Journal of Pharmaceutical Analysis
·
2021
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IF 4.769
Anqi Huang,Wenwen Deng,Xiao Li,Qutong Zheng,Xuanxuan Wang,Yuxiu Xiao
Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature and have low viscosity (<12.26 mPa‧s), low polarity (lower than that of methanol, ChCl-based deep eutectic solvents and other reported HDESs), and low density (<0.928 g/mL). A simple one-pot method based on a novel HDES–water two-phase extraction system was constructed for the extraction of weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma. This HDES-based new extraction method does not consume hazardous organic solvents and can obtain a total anthraquinone yield of 21.52 mg/g, which is close to that obtained by the Chinese pharmacopoeia method (21.22 mg/g) and considerably higher than those by other reported HDESs-based extraction methods (14.20–20.09 mg/g, p < 0.01). The high extraction yield can be mainly attributed to the severe destruction of the RRR cell walls by the extraction system and the excellent dissolving ability of novel HDESs for anthraquinones.
研究领域:
药学
·
天然产物化学
✓ 已验证
DOI
高影响因子
AICHE JOURNAL
·
2018
·Vol. 65
·期 2
·675-683
·
IF 3.326
Hao Qin,Zhen Song,Qian Zeng,Hongye Cheng,Lifang Chen,Zhiwen Qi
The traditional production of long-chain organic esters like isobutyl isobutyrate (BIBE) suffers from severe problems due to the homogenous catalyst in process and complex system thermodynamics. In this work, an innovative bifunctional deep eutectic solvent (DES) is introduced, playing as both reaction catalyst and extraction solvent, to intensify the esterification process. The DES was formed by imidazole (Im) and p -toluenesulfonic acid (PTSA), which was for the first time found acid–base tunable, represented by weak basic DES [3Im:PTSA] and strong acidic DES [Im:2PTSA]. The formation mechanisms of [3Im:PTSA] and [Im:2PTSA] were illustrated by Fourier-transform infrared spectroscopy (FTIR) and COnductor-like Screening MOdel for Real Solvent (COSMO-RS) combined with the Im-PTSA phase diagram. The dual functions of the acidic [Im:2PTSA] in reactive extraction were evaluated by σ -potential analysis and esterification experiments. The high conversion, easy product separation, and good solvent reusability confirm the excellent catalytic and solvent effect of [Im:2PTSA]. © 2018 American Institute of Chemical Engineers AIChE J , 65: 675–683, 2019
研究领域:
化学工程
·
有机合成
✓ 已验证
DOI
高影响因子
Biomass Conversion and Biorefinery
·
2022
·
IF 4.05
Wang Lei,Hu Yang,Guo Guoqing,Li Jie,Fang Xianying,Zhao Linguo
The green extraction and separation of natural produce is a significant part in pharmaceutical industry which has received extensive attention. Comparing with the extraction of hydrophilic products, hydrophobic natural products are further challenging. An extraction means depended in high efficiency hydrophobic deep eutectic solvent (HDES, TCP) was screened by designing ternary HDES. Utilizing the established method, the hydrophobic compound betulin was successfully extracted and recovered from Celtis sinensis leaves. The results showed that HDESs were further productive in extracting hydrophobic compounds than hydrophilic DES. The extractions of TPC were statistically optimized by response surface methodology and central composite design. Under the optimum conditions, the extraction rate of betulin was increased by 125.00% compared with the initial yield. At the same time, it was proved that among the six resins, D-101 macroporous resin had the highest recovery rate of 71.12% for betulin, which was the most effective enrichment and purification method. To sum up, HDES has obvious advantages in the extraction of hydrophobic natural products due to its mild extraction conditions, high yield, and environmental friendliness. At the same time, limitless feasibilities of HDES compositions and their associations furnish a plentiful selection space for the extraction about hydrophobic compounds.
