查找使用阿拉丁产品的科研文献

Evaluation of the inhibitory efficacy of ionic liquids on asphaltene precipitation in crude oil

Li Liu,Shuaishuai Zhao,Bo Zhou,Zhihao Li,Zhiqiang Wang,Jinyun Wei,Yanfu Pi,Mengyi Xing,Junfeng Wang

CO2 flooding technology demonstrates advantages such as injectability and miscibility in low-permeability reservoir development; however, asphaltene deposition during the displacement process leads to pore-throat blockage and permeability reduction. To address this issue, this study systematically investigated the inhibitory effects of three ionic liquids and one commercial inhibitor on asphaltene deposition in crude oil, with the underlying mechanisms elucidated through molecular dynamics simulations based on interaction energy. Additionally, CO2 flooding coupled with nuclear magnetic resonance was employed to quantitatively characterize the damage extent of asphaltenes to reservoir physical properties and pore structures during CO2 displacement. Experimental results demonstrated that after inhibitor addition, the asphaltene precipitation onset point of oil samples significantly increased from 34% to 52%, asphaltene aggregate particle size decreased from 1,082 nm to 410 nm, and turbidity values declined by 10–30%. This improvement is attributed to the ionic liquids’ ability to disrupt asphaltene molecular association via electrostatic interactions, steric hindrance, and hydrogen bonding, while simultaneously modifying the system’s polarity, thereby effectively inhibiting asphaltene deposition. Molecular dynamics simulation results exhibited strong consistency with experimental findings. The inhibitors mitigated the adverse impacts of asphaltene deposition on core porosity, permeability, and blockage rates. This study reveals that ionic liquids hold significant potential for inhibiting asphaltene deposition during CO2 flooding in low-permeability reservoirs.

Phase-change pickering emulsions with solid-core confinement stabilized by tannic acid-functionalized zein nanoparticles for enhanced β-carotene bioaccessibility

Like Wang,Peiyan Feng,Bo Liu,Shuheng Wei,Peng Tang,Shouwei Yin

Novel phase-change Pickering emulsion microcapsules (PCPEs) were constructed using tannic acid (TA)-modified zein nanoparticles (T-zein) and a lauric acid/stearic acid eutectic (LS) to encapsulate β-carotene. The grafting of TA tuned the wettability of zein nanoparticles, enabling stable emulsification at 50 °C. Subsequent cooling resulted in microcapsules with a T-zein shell and crystalline core (LS), achieving an encapsulation efficiency of 88.15 %. The solidified oil phase restricted molecular migration, while interfacial T-zein provided dual protection, reducing β-carotene degradation under UV irradiation and auto-oxidation by 57.19 % and 67.88 %, respectively, compared with liquid-core emulsions. In vitro digestion studies showed that phase change triggered by physiological temperature enabled controlled release. PCPEs displayed superior gastric stability and resistance to coalescence in the intestine, enhancing the bioaccessibility of β-carotene to 42.57 % (36 % higher than liquid-core emulsions and 298 % of the free control). Overall, this solid-core engineering strategy presents a novel platform for the rational design of emulsion for targeted delivery of lipophilic bioactives.

Injectable, Antifouling Granular Zwitterionic Hydrogels for Preventing Postoperative Intrauterine Adhesion and Restoring Fertility

Mengyun Shi,Jiepei Lin,Qilin Wang,Hui Yu,Min You,Qiang Chen,Feng Lin,Sisi Zhang

The development of innovative therapeutic strategies to support endometrial repair and regeneration while preventing adhesion recurrence represents a critical research priority for improving clinical outcomes in women with intrauterine adhesions (IUA). Herein, a granular zwitterionic poly(sulfobetaine methacrylate) (PSBMA) hydrogel was engineered to exhibit injectability, biocompatibility and robust antifouling properties as quantified by reduced nonspecific protein adsorption. Therapeutic efficacy was demonstrated in a rat model, where the hydrogel distinctly reduced collagen deposition, attenuated fibrotic progression, and promoted morphological restoration of the endometrium. Furthermore, significant reductions in inflammatory responses in vivo were achieved through diminished macrophage infiltration and downregulation of pro-inflammatory cytokines, including IL-1β and TNF-α. The hydrogel was also shown to enhance endometrial proliferation, stimulate angiogenesis, and improve endometrial receptivity as indicated by upregulated expression of receptivity markers. Functional recovery was evidenced by successful embryo implantation post-treatment, underscoring the hydrogel’s potential to restore fertility. These findings collectively suggest that the granular PSBMA hydrogel represents a therapeutic platform for addressing endometrial injury, modulating inflammation, and facilitating fertility restoration, thereby offering potential for improved clinical outcomes in IUA management. Statement of Significance Current intrauterine adhesions (IUA) treatments, such as hormonal therapy and surgical adhesiolysis, suffer from high recurrence rates and limited efficacy. This work innovates with an injectable granular zwitterionic PSBMA hydrogel—adaptive to uterine contours, antifouling (reduced nonspecific adhesion), and biocompatible. It attenuates fibrosis (less collagen), suppresses inflammation (diminished macrophages/IL-1β/TNF-α), promotes endometrial proliferation/angiogenesis, and restores receptivity/fertility (successful implantation in rats). This multifunctional platform advances IUA treatment and enables clinical translation potential in reproductive medicine.

