npj Science of Food
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2026
·
IF 9.7
Shi Cong-Rong,Zhang Xiao-Juan,Xie Han,Zhang Wei,Tang Rui-Xin,Lu Zhen-Ming,Geng Yan,Lu Ran,Wang Fang-Zhou,Chai Li-Juan,Zhang Hui-Ling,Xu Hong-Yu,Shi Jin-Song,Xu Zheng-Hong
Hyper-osmotic stress in high-sugar fruits inhibits the fermentation performance of lactic acid bacteria (LAB). Besides, there is a prevailing trend of low-sugar diets for health concern. Therefore, it is essential to develop LAB strains with high-sugar tolerance and efficient sugar metabolism. In this study, three high-sugar-adaptive strains (2–12 mutations) were obtained through random mutagenesis and screening at 150 g/L glucose. When applied to high-sugar goji juice fermentation, they reduced glucose from 92.26 to 28.85 g/L, reached 2.56*10 9 CFU/mL, and shifted the sensory profile from sweet and herbal to fruity and pleasantly sour. Metabolomics revealed enrichment of bioactive metabolites such as indole-3-lactate (+22.32%), linoleate (+16.37%) and spermine (+64.50%) in strain LP-4-3*. Mechanistically, high-glucose-adaptive LAB accumulated more maltose, galactitol, and glycosylated phenolic compounds to alleviate osmotic pressure induced by high glucose. This study highlights the potential of high-glucose-adaptive LAB in developing low-sugar and health-promoting fermented fruit juices.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.4
Yuanxin Zhao
Biobutanol is a superior biofuel alternative, but its recovery from acetone-butanol-ethanol (ABE) fermentation is inefficient due to azeotrope formation and high energy costs. This study investigates fructose-induced sugaring-out for phase separation and breaking the azeotrope, optimizing ABE recovery by analyzing the effects of sugar concentration and temperature. The results demonstrate efficient phase separation, with butanol recovery reaching 93.1%, acetone recovery at 66.0%, ethanol recovery at 59.1%, and water removal at 92.3%. Increasing fructose concentration enhances water exclusion and phase separation, while temperature variations play a secondary role compared to fructose concentration, only affecting separation efficiency at lower sugar concentrations. The findings highlight the dominant role of fructose-induced sugaring-out in phase formation and its potential for optimizing biofuel recovery. This method offers a highly efficient and tunable strategy for solvent recovery and water removal in biorefinery applications.
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Green Energy & Environment
·
2026
·
IF 16.7
Zhiyang Tang,Xianyuan Wu,Jie Qu,Xinjun He,Fukun Li,Jinxing Long,Qiang Zeng,Haixia Su,Hongyan He,Xuehui Li
Selective hydrogenolysis of cellulose into C 6 -ketones offers a promising route for the production of high-value carbonyl compounds. However, conventional metal-catalyzed hydrogenolysis methods typically rely on externally added acids and require high-purity H 2 . Herein, we report an alternative syngas-promoted hydrogenolysis method that eliminates these dual dependencies while enabling the selective transformation of cellulose into value-added C 6 -ketones. Under optimal conditions, using a commercial Pd/C catalyst at 230 °C and 3.0 MPa total pressure (H 2 /CO = 1.5/1.5 MPa) for 2 h, the yield of C 6 -ketones reached 37.8 C-mol%, representing a 6.8-fold enhancement compared to that obtained under pure H 2 . Mechanistic studies demonstrated a dual promotional effect of CO in directing cellulose to C 6 -ketones. First, competitive adsorption of CO on Pd active sites suppresses excessive hydrogenation and undesired hydrogenolysis of cellulose-derived intermediates. Second, CO participates in the water–gas shift (WGS) reaction (CO + H 2 O ⇌ CO 2 + H 2 ), generating carbonic acid (H 2 CO 3 ) in-situ via CO 2 + H 2 O ⇌ H 2 CO 3 , which provides a controllable acidic environment that promotes key intermediate transformations associated with C 6 -ketone precursor formation.