研究领域:
植物化学
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药用植物学
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天然产物化学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Shengchao Xu,Wanting Ma,Junxiong Zhao,Jiaming Yu,Qifeng Wei,Xiulian Ren
Lactic acid (LA) is a typical high added-value chemical and platform molecule derived from renewable biomass. To realize high efficiency and green separation of LA is of both scientific and practical significance. In this work, we proposed a novel mechanism of in-situ formation of hydrophobic deep eutectic solvents (HDES) to couple the separation of LA and synthesis of HDES . Due to the high solubility of LA as hydrogen bond donor in water, three hydrophobic lactams ( N -Octyl-2-pyrrolidone (NOP), N -Dodecyl-2-pyrrolidone (NDP) and 2-Octyl-4-isothiazolin-3-one (OIT)) were optioned as hydrogen bond acceptors. The effect of lactam molecular structure on separation efficiency was discussed and compared in detail. The compositions of HDES forming in-situ were found to be 1.50 for NOP and NDP to LA while 1.20 for OIT to LA using experiments of slope method and continuous variations method. The key evidence of formation of HDES was confirmed by FT-IR, frontier molecular orbital analysis and interaction region indicator analysis. The multistage counter-current extraction experiment results showed the in-situ formation of HDESs can transfer 99% of LA from fermentation broth to the HDES, and LA was separated completely from the impurities. This work provided a new perspective on lactic acid separation and its potential industrial applications.
研究领域:
生物化学
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绿色化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Wanting Guo,Christian Marcus Pedersen,Zhihui Liu,Wenbo Dong,Lingyu Jia,Shuwei Chen,Yingxiong Wang,Yan Qiao
Carbazole (CAR) and anthracene (AN) are high value compounds derived from coal tar, but their separation is challenging due to their structural similarity. Promising results, using deep eutectic solvents (DESs) for the separation, have recently been obtained. However, choosing the optimal DESs for the separation of CAR and AN is difficult due to a lack of knowledge about the interaction of DESs with CAR and AN. Herein, the interactions between CAR and AN with seven DESs containing ethylene glycol (EG) as the hydrogen bond donor (HBD) were investigated by nuclear magnetic resonance (NMR). The interaction between CAR and tetrabutylammonium chloride/ ethylene glycol (TBAC/EG) was investigated using various NMR methods such as chemical shift titration, variable temperature NMR (VT-NMR), relaxation time measurements and diffusion-ordered spectroscopy (DOSY). From the chemical shift differences of the N H proton of CAR, a strong interaction between CAR and the DES consisting of TBAC and EG, was revealed. TBAC/EG was therefore proposed as a promising solvent for the separation of CAR and AN. In addition, VT-NMR showed that the hydrogen bonding interaction between CAR and TBAC/EG increased with decreasing temperature. The changes in relaxation time (T 1 , T 2 ), molecular correlation time (τ c ) and the molecular self-diffusion coefficients (D) supported the existence of interactions between CAR and TBAC/EG, presumably dominated by hydrogen bonding between the N H and the chloride ion. This study introduces an efficient method for screening solvents to separating CAR and AN, and it can also be applied to other fields of separating complex mixtures.
研究领域:
化学
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分离科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Lijiao Yu,Lihong Deng,Jieyu Wu,Subhan Mahmood,Ke Yuan,Haoran Wu,Xiaodong Wang,Jing Zhang,Shun Yao
As a key component in tea tree oil (TTO), terpinen-4-ol exhibits ideal physiological activities. However, the high content of terpenes in crude TTO makes it challenging to enrich terpineol-4-ol. In this study, molecular simulations combined with experimental methods were used to select the optimal hydrogen bond acceptor (HBA), tetrabutylammonium chloride (TBAC), which forms a deep eutectic solvent (DES) with terpinen-4-ol in situ. Combined with necessary post-treatment process, it provided a feasible way for purification of TTO. Related DESs were prepared and characterized, and their main properties were also investigated. When the amount of TBAC was three times that of terpinen-4-ol, the formation of hydrogen bonds became more pronounced. At this point, the DES achieved its highest distribution coefficient for terpinen-4-ol (D t = 15.02), as well as superior selectivity for terpinen-4-ol (S t/c = 24.59, S t/γ = 57.69). Water as the back-extractant and n-hexane as the auxiliary extractant facilitated the deep purification of terpinen-4-ol. Response surface analysis and experimental results confirmed that the optimal enrichment conditions were 30 min of enrichment time, an enrichment temperature of 60℃, and 0.5 g/g of n-hexane dosage. The back-enrichment and recovery of TBAC also proved to be satisfactory, and when applied to real tea oil, the developed method achieved over 90 % enrichment efficiency for terpinen-4-ol.
