Science of Advanced Materials
·
2024
·Vol. 16
·期 1
·85-92
·
IF 0.9
Zhang Xuhui,Hu Wenjun,Wang Jinghua,Wang Xinlei,Wang Li,Fang Yong
This research was aimed to evaluate extension effect of poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA/PEG) thermosensitive hydrogel-encapsulated bupivacaine (BUP) on neuroblockade in cardiothoracic surgery and explore the potential adoption of this thermosensitive hydrogel
as a drug carrier for postoperative neuroblockade. An animal experimental design was adopted. First, PLGA/PEG thermosensitive hydrogel was prepared and BUP was encapsulated as the drug carrier and evaluated. Then, 40 rats were selected for thoracic surgery and randomly rolled into experimental
group (injection of hydrogel in the cardiothoracic region for neuroblockade after cardiothoracic surgery) and control group (conventional BUP injection). The neuroblockade effects (maximum possible effect (MPE), sensory and motor blockade duration) in the two groups of rats were compared and
analyzed. The Results showed that gel-microsphere (Gel-MS) composite drug delivery system was successfully prepared, which exhibited a complete 3D porous structure and favorable encapsulation effect for BUP. Rheological testing showed favorable hardness (G′) and viscosity (G″)
for Gel-MS/BUP (GMB). The experimental group exhibited a notably prolonged period of 100% MPE with a slower rate of decline versus controls. Sensory blockade and motor blockade durations in the experimental group rats were (22.4±3.8) h and (22.7±3.5) h, respectively, both markedly
longer than those in the control group rats (P <0.05). In Conclusion, Gel/MS-BUP demonstrated a remarkable extension effect on neuroblockade in cardiothoracic surgery, indicating its potential adoption value in prolonging anesthesia duration.
研究领域:
药理学
·
外科手术
·
材料科学
·
麻醉学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2025
·
IF 4.3
Xuena Zhang,Fengqiang Zhang,Chongwei Yin,Juan Xu,Ting Wang
Ethinylestradiol (EE) is a clinically used estrogen with antifertility effects that is poorly water soluble, limiting bioavailability and preventing long-term release when administered orally. This study addresses these challenges through the development of a novel injectable thermosensitive hydrogel that both improves hydrophobic EE dispersion and enables sustained in vivo release, presenting significant potential for long-term contraception. Carboxymethyl-β-cyclodextrin (CM-β-CD) was synthesized to encapsulate EE, thereby enhancing its solubility and distribution in the hydrogel matrix. We found that hydrogels prepared by adding 0.5% (w/v) oxidized dextran (ODex) to the chitosan/sodium β-glycerophosphate (CS/ODex/β-GP) system exhibited mechanical strength favorable for cell growth compared to conventional CS/β-GP, resolved the problems of poor stability and mechanical strength of CS/β-GP hydrogels, and ensured effective retention and delivery in vivo . A 240h drug release study demonstrated the hydrogel’s ability to sustain release, highlighting its potential to prolong contraceptive efficacy. Biocompatibility testing showed cell viability in excess of 85%. FTIR and SEM characterization further confirmed the functional structure and morphology of the hydrogel. This thermosensitive injection system provides a promising platform for the long-term release of hydrophobic drugs such as EE, providing an innovative approach to extended contraceptive delivery.
