Physica Status Solidi-Rapid Research Letters
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2026
·Vol. 20
·期 3
·e202500440
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IF 2
Nan Zheng,Yuhan Bian,Mengxiao Chen,Xiandi Wang,Meng Wang
Wearable sweat analytics require sensors that are simultaneously chemically selective, mechanically conformal, and highly breathable. Here, we report a flexible electrochemical platform that integrates a polyaniline-modified gold electrode for pH detection with a laser-reduced graphene oxide electrode for uric acid sensing on a thermoplastic polyurethane nanofiber membrane. The porous substrate (59.5 mm/s air permeability; 2716.6 g/m 2 ·24 h water vapor transmission rate) sustains skin comfort while minimizing sweat-induced drift. The device delivers a near-Nernstian pH response (59.98 mV/pH, pH 4–8) and a linear uric acid signal (50–500 µM) with strong anti-interference capability; on-body tests show <6% deviation from a commercial pH meter and stable dual-analyte readouts during 8 h of activity. The device architecture offers an extensible platform for noninvasive, real-time biochemical monitoring in personal health, athletics, and disease prevention.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Xiangyang Tan,Bing Wan,Bin Zhang,Zijun Zhang,Jiayu Xu,Siyu Hu,Liangchong Yu,Taolei Sun,Guanbin Gao
Accurate detection and quantification of antioxidants are vital for human health and food safety. Here a colorimetric sensor array was developed to detect and quantify 8-typical antioxidants using two core-shell gold-nanostar (AuNS) nanozymes: AuNS@CuO and AuNS@FeS. These were synthesized via a seed growth method and coated with CuO or FeS layers. Both exhibit peroxidase-like activity, catalyzing TMB oxidation by H₂O₂. Different antioxidants inhibit this reaction to varying degrees, producing distinct absorbance patterns (fingerprints) measured at different time points. By means of linear discriminant analysis (LDA) and hierarchical cluster analysis (HCA), the designed colorimetric sensor array was capable of precisely identifying eight kinds of antioxidants within the concentration range of 15–1000 μM, and accurately discriminating mixtures composed of 2–3 kinds of antioxidants. The method was applied to monitor beverage quality, distinguishing soft drinks of different production dates and shelf lives by tracking changes in antioxidant profiles. This work presents a rapid and universal platform based on colorimetric sensors for the precise identification of antioxidants, offering strong potential for the rapid screening of the freshness and safety of liquid beverages with minimal sample preparation.
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Pharmaceuticals
·
2026
·Vol. 19
·期 3
·490
·
IF 5.7
Hailong Zhang,Jiaxin Huang,Wenji Yang,Wenhu Zhou,Jinsong Ding,Qianbin Li,Gaoyun Hu
Background : Hyperuricemia (HUA) is a metabolic disorder that severely threatens human health. Chronic uric acid (UA) overload promotes the progression of tubulointerstitial fibrosis (TIF), leading to impaired UA excretion. Our previous studies identified HIPK2 inhibitor XRF-1021, which exhibits robust anti-TIF activity and lowers UA levels in vivo. This study aimed to elucidate its UA-lowering mechanism and therapeutic potential for HUA. Methods : Uricase and xanthine oxidase (XOD) assays were performed to assess effects on UA degradation/production. HEK293T cells transiently expressing UA transporters and gene-knockdown rats were used to evaluate transporter inhibition, while HK-2 cells were analyzed by Western blot. Pharmacokinetics were characterized in rats. Efficacy was tested in potassium oxonate-induced acute HUA rats, diet/adenine-induced chronic HUA quails, and adenine-induced mice with HUA secondary to TIF. Maximum tolerated dose and long-term toxicity were assessed in rats. Results : XRF-1021 neither activated uricase nor inhibited XOD, indicating no direct effect on UA catabolism or synthesis. Instead, XRF-1021 inhibited URAT1 and GLUT9, reducing renal UA reabsorption, while sparing OAT3, OAT4, and ABCG2 activity and upregulating OAT3 and NPT4, suggesting minimal risk of disrupting drug or uremic toxin handling. XRF-1021 showed dose-dependent systemic exposure in rats, lowered serum UA, and provided renal protection in vivo. LD 50 values were 2345.4 mg/kg (male) and 1078.9 mg/kg (female), with no obvious toxicity after long-term dosing. Conclusions : XRF-1021 lowers UA by inhibiting URAT1 and GLUT9 to enhance renal UA excretion and provides kidney protection, supporting XRF-1021 as a promising candidate for HUA therapy.