Corrigendum to “High-selective dehydration of bio-alcohols to oleffns over vanadium-doped hydroxyapatite catalyst with engineered defect sites” [J. Alloys Compd. 1036 (2025) 181853]

Dongying Yan,Chenxi Bai

The coal slime-derived zeolite-supported Ru catalyst for ethylene hydroesterification

Yibo Tang,Jiabing Chen,Xiaowei Zhu,Xiaojun Lu

Ethylene hydroesterification is an important carbonyl synthesis reaction that allows the production of corresponding esters from CO, alcohols, and olefins, achieving 100% atom efficiency. This study reports a Ru-based catalyst supported on a catalytic carrier material derived from flotation coal tailings, which demonstrates excellent catalytic performance in the methoxycarbonylation of ethylene to produce methyl propionate (MP). The molecular sieve prepared from the flotation coal tailings has a cubic structure, and the rich folds and grooves on its surface provide excellent anchoring sites for loading Ru nanoclusters. This structure allows better fixation of Ru metal clusters and promotes strong metal-support interactions. After loading 2% Ru, the catalyst exhibits the best catalytic performance. The acidic sites on the molecular sieve provide more protonic acid sites, which facilitate the formation of Ru-H species and enhance the dissociative activation of ethylene via a reverse hydrogen spillover mechanism. This leads to a significant increase in the generation rate of reaction intermediates, thereby improving the catalytic activity. The use of waste flotation coal to prepare molecular sieves achieves waste recycling, with a green and simple preparation process. Furthermore, the results of this study offer new insights for future research on olefin hydroesterification and hydroformylation, as well as other carbonyl synthesis reactions.

In-situ microextractive adsorption of α-pinene from fermentation broths by a recombinant yeast

Xu Zhou,Yapeng Zhang,Huipeng Gao,Quan Zhang,Lei Qin,Yuesheng Dong,Chun Li,Yaqin Sun,Zhilong Xiu

α-Pinene, a promising advanced biofuel, has garnered significant attention in the field of synthetic biology. However, its high cytotoxicity and volatility pose substantial challenges for efficient recovery from fermentation broths. This study explores a novel solid–liquid phase microextractive adsorption (SLPMA) technique to achieve in-situ separation of α-pinene from fermentation broths using a recombinant yeast. The extractant was immobilized into a polystyrene (PS) skeleton through copolymerization to prepare six resins for in-situ microextractive adsorption of α-pinene in the fermentation broth. The optimal extractant, isopropyl myristate (IPM), incorporated into the PS resin (PS-IPM) exhibited acceptable biocompatibility. Comprehensive characterization of the PS-IPM resin using FTIR, SEM, nitrogen physisorption, and TGA confirmed the successful immobilization of IPM (41.39 wt%) and material suitability. Compared to traditional extractive fermentation methods, the SLPMA process significantly enhanced cell growth promotion efficiency by 4.5 times. This improvement is attributed to the immobilization of the extractant within the porous material, which increased the extraction interface area and induced a microextraction effect. This effect enriched the α-pinene concentration in the regular fermentation broth toward the IPM phase of the PS-IPM microextractor by 57.9-fold. It increased the α-pinene concentration by 2.3-fold compared to the IPM from the extractive fermentation system. Consequently, the PS-IPM resin exhibited outstanding performance and effectively mitigated product inhibition. The resin successfully facilitated multiple cycles of in-situ α-pinene separation during fermentation, achieving a recovery of up to 95.82%. Furthermore, the removal efficiencies for inorganic salts, pigments, and proteins in the fermentation broth exceeded 98%. A delayed resin addition strategy was also implemented, further enhancing operational efficiency. FTIR analysis, combined with quantum chemical calculations, revealed that the strong van der Waals interaction is the primary driving force behind the separation process. This interaction enables the PS-IPM resin to function as an effective microextractor during adsorption. The study highlights the considerable potential of the SLPMA process for in-situ α-pinene separation during fermentation, providing a valuable reference for addressing challenges in other product-inhibited fermentation systems.