研究领域:
药剂学
·
生物材料
·
生殖医学
·
药物递送系统
·
高分子药物载体
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Yufei Ling,Yuxuan Wang,Yuanpeng Cai,Shizhen Zhao,Hui Liu
Considering the dynamic changes in the wound microenvironment and the risk of bacterial infection during healing, the synergistic design of antibacterial hydrogel dressings has become an effective treatment strategy. A multifunctional hydrogel Cur-F127/CMCs/PDA was prepared through the cross-linking of carboxymethyl chitosan (CMCs) with genipin (GP), followed by the loading of curcumin-F127 (Cur-F127) micelles and polydopamine (PDA) nanoparticles. Successful synthesis of the hydrogel was confirmed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Results showed that the introduction of PDA endowed the hydrogel with excellent photothermal capability, achieving a temperature increase to 54.3 °C within 10 min under near-infrared (NIR) irradiation. Meanwhile, rapid Cur release was observed under NIR irradiation, exhibiting distinct “on/off” switching characteristics. The drug-controlled releasing behavior of the hydrogel was evaluated in physiological environments, and relatively high cumulative Cur release was obtained under simulated wound microenvironmental conditions (acid region and high temperature) due to the shrinking of polymer chains and micelle structure. The synergistic effect of Cur release and PDA photothermal therapy enabled the hydrogel to exhibit excellent antibacterial effects, and the survival rates of E. coli and S. aureus were reduced to 6.25% and 1.31%, respectively. Furthermore, in vitro biological studies demonstrated that the hydrogel possessed a good antioxidant property, hemostatic performance, blood compatibility, cell compatibility, and cell migration ability. In summary, the multifunctional wound dressing Cur-F127/CMCs/PDA provided a synergistic antibacterial strategy combining natural active compound release with photothermal effects, which accelerated the wound-healing process and holds significant clinical translational potential.
研究领域:
生物材料
·
组织工程
·
药剂学
·
创伤修复
·
纳米医学
·
感染控制
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 1
·221-237
·
IF 6.183
Zhiqiang Zhang,Anning Li,Xingqi Min,Qunqun Zhang,Jun Yang,Guo Chen,Meijuan Zou,Wei Sun,Gang Cheng
Chemotherapy and surgery are commonly used clinical treatments for breast cancer. However, unsatisfactory therapeutic effects, unavoidable side effects, and the removal of breast tissue during surgery are still major obstacles to be overcome during breast-cancer treatment. To overcome the aforementioned issues, a biomimetic and thermosensitive hydrogel encapsulating reactive oxygen species (ROS)-sensitive tegafur (TF)-protoporphyrin IX (PpIX) heterodimers (TTP) was prepared aimed at the strategy of synergizing chemotherapy and photodynamic therapy. TF was grafted onto the photosensitizer PpIX through ROS-sensitive thioether bonds. Under 630 nm laser irradiation, the ROS concentration in tumors was increased to help drug release. The “on-demand” drug release maximized the therapeutic effects of TF and effectively reduced its toxicity. Particularly, the ROS concentration was increased, and it was expected that the tumor-cell-killing abilities of ROS could be exploited. A hydrogel formed from temperature-sensitive chitosan and silk sericin was selected as a drug carrier, which formed a drug reservoir intratumorally after intratumoral injection. Intratumoral injection gave the drug precise and long-term release behavior, which allowed for the clever avoidance of various physical and biological barriers in vivo. In vivo and in vitro studies prove that the use of this TTP hydrogel provides a new attempt to overcome the many difficulties related to breast-cancer treatment simultaneously, and this study opens up new paths for breast-cancer treatment.
研究领域:
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Journal of Water Process Engineering
·
2022
·
IF 7.34
Zhihui Pan,Xiongrui Yang,Yilun Liang,Mengze Lyu,Yingru Huang,Hong Zhou,Gang Wen,Huarong Yu,Junguo He
A temperature-sensitive hydrogel modified with sewage sludge ash (SSA) was used as an advanced draw agent for forward osmosis (FO) application in treating chromium-containing wastewater. The performance of the modified hydrogel (SSA-TSH) was measured in terms of the swelling and deswelling properties, as well as adsorption and desorption effects on Cr(VI), chemical oxygen demand (COD), total phosphorous (TP) and ammonium (NH 4 + -N) in chromium-containing wastewater. Furthermore, the efficiencies of wastewater treatment , water flux , and the reusability of the SSA-TSH as draw agent in the FO process (FO-SSA-TSH) using a commercially available thin-film composite membrane (Sterlitech) were also investigated. The results indicated that FO-SSA-TSH achieved high removal rates of pollutants (Cr(VI): 96.9 %–97.4 %, COD: 97.1 %–97.4 %, TP: 97.7 %–99.6 %, and NH 4 + -N: 76.8 %–77.9 %) in various Cr(VI) concentrations (0– 40 mg/L) due to the high rejection rate of FO membrane and notable adsorption capacity of the hydrogel. Moreover, the average water flux of FO-SSA-TSH (1.95– 2.02 LMH) was nearly twice as much as that of the FO with pure temperature-sensitive hydrogel as draw agent (FO-TSH, 1.33– 1.42 LMH) in 24 h chromium-containing wastewater treatment . In addition, SSA-TSH with excellent deswelling property exhibited high water recovery performance and good reusability in low cost and energy consumption after the FO permeation process for wastewater treatment.
