MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Minghui Wang,Qiaolin Guo,Zhenyong Hu,Yue He,Lai Zhang,Cuifei Chen
An ultrasensitive biosensor has been developed for miR-375 detection. • HRP is embedded into COFs to form stable HRP@COFs co-precipitated nanospheres. • The HRP@COFs preserved enzymatic activity and enhanced catalytic efficiency. • The biosensor has been successfully validated using clinical samples. The dysregulated expression of microRNA (miRNA) in various cancers has attracted considerable attention owing to their crucial roles in tumor initiation and progression. Among them, miR-375 has been recognized as a prospective biomarker for early malignancy detection and therapeutic monitoring. In this study, a highly sensitive electrochemical biosensor has been developed based on horseradish peroxidase (HRP)-embedded covalent organic framework (HRP@COFs) co-precipitated nanospheres for the detection of miR-375. The HRP@COFs nanocomposite effectively preserves the enzymatic activity of HRP while providing the structural stability and high loading capacity of COFs, thereby enhancing catalytic efficiency and signal amplification. In the presence of target miR-375, the azide-modified H1 hairpin probes on the HRP@COFs surface are activated, leading to the formation of a rigid H1-H2 duplex structure through competitive hybridization with H2 hairpins. The resulting H2-H1-HRP@COFs complexes are subsequently anchored onto the electrode surface via click chemistry. Upon the addition of H 2 O 2 , HRP catalyzes aniline polymerization and deposition, resulting in a significant electrochemical response. This biosensor achieves ultrasensitive detection of miR-375 with a detection limit as low as 230 aM. It has been successfully validated using clinical samples, demonstrating great potential for reliable breast cancer diagnosis. This work highlights the synergistic advantages of integrating HRP with COFs, providing a robust and efficient platform for microRNA detection and expanding the applications of COFs-based materials in biosensing and clinical diagnostics. Download: Download high-res image (151KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yuan Gao,Jiaqi Sun,Pei-Lin Gao,Qi Zhao,Xinyi Yu,Yujie Song,Jun Hu,Dan Wang,Zhi-Gang Shen,Ze-Hai Xu,Hua Sheng,Zhong-Ting Hu
A bactericidal membrane (CNTs-PEI/CZIS) was designed by anchoring Cu-ZnIn 2 S 4 on CNTs-PEI. • In N coordination contributes to the structural stabilization between the CZIS and CNTs-PEI. • CNTs-PEI/CZIS has ultra hydrophilicity/oleophobicity with O/W separation efficiency of ~100%. • CNTs-PEI/CZIS has bactericidal rate of ~100% both at 10 6 CFU mL −1 (artificial) and actual water. • CNTs-PEI/CZIS has excellent self-cleaning and stable long-term antibacterial activity. Membrane technology for water disinfection (MTWD) offers high effluent quality with a small footprint, but its practical application is still limited by bacterial fouling-induced flux decline and insufficient long-term disinfection capability. Herein, we designed a self-cleaning CNTs-PEI/Cu-ZnIn 2 S 4 composite membrane by depositing an ultralow amount of copper-supported ZnIn 2 S 4 (CZIS) nanoflowers (only 2.5 mg per 50 mm-diameter membrane) onto polyethyleneimine-functionalized carbon nanotubes (CNTs-PEI). This membrane preserves the high permeability and hydrophilic-oleophobic characteristics (oil-water separation efficiency of 99.3 ± 0.6%, with a max flux of 6470 ± 500 L m −2 h −1 bar −1 ) is mainly ascribed to the CNTs-PEI construction, as well as the efficient photocatalytic sterilization activity (with an efficiency ~100% under bacterial concentration of 10 6 CFU mL −1 ) and its self-cleaning capability (overall, >6000 L m −2 h −1 bar −1 ) is demonstrated to CZIS nanomaterial. In practical test, the antibacterial efficiency in natural water reaches ~100% even over 20 cycles. The integrated properties of CNTs-PEI/Cu-ZnIn 2 S 4 composite membrane are related to the design of interfacial coupling between CZIS and CNTs-PEI through In N coordination and the combination of visible-light photocatalytic activity. This work provides a promising strategy on constructing a novel composite membrane for overcoming biofouling by bacterial disinfection. A visible-light-driven carbon nanotubes (CNTs)-based composite membrane enables efficient water disinfection and purification. By anchoring Cu-ZnIn 2 S 4 nanoflowers onto hydrophilic-oleophobic PEI-functionalized CNTs, the membrane achieves ~100% bactericidal efficiency and excellent antifouling/self-cleaning performance. Its functionality in bacterial inactivation highlights its potential in sustainable and advanced water treatment technologies. Download: Download high-res image (211KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Haibo Shi,Haoqi Zhang,Chenxi Liu,Guofu Yi,Yumin Zhang,Jiabao Zheng,Yongxin Teng,Shuangjie Zhu,Rui Jiao,Weizheng Sun
