ACS Nano
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2018
·
IF 13.709
Qing Chen,Yang Du,Kai Zhang,Zeyu Liang,Jinquan Li,Hao Yu,Rong Ren,Jin Feng,Zhiming Jin,Fangyuan Li,Jihong Sun,Min Zhou,Qinggang He,Xiaolian Sun,Hong Zhang,Mei Tian,Daishun Ling
Alzheimer’s disease (AD) remains an incurable disease and lacks efficient diagnostic methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it is time to consider the alternative theranostics due to accumulated findings of weak correlation between Aβ deposition and cognition, as well as the failures of Phase III clinical trial on Aβ targeted therapy. Recent studies have shown that the tau pathway is closely associated with clinical development of AD symptoms, which might be a potential therapeutic target. We herein construct a methylene blue (MB, a tau aggregation inhibitor) loaded nanocomposite (CeNC/IONC/MSN-T807), which not only possesses high binding affinity to hyperphosphorylated tau but also inhibits multiple key pathways of tau-associated AD pathogenesis. We demonstrate that these nanocomposites can relieve the AD symptoms by mitigating mitochondrial oxidative stress, suppressing tau hyperphosphorylation, and preventing neuronal death both in vitro and in vivo. The memory deficits of AD rats are significantly rescued upon treatment with MB loaded CeNC/IONC/MSN-T807. Our results indicate that hyperphosphorylated tau-targeted multifunctional nanocomposites could be a promising therapeutic candidate for Alzheimer’s disease.
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Journal of Cleaner Production
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2018
·
IF 5.651
Hao Zheng,Xia Liu,Guocheng Liu,Xianxiang Luo,Fengmin Li,Zhenyu Wang
Biochar (BC) and activated carbon (AC) amendments have been applied to remediate contaminated sediments because of their benefits in reducing toxicity and/or the bioavailability of contaminants. However, their ecotoxicity to benthic organisms, which are not well understood, should be carefully considered before their practical application. Therefore, a wood-derived BC (WBC) or a coconut shell-derived AC (CAC) was incorporated into a marine sediment at 5% (dw%) to investigate their effects on the growth and nutritional quality of a marine clam ( Meretrix meretrix ). CAC and WBC had no effect on the pH and calcium content of the sediment, but significantly increased the electrical conductivity (EC) and total organic carbon (TOC), and decreased the dissolved organic carbon (DOC). After 28 days of cultivation, WBC reduced the shell growth of the clam by 36.4%, and CAC reduced the soft tissues of the clam by 9.05%. This was probably because WBC and CAC adsorb organic matters and the feeding algae may colonize within their pores, thus, reducing food bioavailability for the clams. Water extracts of CAC and WBC had negligible effects on soft tissue growth, whereas the CAC extract inhibited the growth of clam shells by 57.9%. WBC and CAC had little influence on the nutritional quality of clams, including moisture, crude protein , and crude lipid contents. These findings are helpful to understand the ecotoxicological risks of BC and AC amendments to benthic organisms when used for the remediation of contaminated marine sediments.