研究领域:
环境工程
·
废水处理
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2021
·
IF 4.384
Deqian Zhao,Chenlu Hu,Qiang Fu,Huixia Lv
Triple negative breast cancer (TNBC) is the most dangerous subtype of breast cancer accompanying by unfavorable prognosis due to lack of specific therapeutic targets. Paclitaxel (PTX) is the first-line chemotherapeutic drug for TNBC and niclosamide (NLM) was identified as an inhibitor for TNBC and breast cancer stem cells (BCSCs). Intratumoral drug delivery system was a hopeful alternative for chemotherapeutic drug administration due to its targeting efficiency with lower systemic toxicity. Herein, an injectable PTX nanocrystals (PTX-NCs) and NLM nanocrystals (NLM-NCs) co-loaded PLGA-PEG-PLGA thermosensitive hydrogel (PN NCs-Ts Gel) was designed for TNBC intratumoral treatment. The final formulation realized high drug loading and appropriate particle size. PN NCs-Ts Gel displayed sustained drug release for up to 8 days in vitro. In vitro antitumor tests observed synergetic effects of combined therapy in terms of inhibiting cell proliferation and migration, inducing apoptosis . In vivo combined therapy presented a tumor growth inhibition rate about 68.8% and desired safety. Moreover, tumors after PN NCs-Ts Gel intratumoral injection possessed the lowest ratio of BCSCs, exhibiting this formulation had good ability in suppressing BCSCs and therefore could possibly prevent TNBC recurrence and metastasis. These results suggested that PN NCs-Ts Gel could be a promising strategy for TNBC treatment.
研究领域:
肿瘤学
·
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioengineering & Translational Medicine
·
2023
·
IF 7.4
Jiawei Shu,Chenggui Wang,Yiqing Tao,Shaoke Wang,Feng Cheng,Yuang Zhang,Kesi Shi,Kaishun Xia,Ronghao Wang,Jingkai Wang,Chao Yu,Jiangjie Chen,Xianpeng Huang,Haibin Xu,Xiaopeng Zhou,Haobo Wu,Chengzhen Liang,Qixin Chen,Shigui Yan,Fangcai Li
Spinal cord injury (SCI) causes blood-spinal cord barrier (BSCB) disruption, leading to secondary damage, such as hemorrhagic infiltration, inflammatory response, and neuronal cell death. It is of great significance to rebuild the BSCB at the early stage of SCI to alleviate the secondary injury for better prognosis. Yet, current research involved in the reconstruction of BSCB is insufficient. Accordingly, we provide a thermosensitive hydrogel-based G protein-coupled receptor 124 (GPR124) delivery strategy for rebuilding BSCB. Herein, we firstly found that the expression of GPR124 decreased post-SCI and demonstrated that treatment with recombinant GPR124 could partially alleviate the disruption of BSCB post-SCI by restoring tight junctions (TJs) and promoting migration and tube formation of endothelial cells. Interestingly, GPR124 could also boost the energy metabolism of endothelial cells. However, the absence of physicochemical stability restricted the wide usage of GPR124. Hence, we fabricated a thermosensitive heparin-poloxamer (HP) hydrogel that demonstrated sustained GPR124 production and maintained the bioactivity of GPR124 (HP@124) for rebuilding the BSCB and eventually enhancing functional motor recovery post-SCI. HP@124 hydrogel can encapsulate GPR124 at the lesion site by injection, providing prolonged release, preserving wounded tissues, and filling injured tissue cavities. Consequently, it induces synergistically efficient integrated regulation by blocking BSCB rupture, decreasing fibrotic scar formation, minimizing inflammatory response, boosting remyelination, and regenerating axons. Mechanistically, giving GPR124 activates energy metabolism via elevating the expression of phosphoenolpyruvate carboxykinase 2 (PCK2), and eventually restores the poor state of endothelial cells. This research demonstrated that early intervention by combining GPR124 with bioactive multifunctional hydrogel may have tremendous promise for restoring locomotor recovery in patients with central nervous system disorders, in addition to a translational approach for the medical therapy of SCI.
