WATER RESEARCH
·
2024
·
IF 11.4
Yao Li,Wenhong Fan,Xiaolong Yang,Shu Liu,Ying Wang,Wen-Xiong Wang
Cosmetics and personal care products containing titanium dioxide nanoparticles (TiO 2 NPs) may enter aquatic environments, where the surface coatings of TiO 2 NPs may change with aging due to environmental factors such as light, and potentially affect their bioaccumulation and toxicity. This study examined how aging impacted the physicochemical properties of three commercially available TiO 2 NPs and subsequent influence on the bioaccumulation and toxicity of copper (Cu) in Daphnia magna ( D. magna ). We demonstrated that aging significantly affected the hydrophobicity of TiO 2 NPs, which affected their binding to water molecules and adsorption of Cu. Changes of bioaccumulation of TiO 2 NPs and Cu in D. magna ultimately affected the activities of intracellular antioxidant enzymes such as SOD, CAT, GSH-Px, and the transmembrane protein Na + /K + –ATPase. Molecular docking calculations demonstrated that changes of activities of these biological enzymes were due to the interaction between TiO 2 NPs, Cu, and amino acid residues near the sites with the lowest binding energy and active center of the enzyme. Such effect was closely related to the hydrophobicity of TiO 2 NPs. Our study demonstrated the close relationship between surface properties of TiO 2 NPs and their biological effects, providing important evidence for understanding the behavior of nanomaterials in aquatic environments.
研究领域:
环境科学
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毒理学
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纳米生物学
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产品关联
DOI
PubMed
高影响因子
Environmental Science-Nano
·
2018
·Vol. 5
·期 3
·776-781
·
IF 6.087
Ruifen Jiang,Wei Lin,Jiayi Wu,Yaxin Xiong,Fang Zhu,Lian-Jun Bao,Jing You,Gangfeng Ouyang,Eddy Y. Zeng
Because of their large surface area and high hydrophobicity, nanoplastics (NPs) possess a large sorption capacity for and strong affinity to hydrophobic organic chemicals, which may substantially alter the environmental behavior, especially the bioaccumulation of hydrophobic organic compounds. The present study aims to examine the effects of nano-size polystyrene (PS) on the bioaccumulation of polychlorinated biphenyls (PCBs) in Daphnia magna. A novel passive dosing method was developed to quantify the accumulation of NPs in D. magna in different exposure suspensions with various NP concentrations during 2 h and 24 h exposure. Addition of NPs enhanced the amount of PCBs accumulated in D. magna by 1.4–2.6 times compared to no presence of NPs during 24 h exposure. The relative amounts of NP-bound PCBs accumulated in D. magna were 18% to 81% for different PCB congeners at various NP concentrations. The significance of different uptake pathways in the accumulation of PCBs in D. magna with the presence of NPs was found to relate to the chemical properties of PCBs, the ingestion rate of plastics and the exposure conditions. These results have justified additional research efforts toward investigating the fate and toxic effects of NP-bound contaminants ingested by organisms.
研究领域:
环境科学
·
生态毒理学
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DOI
高影响因子
Water
·
2023
·Vol. 15
·期 9
·1744
·
IF 3.4
Shaolin Qiu,Wenjiao Yuan,Yujie Qin,Xin Feng,Meitong Li,Yuhong Xie
Microplastic pollution is widespread around the world and inevitably comes into contact with organisms. With the accumulation of microplastics in the environment, the negative impact of microplastics on organisms has become the main focus in the field of microplastics. In this study, the different particle and concentration effects of fluorescent polystyrene microplastics (PS-MPs) onNostocaceaeandDaphnia Magnawere researched. The results indicate that PS-MPs adhered toNostocaceaethrough static electricity, which hindered the absorption of photons and CO2byNostocaceae, resulting in a decrease in chlorophyll, a low growth rate and high mortality forNostocaceae. PS-MPs with very small particles may be integrated into the blood ofDaphnia Magna, leading to an increasing trend of mortality and a decrease in spawning rate. The research provides basic data and a reference for the effect of PS-MPs on freshwater organisms and has implications for the further study of microplastics.Keywords:microplastics;fluorescent polystyrene;Nostocaceae;Daphnia Magna;photosynthesis;reproductive effect
研究领域:
环境生物学
·
生态毒理学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 25
·67596-67607
·
IF 5.8
He Yide,Zhang Yiqun,Zhou Wei,Freitas Rosa,Zhang Yunhai,Zhang Yongjun
