CRYSTENGCOMM
·
2022
·Vol. 24
·期 35
·6165-6171
·
IF 3.756
Xinghui Hao,Jinhui Li,Chenguang Wang,Xinghua Zhao,Xin He,Changquan Calvin Sun
Dimetronidazole (DMZ), an veterinary antibiotic, exhibits poor photostability with only 80.38% potency remaining after exposure to illuminance of 4500 lux for 7 days. The photodegradation is accompanied by obvious color change. A 1 : 1 cocrystal of DMZ with saccharine exhibited profoundly improved photostability with 98.95% of DMZ remaining after 7 days under the same light exposure. Thus, this new cocrystal can be used to develop more stable drug products of DMZ.
研究领域:
药学
·
化学
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DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2016
·
IF 4.012
Alberto Romero,Antonio Nieto-Márquez,Esther Alonso
Three different bimetallic Ru:Ni catalysts supported on a mesoporous silica MCM-48 were prepared by consecutive wet impregnations, with a total metal loading of ca. 3% (w w −1 ). Ru:Ni ratios spanned in the range of 0.15–1.39 (w w −1 ) and were compared with the corresponding monometallic Ni/MCM-48. The catalysts so prepared were characterized by X-Ray Diffraction, Transmission Electron Microscopy, adsorption/desorption of N 2 , Temperature Programmed Reduction, NH 3 − TPD and Atomic Absorption, and tested in the liquid phase hydrogenation of d -glucose into sorbitol in the temperature range 120–140 °C under 2.5 MPa of H 2 pressure. Bimetallic catalysts with Ru:Ni ratios higher than 0.45 enhanced the catalytic behavior of the monometallic Ni/MCM-48 in the reaction, increasing the reaction rate and showing complete selectivity to sorbitol by minimizing the production of mannitol. Ru:Ni/MCM-48 (0.45) was recovered from the reaction media and tested for three reaction cycles, showing good stability under the selected experimental conditions.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 27
·
IF 1.768
Lijing Teng,Wangyan Nie,Yifeng Zhou,Linyong Song,Pengpeng Chen
The purpose of this study was to investigate the suitability of a six-arm star-shaped poly( l -lactide)s (s-PLLA) as controlled drug carriers for hydrophobic drug molecules. First, s-PLLA was synthesized by ring-opening polymerization of l -lactide using sorbitol as initiator and stannous octoate as catalyst. The structure and molecular weight ( M w ) of s-PLLA was characterized with 1 H NMR, 13 C NMR, and GPC. Second, rifampicin (RIF) used as a model drug was encapsulated within the microspheres of s-PLLA via oil-in-water emulsion/solvent evaporation technique. The morphology, drug encapsulation efficiency (EE), and in vitro release behavior of the prepared microspheres were studied in details. Results indicated that the average diameters of s-PLLA microspheres can be controlled between 8 and 20 µm by varying the copolymer's concentration or M w . The EE of RIF was mainly determined by the concentration of s-PLLA. The in vitro study showed that the burst release behavior can be depressed by increasing the M w of the s-PLLA. Present work suggests that the synthesized s-PLLA could be used as a new material for drug delivery. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42213.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2020
·Vol. 49
·期 7
·1068-1081
·
IF 1.273
Zhang Bei,Wu Di,Zhu Huaxiang,Fang Jing,Zhou Lina,Hou Baohong,Chen Wei
The solubility data of sorbic acid in binary systems of (ethanol + water), (1-propanol + water) and (2-propanol + water) were measured from 283.15 to 323.15 K using the static equilibrium method under atmospheric pressure. It was found that the solubility of sorbic acid in the three binary solvent systems increased with increasing temperature as well as increasing initial mole fraction of organic solvent in these systems. The van’t Hoff–Jouyban–Acree model, the modified Apelblat–Jouyban–Acree model and the CNIBS/R-K model were proposed for correlating the experimental solubility values in various solution systems. Furthermore, the dissolution thermodynamic properties of Gibbs energy change (Δ sol G o ), molar enthalpy change (Δ sol H o ) and molar entropy change (Δ sol S o ) were calculated from the experimental solubility data, using the van’t Hoff equation. The positive values of Δ sol G o , Δ sol H o and Δ sol S o indicate that these dissolution processes of sorbic acid in the solvents studied were all endothermic and entropically favorable. In addition, the change of dissolution enthalpy was the main contributor to the positive value of the molar Gibbs energy of the dissolution process. The experimental solubility and the models used in this work would be conducive to purifying sorbic acid from its crude mixtures.
