Nature Communications
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2026
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IF 18.1
Lu Zhe,Liu Wenxuan,Zhang Zeshu,Chen Zhongyi,Sun Junchuan,Gao Wanguo,Zhuo Xiaolu,Tu Wenguang,Hu Guoping,Yao Yingfang,Ji Dongxu,Zhao Junhua,Zou Zhigang,Wang Lu
Hydrogen migration is a process of key importance in hydrogenation reactions. In past decades, surface oxygen has been considered the major pathway for hydrogen migration, whereas the reduction reaction may occur to yield water and inhibit the migration. Thus, extending hydrogen migration via precise surface decoration could potentially be beneficial to the activity of hydrogenation reactions, yet it remains challenging. Herein, the Sabatier reaction is chosen as the archetype reaction, in which the catalytic performance is highly dependent on the activity of hydrogen migration. By decorating a minor amount of non-reducible alkylsilane over the benchmark Ni/CeO 2 catalyst, the hydrogen activation, migration, and overall hydrogenation reaction have been enhanced significantly. As a result, with the help of the exothermic nature of the Sabatier reaction, the solely solar-driven reaction can be conducted with a CO 2 single pass conversion of 99.9%, a near-unity CH 4 selectivity, and an energy conversion efficiency of ~25.0% for outdoor practice.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Yong Zhu,Fengyan Chen,Bingmin Wu,Yishan Tong,Kunbo Ning,Zhiyuan Zhen,Jihang Chen
Polysaccharide-based supramolecular self-assembled hydrogels are promising biomaterials owing to their biocompatibility and dynamic controllability. This study was to explore the use of a polysaccharide (PSP) isolated from a well-known Chinese herb, Polygonatum sibiricum Red. (Huangjing) in the supramolecular self-assembled hydrogel. PSP was characterized as a neutral fructan with a backbone of →1)-β-D-Fru f -(2 → and →1,6)-β-D-Fru f -(2 → units bearing O-6–substituted branches. PSP/Chitosan (PSP/CS) hydrogels were prepared with different PSP concentrations (4, 6, 8, 10, 12 wt%), forming 3D network porous structure composed of nanofiber chains, with the pore size ranging from 0.67 to 13.67 μm. Increasing PSP content markedly enhanced gel strength and stability, as evidenced by higher storage modulus (G'), increased compressive modulus (0.03–0.75 kPa), and improved thermal stability (maximum degradation-rate temperature from 290 to 302 °C). In addition, PSP/CS hydrogels exhibited high swelling (2673 ± 65%) and water retention (78.26 ± 1.58%) properties. Hydrogen bonding was the predominant driving force for self-assembly. Furthermore, PSP/CS hydrogel preliminarily showed good cytocompatibility toward Caco-2 cells. In conclusion, these findings clarify the structure–assembly–property relationships of PSP/CS hydrogel and suggest a design strategy for exploiting fructan polysaccharides in advanced biomaterials.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Mengjia Shi,Zirui Jia,Shuang Xu,Zhenguo Gao,Guanglei Wu
Constructing heterogeneous structures to precisely regulate the interface characteristics and loss mechanisms of materials is the key to performance improvement. This study proposes a strategy of constructing the NiS 2 -CdS P-N heterojunction with Porous carbon nanofibers (PCNFs) as the supporting skeleton, and deeply investigates the influence of the interface regulation mechanism of the P-N heterojunction on the absorption performance. The study clarified the structural reconstruction information such as bond parameter distortion, atomic occupation deviation, and lattice disorder caused by the Built-in electric field (BIEF) of the P-N heterojunction through X-Ray Diffraction (XRD) refinement. With the help of Density functional theory (DFT) calculation, the performance regulation mechanism of the heterojunction was revealed at the atomic/electronic scale. A carrier migration model between NiS 2 and CdS was constructed, and the absorption mechanism was analyzed. By utilizing the BIEF and space charge region formed by NiS 2 and CdS, the equivalent impedance is regulated. Ultimately, the cooperative optimization of material impedance matching and energy dissipation is achieved, providing new ideas and development of high-performance electromagnetic wave (EMW) absorbing materials. This research provides theoretical support for the subsequent shift of absorbing materials from empirical synthesis to precise design.