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ACS Nano
·
2019
·
IF 13.903
Qinjie Weng,Xi Hu,Jiahuan Zheng,Fan Xia,Nan Wang,Hongwei Liao,Ying Liu,Dokyoon Kim,Jianan Liu,Fangyuan Li,Qiaojun He,Bo Yang,Chunying Chen,Taeghwan Hyeon,Daishun Ling
Gadolinium-based contrast agents (GBCAs) are widely used for T1-weighted magnetic resonance imaging (MRI) in clinic diagnosis. However, a major drawback of GBCAs is that they can increase the toxicological risk of nephrogenic systemic fibrosis (NSF) in patients with advanced renal dysfunction. Hence, safer alternatives to GBCAs are currently in demand, especially for patients with renal diseases. Here we investigated the potential of polyethylene glycol (PEG)-stabilized iron oxide nanoclusters (IONCs) as biocompatible T1MRI contrast agents and systematically evaluated their NSF-related risk in rats with renal failure. We profiled the distribution, excretion, histopathological alterations, and fibrotic gene expressions after administration of IONCs and GBCAs. Our results showed that, compared with GBCAs, IONCs exhibited dramatically improved biosafety and a much lower risk of causing NSF, suggesting the feasibility of substituting GBCAs with IONCs in clinical MRI diagnosis of patients with renal diseases.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2012
·Vol. 39
·期 3
·869-874
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IF 0.697
Dong Shuangjian,Li Yunling,Li Qiuxiao
The synthesis of unsaturated tertiary amine by the amination of oleyl alcohol and dimethylamine under atmospheric pressure over Cu–Ni catalysts supported on CaCO 3 was studied. The yield of tertiary amine and the retention rate of the unsaturated bond can reach 95.4 and 93.3 %, respectively. The yields of tertiary amine over different Cu/Ni ratios catalysts were close to each other, which meant that Cu/Ni ratios had no obvious influence on the production of tertiary amine, while the retention rate of the unsaturated bond over the catalyst containing only Cu was higher than the catalysts containing Cu–Ni. The major effect of the Cu element was dehydrogenation, and the ability of the hydrogenation was weak. The ability of the Ni element to break the carbon–carbon bonds and hydrogenation was strong. Therefore, the performance of the Cu catalyst was better than the conventional Cu–Ni-based catalyst for the retention of the unsaturated bond in long-chain R of the tertiary amine.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Min Wang,Yajie Yue,Xiaoning Wei,Jinyuan Zhang,Xinyuan Bi,Liyan Jia,Xu Jing
Strobilurin fungicides are widely used pesticides globally; however, their residues pose a risk to environmental safety and human health. This study aimed to develop a rapid and green method for detecting strobilurin fungicide residues. Chitosan and magnetic deep eutectic solvent-based emulsive liquid-liquid microextraction method combined with high-performance liquid chromatography was developed to determine strobilurin fungicides in water samples. A high-concentration oil-in-water emulsion containing chitosan solution and extractant was formulated, followed by the addition of samples to form a low-concentration oil-in-water emulsion to complete the rapid pretreatment, therefore solving the limitation of emulsive liquid-liquid microextraction in the inapplicability of extractants. Traditional microextraction required toxic solvents and complex equipment to facilitate the dispersion of extractants, whereas this study used only chitosan solution to aid in emulsifying extractants. The new green magnetic deep eutectic solvent synthesized by tetraoctylammonium bromide, ferric chloride, and oleic acid was used instead of toxic extractants. An external magnetic field assisted the extractant phase collection, which shortened the separation time. Under optimal conditions, the recovery of this method was 83.3 %–107.4 %, the limit of detection was 0.0010–0.0021 mg L −1 , and the coefficient of determination was >0.994. This rapid, green, simple, and efficient chitosan-based microextraction method could detect strobilurin fungicide residues in water samples because of its enhanced compatibility with hydrophobicity extractants.
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JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
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2016
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IF 2.189
Yicheng Bi,Min Yu,Haiyan Zhou,Hua Zhou,Ping Wei
In our study, oleyl oleate was synthesized through enzymatic esterification of oleic acid with oleyl alcohol using Candida rugosa lipase (CRL) immobilized on macroporous resin in a solvent-free system. CRL was immobilized flexibly on the support via aldehyde-dextran, and the effectiveness of aldehyde-dextrans, as cross-linking agents with different molecular weights, was compared and discussed. The impact of various factors, such as different molecular weights of dextran , molar ratio between oleic acid and oleyl alcohol, and the temperature and stability of enzymes, on esterification was investigated as well. Our study indicated that lipase immobilized by 20000 Da dextran yielded the best result. The optimal condition to produce oleyl oleate using immobilized CRL was found in our study and turned out to be molar ratio of 1, reaction temperature of 40 °C, and a 12-h reaction time to reach reaction equilibrium. Under the optimal reaction conditions, a high percentage yield of ester was achieved (92.6%). The immobilized CRL also reached a conversion rate of 86.7% with excellent stability even after 8 cycles.