研究领域:
化学工程
·
植物化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Zhaojin Zhang,Subhan Mahmood,Ahmad Ali,Zhiyi Ye,Shun Yao
For the first time, the valorization of waste shells from the Siraitia grosvenorii industry involves their conversion into carbon dots (CDs) for the detection of deep eutectic solvents (DESs) concentrations through their fluorescence effect. The material composition of the fruit shells was first analyzed, revealing that lignin constitutes 29.8 % of their total mass. Then four types of DESs were prepared for the extraction of lignin from these shells; among them, choline chloride-lactic acid (ChCl-Lac) achieving the highest extraction rate of 92.49 %. The obtained lignin was characterized and subsequently used as a raw material to synthesize carbon dots possessing tunable fluorescent properties with a quantum yield of 5.73 %. Moreover, it was found that Fe 3 + could quench the fluorescence of the CDs, while the addition of certain DESs could restore the quenched fluorescence. The presence of DESs alone could also induce changes in fluorescence when interacting with the CDs. Based on this effect, a new system for the effective quantitation of the concentration of DESs in aqueous solutions using CDs was established, and DESs were used in several main steps and played multiple roles. This study provides not only a solution for the value-added utilization of solid waste from current fruit industry, but also a new approach for the concentration detection of DESs in aqueous solutions.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2025
·
IF 2.2
Wentao Zheng,Jialing Chen,Yujiao Jia,Nengqi Sun,Xiankun Wu
Four deep eutectic solvents (DESs) based on 1,1,3,3-tetramethylguanidine (TMG) and N-heterocycles (succinimide, 2-pyrrolidinone, 2-oxazolidone, N -methylurea) were prepared and assessed for NO capture. At 313.2 K and 1 bar, the viscosities of TMG/succinimide (TMG-Succ) and TMG/2-pyrrolidinone (TMG-Pyrr) were measured as 49.23 mPa·s and 2.85 mPa·s, respectively, while their corresponding nitric oxide (NO) uptake capacities reached 1.62 Mol·kg −1 and 1.10 Mol·kg −1 under identical conditions. Spectroscopic analysis confirmed chemisorption in TMG-Succ versus physical dissolution in TMG-Pyrr. Thermodynamic fits yielded the absorption enthalpy ΔH = −16.94 kJ·Mol −1 for TMG-Succ and − 70.1 kJ·Mol −1 for TMG-Pyrr DES. In addition, the absorption capacities of both DESs remained almost unchanged during the 10 cycles of absorption-desorption experiments, highlighting their low-viscosity, high-capacity, and energy-efficient reversible NO capture performance
研究领域:
物理化学
·
环境科学
·
化工过程
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2017
·
IF 4.601
Youan Ji,Yucui Hou,Shuhang Ren,Muge Niu,Congfei Yao,Weize Wu
Indole plays a significant role in the production of products such as spices, medicines, and exogenous auxins. Deep eutectic solvents (DESs) formed by indole and quaternary ammonium salts (QASs, including tetraethylammonium chloride-TEAC, tetrapropylammonium chloride-TPAC, triethylmethyl-ammonium chloride-TEMAC) were found and proposed to efficiently extract indole from model wash oil. The effects of time, temperature, mole ratio of QAS to indole and initial indole concentration on the extraction of indole were studied. The results indicate that these QASs can extract indole from wash oil with efficiencies up to 96.7% (TPAC). The extraction process can be finished within 5 min. It is also found that the ultimate concentrations are almost identical for one kind of QAS although their initial concentrations are different, and the indole concentration in model wash oil can be reduced to a very low level of 1.3 g/dm 3 (TPAC). The maximum distribution coefficients of indole are 40.8 for TEAC, 91.9 for TPAC, and 29.5 for TEMAC at the studied conditions, and the extraction ability follows the order of TPAC > TEAC > TEMAC. Moreover, QASs in DESs can be reused without obvious reduction in extraction efficiency. The extraction mechanism was studied by FT-IR, and the results indicate that there is a hydrogen bond between QAS and indole. Finally, a comparison was made between this method and other methods to verify and demonstrate its desirable properties of efficiency and environmentally friendliness.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