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Journal of the Taiwan Institute of Chemical Engineers
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2026
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IF 6.9
Lin Cao,Jinming Piao,Yue Zhang,Ning Wang,Dean Song,Chao Feng,Wei Wang
Background Conventional single-layer coatings offer limited durability and lack active self-healing, making them inadequate for protecting copper in aggressive environments. A multilayer strategy combining passive barriers with responsive inhibitor release is therefore essential for enhanced corrosion resistance. Methods A hierarchical self-healing coating was constructed by combining an in-situ grown, silane-modified layered double hydroxides (LDH) film, core–shell PVDF@BTA (PB) nanofibers, and an epoxy (EP) topcoat. The LDH layer extended ion-diffusion pathways and enhanced adhesion, while the nanofibers enabled controlled BTA release upon damage. Interfacial interactions were examined using spectroscopy, SEM/EDS, XRD, FTIR, and molecular dynamics (MD) simulations. Anticorrosion and self-healing performance were evaluated by EIS, OCP, polarization testing, and BTA-release kinetics . Significant Findings The LDHA/PB/EP coating exhibited outstanding long-term corrosion resistance, achieving a high |Z| 0.01 Hz of 4.32 × 10 9 Ω·cm 2 and maintaining stability after 60 days of immersion. Upon mechanical damage, the coating restored up to 90.3% of its original corrosion resistance through synergistic formation of LDHA–BTA and Cu–BTA protective complexes. MD simulations and electrochemical tests confirmed ATES-enhanced BTA adsorption, enabling dense inhibitor films. This multilayer design affords both passive barrier protection and active self-healing, offering a promising strategy for high-performance, intelligent anticorrosion coatings for copper systems.
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ORGANIC PROCESS RESEARCH & DEVELOPMENT
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2026
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IF 3.3
Ran Wang,Liming Xu,Yifan Yang,Wenqing Wang,Mingzhe Liu,Xiaoye Su,Yu Shao
In recent years, oligonucleotide drugs, as a novel class of drug molecules, have provided new treatment modalities for patients with chronic diseases. Although the traditional synthesis process system for oligonucleotide drugs is continuously improving and maturing, the ammonolysis process still commonly uses offline methods. Especially during industrial scale-up, limitations such as difficulties in material transfer, nonuniform sampling, and monitoring of high-concentration supersaturation have highlighted the lack of an efficient, real-time, and accurate online control system for monitoring the oligonucleotide ammonolysis process. In this study, a novel online ammonolysis process system for oligonucleotides was constructed for the first time. This system is equipped with online Fourier transform infrared spectroscopy (FTIR), enabling real-time monitoring and endpoint control of the oligonucleotide ammonolysis process. The experimental results showed that under conditions of different temperatures and various types of solid supports, this method can stably and accurately reflect the oligonucleotide ammonolysis process. The detection results at multiple wavelengths (IR 1232 cm–1, 1457 cm–1, 1504 cm–1, 1635 cm–1) are comparable to the traditional offline ultraviolet (UV) detection method (UV 260 nm) (Pearson correlation coefficient r > 0.9). To the best of our knowledge, this study is the first to achieve real-time online infrared monitoring and control of the ammonolysis process for oligonucleotides within the public literature. This achievement lays a solid foundation for deploying IR process analytical technology on an industrial scale and realizing online quality control and process optimization for the production of oligonucleotide drugs.