Gastric disintegration of myofibrillar protein gels occurred via surface erosion. • CaCl 2 substitution caused early soft region decomposition and rigid residue. • Swelling capacity correlated with gel compactness and initial moisture content. • Decreased inter-cluster gaps influenced steric hindrance and pepsin diffusivity. The effects of salt mixtures on the in vitro gastric digestion, disintegration, and gastric juice diffusion of sodium-substituted myofibrillar protein gels were investigated. The results showed that gel disintegration occurred via surface erosion, with no significant differences in apparent morphology among substitution treatments. However, KCl/CaCl 2 -substituted gels exhibited preferential early decomposition of soft regions, leaving rigid structures that impeded later digestion. Acid swelling tests and magnetic resonance imaging revealed that the sodium-substituted gels containing CaCl 2 had lower inherent moisture content and inflexible structural units, resulting in lower swelling ratios and hydrogen proton signal intensities compared with KCl/MgCl 2 -substituted gels. At a 40% substitution level, CaCl 2 -substituted gels exhibited lower liquid loss during digestion, and post-digestion inter-particle extrusion enhanced their elastic recovery ability. Acid diffusion experiments indicated that methylene blue-labeled acid water penetrated deeper into KCl/MgCl 2 -substituted gels, which possessed a uniform porous network. The bleaching radius of fluorescein isothiocyanate-labeled pepsin was smaller in CaCl 2 -substituted gels, attributable to the reduced cluster gaps from dehydration during gel formation and numerous clustered protein aggregates, leading to increased steric hindrance and decreased pepsin diffusivity. These findings may provide a mechanistic baseline for understanding how sodium substitution strategies influence the gastric digestion of protein gels, thereby guiding the design of meat products with controlled digestibility and texture. Download: Download high-res image (147KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Jinping Xu,Quanshuang Li,Bingjie Lu,Mengyao Wang,Huanchen Hou,Wangli Bao,Junyu Xia,Shibao Li,Jing Chen,Liangwen Hao
One-pot scalable synthesis of phenylboronic acid-modified AuNPs at room temperature. • Rapid Fc-oriented antibody immobilization enabled by boronate-affinity interaction. • The oriented bio-interface enhances lateral flow immunoassay sensitivity by 16-fold. • The developed LFIA enables reliable assay of fecal occult blood in clinical samples. • This method offers a promising platform for colorectal cancer point-of-care testing. The analytical performance of lateral flow immunoassay (LFIA) is largely determined by the bio-interfacial orientation of antibodies immobilized on colloidal gold nanoparticles (AuNPs). Conventional citrate-capped AuNPs (Cit-AuNPs), however, mainly rely on random physical adsorption, which often produces unfavorable antibody orientations and poor accessibility of antigen-binding sites. In addition, Cit-AuNPs typically require harsh high-temperature reflux synthesis and specialized equipment for large-scale production, increasing industrialization costs. Here, we report a facile one-pot, room-temperature strategy for the large-scale synthesis of phenylboronic acid-modified AuNPs (PBA-AuNPs), achieving 5 L batch production within 10 min. The obtained PBA-AuNPs exhibit excellent monodisperse and a uniform size of 23.5 nm, and enable an oriented antibody immobilization via boronate-affinity interactions with the carbohydrate moieties of Fc fragments. When applied to fecal occult blood (FOB) detection, the PBA-AuNPs showed a remarkable 16-fold improvement in sensitivity compared with Cit-AuNP probes. Overall, this work provides a robust, scalable nanoplatform with strong clinical translational potential for high-sensitivity LFIA diagnostics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Energy
·
2026
·
IF 8.1
Shen Zhang,Jinxiong Wan,Jihuai Wu,Weichun Pan,Ying Wang,Jiexi Pan,Zeyuan Zhao,Mengyao Guo,Xuping Liu,Zhang Lan
Interface-associated recombination at the interface of perovskite active layer/hole transport layer (PVK/HTL) remains an important loss pathway in high-performance perovskite solar cells (PSCs). In this work, cobalt benzoate [(C 6 H 5 COO) 2 Co, CoBz] is introduced as a post-treatment modifier to regulate the upper surface of the PVK before deposition of the HTL. The introduction of CoBz lowers the trap-state density from 4.16 × 10 15 cm −3 to 2.84 × 10 15 cm −3 , and enlarges the average grain size from 0.70 to 1.19 μm, improving the crystalline quality of perovskite. At the same time, the optimized interface facilitates charge extraction and transport and suppresses recombination losses. Benefiting from these effects, the CoBz-treated device delivers a power conversion efficiency of 23.84%, exceeding the value of 21.98% for the pristine device. Moreover, the unencapsulated modified device maintains 89.23% of its initial efficiency after 1000 h of exposure to air at 25 °C and 30% relative humidity, and 89.0% after 400 h of maximum power point tracking (MPPT) under N 2 . Overall, CoBz interfacial engineering offers an effective route to concurrently improve the efficiency and stability of PSCs.