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RSC Advances
·
2016
·Vol. 6
·期 33
·28023-28033
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IF 3.289
Jinsong He,Jiangdong Dai,Tao Zhang,Jun Sun,Atian Xie,Sujun Tian,Yongsheng Yan,Pengwei Huo
Hierarchical carbon materials with ultrahigh specific surface area and high porosity were synthesized by KOH activation from sustainable α-cellulose and employed as adsorbents to study adsorption performance of tetracycline (TC) and sulfamethazine (SMZ) from aqueous solutions. The physical and chemical properties of the as-prepared materials were characterized by SEM, TEM, FT-IR, XPS, Raman and a surface area analyzer. The obtained porous carbon exhibited a hierarchical pore structure, large BET specific surface area (3187.91 m2 g−1) and pore volume (1.781 cm3 g−1) when the activation temperature reached 850 °C. The maximum adsorption capacities were 1072.86 and 786.18 mg g−1 for TC and SMZ removal at 298 K, respectively. Moreover, TC and SMZ showed similar adsorption features, kinetic results could fit well using a pseudo-second-order model, intraparticle diffusion was not the rate-controlling step and adsorption isotherm results fit well with the Langmuir model. The adsorption capacities increased with contact time and adsorption temperature and, moreover, pH and external ionic species have a significant effect on adsorption efficiency. Thermodynamic studies implied that physisorption might dominate adsorption and the adsorption process is spontaneous and thermodynamically favorable. The results are of importance to indicate that the as-prepared porous carbon could be used as a low-cost and effective adsorbent in pharmaceutical wastewater treatment.
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RSC Advances
·
2017
·Vol. 7
·期 20
·12283-12291
·
IF 3.108
Yicheng Bi,Hua Zhou,Honghua Jia,Ping Wei
In our study, a polytetrafluoroethylene (PTFE) open-tubular enzyme-immobilized microreactor has been successfully prepared using dopamine polymerization and multi-layer deposition. The polydopamine layer was utilized as a primer layer in the microchannel to provide PTFE surface reactable groups, and polyethylenimine and Candida antarctica lipase B were alternatively adsorbed on the PTFE surface by the layer-by-layer method. The lipase loading kept increasing as the number of layers increased and reached a plateau at the 8th layer. The formation of multilayers and increase of enzyme loading were described and explained by the water contact angle measurement, Fourier transform infrared spectroscopy (FI-IR), and X-ray photoelectron spectroscopy, while the morphological characteristics were observed using Atomic Force Microscopy (AFM) and field emission scanning electron microscopy (FE-SEM). Preparation of a wax ester using the microreactor had much better production efficiency (35 minutes to reach 95% yield) than that using traditional reactors (over 4 hours to complete the reaction). Very excellent stability can be achieved by the microreactor, which could be used for 144 hours with the residual activity remaining at 83% of the initial activity.
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Advanced Healthcare Materials
·
2024
·
IF 10
Ting Zhou,Yanzhi Dong,Xiaoyi Wang,Ruxia Liu,Ran Cheng,Jinbin Pan,Xuejun Zhang,Shao-Kai Sun
Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitable for early kidney damage detection through MRI. Herein, a renal clearable ultra-small ferrite nanoprobe (UMFNPs@ZDS) is proposed for highly sensitive early diagnosis of kidney damage via structural and functional MRI in vivo for the first time. The nanoprobe comprises a ferrite core coated with a zwitterionic layer, and possesses a high T 1 relaxivity (12.52 m m −1 s −1 ), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage.