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Small Methods
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2026
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IF 8.7
Tianchang He,Wenhua Zheng,Lina Zhu,Xiaoyan Fang,Chunjie Miao,Xinyang Shi,Lemei Zhao,Shuai Jiang
Coating nanoparticles with cell membranes has emerged as a powerful strategy for developing biomimetic nanocarriers that replicate essential cellular features such as immune evasion, prolonged circulation, and site-selective distribution. Despite substantial efforts to optimize ligand presentation on cell membranes, achieving efficient, uniform, and scalable membrane coating remains challenging. Moreover, precise quantification of coating degree, particularly at the single-particle level to reveal inter-particle heterogeneity, has been lacking. Here, we establish S ingle- P article A nalysis of CE ll M embr AN e ( SPACEMAN ), a quantitative platform that enables accurate evaluation of coating integrity and heterogeneity with single-nanoparticle resolution. Using SPACEMAN, we demonstrate that a nano-vesiculation strategy based on ultrasonication achieves a significantly higher overall coating rate (82.2% of particles) compared with extrusion (68.0%) and sonication (61.0%), and yields a greater proportion of particles with high surface coverage (50%–75% and 75%–100% of surface area). Nanoparticles coated via this method exhibited superior immune evasion and prolonged circulation in both in vitro and in vivo models. Indeed, SPACEMAN offers a generalizable single-particle analytical framework for quantitatively probing heterogeneity in physicochemical properties, drug loading, and surface modifications of nanoparticle formulations.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yi-Fan Luo,Xiao-Juan Lei,Kai Zhang,Ming Wang
Multifunctional fibers capable of achieving switchable electromagnetic shielding effects while integrating versatile responsive capabilities are critically important for wearable electronics and electromagnetic shielding technologies. Nevertheless, existing conductive fibers typically suffer from passive shielding characteristics and insufficient mechanical performance, whereas poly( p -phenylene-2, 6-benzobisoxazole) (PBO) fibers exhibit superior mechanical properties yet lack multifunctionality. To resolve this, we developed a metallized PBO fiber platform featuring switchable microwave shielding and Joule heating through interfacial engineering of self-assembled copper-polymer networks. A polydopamine-mediated electroless plating strategy, utilizing polydopamine-anchored silver nanoparticles as catalytic sites, enables uniform Cu 2 O/Cu coatings with high electrical conductivity (up to 1.6 × 10 5 S/m), while remarkably enhancing mechanical properties within an optimal conductivity range compared to pristine PBO fibers. The aligned conductive fibers demonstrate a 55 dB dynamic EMI shielding range via angle-dependent grating effects, enabling real-time switching between shielding (45 dB) and transmission (5 dB) states through rotational adjustment. Simultaneously, the metallized coating delivers multifunctional capabilities including rapid electrothermal response (reaching 110 °C at 0.07 A), superhydrophobicity (157.4° contact angle), and self-cleaning performance. This work successfully reconciles the longstanding conflict between ultrahigh mechanical strength and active EMI/thermal regulation functionalities, establishing a new paradigm for multifunctional fiber development in aerospace and wearable systems.
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Advanced Science
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2026
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IF 14.1
Yanli Huang,Haifen Luo,Jie Yin,Shuai Cao,Gaolei Dong,Zhi Tan,Chunlin Zhao,Peiye Wen,Fengwei Sun,Shan Zhang,Xianzeng Zhang,Yunlu Dai,Zhen Yang,Wei Huang
Pyroelectric catalysis has shown promising prospects for sustainable energy generation and medical treatments. However, its potential is limited by intrinsically low pyroelectric coefficients and insufficient interfacial reactivity, resulting in poor reactive oxygen species (ROS) output. In this study, we design Ba(Ti 0.85 Zr 0.15 )O 3 (BTZ) nanocatalysts, featuring enhanced polarization tunability and oxygen-vacancy-rich interfaces, for efficient NIR-II-driven photo-pyroelectric cancer therapy. Molecular dynamics and phase-field simulations indicate that Zr incorporation maintains strong polarization while facilitating rapid polarization switching via multiscale nanodomain formation. This results in an ultrahigh pyroelectric coefficient (3505 µC m −2 K −1 ), representing a 678% enhancement over pristine BaTiO 3 . Interface engineering introduces oxygen vacancies that enhance NIR-II photothermal conversion and serve as reactive sites to facilitate the dissociation of water molecules. Density functional theory calculations reveal that Zr doping narrows the bandgap and redistributes conduction band electrons, while interfacial oxygen vacancies facilitate water adsorption through optimized hydroxyl binding. As a result, synergistic pyrocatalysis and peroxidase-like activity under NIR-II-driven mild thermal cycling enable robust multipath ROS generation. Both in vitro and in vivo studies confirm efficient tumor cell ablation via NIR-II induced pyroelectric therapy. This work presents a co-engineering strategy integrating polarization and interface design to overcome long-standing limitations in pyroelectric catalysis, advancing its application in precision oncology.