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JOURNAL OF FOOD PROCESS ENGINEERING
·
2026
·Vol. 49
·期 2
·e70394
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IF 3.5
Shutian Ma,Hongyu Zou,Manling Zhang,Jinyuan Zhang,Zhuang Shi,Yi Yang,Jinglin Zhang,Yuang Zhang,Liming Zhang,Enjie Diao
Black garlic (BG) was prepared at 70°C–75°C with different processing relative humidities (RHs) for 9 days. The effects of processing RH (65%–95%) on the physicochemical properties and antioxidant capacity of BG were investigated. The results showed that higher processing RH was not conducive to the browning of BG. When the processing RH increased from 65% to 95%, the glucose and fructose contents in BG obviously increased by 42.96% and 112.80% ( p < 0.05), respectively; while the browning degree, total acid, total polyphenol, total flavonoid, allicin, and alliin contents decreased by 4.01%, 11.44%, 27.36%, 44.26%, 40.98%, and 48.10% ( p < 0.05), respectively. The potentially harmful substances acrylamide and 5-hydroxymethylfurfural (5-HMF) also significantly decreased by 69.63% and 82.61% ( p < 0.05), respectively. However, the IC 50 values for DPPH and ABTS increased by 28.75% and 46.96% ( p < 0.05), respectively, indicating the decrease in antioxidant capacity of BG. The changes in fructose content and IC 50 values could be well simulated by the zero-order kinetic models, while other physicochemical parameters all followed the pseudo-first-order kinetic models with different regression equations. Overall, 85% processing RH can effectively balance sensory, nutritional, and antioxidant properties of BG, as well as better inhibit the formation of acrylamide and 5-HMF, which can be used as a reference to guide the industrial production of BG for enhancing its quality and safety.
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
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2026
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IF 7
Chen Liu,Xue Zhou,Hanyu Bai,Yana Zhang,Yong Zhao,Xuegang Li
Beta-actin (ACTB), a highly conserved cytoskeletal protein, is frequently dysregulated in early-stage malignancies, making its sensitive and specific detection crucial for cancer screening. Here, we develop a reflective fiber-optic SPR biosensor functionalized with copper–glycine engineered WS₂ nanosheets for label-free ACTB detection. The Cu–glycine modification not only enables WS₂ surface amination for efficient antibody conjugation, but also introduces Cu²⁺-mediated near-infrared absorption to amplify the plasmonic resonance response. Combined with the intrinsically large surface area and high refractive index sensitivity of WS₂, this synergistic design markedly enhances both molecular binding and signal transduction. The resulting WS₂-NH₂-based sensor achieves a refractive index sensitivity of 1467.5 nm/RIU, representing a 1.67-fold enhancement over unmodified fiber probes. For ACTB detection, it delivers an ultralow detection limit down to 9.766 pM, a broadened linear range of 2.4–120 pM (5×expansion), and a biosensing sensitivity of 84.477 nm/nM (1.4× improvement). Furthermore, at 1 ng/mL, a rapid response time of 20 min is achieved, demonstrating applicability for trace-level biomarker screening. Integrating high sensitivity, broad dynamic range, amplified spectral response, and strong anti-interference capability, this plasmonic WS₂-NH₂-modified fiber platform enables highly selective, label-free ACTB quantification. These findings highlight its strong potential for early cancer diagnosis, biomarker monitoring, and precision medical applications.
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ACS Sustainable Chemistry & Engineering
·
2026
·Vol. 14
·期 35
·15794-15811
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IF 7.6
Peng Weilong,Wang Lijun,Wang Xiaoguang,Ren Yu,Li Jingui
The sustainable recovery of plant-derived polyphenols requires extraction systems that can simultaneously reduce organic solvent use, improve process efficiency, and provide mechanistic clarity. Herein, a computationally guided natural deep eutectic solvent (NADES) strategy was developed for efficient and sustainable polyphenol recovery from Dioscorea cirrhosa Lour. The conductor-like screening model for realistic solvents (COSMO-RS) was first employed to predict solvent-solute affinities among eight NADES candidates, identifying betaine-maleic acid (Bet-MA) as the most promising green solvent due to its favorable polarity distribution and hydrogen-bonding complementarity. The ultrasound-assisted extraction process was subsequently optimized using an artificial neural network coupled with a genetic algorithm. Under identical initial extraction conditions, Bet-MA achieved a 1.63-fold higher TPC yield than 70% ethanol. After ANN-GA optimization, the UABM process reached 38.14 mg GAE/g DW, corresponding to a 1.73-fold increase compared with the conventional UAE control. Mechanistic investigations combining FT-IR, SEM, and 100 ns molecular dynamics simulations revealed a synergistic dual mechanism: ultrasonic cavitation disrupted the compact plant cell wall architecture, while Bet-MA provided stronger thermodynamic stabilization of released phenolics through electrostatic and van der Waals interactions. UPLC-Q Exactive/MS profiling confirmed the enrichment of diverse phenolic acids and flavonoids, and antioxidant assays verified that the intensified process preserved the bioactivity of the recovered extract. The Bet-MA solvent retained approximately 62 and 49% of its initial extraction capacity after the fifth and sixth reuse cycles, respectively, suggesting its reuse potential under the tested conditions. An AGREEprep-based greenness assessment gave a score of 0.80 for the Bet-MA-based process, compared with 0.59 for conventional ethanol extraction, indicating a more favorable greenness profile. This work provides a rational framework for sustainable biomass valorization through computational solvent design, process intensification, molecular-level mechanism elucidation, and solvent reuse.
