MICROCHEMICAL JOURNAL
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2020
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IF 3.594
Ru-Ru Gao,Wei Dong
A new strategy was put forward to fabricate amorphous coordination polymer nanoparticles (CPNs) self-assembled by lanthanide ions (Ln 3+ ) and ATP whose adenine subunit and phosphate group served as bidentate ligands for Ln 3+ . These ATP/Ln 3+ CPNs showed weak luminescence but could be sensitized by introduction of external stimuli. Hence, they could be “artificial tongues” to respond to multifarious analytes (pyridine carboxylic acids or metal ions). Inspired the fact that both ATP/Tb 3+ and ATP/Eu 3+ CPNs presented ultrasensitive responses to 2, 6-pyridinedicarboxylic acid, a tunable chromaticity of emission from red to green was achieved by simply varying the doping ratio of Tb 3+ and Eu 3+ into ATP. Moreover, the ATP/Ln 3+ CPNs exhibited surprisingly encapsulation properties for guest dye, indicating the feature of self-adaptive assembly. These features above provided the possibility of performing logic operations. By employing these CPNs as logic operators, the implementation of Boolean logic gates (INH and AND) and integrative logic operation (INH-INH) connecting the elementary logic operations has been successfully achieved.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Shasha Feng,Fubin Pei,Yi Wu,Jingjing Lv,Qingli Hao,Tinghai Yang,Zhaoyang Tong,Wu Lei
A novel ratiometric fluorescent sensor based on Förster resonance energy transfer (FRET) platform was designed for riboflavin (RF) detection. The graphitic carbon nitrides quantum dots - Zn-MOF composite (g-CNQDs@Zn-MOF) was used as the fluorescent probe . In the FRET system, g-CNQDs@Zn-MOF and RF acted as donor and acceptor, respectively. The probe exhibited high sensitivity and good selectivity to RF, and had been successfully used for the detection of RF in milk and vitamin B 2 tablets. The detection limit of the sensor was 15 nM. The strategy expanded the application of MOF in sensing filed and provided a new method for the detection of RF.
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高影响因子
ACS Applied Bio Materials
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2020
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IF 0
Zhong-Xia Wang,Lei Hu,Yuan-Fei Gao,Fen-Ying Kong,Heng-Ye Li,Jing Zhu,Hai-Lin Fang,Wei Wang
The development of near-infrared (NIR) emission nanoprobes for the ratiometric fluorescent determination of living cells in vitro/vivo is of great analytical importance. In this work, dual-NIR-emissive Zn-doped carbon-based nanosheets (Zn-CNSHs) were prepared with a beneficial and special donor−π–acceptor-conjugated (D−π–A-conjugated) spatial framework, which resulted in not only a much lower HOMO–LUMO energy level but also excellent biocompatibility and physicochemical properties. The Zn-CNSHs were prepared by simple one-pot solvothermal synthesis with zinc gluconate (ZGN) and a strong acid and exhibited two distinctive photoluminescence (PL) peaks at 620 and 720 nm with the 600 nm excitation. The 620 nm peak intensity was dependent on dipicolinic acid (DPA) owing to the aggregation-induced emission enhancement effect via the strong intersheet hydrogen bonds between Zn-CNSHs and DPA, enabling the ratiometric fluorescent determination of DPA, an important clinical anthrax biomarker. An excellent calibration curve showed linear regions over the range of 0.05–500 μM between the ratio of PL intensity (PL620 nm/PL720 nm) and the concentrations of DPA. The detection limit was down to 21.7 nM. Based on the high stability, low cytotoxicity, high selectivity, and outstanding PL-reliant sensitivity for the DPA assay, the nanoprobe has been successfully used to monitor DPA in serum, wastewater, and cells.