Molecular dynamics guided design of a dual-functional viscosity reducer to break asphaltene aggregates in heavy oil

Saiyi Song,Xiangyu Chen,Xiaojie Feng,Xiaoxiao Wei,Yinghua Sun,Shuqian Xia

The depletion of conventional light oil reserves and the escalating global energy crisis have intensified the strategic imperative to develop unconventional heavy oil resources. However, the efficient extraction and transportation of heavy oil are severely hampered by its inherent high viscosity, primarily caused by elevated contents of asphaltenes. In this work, an oil-soluble polymeric viscosity reducer (MPPMO) was pre-designed using molecular dynamics (MD) simulations and realized by grafting polyethylene glycol monomethyl ether (PGME) onto the PMO backbone to integrate polar functionalities with a long-chain structure. Performance evaluation demonstrated that MPPMO achieves a net viscosity-reduction efficiency of 42.51%, markedly outperforming PMO (35.54%) with a relative improvement of about 20% in high-viscosity crude oil (OIL A, 17951 mPa·s) at 50 °C, while maintaining an exceptional stability over 14 h. Molecular dynamics simulations illustrate that introducing polar groups (–COOH and –O–) enables MPPMO to interact more strongly with asphaltenes than PMO, leading to the breakdown of asphaltene aggregates and viscosity reduction, while the long-chain backbone of MPPMO further inhibits their re-aggregation through steric hindrance. Therefore, these findings support a molecular-design strategy that couples long-chain backbones with multiple polar functional groups to improve the dispersion of asphaltene aggregates and enhance heavy-oil flowability.

Anti-biofouling hydrophobic liquid surface for plasmid extraction on a digital microfluidics chip

Liu Zhen,Chen Rifei,Huang Kaicheng,Zhu Haiping,Liu Jiaze,Wu Chunhui,Wang Liqiu,Cheng Xing

Digital microfluidics (DMF) shows a great application prospect in droplet manipulation. However, the fouling of the hydrophobic surfaces caused by biomolecules limits its development. In this study, we report a new strategy to enhance the functionality and anti-biofouling performance of the DMF chip by using a hydrophobic liquid surface (HLS) rather than a regular hydrophobic solid surface (HSS). The DMF chip with such a configuration can efficiently drive various liquids with full-function operations. Moreover, our DMF chips can directly manipulate biomolecular droplets without restrictive conditions like adding surfactants or filling with silicon oil. The liquid-liquid contact between the droplet and the hydrophobic surface ensures that the non-specifically adsorbed biomolecules move along with the droplet. Thus, no residue is left behind to ruin the hydrophobicity of the hydrophobic surface. Meanwhile, the long-term reversibility of contact angle change and stability of droplet movement demonstrate the excellent ability against biofouling. In addition, high- and low-temperature tests also show the temperature stability of the HLS. Finally, a biochemical application, plasmid extraction of Escherichia coli ( E.coli ) cells, is successfully carried out on the DMF chip with HLS as a proof of its usability. This HLS is expected to offer versatile functionalities and anti-biofouling performance for DMF chips in handling biomolecular droplets.

Stabilizing an scu-topology Zr-MOF via linker installation for enhanced gas chromatographic separation

Chu Zeng,Hong-Tao Jiang,Ming Xu,Zhi-Yuan Gu

Flexible metal–organic frameworks (MOFs) with dynamic adaptability offered exciting opportunities for advanced separation, yet their tendency to undergo void collapse severely limited their application as gas chromatography (GC) stationary phases. Here, we overcame this challenge by stabilizing the scu -topology Zr-MOF NU-903 through a linker installation strategy. By incorporating biphenyl-4,4′-dicarboxylic acid (BPDC) into the vacant coordination pockets along the c-axis, the resulting material, NU-903-BPDC, exhibited markedly enhanced stability and structural rigidity, retaining its porosity even at 250 °C. Comprehensive characterization confirmed that the original structure was preserved, while framework flexibility was effectively suppressed. Fluorescence spectroscopy further revealed restricted ligand dynamics, corroborating the rigidified framework environment. When employed as a GC stationary phase, NU-903-BPDC delivered significantly improved resolution for C 7 hydrocarbons and dichlorobenzene isomers, benefitting from stronger thermodynamic interactions and reduced band broadening. Crucially, NU-903-BPDC maintained stable separation performance after thermal treatment, in sharp contrast to the pronounced degradation observed for pristine NU-903. This work demonstrated linker installation as an effective strategy to modulate framework flexibility, opening a general pathway toward robust, high-performance MOF-based stationary phases for chromatographic separations.