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ACS Central Science
·
2024
·
IF 12.7
Yaqi Li,Yixin Sun,Qing Wang,Shuo Wang,Cuiyun Liu,Yuetong Huang,Wenxin Zhong,Xiyan Wang,Wenjing Wang,Shiyi Zuo,Xianbao Shi,Xiaohui Pu,Jin Sun,Zhonggui He,Bingjun Sun
Prodrug-based nanoassemblies are promising platforms for cancer therapy. Prodrugs typically consist of three main components: drug modules, intelligent response modules, and modification modules. However, the available modification modules are usually hydrophobic aliphatic side chains, which affect the activation efficiency of the prodrugs. Herein, hydrophilic ethylene glycol fragments were inserted between the modification modules and the response modules, and the important effects of hydrophilic fragments on the assembly, drug release, and therapeutic index of the prodrugs were investigated. Notably, the introduction of hydrophilic fragments affected the intermolecular forces of the prodrugs and increased the interaction of hydrogen bonding. In addition, hydrophilic fragments significantly improved the redox drug release profiles, which affected the therapeutic index of the prodrug nanoassemblies. PTX-SS-OA NPs with hydrophilic fragments exhibited increased redox sensitivity, enhanced cytotoxicity, and superior antitumor efficacy. In comparison, PTX-SS-OAL NPs without hydrophilic fragments showed limited redox sensitivity and cytotoxicity but displayed better safety. Overall, the hydrophilic fragment is a critical determinant in modulating the therapeutic index of the prodrug nanoassemblies, which contributes to the development of advanced prodrug nanodelivery systems.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Junbo He,Xinyu Zhang,Yijie Li,Hong Lin,Weinong Zhang
Selachyl alcohol (SA), a naturally occurring 1- O -alkylglycerol, has garnered significant attention due to its wide biological activities. To enhance its aqueous solubility, the complexation with sodium caseinate (NaCas) was investigated. Results showed the SA-NaCas complex, optimally formed at a 1:4 mass ratio, yielded a nanoscale dispersion with enhanced surface hydrophobicity, reduced dynamic surface tension, and superior emulsifying indices compared to NaCas alone. Fluorescence spectroscopy elucidated the interaction between SA and NaCas as a spontaneous process, mainly driven by hydrophobic forces. The binding constant and Gibbs free energy change were 1.17 × 10 3 L/mol and − 18.09 kJ/mol at 308 K. Molecular docking revealed that hydrophobic and hydrogen bonding interactions were the main forces driving the binding of SA to the α- and β-casein components of NaCas. The SA-NaCas nanocomplex not only enhances SA's water solubility, but also can be used as an effective nano-delivery system with better physicochemical properties than NaCas.
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Biomaterials Science
·
2024
·
IF 5.8
Yanzhi Dong,Jiaojiao Wang,Ting Zhou,Jinbing Pan,Xu Wang,Shao-Kai Sun
Highly sensitive iron oxide nanoparticles with stable, safe and efficient surface functionalization, as potential substitutes for gadolinium-based contrast agents (GBCAs) with increasing biosafety concerns, exhibit great potential for high-performance magnetic resonance angiography (MRA). Herein, we developed ultrasmall catechol-PEG-anchored ferrite nanoparticles (PEG-UMFNPs) for highly sensitive MRA. The obtained nanoprobe has a high T1 relaxivity value (7.2 mM−1 s−1) due to its ultrasmall size and Mn doping. It has a suitable hydrodynamic size of 20 nm, which prevents rapid vascular extravasation and renal clearance and prolongs its blood circulation time. In vivo MRA at 3.0 T using the nanoprobe shows that the arteries and veins of rats, even blood vessels as small as 0.32 mm, are distinctly visible, and the contrast enhancement can last for at least 1 h. In addition, due to the outstanding contrast enhancement and long circulation time, the stenosis and recanalization process of the rat’s carotid artery can be continuously monitored with a single injection of the nanoprobe. Our study indicates that PEG-UMFNPs are outstanding MR imaging nanoprobes that can be used to diagnose vascular diseases without the biosafety issues of GBCAs.
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