probes, the dendron-based probe has several significant advantages, such as well-defined chemical structure, precisely controllable fluorophore/quencher conjugation sites and ratio, desirable chemical stability, and reproducible pharmacokinetic and pharmacological profiles, and is very promising in tumor detection.
研究领域:
生物化学
·
医学影像
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2018
·
IF 5.123
Weiguo Wang,Junmin Li,Changzhi Dong,Yafang Li,Qiuye Kou,Jinwu Yan,Lei Zhang
Amplifying the signal of ELISA is important in the early disease diagnosis. Herein we report an ultrasensitive ELISA applying for the detection of hCG based on the assemble of AuNPs induced by functional PAMAM . The AuNP-PAMAM probe shows a competitive advantage sensitivity of 0.03 IU L −1 compared to traditional ELISA and mAb 1 -AuNP-HRP probe. The line range is ranged from 0.1 to 6.4 IU L −1 . Moreover, the precision and reproducibility and specificity of AuNP-PAMAM probe are also eligible for the detection of hCG. The assembled AuNPs was firstly used in the signal enhancement in immunoassay .
研究领域:
生物医学
·
纳米技术
·
诊断学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Guoqing Cui,Xu Zhao,Li Liu,Guangfeng Wu
Hydrogels prepared from polyvinyl alcohol by freeze-thaw method have high mechanical strength and poor toughness due to high crystallinity, which severely limits the application of polyvinyl alcohol hydrogels. Usually, the toughness of hydrogels is often improved by sacrificing their mechanical strength. However, only a few hydrogels can improve their toughness by relying on only one single component to keep the mechanical strength unchanged. More similar hydrogels need to be developed. Herein, PVA/O20AC/EG ion-conducting hydrogels were prepared by dissolving poly (vinyl alcohol) (PVA), poly (oxyethylene 20 oleyl ether acrylate) (O20AC), and sodium chloride (NaCl) in ethylene glycol (EG)/water binary solvent. The longer hydrophobic chains of O20AC can form hydrophobic association micelles that act through hydrogen bonding in the crystalline microdomains between the polyvinyl alcohol chains. The dynamic micelles can effectively achieve energy dissipation in the hydrogel, allowing the hydrogel to improve its toughness without sacrificing mechanical strength. At the same time, the hydrogels have excellent anti-swelling properties. Additionally, a significant number of hydrogen bonds are formed in this system, enhancing the mechanical properties of the hydrogel, with a tensile strength of 1155.94 kPa and elongation at break of 722.49%, and its mechanical properties remain relatively unchanged after three cycles of processing. It can be processed into various desired shapes. The binary solvent strategy provides the hydrogel with good anti-freezing (−33.7 °C) and water retention (the weight of the PVA/O20AC/EG hydrogel remained 89.3% of the original after 7 days under conditions of 20 °C and 50 RH%). Furthermore, the presence of Na + and Cl − enables the hydrogel to exhibit highly sensitive conductivity changes with deformation (GF = 4.73). Therefore, the construction of poly (vinyl alcohol)-based hydrogels by amphiphilic O20AC, forming hydrophobic micelles and a large number of hydrogen bonds, provides a new idea for the development of multifunctional hydrogel sensing materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）