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Global Change Biology Bioenergy
·
2026
·Vol. 18
·期 9
·e70172
·
IF 4.9
Qingsong Wang,Xin Wang,Yunkai Zhou,Wenjia Li,Jia Wang,Dongbing Li
The catalytic hydrogenolysis of glucose to produce 1,2-propylene glycol (1,2-PG) has opened promising avenues for sustainable chemical production. However, traditional Ru-based catalysts suffer from issues such as high metal loading, poor dispersion, and a tendency to agglomerate under harsh conditions, leading to rapid deactivation. This work reports a highly dispersed, low-loading Ru catalyst supported on a magnesium–aluminum ferrite (MAFO) spinel to address these limitations. Strong covalent metal–support interactions (CMSI) between Ru species and the MAFO support not only achieve efficient stabilization of Ru nanoparticles but also promote their redispersion. Under optimized reaction conditions (518 K, 5 MPa H 2 , and 1 h), the Ru/MAFO catalyst achieves 100% glucose conversion and 59.3% selectivity to 1,2-PG. Notably, the catalyst maintains outstanding activity and stability after six consecutive reaction cycles. This study provides an efficient and robust catalytic strategy for 1,2-PG production from glucose, offering significant insights for designing high-performance and stable catalysts for biomass valorization.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124471
·
IF 7.5
Sijun Chen,Yang Liu,Jingrong Liu,Tingwei Zhang,Yongcan Jin,Huining Xiao
Sulfonated carbon materials are promising heterogeneous Brønsted acid catalysts for biomass valorization, but the facile construction of carbon frameworks with accessible acid sites remains challenging. Herein, a sulfonated fructose-based porous nanosheet carbon (SPC) was synthesized via a facile and energy-efficient two-step strategy involving P 2 O 5 -assisted rapid self-propagating carbonization and concentrated sulfuric acid sulfonation, and subsequently employed for fructose dehydration to HMF in a low-boiling 1,4-dioxane/H 2 O solvent system. During carbonization, P 2 O 5 simultaneously promoted fructose carbonization and directed the formation of a porous nanosheet architecture, avoiding conventional high-temperature activation processes. The resulting porous nanosheets provided abundant sites for -SO 3 H grafting and enhanced Brønsted acid site accessibility. Consequently, SPC exhibited efficient catalytic performance for the selective dehydration of fructose, affording an HMF yield of 70.1% at 140 ℃ for 30 min. Moreover, SPC efficiently converted concentrated fructose (1.0 g fructose) to HMF with a 59.4% yield and exhibited moderate recyclability. This work provides a facile strategy for constructing biomass-derived sulfonated carbon solid acids with effectively utilized Brønsted acid sites for biomass upgrading.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Zhichen Qiu,Liping Xu,Xin Geng,Hongli Li,David Da Yong Chen
Real-time online monitoring of Maillard reaction dynamics is achieved. • A custom device enables direct DART-MS analysis of reaction headspace. • Substrate-dependent kinetics and molecular evolution are tracked. • Method links complex food flavors to specific precursor models. • Platform is simple, rapid, and requires minimal sample preparation. Controlling the Maillard reaction (MR) is critical for producing food flavor and color, yet real-time monitoring of its dynamics remains challenging. We developed an online monitoring system by integrating a custom reaction-transfer device with a Direct Analysis in Real Time (DART) ion source and high-resolution mass spectrometry. The system continuously transfers volatile MR products from the reaction headspace via a heated transfer line, enabling real-time, high-resolution analysis. The system successfully captured time-resolved molecular profiles, from early-stage sugar degradation intermediates to late-stage formation of nitrogen-containing heterocycles. Substrate-dependent kinetics and products were clearly differentiated. Elemental composition analysis via Van Krevelen plots further revealed distinct reaction pathways. The method was applied to monitor 12 MR model reactions and 5 real food samples, and correlation analysis linked complex food flavors to specific precursor reaction systems. Method validation confirmed the method's precision and robustness, establishing a simple and informative platform for online MR monitoring. Download: Download high-res image (145KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2025
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IF 6.7
Muhammad Saqib,Wen-Xin Chen,Yun Lei,Ai-Lin Liu