研究领域:
神经科学
·
生物医学工程
·
药学
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DESALINATION
·
2021
·
IF 9.501
Zhihui Pan,Haoyong Guo,Huarong Yu,Gang Wen,Fangshu Qu,Tingjian Huang,Junguo He
This work made use of the sewage sludge ash (SSA) to enhance thermo-responsive hydrogel for driving forward-osmosis (FO) process. Results showed that owing to the porous structure and intermolecular interactions between the ionized groups of monomers and the chemical surface of silica , the SSA-based thermo-responsive hydrogel (SSA2.5H) had increased swelling capacity and osmotic pressure , resulting in an average water flux (2.33 LMH) twice as high as the hydrogel without adding SSA (1.18 LMH) during 24 h FO with DI water or different concentrations (2000–8000 ppm) of NaCl as feed solution. More importantly, SSA2.5H can maintain good thermo-responsive dehydration performance in spite of an enhancement to its swelling ability. 93.8% of the adsorbed water can be retrieved from SSA2.5H in water bath of moderate temperature (60 °C) for 10 min and water flux can be recovered to 94.4% of the initial value after 4 times of hydrogel regeneration during FO as draw agent. Therefore, this work showed that SSA was an excellent modifier to enhance the thermo-responsive hydrogel for improving permeation performance in FO and lowering down the actual energy requirement for water recovery and draw agent regeneration.
研究领域:
环境科学
·
材料科学
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
You Huang,Pei Wang,Pengyu Zhao,Weijian Cheng,Hao Fu,Xiao Zheng,Lin Chen,Wenyi Huang,Jiajia Xu,Chaomei Fu,Zhen Zhang,Xiao Wang
Patchouli essential oil (PEO) is acknowledged as a potent contender for the management of ulcerative colitis (UC). However, the limited ability of PEO to be absorbed by the body and its low stability substantially limit its potential uses. Furthermore, UC lesions are mainly concentrated in the rectal and colonic mucosa, with excessive production of reactive oxygen species (ROS). Herein, a nanoemulsion of PEO (PEONE) was developed to enhance the stability and bioavailability of a drug. Subsequently, we developed a novel platform for the rectal administration of a ROS/thermo dual-sensitive Bletilla striata polysaccharide-based hydrogel (RTH) co-loaded with PEONE to efficiently treat UC. As expected, the sol–gel transition of PEONE@RTH, after its intrarectal administration, resulted in its extended presence in the colon and facilitated its attachment to the inflammation site. Moreover, PEONE@RTH alleviated dextran sulfate sodium-induced UC symptoms by suppressing inflammation and oxidative stress, repairing the damage to the intestinal epithelial barrier (claudin-1 and occludin), increasing short-chain fatty acid content and inhibiting the MAPK signalling pathway. Additionally, PEONE@RTH exhibits exceptional safety and biocompatibility. Thus, PEONE@RTH has the potential to provide a novel approach for treating UC and other intestinal disorders characterised by similar clinical conditions.