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ELECTROCHIMICA ACTA
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2026
·
IF 5.8
Dongxin Wang,Jinglei An,Xinwei Chang,Yan Xu,Junxiu Zhao,Linying Gao,Ping Zhang,Xiangjun Li,Jisheng Nie,Hong Cui
Fluctuations in neurotransmitters and essential metabolites are closely linked to the development and progression of multiple diseases. Accurate monitoring of these biomolecules provides critical information for early diagnosis, disease evaluation, and timely clinical intervention. However, their coexisting electrochemical detection remains impeded by signal overlap due to similar redox potentials, such as uric acid (UA), dopamine (DA) and ascorbic acid (AA). This work reports a universal in-situ synthesis strategy to construct Zr-based metal-organic frameworks (MOFs) (UiO-66)/graphene oxide (GO) complexes, wherein the GO dosage critically regulates the crystallinity and pore architecture of UiO-66. Subsequent integration with protonated polyaniline (PANI) yields ternary composites (UiO-66/GO/PANI) as an electrochemical sensing platform for the simultaneous detection of UA, DA, and AA. Significantly, the partial autogenous reduction of GO during solvothermal synthesis eliminates the need for dedicated reduction steps and toxic reductants while enhances conductivity. The UiO-66/GO/PANI-modified glassy carbon electrode exhibits well-separated oxidation peaks for UA (0.32 V), DA (0.19 V), and AA (0.007 V). The sensor achieves low detection limits of 2.12 μM for UA, 1.68 μM for DA, and 18.49 μM for AA, together with excellent selectivity and practical applicability in complex samples. This work establishes a green synthesis paradigm for MOF/GO hybrids and provides a universal biosensing strategy for neurotransmitter and metabolite, with potential extensibility to complex biomarker panels in neurological diagnostics.
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TALANTA
·
2026
·
IF 6.7
Hui Kong,Chengchen Tang,Daiyue Zhang,Kexin Chen,Yinhua Liu,Lianqun Zhou
Dynamic assessment of renal function has become a critical requirement in clinical and health management. Existing detection methods primarily rely on samples such as blood or urine, posing significant challenges for portable, continuous, real-time monitoring. This study introduces a novel wearable electrochemical biosensing platform based on sweat analysis for non-invasive detection of creatinine, a key biomarker of renal function. The platform employs o-phenylenediamine as a functional monomer to construct a molecularly imprinted polymer recognition layer. Leveraging the multi-point hydrogen bonding interactions provided by its o-diaminic groups, this layer forms strong and specific bonds with creatinine, endowing the sensor with high molecular specificity and anti-interference properties. The system integrates a flexible skin-adhesive interface, an electrochemical detection unit, and a pentagonal star-shaped sweat collection module. It induces localized sweating at rest via built-in electrodes, enabling efficient transport and real-time analysis of fresh sweat. The sensor exhibits excellent linear response characteristics across a concentration range of 0.1 to 400 μM, with two linear regions, both showing correlation coefficients R 2 > 0.99. The platform demonstrated stable detection performance in authentic human sweat samples. Tests evaluating circadian variations in serum creatinine and the impact of protein intake confirmed the sensor's ability to capture fluctuations linked to dietary intake and physiological rhythms. This validates its feasibility for non-invasive, dynamic monitoring of renal function. This wearable device platform shows significant potential as a sweat biomarker monitoring tool, offering possibilities for convenient tracking and personalized management of kidney health.
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MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Yifan Zhu,Renjie Wang,Mengyao Ma,Hanyu Ji,Jinnan Gan,Xudong Song,Huijuan Ran,Qianqian Chen,Qiaohan Cheng,Hongyu Zhu,Qingsong Zhu
Uric acid (UA) concentrations serve as pivotal health indicators. This study developed a novel carbon paper (CP) and Fe-MOF composite and utilized it as an efficient electrochemical sensor for the detection of UA. SEM, XRD and FT-IR confirms the successful in-situ growth of Fe-MOF on the carbon paper substrate. The sensor exhibits a linear response to UA concentrations ranging from 3 to 400 μM, with a high correlation coefficient (R 2 = 0.998) and a LOD of 2.798 μM. The sensor demonstrates excellent reproducibility, with an RSD of less than 5%, and notable long-term stability, retaining 96.4% of its initial current response after one month. Furthermore, it exhibits selectivity in UA detection even in the presence of interfering species such as ascorbic acid and dopamine. The feasibility of using the CP/Fe-MOF sensor to detect UA in a typical biological fluid, bovine serum, was also evaluated by the standard addition method. The enhanced sensing performance can be attributed to the preservation of the carbon paper's superior electron transport properties within the composite material, combined with the increased specific active sites by the Fe-MOF components, which significantly boost the electrochemical sensing capabilities.