✓ 已验证
产品关联
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2026
·
IF 7.9
Shengkai Liu,Ruimeng Liu,Wenxuan Wang,Dandan Hu,Yu Han,Cong Li,Huiling Li,Chang Wan,Tai Peng,Wei Wang,Daxin Liang
A Hofmann-degraded HTO/CMC/PVA composite film solves powdered HTO’s solid-liquid separation issue via a dense cross-linked network. • Protonated primary amine groups boost lithium selectivity by nearly twofold through the Donnan exclusion effect. • Superior lithium adsorption in real samples, retaining 91.3% capacity after six adsorption-desorption cycles. Rapid global new energy development fuels explosive lithium demand, with efficient purification of salt lake brine and battery leachate a research hotspot. Liquid-phase lithium recovery is severely hindered by coexisting metal ions with ionic radii similar to lithium, leading to high system complexity. Although powdered H 2 TiO 3 (HTO) lithium ion sieves have inherent advantages of stable structure and excellent adsorption capacity, they face critical technical bottlenecks including low solid-liquid separation efficiency and easy co-adsorption by high-valence interfering ions. To solve these problems, this study modified polyacrylamide (PAM) through Hofmann degradation reaction to introduce primary amine groups, and further compounded modified PAM with carboxymethylcellulose (CMC) and polyvinyl alcohol (PVA) to prepare an HTO-loaded CMC/PVA/PAM composite adsorption film. The film forms a dense cross-linked network via intermolecular hydrogen bonds among the three polymers, fundamentally solving the solid-liquid separation issue of powdered HTO. In an alkaline adsorption environment (pH < 10.5), primary amine groups on modified PAM are protonated to form positive charge sites, which exert the Donnan exclusion effect through electrostatic repulsion to effectively inhibit co-adsorption of magnesium, cobalt, manganese and nickel ions, raising the lithium selective separation efficiency of HTO/CPP2 by nearly twofold compared with HTO/CP. The film showed outstanding specific adsorption performance in actual Da Qaidam Salt Lake water samples and waste battery residue leachate, with good cycling stability that retains 91.3% of the initial adsorption capacity after six cycles. This research thus provides a novel and feasible technical solution for the integrated green extraction of high-purity lithium from two typical complex lithium-containing systems. Download: Download high-res image (225KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
IEEE SENSORS JOURNAL
·
2026
·
IF 4.5
Jiasheng Yan,Tao Chen,Jie Cheng,Yuanyuan Zou,Diangeng Li,Jinhong Guo
Interstitial fluid (ISF) contains biomarker concentrations that closely correlate with those in plasma, making it a highly suitable medium for continuous physiological monitoring systems. To address the demand for multi-analyte adaptability in continuous monitoring applications, a modular, disposable, flexible microneedle-based sensing system is developed in this study. The proposed system is fully constructed using 3D-printed structural components, enabling a simplified fabrication process and cost-effective manufacturing. Modularity is achieved through the replacement of specific biorecognition layers, allowing potential adaptation for the detection of different biomarkers. The overall system architecture and key fabrication procedures of the microneedle electrode are systematically presented. Glucose (GLU) in ISF is selected as a model analyte for proof-of-concept validation. By integrating an auxiliary insertion mechanism and a signal acquisition module, continuous glucose monitoring is successfully demonstrated. The sensor exhibits a linear response over a concentration range of 2.2–27.8 mM, with a limit of detection (LOD) of 0.26 mM (S/N = 3), covering the physiological glucose concentration range in humans. In addition, the system demonstrates fast response characteristics and high sensitivity, while maintaining stable performance under moderate temperature variations. It is noted that the current experimental validation is limited to glucose detection, whereas sensing capabilities for other biomarkers such as lactate and uric acid remain at the level of platform design and potential methodological extension, and require further systematic verification. Overall, the proposed modular design strategy provides a flexible and scalable technical framework for dynamic continuous monitoring of multiple biomarkers in physiological environments.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jingze Luan,Yue Zhang,Weiwei Jian,Jialin Geng,Chunbo Xu,Yihao Yang,Dandan Han