Lignin Nanoparticle Stabilized Pickering Emulsion Coating for Fabricating Water- and Oil-Proof, Biodegradable, and Recyclable Paper

Zhenke Wei,Jiayu Liu,Yonggui Wang,Zefang Xiao,Yanjun Xie

Paper derived from plant fibers is considered a highly promising alternative to non-degradable plastic packaging. However, its widespread use in packaging is limited by its poor water- and oil-proof properties. To address this challenge, this study developed a polyvinyl alcohol (PVA)/lignin nanoparticles (LNPs)/stearic acid (SA) (PLS) Pickering emulsion composite coating to fabricate high-performance biodegradable paper. In the emulsion system, the PVA acted as an oil-repellent in the aqueous phase, the SA served as a water-repellent in the oil phase, and the LNPs functioned as emulsifiers that effectively stabilized the emulsion. Owing to the synergistic effect among PVA, SA, and LNPs, the coated paper exhibited good water- and oil-proof properties (with a water contact angle of 111.2°, Cobb 60 value of 17.73 g/m 2 , and Kit rating exceeding 9/12), along with high mechanical strength (including a dry tensile strength of 7.12 kN/m and a wet tensile strength of 0.97 kN/m). While significantly enhancing performance, the PLS emulsion coating retained the environmental benefits of paper, could be easily removed to facilitate fiber recycling, and the coated paper was fully degradable in soil within 120 d. Overall, the PLS emulsion coating effectively enhanced the properties of paper without compromising its eco-friendly characteristics, demonstrating significant potential for promoting the substitution of plastic with paper.

COF Scaffold Membrane with Gate-Lane Nanostructure for Efficient Li+/Mg2+ Separation

Zhang Zixuan,Kong Yan,Li Runlai,Yue Xiaolin,Deng Hao,Zheng Yu,Zhang Sui,Zhang Runnan,Jiang Zhongyi

Covalent organic framework (COF) scaffold membranes with gate-lane nanostructure were prepared. The gating layer affords high rejection to Mg 2+ and thus high Li + /Mg 2+ selectivity. The permeating layer bearing Li + lanes and Cl − lanes facilitates Li + transport and thus high Li + permeability. The COF scaffold membrane exhibits the true selectivity of 231.9 with Li + enrichment of 120.2% at the Mg 2+ /Li + mass ratio of 50, exceeding the ideal selectivity of 80.5.

Enhanced permselectivity and resistance of nanofiltration membrane through short hydrophobic chain-based surfactant-regulated interfacial polymerization

Kunyu Jin,Senhao Wang,Yingying Liu,Haifeng Zhang,Ming Wang,Zhi Wang

Membranes with high selectivity and water permeance are required for improving product water quality and increasing process efficiency. Traditional surfactant-assisted interfacial polymerization (IP) could improve selectivity of polyamide (PA) nanofiltration (NF) membranes but usually decreased water permeance. Here, short hydrophobic chain surfactant, sodium p-styrene sulfonate (SSS) with styrene and sulfonic acid groups was utilized as a new aqueous surfactant during IP process to prepare the PA-NF membrane, improving water permeability and salt rejection simultaneously. SSS had higher critical micelle concentration and can be richly incorporated within PA layer. The membranes characterizations were conducted by atomic force microscopy, scanning electron microscopy, attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, goniometer, and zeta potential analyzer. The regulated membrane exhibited slightly enlarged and more uniform pore size, as well as smoother, more hydrophilic and negatively charged membrane surface. The water flux increased from 46.6 ± 3.7 L∙m −2 ∙h −1 to 61.9 ± 2.6 L∙m −2 ∙h −1 (increasing by 32.83%), while Na 2 SO 4 rejection increased by 10.18%. The Cl − /SO 4 2− selectivity increased from 15.2 to 45.1 when using mixed salts solution as feed. Furthermore, SSS-regulated membrane demonstrated increased tetracycline rejection. Enhanced resistance properties (pH stability and antifouling properties) were also observed for SSS-regulated membrane. The study presents a novel surfactant for the fabrication of PA-NF membrane.