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ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Xiaoli Zhou,Xinyue Yan,Xiaofeng Liang,Ziyi Zhao,Yong Huang,Kun Hu
Background The overuse of nonsteroidal anti-inflammatory drugs (NSAIDs) has raised public health and environmental concerns, and their concentrations are low in environmental and biological samples, where complex sample matrices can interfere with analytical accuracy, creating an urgent need for a simple, effective, and sensitive method to detect NSAIDs in complex samples. Covalent organic frameworks (COFs) have emerged as promising adsorbents owing to their tunable pore structures and abundant functional groups. Nevertheless, synthesizing COFs that simultaneously exhibit high adsorption performance and enable sensitive detection of NSAIDs remains a remarkable challenge. Results To address this, we synthesized triazine COFs with the assistance of an ionic liquid (IL), termed T-IL-COFs, and employed them as adsorbents for enriching and detecting various NSAIDs. For comparison, W-COFs (lacking IL assistance and triazine units) and T-COFs (containing triazine groups but synthesized without IL) were also prepared. Compared with these two COFs, T-IL-COFs contained triazine units and exhibited larger specific surface areas and pore sizes, enhancing their adsorption performance and selectivity. Adsorption mechanisms were examined using multiple spectroscopic techniques, revealing that interactions were driven by π–π stacking, hydrophobic, electrostatic, and hydrogen-bonding forces. A T-IL–COF–based high-performance liquid chromatography–ultraviolet (HPLC–UV) method was then developed for dispersive solid–phase extraction of NSAIDs. The proposed method exhibited excellent linear ranges (ibuprofen: 1–800 ng/mL; flurbiprofen and ketoprofen: 0.5–800 ng/mL), high enrichment factors (50–81), low limits of detection (0.12–0.33 ng/mL), and excellent recoveries (80.51%–104.70%) in urine and river water samples. Significance This study presents an alternative strategy to enhance the adsorption performance and selectivity of COFs for NSAIDs by introducing functional groups and increasing the specific surface area and pore size. Moreover, it offers an efficient HPLC–UV method for the selective enrichment and sensitive detection of NSAIDs in environmental and biological samples.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Lidong Wang,Yongyan Sun,Yuting Sun,Changbin Zhang,Guixi Wang,Junnan He,Yan Zhao,Ming Li
Photodynamic therapy (PDT) holds promise for oral squamous cell carcinoma (OSCC) but is limited by the tumor microenvironment─specifically hypoxia, elevated glutathione (GSH), and the lack of tumor-selective photosensitizer activation. To overcome these barriers, we developed a GSH-activated nanoplatform Cu-TCPP(Zn)/Ti3C2Tx for fluorescence imaging-guided synergistic photodynamic/chemodynamic therapy (PDT/CDT). The system is constructed from two-dimensional Cu-TCPP(Zn) MOF nanosheets, where Cu2+ and Zn2+ completely quench the fluorescence and PDT activity of TCPP and surface-anchored Ti3C2Tx MXene. In the TME, overexpressed GSH reduces Cu2+ to Cu+ and abstracts Zn from the Zn–N4 complex, triggering nanocomposite disintegration to restore fluorescence, activate PDT, and simultaneously deplete GSH to reduce antioxidant defense. The resulting Cu+ catalyzes a Fenton-like reaction with endogenous H2O2 to generate •OH for CDT, while Ti3C2Tx acts as a catalase-like nanozyme, decomposing H2O2 into O2 to alleviate hypoxia, promote charge transfer, improve the utilization efficiency of photogenerated electrons, and enhance PDT efficacy. In vitro, the platform showed excellent biocompatibility and GSH-responsive activation, inducing 41.21% apoptosis in CAL-27 cells under 660 nm laser irradiation, significantly outperforming controls. In vivo, the nanocomposite accumulated efficiently in tumors via the EPR effect, suppressed tumor growth, and exhibited no observable systemic toxicity. This work provides a TME-responsive theranostic platform that integrates tumor-specific activation, GSH depletion, hypoxia alleviation, and enhanced ROS generation for precise and effective OSCC treatment.