PROCESS BIOCHEMISTRY
·
2019
·
IF 2.883
Yuan-Yuan Zang,Xi Yang,Zhi-Gang Chen,Tao Wu
In this study, we have established a green and efficient preparation method of quercetin. Rutin was first extracted from Sophora japonica using natural deep eutectic solvents (NADESs), then hydrolyzed into quercetin by rutin degrading enzyme (RDE) obtained from germinated tartary buckwheat in situ. Rutin solubility tests showed that most of the 11 NADESs increased the solubility of rutin by 67-3116 times compared to water. Thus, NADESs could be prior candidate to extract rutin. Extraction efficiency of rutin varied with different NADESs, and a maximum of 291.57 mg g −1 was achieved in NADES ChGly, which was prepared by mixing choline chloride and glycerol at a molar ratio of 1:1. After that hydrolysis was performed directly in extraction system by adding RDE with degradation rate of up to 8.36 mg min -1 ·L -1 . Our findings suggest that preparation of quercetin using NADESs was simple and feasible to operate, environmentally friendly, efficient, and inspired the preparation method of bioactive components from a new perspective.
研究领域:
植物化学
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绿色化学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yu Zhao,Kai Zhang,Peng Gan,Jinze Li,Guihua Yang,Qixi Xu,Baobin Wang,Lei Zhang,Jiachuan Chen
In this study, a series of ternary deep eutectic solvent systems composed of choline hydroxide (ChOH), urea (Ur), and zinc salt compounds (ZSCs) were synthesized and utilized to investigate the dissolution and regeneration performance of cellulose. The results indicated that the DES system composed of ChOH, Ur, and zinc glycinate (ZG) exhibited excellent cellulose dissolution capabilities. OH − in this system attacks the hydroxyl groups of cellulose, while glycine anions may form hydrogen bonds with cellulose hydroxyl groups. Meanwhile, urea and Zn 2+ may stabilize the solution and prevent cellulose self-aggregation, thus facilitating its dissolution. Water content of 3.85 wt% ChOH/Ur/ZG showed the best cellulose dissolution at 65 °C, able to dissolve 12 wt% of microcrystalline cellulose with a degree of polymerization of 152 and confirmed the system's suitability for a wide DP by dissolving a wide range of feedstocks. The crystalline form of regenerated cellulose is typical of type II cellulose, with good thermal stability and low consumption of crystallinity and polymerization during dissolution. Notably, ChOH/Ur/ZG also showed excellent reusability, maintaining more than 80 % cellulose solubilization efficiency after three cycles. ChOH/Ur/ZG broadens the versatility of cellulose solvent systems and opens up new avenues for the preparation of regenerated cellulosic functional materials.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2017
·
IF 3.648
Yingna Cui,Changping Li,Jingmei Yin,Shenmin Li,Yingping Jia,Ming Bao
Four deep eutectic solvents (DESs) based on different acids as hydrogen bond donors (HBDs), namely p -toluenesulfonic acid (PTSA), trichloroacetic acid (TCA), monochloroacetic acid (MCA), and propionic acid (PA) with hydrogen bond acceptor (HBA) choline chloride (ChCl) are synthesized with a mole ratios of HBD to HBA is 2:1. The density, electrical conductivity, dynamic viscosity and refractive index of the four DESs were determined at atmospheric pressure and temperatures from (288.15 to 338.15) K at an interval of 5 K. The results show that the temperature has great influences on the physical properties of DESs. The thermal expansion coefficient , molecular volume, standard molar entropy, and lattice energy were calculated by empirical equation. The molar conductivity was determined from the data of density. and conductivity. The temperature dependence of electrical conductivities and dynamic viscosities for the DESs were fitted by Vogel–Fulcher–Tamman (VFT) and Arrhenius equation. The relationship of the molar conductivity and viscosity was determined using the Walden rule. The acidities of the above DESs were measured by Hammett acidic functions. The present study will help to understand the properties of DESs and provide a guide for further applications of DESs.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）