研究领域:
化学
·
物理化学
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产品关联
DOI
高影响因子
JOURNAL OF TEXTURE STUDIES
·
2022
·Vol. 53
·期 5
·662-671
·
IF 3.942
Xuehui Cao,Ge Bai,Jianrong Zheng,Danshi Zhu,Jianrong Li
Freezing is a way to preserve the quality of fruit for a long time. Nanguo pear stored at low temperature is prone to browning and lignification. In this study, freeze–thaw cycles were used to simulate the temperature fluctuation in the process, storage, and transportation. The texture properties were taken as the research focus to analyze the lignification phenomenon of Nanguo pear under freeze–thaw cycles. The results showed that freeze–thaw treatment significantly reduced the firmness and propectin content of Nanguo pear, increased the content of stone cells in the fruit, but also destroyed the size of stone cells in the fruit. However, with the increase of freezing–thawing cycles, the content of lignin, stone cell content, and PAL activity increased significantly, while the content of chlorogenic acid increased first and then decreased. These results are helpful to further understand the correlation between texture change with fruit firmness and formation mechanism of stone cells during freeze–thaw cycles of Nanguo pear.
研究领域:
食品科学
·
植物生理学
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2023
·Vol. 25
·期 34
·4889-4901
·
IF 3.1
Chang Li,Di Wu,Zhenguo Gao,Wei Chen
The cocrystals and salts of sorbic acid (SA), nicotinamide (NIA), piperazine (PIP) and 2,6-diaminopyridine (2,6-DAP) were synthesized for the first time and characterized by XRD, FT-IR, DSC and TG. The solubility of SA and its multicomponent crystals in aqueous solution at 37 °C was measured. The results showed that the formation of the multicomponent crystals of SA increased its equilibrium solubility in water. Ternary phase diagrams (TPDs) of SA–NIA in ethanol were constructed at 20 °C and 30 °C. The results show that as the temperature increases, the preparation region of the pure SA–NIA cocrystal becomes larger, and the shape of the TPD remains unchanged. To further reveal the causes of salt or cocrystal formation, intermolecular interactions were evaluated using the Hirshfeld surface (HS), molecular atomic quantum theory (AIM) and independent gradient model (IGM). The chemical reactivity of molecules was discussed differently using molecular electrostatic potential (MEP) analysis, frontier orbital analysis and global electron reactivity descriptors.
研究领域:
化学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Xiaoyu Shi,Yang Yang,Xin Ye,Heng Zhong,Chunling Wang,Fangming Jin
Catalytic conversion of cellulosic biomass into polyols is an effective approach for biomass upgrading. However, the conversion involves cascade reactions which require various catalytic sites cooperation for activating specific steps, resulting in low efficiency. Here, we propose a bifunctional catalyst containing acid sites and hydrogenation capacity for polyol production with cellobiose as the model compound of cellulose. Phosphonic acids (PAs) containing either methyl (MPA) or aminomethyl (NH2MPA) tails were used to tune the Pd/Al2O3 catalyst to form monolayers, thereby modulating the surface physiochemical properties and introducing multiple catalytic sites. An increasing ratio of PdO/Pd and a strong metal–support interaction were observed after PA modification, which could boost the hydrogenation activity for cellobiose. Furthermore, Pd/Al2O3-MPA exhibited excellent hydrolytic hydrogenation activity due to the increase of Lewis acid sites with good durability under hydrothermal conditions by MPA modification, achieving a 78.5% yield of sorbitol at 180 °C for 5 h. A plausible mechanism for enhancing the synergistic effect of Pd and support over Pd/Al2O3-MPA was also proposed. This investigation provides a novel strategy for rationally designing hydrothermally stable bifunctional catalysts to utilize biomass in a more effective way.
研究领域:
催化化学
·
生物质能
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Ming Zhang,Wenqin Lai,Lili Su,Guozhang Wu
The effects of catalyst on the molecular weight, chemical structure, and yellowness of isosorbide-based polycarbonate (ISB-PC) in the melt-transesterification and polycondensation stages were investigated. Results showed that the high steric hindrance and intramolecular hydrogen bonding of the endohydroxyl group (endo–OH) of ISB enabled its reactivity to be lower than that of the exohydroxyl group (exo–OH). We also found that the reactivity of endo–OH with diphenyl carbonate can be preferentially activated by strong electrophilic catalysts, and that the configuration of the ISB-PC chain strongly depended on the reactivity balance between endo–OH and exo–OH. Various catalysts with different coordinate capacities, acidity coefficients, and radius of metal ion were further tested. Catalysts with a calcium or zinc ion showed a higher reactivity of endo–OH than exo–OH, resulting in a high glass-transition temperature of ISB-PCs. Results suggested as well that the thermal stability of ISB-PC may be correlated to the amount of OH groups at the chain ends, whereas its yellowness mainly arose from 1,4-sorbitan due to the hydrolysis of ISB.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Duan Zhou,Mouming Zhao,Jiankang Wang,Muniba Faiza,Xuefeng Chen,Junjie Cui,Ning Liu,Daoming Li
