Advanced Healthcare Materials
·
2024
·Vol. 14
·期 1
·2402272
·
IF 10
Hongwei Zhang,Linfu Chen,Qian Chen,Qiufang Chen,Jun Zhou
Tirapazamine (TPZ), an antitumor prodrug, can be activated in hypoxic environment. It specifically targets the hypoxic microenvironment of tumors and produces toxic free radicals. However, due to the tumor is not completely hypoxic, TPZ often fails to effectively treat the entire tumor tissue, resulting in suboptimal therapeutic outcomes. Herein, a low pathogenic Escherichia coli TOP10 is utilized to selectively colonize tumor tissues, disrupt blood vessels, and induce thrombus formation, leading to the expansion of hypoxic region and improving the therapeutic effect of TPZ. Additionally, a thermosensitive hydrogel is constructed by Pluronic F-127 (F127), which undergoes gelation in situ at the tumor site, resulting in sustained release of TPZ. To monitor the therapeutic process, it is genetically modified TOP10 by integrating the bioluminescent system luxCDABE (TOP10-Lux). The bioluminescent signal is associated with tumor hypoxia enhancement and thrombus formation, which is beneficial for therapeutic monitoring with bioluminescence imaging. In the murine colon cancer model, the TOP10-Lux combined with TPZ-loaded F127 hydrogel effectively suppressed tumor growth, and the treatment process is efficiently monitored. Together, this work employs genetically modified TOP10-Lux to enhance the therapeutic efficacy of TPZ and monitor the treatment process, providing an effective strategy for bacteria-based tumor-targeted chemotherapy and treatment monitoring.
研究领域:
肿瘤学
·
微生物治疗
·
分子影像学
·
药物递送
·
生物材料
·
转化医学
·
合成生物学
✓ 已验证
DOI
高影响因子
Laser & Photonics Reviews
·
2024
·Vol. 19
·期 1
·2401012
·
IF 9.8
Pengcheng Jian,Maohua Chen,Dongyan Li,Yongming Zhao,Weijie Liu,Yuang Luo,Xiantai Tian,Meng Peng,Xing Zhou,Jiangnan Dai,Feng Wu,Changqing Chen
The extraordinary mechanical compliance of 2D molybdenum disulfide (MoS 2 ) makes it an ideal candidate for strain modulation of various electrical and optical properties. However, developing facile methods for accurate and stable engineering of strain still remains a major challenge. Here, a novel and effective method is demonstrated for introducing periodic strain into monolayer MoS 2 by direct growth on nano-patterned sapphire substrates (NPSS). A mixed aqueous solution of Na 2 MoO 4 and NaOH is spin-coated on the NPSS and sulfurated in one step by chemical vapor deposition (CVD). Highly oriented monolayer MoS 2 single-crystal nanosheets with high quality and few sulfur vacancies are achieved conformally on the NPSS via a liquid-mediated growth mode. Notably, the periodically distributed blue shift of the PL emission peak demonstrated periodic compressive strain is introduced into the nano-patterned MoS 2 via the thermal expansion difference between MoS 2 and substrates. Furthermore, photodetectors fabricated using the nano-patterned monolayer MoS 2 exhibit a high photo-to-dark current ratio (PDCR) over 10 6 , an excellent detectivity of 5.4 × 10 13 Jones, and a fast photoresponse of 7.7 ms, owing to the strain-induced back-to-back built-in electric field, enhanced light absorption by light-scattering effect and fewer S vacancy defects. The scanning imaging demonstration based on the single-pixel nano-patterned MoS 2 photodetector further confirms its great potential in image sensors. This work hereby presents a pathway for direct conformal growth of nano-patterned monolayer MoS 2 with precisely periodic strain, which should inspire the applications for high-performance optoelectronic devices via the strategy of patterned substrate engineering by the periodic nanostructures.