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TALANTA
·
2020
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IF 5.339
Feiyao He,Jinwei Yin,Tianzhi Wang,Juan Pu,Jianxiong Dai,Zhongjun Zhao,Yixiang Duan
A new ambient ionization technique named laser ablation micro-fabricated glow discharge plasma (LA-MFGDP) was developed for mass spectrometry in this study. This technique used low energy laser for sample ablation and ionized sample aerosol with MFGDP in sequence. The combination of laser ablation and MFGDP exhibited a synergetic effect that significantly improved the performance of MFGDP. Experimental results showed that MFGDP dominated the ionization process while laser played the role of desorption in LA-MFGDP. [M+H] + and M + proved that proton transfer reactions and charge transfer reactions were involved in the ionization process, respectively, indicating that the ionization character was the same as MFGDP. LA-MFGDP could analyze less volatile samples that were unable to be detected by MFGDP because laser significantly improved the ionization capability of MFGDP. Strong ion signals were obtained by LA-MFGDP with low sample consumption. The limits of detection (LODs) of LA-MFGDP was as low as three orders of magnitude than that of MFGDP, which demonstrated that LA-MFGDP possessed an outstanding advantage in detecting trace substances. LA-MFGDP was successfully applied to detect pharmaceutical tablets without any pretreatment. Benefited from the excellent performance, LA-MFGDP offers great potential in broadening the application of ambient mass spectrometry.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
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IF 4.098
Xueqing Guo,Yang Liu,Wenjuan Dong,Qin Hu,Yong Li,Shaomin Shuang,Chuan Dong,Lishuai Cai,Xiaojuan Gong
Azithromycin (AZM) 1 is one of the most widely used antibiotics. AZM abuse is easy to cause great harm to human body, so developing a rapid and sensitive method to detect AZM is of great importance. Herein, 3-aminothiophenol as only reaction precursor, nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) 2 were fabricated by one-step hydrothermal carbonization method. All characteristics demonstrate that N,S-CQDs possess good water solubility, high fluorescence stability and low cytotoxicity. Without being disturbed by amino acids and drugs, the most interesting finding is that AZM can efficiently quench the fluorescence of N,S-CQDs by a synergistic effect of electrostatic interaction and static quenching. A fluorescent probe for the detection of AZM was constructed with high selectivity and good sensitivity, achieving two linear ranges of 2.5–32.3 μM and 37.2–110 μM and a limit of detection of 0.76 µM. The proposed fluorescent method was used for the detection of AZM in cells with fulfilling results. More importantly, the fluorescent probe was successfully used to the detection of AZM in tablets and human urine with recovery rate and relative standard deviations of 98.2–104.8% and 0.04–3.46%, respectively, which was confirmed by the standard method of HPLC-UV. This finding illustrates the usefulness and feasibility of N,S-CQDs as an effective fluorescent probe for the detection of AZM in tablets and human urine, which is helpful for supervising and guiding pharmacy.
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高影响因子
TALANTA
·
2020
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IF 5.339
Xinrong Jiang,Xiaoming Chen,Tao Wang,Yuexin Li,Aiwu Pan,Jianmin Wu
Metabolites in the body fluid are becoming a rich source of disease biomarkers. Developing an effective and high throughput detection and analysis platform of metabolites is of great importance for potential biomarker discovery and validation. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been successfully applied in rapid biomolecules detection in large scale. However, non-negligible background interference in low molecule-weight region still constitutes a main challenge even though various nanomaterials have been developed as an alternative to traditional organic matrix. In this work, a novel composite chip, silicon nanowires loaded with fluorinated ethylene propylene (FEP@SiNWs) was fabricated. It can serve as an excellent substrate for nanostructure-initiator mass spectrometry (NIMS) detection with ultra-low background noise in low molecular weight region (<500 Da). Ion desorption efficiency and internal energy transfer of FEP@SiNWs were studied using benzylpyridinium salt and tetraphenylboron salt as thermometer chemicals. The results indicated that a non-thermal desorption mechanism might be involved in the LDI process on FEP@SiNWs. Owing to the higher LDI efficiency and low background interference of this novel substrate, the metabolic fingerprint of complex bio-fluids, such as human saliva, can be sensitively and stably acquired. As a proof of concept, FEP@SiNWs chip was successfully used in the detection of salivary metabolites. With the assistance of multivariate analysis, 22 metabolic candidates (p < 0.05) which can discriminate type 2 diabetes mellitus (2-DM) and healthy volunteers were found and identified. The role of these feature metabolites in the metabolic pathway involved in 2-DM was confirmed by literature mining. This work demonstrates that FEP@SiNWs-based NIMS might be served as an efficient and high throughput platform for metabolic biomarker exploration and clinical diagnosis.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Lan-Fang Pang,Hao Wu,Meng-Xia Wei,Xiao-Feng Guo,Hong Wang