Polystyrene microplastics (PS MPs) and carbamazepine (CBZ) are frequently detected in freshwater ecosystems. However, the transgenerational effects of PS MPs and CBZ on the reproduction of aquatic organisms and the corresponding mechanisms are still unclear. In the present study, Daphnia magna was used to evaluate the reproductive toxicity in two consecutive generations (F0, F1). The molting and reproduction parameters, the expression of reproduction, and the toxic metabolism genes were examined after 21-day exposure. A significantly enhanced toxicity was observed in the presence of 5 μm PS MPs and CBZ. Chronic exposure results showed that the 5 μm PS MPs alone, CBZ alone, and their mixtures exerted significant reproductive toxicity of D. magna . The results of RT-qPCR showed transcripts of genes related to reproduction ( cyp314 , ecr-b , cut , vtg1 , vtg2 , dmrt93b ) and toxic metabolism ( cyp4 , gst ) were altered in both the F0 and F1. In addition, for the F0, gene transcriptional changes of reproduction were not fully translated into physiological performance, probably due to the compensatory responses caused by the low dose of PS MPs alone, CBZ alone, and their mixtures. Whereas for the F1, the trade-off between reproduction and toxic metabolism at gene levels was observed, which translated into a significant reduction in the total neonate number of F1. These findings suggest that long-term exposure to MPs and CBZ can cause serious reproduction damage to aquatic animals, which needs to be given sufficient attention. Graphical Abstract
研究领域:
环境科学
·
毒理学
·
水生生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Xuexia Zhu,Zeshuang Wang,Yunfei Sun,Lei Gu,Lu Zhang,Jun Wang,Yuan Huang,Zhou Yang
The ecotoxicology of surfactants is attracting wide attention due to the rapidly expanding global application. As interspecific relationships play one of the central roles in structuring biological communities, it is necessary to take it into risk assessments on surfactants. With this aim, our study investigated the interference of three common surfactants on the inducible defense of a freshwater phytoplankton Scenedesmus obliquus . Nonlethal environmentally relevant concentrations (10 and 100 μg L −1 ) of several surfactants were set up. Results showed that growth and photosynthetic efficiency of Scenedesmus were inhibited during first 96 h, but recovered in the later stage. Surfactants interfered inducible defense of Scenedesmus against Daphnia grazing, and the interference was related to chemical characteristics of surfactants. The anionic surfactant sodium dodecyl sulfate (SDS) enhanced the colony formation even without grazing cues, whereas fewer defensive colonies were formed under the effects of cationic surfactant benzalkonium bromide (BZK) and nonionic surfactant polyoxyethylene (40) nonylphenol ether (NPE). These findings highlighted the sensitivity of grazer-induced morphological defense of Scenedesmus to surfactants even at nonlethal concentrations, which potentially affects the energy and information flow between trophic levels . This study appeals for more attention to take interspecific relationships into consideration in assessing the potential ecological risk of pollutants.
研究领域:
生态毒理学
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环境科学
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水生生态学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Qianqian Geng,Pingyang Sun,Gang Tang,Pingliang Li,Yuxiu Zhai
Poor water solubility results in limited fungicidal bioavailability and poses a great risk to non-target organisms due to the use of organic solvent in formulation processing. Here, the water solubility of fludioxonil (Flu) was improved by generating an inclusion complex with β-cyclodextrin (β-CD) at 1:1 host-guest stoichiometric ratio. The formation of the inclusion complex was confirmed by SEM, XRD, FT-IR, DSC, and 1 H-NMR spectra. Molecular docking simulation found that Flu was imbedded into the β-CD cavity, folded, and centrally aligned inside. In addition, Flu/β-CD displayed increased soil mobility, sustained release behavior, and a 2.75-fold increase of the fungicidal activity against Botrytis cinerea . Importantly, the prepared inclusion complex exhibited decreased acute toxicity to phytoplankton ( Chlorella vulgaris ), zooplankton ( Daphnia magna ), and fish ( Danio rerio ) than technical Flu. This study provided useful information for the rational use of Flu in agriculture, as well as the reduction of ecological risk to the aquatic environment.