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BIOMEDICAL CHROMATOGRAPHY
·
2026
·Vol. 40
·期 3
·e70382
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IF 1.7
Linghao Zhao,Wei Yang,Shengjin Cui,Jingang Luo,Yaxin Cao,Nan Yan,Hongying Wang
Interference is a significant source of laboratory errors that can cause erroneous measurement results. In clinical practice, all the measured results should exclude the influence of interference. In this study, the ion exchange high-performance liquid chromatography of hemoglobin A1c (HbA1c) was evaluated via three brands of HbA1c analyzers, and 12 endogenous and 24 exogenous substances were added to hemoglobin solutions with different HbA1c levels to simulate the corresponding clinical samples. After the potential interfering substances were screened via interference screening testing, the interference concentration thresholds of each potential interfering substance were determined on the basis of dose–response experiment. When these substances exceed the interference concentration thresholds, elevated HbA1c values are caused by endogenous cholic acid and low pH, whereas exogenous ethanol increases HbA1c measurements in samples with low values. However, HbA1c measurements decreased in samples with high values. Although there are some differences in the thresholds of interferent concentrations between different brands of analyzers, the differences are not significant. On the basis of the detailed interference concentration thresholds and interference substances, this evidence can be provided to clinical laboratory experts and help them interpret and determine the testing results of clinical laboratories.
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BIOSENSORS & BIOELECTRONICS
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2026
·
IF 11.8
Xue Wang,Lin He,Zihan Li,Zongqian Hu
In modern medicine, glycemic control is critical for the health of individuals with diabetes. Over decades of care, patients with diabetes have relied on glucose meters for monitoring and on insulin or adjunct hypoglycemic agents for glycemic control. Frequent blood sampling and injections increase infection risk, restrict patient mobility, and generate substantial single-use medical waste. We present a simple, user-friendly closed-loop blood-glucose management system. The system integrates a highly sensitive glucose sensor and a controllable drug-release module within a dual-mode microneedle array, coupled with a miniature electrochemical workstation, thereby enabling dynamic glucose monitoring, precise drug delivery, and stable glycemic control with minimal patient intervention. The system's design demonstrates potential for achieving closed-loop glucose management. Preliminary proof-of-concept studies in diabetic mouse models yielded positive trends in relevant data. This work establishes an engineering framework integrating dual-mode microneedle devices with portable bioelectronic devices, providing a technical foundation for future mid-to-long-term closed-loop glucose management.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Jun Cao,Wen-Tao Yang,Dan Cao,Chang-Yi Wu,Peng-Cheng Zhou,Wei Zhu,Si-Jie Liao,Ji-Ming Hu,Ai-Guo Shen,Jürgen Popp
Excessive oxidative stress and chronic inflammation are key obstacles to diabetic foot ulcer (DFU) healing. However, indiscriminate scavenging of reactive oxygen species (ROS) can disrupt physiological redox signaling that supports tissue repair. Here, we present a flexible feedback-guided sensing-and-treating patch integrating a ratiometric surface-enhanced Raman scattering (SERS) probe for real-time H2O2 monitoring with a photothermal-triggered dimethylthiourea (DMTU) release system. The SERS probe enables quantitative detection of H2O2 through a phenylboronic acid reporter, while near-infrared (808 nm) irradiation precisely triggers on-demand antioxidant delivery to restore physiological H2O2 levels. In diabetic mouse models, this hybrid patch effectively reduced oxidative stress, modulated inflammatory cytokines, promoted angiogenesis and collagen deposition, and markedly accelerated wound closure without adverse systemic effects. This work establishes a monitoring-guided redox-regulation strategy for intelligent, responsive wound management and highlights the potential of SERS-based theranostic materials in advanced biomedical applications.