研究领域:
药学
·
材料科学
·
胃肠病学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 28
·4402-4412
·
IF 5.047
Mengwei Zou,Rongrong Jin,Yanfei Hu,Ying Zhang,Haibo Wang,Gongyan Liu,Yu Nie,Yunbing Wang
Indomethacin (IND) is a nonsteroidal anti-inflammatory drug (NSAID), which is widely used to relieve inflammation. However, general eye drops cannot reach lesions efficiently due to the presence of complicated and special biological barriers in the eye. Repeated administration of this drug for chronic ophthalmic diseases also showed poor patient compliance. Herein, an in situ injectable thermo-sensitive hydrogel of indomethacin-conjugated polymer was fabricated to overcome these crucial problems. The poly(NIPAAm-co-MAA-co-HTI) (PNMHTI) hydrogel, composed of N-isopropylacrylamide (NIPAAm), methacrylic acid (MAA), and 2-hydroxylethyl methacrylate-g-poly(trimethylene carbonate)-indomethacin (HEMA-g-PTMC-IND) (HTI), was synthesized by radical polymerization of NIPAAm, MAA and HTI. According to the rheology investigation, the sol–gel conversion temperature of the hydrogels was around 33 °C, and the sol–gel transition occurred at physiological temperature (37 °C). The release of indomethacin from the injectable hydrogels was sustained for over 2 weeks in phosphate buffer saline with esterase due to the sustained biodegradable behavior by the hydrolytic cleavage of the residual PTMC chains. In addition, these hydrogels displayed excellent biocompatibility against mouse fibroblasts, reduced cytotoxicity for indomethacin and a significant anti-inflammatory effect against macrophages. Uveitis was successfully established in New Zealand rabbits, and the PNMHTI hydrogels were injected into the vitreous body. Histopathological examination of retinas confirmed the good biocompatablity and anti-inflammatory effects of PNMHTI hydrogels in vivo. Overall, the PNMHTI hydrogels reported herein offer an attractive biomaterial-centered treatment option for uveitis.
研究领域:
药学
·
材料科学
·
眼科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Jing Hu,Xin Liu,Qun Gao,Chunfa Ouyang,Kangsheng Zheng,Xiaoqian Shan
Chronic wounds are prone to produce excessive reactive oxygen species (ROS), which are the main reason for multiple bacterial infections and ulcers at the wound. Therefore, regulating ROS is the key in the process of wound healing. Herein, a new type of thermosensitive hydrogels is developed to improve the scavenging efficiency of ROS and accelerate wound repair. Nano-CeO2 was uniformly dispersed on the surface of mesoporous silica (MSN). The nanocomposite particles were physically crosslinked with poly(N-isopropylacrylamide) (PNIPAM) to form a MSN-CeO2@PNIPAM thermoresponsive hydrogel (PMCTH). The stability, temperature sensitivity, rheological properties, biocompatibility, and wound healing ability of the PMCTH were evaluated in detail. The results showed that the hydrogel could not only maintain the stability of the system for a long time with low biological toxicity but also have a phase transition temperature close to the human body temperature. In addition, the PMCTH was directly applied onto the skin surface. The MSN-CeO2 nanoparticles would be dispersed in the hydrogel to restrict ROS exacerbation effects and promoted the formation of blood vessels as well as surrounding tissues, accelerating the wound healing. More importantly, animal experiments showed that when the mass ratio of CeO2 to MSN was 40%, the wound healing rate reached up to 78% on the 10th day, which was far higher than that of other experimental groups. This study provides a new strategy and experimental basis for the applications of functional hydrogels in wound repair.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xiansen Lv,Hui Li,Ya Chen,Yanting Wang,Jinhua Chi,Shuo Wang,Yan Yang,Baoqin Han,Zhiwen Jiang
Burns are the fourth most common type of civilian trauma worldwide, and the management of severe irregular scald wounds remains a significant challenge. Herein, crocin-1 laden hydroxybutyl chitosan (CRO-HBC) thermosensitive hydrogel with smart anti-inflammatory performance was developed for accelerating full-thickness burn healing. The injectable and shape adaptability of the CRO-HBC gel make it a promising candidate for effectively filling scald wounds with irregular shapes, while simultaneously providing protection against external pathogens. The CRO-HBC gel network formed by hydrophobic interactions exhibited an initial burst release of crocin-1, followed by a gradual and sustained release over time. The excessive release of ROS and pro-inflammatory cytokines should be effectively regulated in the early stage of wound healing. The controlled release of crocin-1 from the CRO-HBC gel adequately addresses this requirement for wound healing. The CRO-HBC hydrogel also exhibited an excellent biocompatibility, an appropriate biodegradability, keratinocyte migration facilitation properties, and a reactive oxygen species scavenging capability. The composite CRO-HBC hydrogel intelligently mitigated inflammatory responses, promoted angiogenesis, and exhibited a commendable efficacy for tissue regeneration in a full-thickness scalding model. Overall, this innovative temperature-sensitive CRO-HBC injectable hydrogel dressing with smart anti-inflammatory performance has enormous potential for managing severe scald wounds.
研究领域:
药学
·
生物医学工程
·
伤口愈合
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）