研究领域:
农业科学
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环境科学
·
药物化学
✓ 已验证
DOI
高影响因子
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2025
·Vol. 116
·期 1
·9
·
IF 2.2
Huang Junyun,Liu Boying,Yuan Sijia,Zhou Haiyun,Bao Jian,Tu Yong,Wang Zunyao,Wang Weixia
Benzophenone-3 (BP-3), a widely used ultraviolet filter in personal care products, has been extensively detected in aquatic environments and poses potential ecological risks. This study innovatively investigated the pH-dependent acute toxicity of BP-3 to three model aquatic organisms— Daphnia magna , Photobacterium phosphoreum , and Danio rerio —by determining the EC 50 and LC 50 values across a pH range of 5.0 to 9.0. Our results revealed that BP-3 exerted greater acute toxicity on all three tested aquatic organisms under acidic conditions (pH 5.0) than under alkaline conditions (pH 9.0). The increased toxicity with lower pH was attributed to the predominance of the more lipophilic molecular form of BP-3, emphasizing the significant influence of environmental pH on BP-3 toxicity. These findings provide essential toxicological data for assessing the ecological risks of BP-3 in diverse aquatic environments, highlighting the necessity of considering BP-3 concentration, environmental pH and exposed species in ecological risk assessments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2022
·
IF 13.4
Ciara Chun Chen,Yihan Shi,Yanjie Zhu,Jiamin Zeng,Wei Qian,Shuang Zhou,Jie Ma,Ke Pan,Yuelu Jiang,Yi Tao,Xiaoshan Zhu
Microplastics (MPs) have worldwide accumulated in aquatic environments and coexisted with various water contaminants including perfluorinated compounds (PFCs) that are frequently detected. The adverse effects of individual MPs or PFCs on aquatic organisms have been extensively reported; however, the combined toxicity of MPs and PFCs remains unknown. This study evaluated the combined toxicity of MPs [pristine and aged polystyrene (PS)] and a PFC [ammonium perfluorooctanoate (APFO)] to Daphnia magna under different concentration ratios by three classic methods: toxicity unit, additive index, and mixed toxicity index. The adsorption kinetics of APFO on MPs, aggregation of MPs in exposure medium, MP gut fullness of daphnids, intestinal histology, and lipid peroxidation were analyzed to reveal the mechanism underlying the combined toxicity. Our results showed that the combined toxic modes varied with the concentration ratios of MPs to APFO (antagonism at 4:1 and 1:4, synergism at 3:1, 1:2, and 1:3, and partial addition/antagonism at 2:1 and 1:1 for pristine PS + APFO; antagonism at all ratios except partial addition/antagonism at 3:1 and 1:3 for aged PS + APFO), which could be attributed to the alteration of MP aggregation and thus MP gut fullness in the daphnids. The combined toxicity was further confirmed to occur in the daphnid's gut, which was reflected in physiological and biochemical responses mediated by intestinal blockage. Observable intestinal damages under co-exposures at μg•L − 1 levels indicated the risks from future long-term exposure to MPs and PFCs in aquatic environments. This work demonstrates the necessity of assessing combined toxicity with different concentration ratios and provides new insights into the potential risks of MPs in aquatic environments.
研究领域:
环境科学
·
毒理学
·
水生生态学
✓ 已验证
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2019
·
IF 4.527
Matthew Nkoom,Guanghua Lu,Jianchao Liu,Haohan Yang,Huike Dong
Owing to its persistence, carbamazepine an antiepileptic drug is regularly detected in the aquatic environment. The motive for our research was to assess the bioconcentration, physiological and biochemical effects of carbamazepine in Daphnia magna . A 48 h aqueous exposure of carbamazepine yielded bioconcentration factors of 202.56 and 19.95 in Daphnia magna for the respective nominal treatments of 5 and 100 µg/L. Apparently, the inhibition of the capability of Daphnia magna to obtain food attributable to carbamazepine exposure will reduce their fitness to reproduce as well as to grow. Also, a significant alteration in the phototactic behaviour of Daphnia magna exposed to carbamazepine is maladaptive since it will increase their chance of being preyed upon in the surface water during daylight. Again, a significant decline in the acetylcholinesterase activity observed herein brings to light the neurotoxicity of carbamazepine to Daphnia magna . Moreover, significant inhibition of the superoxide dismutase, catalase and glutathione reductase activities coupled with the simultaneous induction of the malondialdehyde content imply that carbamazepine evoked a life-threatening oxidative stress that overpowered the antioxidant defence system of Daphnia magna . These observations confirm that carbamazepine can accumulate and consequently cause negative physiological and biochemical changes to wild Daphnia magna populations.