研究领域:
材料科学
·
纳米科技
·
光电子学
·
凝聚态物理
·
表面科学
·
半导体器件
✓ 已验证
DOI
高影响因子
Materials Today Physics
·
2022
·
IF 11.021
Zilin Ruan,Jianchen Lu,Baijin Li,Qizan Chen,Zhenliang Hao,Lei Gao,Jinming Cai
Structural defects in two-dimensional materials offer an effective way to engineer their functionalities. In-situ local measurements to build the structure-function relationship are crucial for future device technology. Here, we present a comprehensive study of intrinsic defects in single-layer WS 2 grown by chemical vapor deposition using a combination of scanning tunneling microscopy/spectroscopy, non-contact atomic force microscopy and density functional theory calculations. We probed the rarely observed positively charged defects and the intersection of adjacent charging rings at sufficiently high bias caused by subsurface defects. We also directly identified and visualized the widely observed negatively charged defects as chalcogen vacancies-related defects. The results reported here will guide future efforts of targeted defect engineering and doping of the single-layer transition metal dichalcogenides .
研究领域:
材料科学
·
凝聚态物理
·
纳米科技
·
表面科学
·
二维材料
·
半导体物理
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yang Bai,Yanbiao Zhao,Weidong Li,Linghui Meng,Yongping Bai,Guorong Chen
The developing sulfide solid electrolyte is a promising way to overcome shuttle effect of polysulfide in the traditional liquid Li-S battery. However, an air stable sulfide solid electrolyte and competitive solid–solid interface structure must be constructed firstly. Herein, we have designed an organic–inorganic multi-scale composite electrolytes to overcome the interfacial issues of solid state Li-S batteries (SSLSBs). The organic–inorganic composite electrolyte consists of a gel polymer electrolyte (GPE) and an oxygen doped inorganic sulfide solid electrolyte. The O doped sulfide solid electrolyte improves its chemical stability and suppresses the lithium dendrites. A thin GPE film protects the crystal structural stability during cycles and greatly enhances the performance of O doped sulfide solid electrolyte due to the GPE not only constructs soft interface contact between S cathode and solid electrolyte, but also builds lithium ion transport paths by ionic liquid between them. Those SSLSBs display a very good cycling performance with the specific capacity of 1023 mAh/g after 50 cycles at 60 °C and 541 mAh/g after 150 cycles at 30 °C under same rate of 0.1 C. This study demonstrates that the development of advanced solid-state Li-S battery needs to fully integrate a number of technical advantages.
研究领域:
电化学
·
材料科学
·
固态电池
·
能源存储
·
界面化学
·
纳米材料
·
电极材料
✓ 已验证
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2023
·
IF 5.4
Yang Guo,Xiaoying Guo,Haipeng Lu,Xian Jian
Developing high–efficient microwave absorbing (MA) materials with anti–corrosion (AC) properties to tackle the harsh hygrothermal marine conditions remains a challenge. Herein, we employed catalytic chemical vapor deposition and the Stöber technique to fabricate gradient multilayer interface–coupled FeNi@C@SiO 2 composites, guided by the hetero–interface engineering. The resulting composites exhibited exceptional MA properties and AC behavior. Specifically, they showcased a remarkable effective absorption bandwidth of 6.27 GHz at 1.40 mm, outperforming that of FeNi (3.80 GHz). This improved bandwidth was attributed to the electron conduction pathway provided by the C layer, which facilitated electron migration and hopping. The C@SiO 2 layer, containing defects and –OH functional groups, induced abundant dipole polarization and optimizes the impedance matching of FeNi. Furthermore, the RCS reduction value of FeNi@C@SiO 2 could reach 16.73 dB·m 2 . Moreover, the corrosion rate of FeNi@C@SiO 2 was 7.48 × 10 −11 m/s, significantly lower than that of FeNi (1.29 × 10 −10 m/s). This reduction was primarily due to the intrinsic inertness and impermeability of the C@SiO 2 layer, effectively isolating the corrosive medium from the substrate. This investigation presents a novel point of reference for the advancement of bifunctional MA materials intended to cope with extreme environments.
研究领域:
材料科学
·
纳米复合材料
·
表面工程
·
电磁功能材料
·
腐蚀防护
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）