A biomimetic triple-synergistic Zn-ICH hydrogel is developed for wearable strain sensing. • The hydrogel mimics extracellular-matrix-inspired multiple weak interaction coupling. • Zn-ICH integrates toughness, ionic conductivity, adhesion, and anti-freezing ability. • The sensor enables reliable human motion monitoring and real-time HMI control. • Zn-ICH also shows promise for flexible zinc-ion energy-storage devices. Inspired by the synergistic coupling of multiple weak interactions in natural extracellular matrices, here a triple-synergistic biomimetic double-network ionic conductive hydrogel (Zn-ICH) strategy is proposed to achieve high-performance flexible strain sensors with balanced comprehensive properties. Specifically, the rigid polyacrylamide/sulfobetaine methacrylate (PAM/SBMA) covalent network provides structural stability under large deformations, while the reversible Zn 2+ -sodium alginate (Zn 2+ -SA) dynamic coordination network enables efficient energy dissipation, and the zwitterionic glycerol hydration microenvironment ensures continuous ion transport, robust interfacial adhesion and wide-temperature tolerance, breaking the inherent performance trade-offs of conventional conductive hydrogels. The Zn-ICH-based strain sensor exhibits a gauge factor of 0.93–1.29 over 0–500% strain, enabling reliable detection of human motions and physiological signals. Furthermore, the constructed wearable human-machine interaction system enables stable and near-real-time robotic arm actuation with a motion synchronization accuracy of 99%. Additionally, when used as a zinc-ion capacitor electrolyte, the Zn-ICH hydrogel enables the flexible device to deliver a specific capacity of 150 mAh·g −1 at 0.3 A·g −1 and maintain 95% capacity retention after 5000 cycles. This work establishes a universal design principle for multifunctional conductive hydrogels, offering broad application prospects in wearable electronics and flexible energy storage. Download: Download high-res image (432KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CORROSION SCIENCE
·
2026
·
IF 10.3
Yueqi Wu,Mingyong Jia,Qiang Shen,Fei Chen
Silicon nitride (Si 3 N 4 ) ceramics are promising structural materials for next-generation concentrated solar power (CSP) systems, while their long-term stability in aggressive molten chloride salts remains insufficiently understood. Here, we investigate the corrosion behavior and decomposition mechanism of a conventional Y 2 O 3 -sintered β-Si 3 N 4 ceramic in molten MgCl 2 –NaCl–KCl at 600 °C. The corrosion process proceeds through three sequential stages: preferential dissolution of the amorphous intergranular phase (IGP), formation of a detrimental Mg 2 SiO 4 layer, and subsequent chemical attack of β-Si 3 N 4 grains. Guided by this mechanistic understanding, we propose a grain boundary engineering strategy using YF 3 /MgF 2 sintering aids to fabricate corrosion-resistant Si 3 N 4 ceramics. The engineered ceramic exhibited a 25% reduction in average corrosion depth and excellent property retention after 800 h of exposure. Its bending strength loss is only 8.3%, compared with 13.8% for the reference material, and its thermal conductivity loss is 4.8%, compared with 8.4% for the reference material. The improved corrosion resistance is attributed to the combined effects of a chemically stable crystalline Y 4 Si 2 N 2 O 7 intergranular phase, elimination of residual SiO 2 impurities, and a coarsened microstructure. Salt purification experiments further confirmed the proposed corrosion mechanism by suppressing impurity-driven decomposition. In purified molten salt, the engineered ceramic shows an extrapolated corrosion rate of approximately 16.8 μm·year - ¹ , meeting the U.S. DOE corrosion target of < 20.0 μm·year - ¹ . These results demonstrate that grain boundary engineering is an effective strategy for improving the durability of Si 3 N 4 ceramics in high-temperature molten chloride salt environments.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2026
·
IF 3.8
Xiao Cheng,Hao Zhang,Zixu Chen,Haozhuo Dong,Ting Yu,Ruifang Guan
Room-temperature phosphorescent carbon dots (RTP-CDs) exhibit exceptional biocompatibility and tunable luminescence but are limited by short lifetimes and exciton quenching. Herein, we develop a one-step pyrolysis strategy using m-phenylenediamine and boric acid to fabricate boron-doped RTP-CDs (M-CDs) with ultralong green afterglow (16 s) and extended lifetime (37.03 ms). The rigid polycrystalline boron oxide matrix effectively confines molecular motion, isolates quenchers, and stabilizes triplet excitons, while boron doping reduces the singlet-triplet energy gap (ΔE ST = 0.206 eV) to promote intersystem crossing (ISC). Further heavy-atom doping (Cl/Br) enhances spin-orbit coupling, boosting afterglow to 18 s and lifetime to 41.16 ms, whereas iodine disrupts the matrix. Leveraging tunable afterglow dynamics, we demonstrate dynamic information encryption with visible/UV-switchable patterns. This work provides a cost-effective route to high-performance RTP-CDs and clarifies synergistic regulation mechanisms for advanced optoelectronic applications.