The spores of Bacillus anthracis are highly deadly to human beings and animals, and are concurrently potential biological warfare agents. Hence, the rapid and sensitive monitoring Bacillus anthracis biomarker, dipicolinic acid (DPA), is very desirable. Herein, orange/green dual-emissive carbon dots (OG-CDs) were synthesized via the hydrothermal approach. The OG-CDs not only emitted dual fluorescence at 527 and 590 nm under the single 503 nm excitation, but also exhibited excellent water solubility, good photostability and great salt tolerance. The fluorescence of the OG-CDs at 527 nm can be completely quenched when chelated with Cu(II). However, because of the stronger chelation between DPA and Cu(II), the fluorescence restored rapidly on subsequent addition of DPA. As such, the CD-Cu(II) system can be used for determination of DPA based on the fluorescence “off-on” response. Under optimum conditions, the detection limit for DPA was 56 nM, with a linear range of 0.5–12.5 μM. The established CD-Cu(II) based spectrofluorometric method has been applied to the analysis of DPA in real water samples with recoveries of 93.6%–104.3%. More remarkably, the CD-Cu(II) probe also has been successfully applied for the imaging of DPA in Escherichia coli with excellent bio-compatibility.
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ANALYTICAL CHEMISTRY
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2020
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IF 6.785
Huifang Wu,Changlun Tong
Nitrite (NO2–) and mercury (Hg2+) ions are recognized as two typical inorganic contaminations that can cause severe damage to the environment and humans. In this paper, the energy transfer from carbon quantum dots (CQDs) to Tb3+ by the antenna effect was found, which can promote the f–f transition of Tb3+ and emit strong characteristic fluorescence of Tb3+. Based on CQD-Tb3+ and 3-aminophenylboronic acid (APBA), which have respectively sensitive and specific fluorescent response to NO2– and Hg2+ with different fluorescent signals, a dual-emission fluorescent probe of the CQD-Tb3+/APBA hybrid was thus fabricated for the simultaneous detection of NO2– and Hg2+ in environmental water samples. They emit dual-emission fluorescence peaks centered at 373 and 545 nm, respectively. A good linearity between the quenching efficiency of (F0 – F)/F0 and the concentrations of NO2– and Hg2+ was in the range of 5.0–1200.0 nM for NO2– and 0.1–6.0 μM for Hg2+. The limit of detection (LOD, 3σ/K) is ultrasensitive for NO2– (2.0 nM), and the LOD for Hg2+ is 38.1 nM. The dual-emission fluorescent probe was successfully applied for the determination of NO2– and Hg2+ in various environmental water samples. The possible luminescence and fluorescence quenching mechanisms of the probe are also discussed in detail. This study provides a new approach for fabricating a multifunctional fluorescent probe or sensor and a prospective application in environmental monitoring.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2020
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IF 6.551
Naiyi Yin,Zeliang Han,Huili Du,Pengfei Wang,Yunpeng Li,Xiaochen Chen,Guoxin Sun,Yanshan Cui,Zhengyi Hu
To determine the effect of vitamin supplements on the oral bioaccessibility of Pb in soils, Pb bioaccessibility was measured in the presence of 9 vitamins by a physiologically based extraction test. Gastric Pb bioaccessibility (G-BA, 2.6–83.3%) was found to be mostly reduced (1.1–3.1 fold) in the presence of B vitamins, specifically vitamins B1, B6, and B9. In contrast, a significant increase in Pb G-BA was observed with vitamin C and E involved. In the small intestinal phases, Pb bioaccessibility (I-BA) ranged from 0.1% to 16.0%, being 5–50 fold lower than the corresponding G-BA values. Vitamin C supplementation showed a 7-fold increase in Pb I-BA, with a similar increase presented in approximately 30% of samples treated to vitamin B involvement. Lead liberation in gastrointestinal digests was associated with the dissolution of Fe and Mn regulated by vitamins. In conclusion, the addition of B vitamins resulted in the reduction of gastric Pb bioaccessibility, but the bioaccessibility value increased in participation of vitamin C and E. Elevated intestinal bioaccessibility was found especially for vitamin C. This should contribute to more accurate assessment of health risks from contaminated soils. Nutritional management aimed at preventing Pb-induced toxicity can benefit from knowledge of vitamin influence on soil Pb bioaccessibility.