Punicic acid (PA)-enriched diacylglycerol (DAG) possesses both the beneficial effects of PA and DAG. However, few studies have focused on the preparation of PA-enriched DAG. Here, we report a novel and highly efficient method for the preparation of PA-enriched DAG through Lipozyme 435-catalyzed ethanolysis of pomegranate seed oil (PSO). Firstly, PSO was obtained through microwave-assisted extraction. Subsequently, four lipases were screened for their capability in the preparation of PA-enriched DAG through ethanolysis of PSO (containing 82.98% PA), and Lipozyme 435 was selected. Under the optimal conditions, the resultant mixture containing 32.86% DAG was obtained. Interestingly, Lipozyme 435 maintained superior operational stability after ten successive cycles. A scale-up reaction was then conducted under the optimized conditions and the purified product containing 51.83% DAG (containing 81.95% PA) was obtained. The final product with a low peroxide value (1.45 mmol/kg) and undetectable acid value reached edible quality. This is the first study for the preparation of PA-enriched DAG through ethanolysis and Lipozyme 435 exhibited superior capability and recyclability. Compared with other approaches for DAG preparation, this approach favored shorter reaction time and better quality of the product. This study provides useful information for further studies involving DAG preparation and modification of PSO.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Yanqiu Liu,Mengtian Wang,Jingbo Mao,Hui Lv,Jinxia Zhou
It is of significant importance to develop cost-effective transition metal catalysts for the hydrogenation of glucose to sorbitol. While Ni-based catalysts have been frequently reported, investigations involving Co-based catalysts in this reaction remain relatively limited. Here, a Co catalyst supported on a coconut-shell activated carbon (AC) was prepared and utilized for the first time to produce sorbitol from glucose via aqueous hydrogenation. Characterization results revealed that the Co components were highly dispersed on the AC surface, forming CoO–Co polyvalent complexes incorporating oxygen vacancies and Lewis acids after calcination in N2 at 500 °C. In contrast, Ni species on the AC surface tend to aggregate into metallic Ni particles. Compared with Ni/AC, the Co/AC catalyst not only demonstrates a superior ability to generate more active H with multiple forms, but also possesses various strengths of Lewis acid sites to activate the CO bond of glucose. Consequently, the Co/AC catalyst exhibited higher activity with 100% selectivity towards sorbitol in the aqueous hydrogenation of glucose under mild conditions of 100 °C and 3 MPa H2 pressure, showcasing significant potential for the formation of sorbitol from biomass-derived glucose due to its low cost, simple preparation process, and excellent performance in hydrogenation.
研究领域:
化学工程
·
可再生资源利用
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 8
·1301
·
IF 5.1
Rifeng He,Ziling Lian,Zhongjun Cheng,Yang Liu,Xiaoyan Peng,Yong Wang,Hang Ma,Xue Zhou,Fahuan Ge
Cili (Rosa roxburghiiTratt) fruit is a nutrient-rich edible plant known for its antioxidant and hepatoprotective properties. However, conventional extraction methods often lead to the degradation of its bioactive compounds. In this study, we developed a low-temperature homogenate-assisted high-pressure disruption extraction (HHPD) method to obtain a phytochemically enriched cili fruit extract (HHPD-CFE). The chemical characterization of the HHPD-CFE showed that it contained higher levels of polyphenols, polysaccharides, and superoxide dismutase (SOD) than those in conventional squeeze extraction. The hepatoprotective effects of the HHPD-CFE were evaluated in oxidative stress-induced liver injury and hepatic fibrosis models. The HHPD-CFE mitigated oxidative damage by reducing malondialdehyde while enhancing SOD and glutathione activity. Additionally, the HHPD-CFE inhibited the activation of hepatic stellate cells (HSC-T6) and reduced collagen deposition, suggesting a protective role against liver fibrosis. These findings support that the HHPD-CFE is a promising botanical extract with enriched bioactive compounds and liver-protective properties. This study supports the potential application of optimized extraction techniques to preserve thermosensitive compounds and improve the efficacy of functional foods for liver health.
研究领域:
植物化学
·
食品科学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 48
·46885
·
IF 1.901
Yu Cao,Jiayu Li,Jun Liu,Yuying Tang,Huan Liu,Yan Jiang,Hongwen Zhang
Four inclusion complexes were synthesized from β-cyclodextrin (β-CD) copolymers and potassium sorbate (PSA) using the self-assembly principle. Reactive β-CD monomers carrying unsaturated ester functional groups [β-CD-acryloyl chloride (AC)] were synthesized from β-CD and AC and copolymerized with styrene to obtain β-CD copolymers of the general formula poly(β-CD-AC- co -St). These β-CD copolymers having cavity structures were complexed with PSA to obtain the corresponding inclusion complexes of the general formula poly(β-CD-AC- co -St)/PSA. These complexes were added to the polystyrene (PS) sheets, as an antibacterial additive, to inhibit the adhesion and growth of bacteria on its surface. The chemical and physical structures of copolymers were characterized by Fourier transform infrared, nuclear magnetic resonance, and the slow release performance was investigated using ultraviolet spectroscopy. The results showed that the composition of the copolymers and their molecular weight could be controlled by changing the rate of charge while the rate and the amount of slow release could be controlled by altering the content of β-CD in the copolymer. The PS sheets containing the inclusion complexes exhibited excellent antibacterial activity that significantly reduced the adhesion of yeast and Staphylococcus aureus to its surface. With the increase of the β-CD content in the copolymers, they contained more of PSA and their bacteriostatic property became more pronounced. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46885.
研究领域:
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）