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ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Weizhao Yao,Yaru Li,Yuling Du,Rongzi Gao,Junhao Tan,Jinlong Fan,Yuan Liu
Liquid biopsy faces critical limitations in detecting low-abundance protein biomarkers due to serum complexity, single-target constraints, and insufficient sensitivity. Here, we present an integrated microfluidic protein aptamer corona-CRISPR (PACC) platform that synergizes nanoparticle protein corona (PC) enrichment, multiplexed aptamer recognition, and CRISPR-Cas12a-driven signal generation for facile and rapid point-of-care testing. Fe3O4@SiO2 nanoparticles capable of streamlining PC isolation via magnetic separation were employed to concentrate cancer-associated proteins from serum. A 6-plex aptamer panel, which selectively bound target proteins via forming protein–aptamer coronas (PACs), was used to initiate the in situ activation of CRISPR-Cas12a via complementary crRNAs for fluorescence signal generation. This entire workflow was miniaturized into a 3D-printed microfluidic chip and portable reader, achieving a fast sample-to-answer process. Clinical validation with 112 serum specimens demonstrated excellent diagnostic performance, achieving an area under the curve (AUC) of 0.95 and 88.24% accuracy. By integrating these modalities, the PACC platform overcomes serum matrix interference and biomarker scarcity, providing a scalable and low-cost avenue for detecting low-abundance protein biomarkers and advancing liquid biopsy toward precision oncology.
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INORGANIC CHEMISTRY COMMUNICATIONS
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2026
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IF 5.9
Xiaojun Su,Congming Tang,Xinli Li
The direct dehydrogenation of lactic acid (LA) to pyruvic acid (PyA) presents a sustainable and atom-economical route for biomass valorization, yet it demands high-performance catalysts to achieve satisfactory activity and selectivity. While bimetallic catalysts often show enhanced performance, a deep understanding of the interfacial synergy remains a challenge. Herein, we report a series of CuCo bimetallic oxide catalysts that exhibit remarkable performance in the direct dehydrogenation of LA to PyA, significantly outperforming their monometallic counterparts. A combination of detailed catalyst characterization and kinetic analyses unravels the critical role of the CuCo oxide interface. It is demonstrated that the Co sites at the interface are primarily responsible for the activation and cleavage of the α-C-H and α-O-H bond in lactate, while the adjacent Cu species facilitate the stabilization of the reaction intermediate and the recombination and desorption of hydrogen. This synergistic cooperation at the interface not only promotes the reaction rate but also effectively suppresses undesired side reactions, such as decarbonylation and dehydration, thereby ensuring high selectivity to PyA. The optimized catalyst with a Cu/Co molar ratio of 3:2 demonstrated enhanced performance, delivering 73.4% LA conversion and 78.1% PyA selectivity at 300 °C, which surpasses the results obtained over the CuO 1-x /SiO₂-H400 benchmark under identical conditions. This work provides fundamental insights into the bifunctional mechanism of bimetallic oxides in direct dehydrogenation reactions, offering a strategic guideline for the rational design of efficient and selective catalytic systems for sustainable chemistry.
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