✓ 已验证
产品关联
DOI
高影响因子
Small Methods
·
2026
·
IF 8.7
Li Dai,Ying Chen,Daisan Zha,Defang Ding,Ying Shen,Xin Lei,Huiyang Jie,Qian Liu,Lei Jiang,Meihua Lin,Yu Huang,Fan Xia
Accurate environmental detection fundamentally depends on reliable calibration. Although AI-assisted curve fitting improves analytical efficiency, it often relies on empirical, concentration-dependent correction coefficients that can introduce deviations from true values and compromise accuracy. Thus, instead of over-relying on AI-driven fitting, rigorous mechanistic understanding of sensing processes and deviation sources is essential to ensure reliable detection. Herein, we constructed a self-calibrating sensing system by functionalizing solid-state nanochannels with rationally designed super-sandwich (SSW) DNA probes, enabling reliable sensing and providing clear insight into the mechanisms underlying signal deviations. By integrating complementary fluorescence and ionic current readouts derived from the same molecular recognition event between the SSW-DNA probe and the target, the negative deviation of the fluorescence signal (exceeding −20.0%) and the positive deviation of the electrical signal (exceeding +20.0%) can effectively offset each other. These deviations, originating from incomplete SSW-DNA disassembly, were reduced to below ± 5.0% through this cancellation mechanism. This work not only significantly improves sensing reliability but also clarifies the underlying deviation mechanisms of nanochannel-based sensors, offering valuable insights for environmental, food, and biomedical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2026
·
IF 4.3
Rongrong Li,Wenbin Huang,Tianyu Bai,Fan Shao,Jingxiao Sun,Shixuan Guo,Qiang Wei,Yasong Zhou
Preparation of BiOCl with abundant active sites via PVP-assisted aqueous/solvothermal method and Its application in photocatalytic CO 2 reduction. • Increased active site facilitates CO 2 adsorption and activation. • The mechanism of action of EG and PVP in the BiOCl crystal growth process has been proposed. Photocatalytic CO₂ conversion represents a promising green approach to mitigate carbon emissions, yet the fast recombination of photogenerated charge carriers severely restricts the catalytic efficiency of conventional photocatalysts. Rational surface and crystal engineering is therefore essential to address this issue. In this work, we report a facile solvothermal synthesis of BiOCl with enriched active sites, where EG and PVP act as co-regulators for crystal growth. The two additives sequentially coordinate with Bi³⁺, and the stronger competitive adsorption of PVP, together with the modulation effect of EG, collaboratively decreases grain size and drives the preferential exposure of catalytically favorable (110) facets. Spectroscopic characterizations confirm the surface functionalization by PVP. Benefiting from the optimized structure, the as-prepared BiOCl delivers a 1.6-fold increase in CO generation rate. More importantly, we establish the molecular-level synergistic mechanism of EG and PVP for (110) facet regulation, and clarify the underlying mechanism of photocatalytic CO 2 reduction over the as-obtained material. The synergistic effect of PVP and EG promotes the exposure of highly active crystal planes on the BiOCl surface. Simultaneously, PVP modification of BiOCl increases the surface charge density, collectively enhancing photocatalytic activity. Download: Download high-res image (189KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）