Chemiluminescence (CL) assays are often constrained by the limited availability of coreactants that combine strong signal amplification with biocompatibility. Herein, we report for the first time that sericin, a natural protein derived from silk, serves as a highly efficient coreactant in the lucigenin CL system under alkaline conditions. Impressively, this new lucigenin–sericin CL system generates an unprecedented ∼43-fold higher emission intensity compared to the traditional lucigenin–hydrogen peroxide system. Moreover, the mechanistic studies reveal that sericin, with its electron-rich functional groups, significantly promotes the generation of superoxide radicals (O2•–). This, in turn, accelerates the lucigenin oxidation pathway, leading to significant enhancement in CL signal. Leveraging this enhanced system, we developed a dual-function CL platform for the ultrasensitive detection of sericin (limit of detection, LOD = 0.12 μM) and superoxide dismutase (SOD, LOD = 0.28 ng/mL), exhibiting an extended linear range spanning from 0.25 to 50 μM and 0.5 to 60 ng/mL, respectively, the latter based on CL quenching phenomena. This method offers compelling superiority in terms of simplicity, rapid analysis, enhanced sensitivity, higher selectivity, and cost-effectiveness. Moreover, this method successfully achieved the detection of sericin in cosmetics and the SOD in human serum samples. Importantly, this work represents the first chemiluminescent method for sericin detection. In addition, the system exhibited high sustainability and practical utility, as confirmed by AGREE (greenness) and BAGI (blueness) assessment tools. Furthermore, it introduces a new class of protein-based coreactants for CL systems, expanding the frontier of (bio)analytical detection.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jiahui Zhang,Chen Zhan,Min Liu,Chengguo Hu
On-site high-throughput photoelectrochemical (PEC) detection of sweeteners in foods and drinks by cost-effective portable devices is highly desirable for food safety and health management. However, current high-throughput PEC sensors usually suffer from high costs, complex fabrication processes, or poor mechanical properties. Here, a highly flexible and robust light-addressable PEC sensor for the enzyme-free high-throughput detection of sweeteners using single-channel electrochemical analyzers is reported. This solar cell-type sensor consists of a bismuth vanadate-multi-walled carbon nanotubes (BiVO 4 -MWCNTs) photoanode and a silver/silver chloride (Ag/AgCl) cathode. Amongst these electrode materials, BiVO 4 exhibits strong photochemical oxidation capacity towards various sugar and sugar substitute sweeteners, MWCNTs enhance the film-formation ability and the photo-induced electron transfer process of BiVO 4 , while Ag/AgCl greatly simplifies the structure of the sensor and promotes its PEC response by efficient cathodic compensation reaction. The resulting PEC sensor has good mechanical and PEC properties, and allows the rapid high-throughput detection of typical sweeteners such as glucose (GLU) and erythritol (ERY) with a calibration range of 10–240 mg/L. Moreover, the detection throughput of the sensor can be easily extended by connecting a series of sensors in parallel. The present work thus establishes a portable and flexible PEC platform for the rapid high-throughput detection of sweeteners in foods and drinks.
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Food Science & Nutrition
·
2025
·Vol. 13
·期 6
·e70425
·
IF 3.8
Liang Chen,Yingying Song,Yurou Huang,Junjie Hu,Yan Meng,Ming Yuan,Guohua Zheng,Xuanbin Wang,Cong Zhang,Zhenpeng Qiu
Cornus officinalis Sieb. et Zucc. ( Cornus officinalis ), an edible natural plant fruit, has beneficial effects on a multitude of metabolic diseases, but the mechanism to improve hepatic steatosis remains elusive. In this study, the curative effect of Cornus officinalis extract (COE) is evaluated in a fructose-induced NAFLD mouse model using biochemical indicators monitoring, histological staining, 16S rRNA sequencing analysis, and fecal microbiota transplantation. Our results showed that COE attenuates hepatic steatosis in fructose-fed mice. Mechanistically, COE repairs intestinal barrier damage and gut flora dysbiosis to suppress proinflammatory microbe-derived metabolite transportation to the liver, thus inhibiting the hepatic inflammation and lipid metabolic dysfunction. Notably, transplantation of fecal microbiota isolated from the fructose-fed mice could reverse the beneficial effect of COE on attenuating NAFLD. Therefore, our study demonstrates that COE delays the progression of fructose-driven NAFLD by suppressing lipid metabolic dysfunction and gut microbiota-mediated liver inflammation, highlighting the potential of C. officinalis as a resource for the treatment of NAFLD drugs.
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