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TALANTA
·
2026
·
IF 6.7
Ning Sheng,Qinghui Zhao,Jianqiang Wang,Xu Yao,Boyuan Li,Xianyang Zeng,Jingwen Sun,Jingquan Sha
The development of high-performance oxidase-like nanozymes is crucial for advancing biocatalysis and biosensing. Polyoxometalates (POMs) are promising candidates but suffer from high solubility and inefficient interfacial electron transfer. Conventional immobilization often overlooks the matrix's role in catalysis. Herein, a dual-strategy enhanced nanozyme was developed by in-situ oxidative polymerization of a mono-V-substituted phosphomolybdic acid H 5 [PMo 11 VO 40 ] (PMo 11 V 1 ) into a conductive polypyrrole (PPy) matrix. The optimal composite PMo 11 V 1 @PPy-2 exhibits 2.2-fold higher oxidase-like activity than its conventional immobilized counterpart. Ultrasonic irradiation (100 kHz) further enhances its activity by ∼ 80% through improved mass transfer. Leveraging this synergy, a highly sensitive colorimetric biosensor for glutathione (GSH) detection was constructed, achieving a low detection limit (0.73 μM), a wide linear range (1-80 μM), excellent recovery in serum (99.4% to 100.6%), and high selectivity. This work demonstrates that rational integration of static material design with dynamic process engineering can overcome fundamental limitations in heterogeneous nanozyme catalysis, providing a generalizable strategy for developing high-performance enzymatic mimics for biomedical applications.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·649
·
IF 5.4
Cai Chuangui,Lin Zhen,Yao Wensong,Lian Shan,Huang Kaiyuan,Deng Haohua,Lin Xinhua,Chen Wei
Arginine surface-engineered 6-aza-2-thiothymine gold nanoclusters (Arg/ATT-AuNCs) via host-guest assembly were synthesized which exhibit exceptional catalytic activity and intense photoluminescence. Arg/ATT-AuNCs enhanced the CL intensity from NaIO 4 -H 2 O 2 system by 1200-fold. The CL mechanistic studies revealed that Arg/ATT-AuNCs not only accelerated decay of H 2 O 2 to form reactive oxygen species, but also acted as efficient energy acceptors of singlet oxygen ( 1 O 2 ) via a CL resonance energy transfer (CRET) pathway. It was observed that doxorubicin (DOX) quenches the CL signal through an inner filter effect that disrupts the CRET process. Based on this, a straightforward, rapid, and highly sensitive biosensor has been developed for the detection of DOX in human serum samples, achieving a low detection limit of 0.029 µM. The biosensor was applied to DOX determination in human serum samples with recoveries ranging from 91.1 to 106.2%. This study not only provides a new method for the detection of DOX, but also broadens the application scope of AuNCs in the field of CL. Graphical
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·644
·
IF 5.4
Yang Mengyin,Yang Weiqiang,Ni Chengliang,Song Zhiping,Chen Xiaoping,Wang Qingxiang,Ni Jiancong,Lin Zhenyu
A biochemical reaction-regulated electrocatalysis strategy for quantitative cholesterol detection using platinum nanoparticle-functionalized indium tin oxide electrodes for electrochemiluminescence. In this system, cholesterol is oxidized by cholesterol oxidase to generate H 2 O 2 in situ, which serves as an endogenous electroactive species and undergoes reduction at the BPE cathode. According to the charge balance principle, the cathodic reaction drives the anodic oxidation of the Ru(bpy) 3 2+ /TPrA system, generating an ECL signal that correlates quantitatively with cholesterol concentration. PtNPs at the BPE cathode enhance the electrocatalytic reduction of H 2 O 2 and accelerate interfacial electron transfer, leading to an amplified anodic ECL response. Under optimized conditions, the platform exhibits a linear range of 0.1–10 mM with an extrapolated detection limit of 98.4 µM. The proposed sensing strategy was successfully applied to cholesterol detection in human serum samples, demonstrating good accuracy and anti-interference capability. Notably, the ChOx-catalyzed oxidation of cholesterol proceeds homogeneously in the sensing solution, while no enzyme-immobilization step is required during sensor preparation. In addition, no externally added electroactive species are required in the sensing cell, while the Ru(bpy) 3 2+ /TPrA ECL system is confined to the reporting cell. This sensing/reporting separation effectively minimizes cross-interference. Graphical abstract
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