研究领域:
环境科学
·
毒理学
·
水生生态学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Jingyi Guo,Na Liu,Qiting Xie,Lizhong Zhu,Fei Ge
Ubiquitous microplastics (MPs) may affect the trophic transfer of nanoparticles (NPs), in turn threatening aquatic organisms and even human health. Thus, this study explored the influence of polystyrene microplastics (PS MPs) on the biotoxicity and biomagnification of ZnO nanoparticles (ZnO NPs) in the aquatic food chain from Chlorella vulgaris ( C. vulgaris ) to Daphnia magna ( D. magna ). The results showed that PS MPs facilitated the biotoxicity of ZnO NPs towards D. magna after dietary exposure. Compared to the control (single ZnO NPs), the heart rate and the level of reactive oxygen species were remarkably increased by 21.25% and 16.32% in the combined system (PS MPs + ZnO NPs), respectively. Notably, PS MPs suppressed the ZnO NPs accumulation in C. vulgaris , while remarkably facilitating the trophic transfer of ZnO NPs to D. magna . The biomagnification of ZnO NPs was evident with a maximal biomagnification factor (BMF) of 1.49 under acute dietary exposure of PS MPs (72 h), but was absent in the single ZnO NPs system (BMF <0.90). Moreover, PS MPs resulted in a larger biomagnification of ZnO NPs with a maximal BMF of 2.11 under chronic dietary exposure (21 days). Furthermore, the Zn element (including ZnO NPs and released Zn 2+ ) was observed to accumulate in the intestine, thus causing ultrastructural damage and lipid droplet (LD) aggregate. Overall, these findings highlight the importance of considering the impact of MPs on co-existed pollutants and contribute to a better understanding of the ecological risks of MPs in aquatic ecosystems .
研究领域:
环境科学
·
水生生态学
·
纳米毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Xiaokang An,Xinglu Pan,Runan Li,Fengshou Dong,Wentao Zhu,Jun Xu,Xiaohu Wu,Yongquan Zheng
Racemates in the environment can lead to inaccurate risk assessment. To obtain the enantiomeric level information of benzovindiflupyr for accurate risk assessment, the absolute configuration of benzovindiflupyr was first confirmed, and the enantioseparation method was developed by supercritical fluid chromatography tandem mass spectrometry. The enantioselectivity for bioactivity and toxicity was investigated, and the mechanism was explored by molecular docking and detecting succinate dehydrogenase (SDH) activity and content of succinate acid. 1S , 4R -(−)-benzovindiflupyr was identified as the most active against the six targeted phytopathogens, which showed higher 1.7–54.5 times than 1R , 4S -(+)-benzovindiflupyr. Additionally, 1S , 4R -(−)-benzovindiflupyr (LD 50 : 21.54 μg L −1 ) was 103.7 times more toxic than 1R , 4S -(+)-benzovindiflupyr against Daphnia magna . 1S , 4R -(−)-benzovindiflupyr had a stronger affinity for SDH and significantly inhibited SDH activity, resulting in an increase in succinate acid in the tricarboxylic acid cycle, while its downstream products, fumaric and L -malic acid were significantly reduced. Moreover, the dissipation behavior of benzovindiflupyr on three vegetables was evaluated. 1S , 4R -(−)-benzovindiflupyr was preferentially degraded in tomato, but opposite in leaves. The enantioselectivity in pepper and cucumber leaves was the same as in tomato, while there was no enantioselectivity in pepper and cucumber. The study provides a basis for accurate risk assessment and the development of high-effective and low-risk fungicides.
研究领域:
农药科学
·
环境科学
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植物病理学
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毒理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Chi Wu,Kai He,Huizhen Li,Lan Zhang,Liangang Mao,Lizhen Zhu,Jinhua Jiang,Xingang Liu
The transgenerational impacts of pesticide mixture on Daphnia magna ( D. magna ) following long-term exposure, particularly regarding transcriptomic effects, remain poorly understood. We analyzed 470 irrigation water samples from various Chinese provinces. Imidacloprid (IMI, 71.1 %), clothianidin (CLO, 60.43 %), and tebuconazole (TEB, 64.68 %) were the most frequently detected pesticides, with nearly 50 % of samples showing mixtures of TEB with IMI or CLO. D. magna were exposed to environmentally relevant concentrations (0.89–1.62 μg/L) over 12 generations. Key effects included reduced fecundity, delayed development, and smaller body size, with these impacts exacerbating across generations. A Leslie matrix model revealed declines in population size, intrinsic rates of increase, and age structure. Notably, mixed pesticide exposures induced specific pathways related to oocyte meiosis, resulting in greater toxicity than single exposures. Additionally, disrupted lipid metabolism and feeding behaviors were linked to insufficient energy for growth and reproduction, affecting ovarian development. These findings highlight the ecological risks of long-term pesticide exposure and offer insights for mitigation strategies in aquatic ecosystems.
研究领域:
生态毒理学
·
环境科学
·
水生生态学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）