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TALANTA
·
2020
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IF 5.339
Jing Wang,Daquan Li,Yu Qiu,Xinyue Liu,Liang Huang,Huimin Wen,Jun Hu
We reported Eu(III) functionalized carbon dots (CDs-Eu) as a novel ratiometric fluorescent probe for point-of-care testing (POCT) of dipicolinic acid (DPA), a biomarker of anthrax. The probe was synthesized simply by coordination interaction between Eu(III) ions and the CDs with carboxyl and amino groups. Upon addition of DPA, the intrinsic red luminescence of Eu(III) ions can be sensitized due to the presence of energy transfer when DPA chromophore coordinated with Eu(III) ions. The fluorescence peaking at 530 nm as a reference remained essentially constant, leading to ratiometric fluorescence response toward DPA. This approach exhibited a linearity range from 0.5 nM to 5 μM and a detection limit of 0.8 nM. More Importantly, the combination of probe-based test paper and smartphone provided a convenient approach for visual POCT of DPA with a detection limit of 67 nM, which was lower than other reported test paper for DPA detection. The color of fluorescence gradually changed from green to red as the DPA increases, which can be captured by a smartphone and further quantitatively analyzed with a built-in Color Analyzer App. The satisfactory result of detecting DPA accurately and reliably in real samples by the test paper certified its practicality in POCT of DPA.
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高影响因子
FOOD CHEMISTRY
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2019
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IF 5.399
Shi-Qi Zhang,Jing Li,Lin Li,Xiaoting Yuan,Li Xu,Zhi-guo Shi
In the present study, submicrometer flow-through silica microspheres (Sub-FTSiO 2 ) was for the first time obtained via a suspension polymerization method coupled with sol-gel transition and phase separation. The Sub-FTSiO 2 was characteristic of rich mesopores, penetrable macropores and small particle size, which would be beneficial to fast mass transfer, low column backpressure and high column efficiency. It was directly used as the hydrophilic interaction liquid chromatographic (HILIC) stationary phase, and the fast separation of seven water-soluble vitamins in 2.2 min was realized. The proposed method was successfully applied to the determination of water-soluble vitamins in two functional beverages on the market. The prepared Sub-FTSiO 2 was well demonstrated for fast HILIC, and would be potential as the stationary phase matrix for fast liquid chromatography in diverse separation modes.
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DYES AND PIGMENTS
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2022
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IF 5.122
Lin Yuan,Lei Jiang,Ze Liu,Yingying Xiang,Fei Song,Yujiao Tu
Tartrazine preferred in food and textile industries, but excessive consumption threats human health. Due to toxicity, non-biodegradability, and trace accumulation in the food chains, Hg 2+ has attracted people's attention. Thus, it is important to detect tartrazine and Hg 2+ with sensitivity way. Using VB 2 and citrate as precursors, yellow-green fluorescent carbon dots were prepared by hydrothermal method . The N-CDs were purified by dialysis, thin layer chromatography and chromatographic column. Excellent linear ranges of 0.25–5 μM and 5–50 μM of tartrazine were obtained with low detection limits 34.98 nM, while good linear ranges of 0.25–5 μM and 10–50 μM of Hg 2+ with low detection limits 29.64 nM, respectively. In addition, the quenching mechanisms of targets to the fluorescent of N-CDs were illuminated. Furthermore, the nanoprobe was efficiently applied to determine the content of tartrazine in carbonated drink, fruit jelly and sugar samples, and Hg 2+ in tap water, lake water, and river water samples. It showed great potential to detect tartrazine and Hg 2+ .
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