Journal of Pharmaceutical Analysis
·
2016
·
IF 0
Cao Li,Jia Xu,Dan Chen,Yuxiu Xiao
Hexafluoroisopropanol (HFIP)-induced sodium dodecyl sulfate/dodecyltrimethylammonium bromide (SDS/DTAB) catanionic surfactant coacervate extraction method coupled with high performance liquid chromatography (HPLC) was used to detect the migration of phthalates from disposable tablewares to drinking water. The concentration factors are larger than 82 and extraction recoveries over 53% for water samples spiked with 100 or 200 ng/mL phthalates. Limit of detection is in the range of 1.0–2.6 ng/mL. Good linearity with correlation coefficients larger than 0.9985 is obtained in the concentration of 20–1500 or 40–3000 ng/mL. Relative recoveries are from 82.4% to 123.6% for water samples spiked with 30/60, 250/500, and 1500/3000 ng/mL phthalates, respectively. Relative standard deviations (RSDs) are 0.4%–7.4% for intraday precision ( n =5) and 0.6%–7.8% for interday precision ( n =3). Four of studied phthalates are found in the drinking water samples prepared from four kinds of tablewares.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
PubMed
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Meijing Wang,Hao Xu,Qiansong Li,Guanyu Zhou,Qian Ye,Qingguo Wang,Jing Zhang
Carbonaceous materials have emerged as promising metal-free catalysts to activate peroxymonosulfate (PMS) for the degradation of organic contaminants . In this study, a low-cost carbonaceous material panda manure biochar (PBC) was prepared by pyrolysis . The panda manure biochar showed excellent performance in the degradation reaction, and the removal efficiency of sulfamethazine (SMT), which was selected as a representative organic pollutant , exceeded 85% in 40 min. The X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) characterization confirmed that the improved catalytic performance was attributed to the oxygen-containing functional groups on the surface of the biochar. Radical quenching and electron paramagnetic resonance (EPR) experiments qualitatively demonstrated that 1 O 2 played an important role in the degradation of SMT. Moreover, the non-radical process that dominated in the panda manure biochar/PMS system was proposed by cyclic voltammetry (CV) and linear sweep voltammetry (LSV) measurements. Sulfamethazine (SMT) was direct oxidized by the activated PMS where panda manure biochar acted as the electron transfer shuttle. The panda manure biochar /PMS system exhibited a high anti-interference ability to Cl − , HPO 4 − , HCO 3 - , SO 4 2- , NO 3 − , and humic acid (HA) containing environments. This study provides a novel panda manure reuse process with high practicability, and proposes a reasonable degradation pathway for sulfamethazine (SMT) based on non-radical oxidation .
研究领域:
环境科学
·
催化材料
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DOI
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2023
·Vol. 37
·期 4
·e5580
·
IF 1.8
Rathnakar Nathi,Leela Prasad Kowtharapu,Siva Krishna Muchakayala,Naresh Konduru
A nonsteroidal drug called flurbiprofen (FBN) has analgesic, anti-inflammatory and antipyretic activity. Currently the determination of FBN in cataplasm does not have any pharmacopeial method. However, the drug substance, tablet and ophthalmic solution formulations do have pharmacopeial methods. The development and validation of an accurate, precise and stability-indicating analytical method for the determination of FBN in cataplasm formulations is reported. The gradient method was employed for the quantification of FBN in the presence of internal standards such as biphenyl. A nonpolar separation phase (C 18 , 250 × 4.6 mm, 5 μm Inertsil column; GL Sciences) was used. The optimal flow rate, column oven temperature, injection volume and detector wavelengths were 1.0 ml/min, 40°C, 20 μl and 245 nm, respectively. Mobile phase A was a mixture of water and glacial acetic acid (30:1 v/v) pH adjusted to 2.20 with glacial acetic acid or 1 m NaOH; mobile phase B was methanol (100%). The gradient elution program was [time (min)/% B]: 5/60, 20/70, 25/70, 30/60 and 40/60. The obtained RSDs for the precision and intermediate precision were 0.7 and 0.5%. The percentage recovery ranged from 99.2 to 100.4%. The linear regression coefficient >0.9996 indicates that all peak responses were linear with the concentration. The sample and standard solutions were stable for up to 24 h on the benchtop and in the refrigerator. The critical peaks were well separated from the generated peaks owing to forced degradation, including diluent and placebo peaks. The method validation data and quality by design-based robustness study results indicate that the developed method is robust and fit for routine use in the quality control laboratory. The proposed method is specific, accurate and precise, and the quality by design utilized the first method for the determination of FBN in cataplasm formulations. Transdermal patches and gels have low extraction capacity and this method is applicable for quantification.
研究领域:
药学
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分析化学
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产品关联
DOI
PubMed
高影响因子
Journal of Bionic Engineering
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2025
·
IF 5.8
Yu Zerun,Liu Jiaan,Yang Tian,Zhang Linyang,Hu Chunhua
Insufficient interfacial activity and poor wettability between fibers and matrix are the two main factors limiting the improvement of mechanical properties of Carbon Fiber Reinforced Plastics (CFRP). Owl feathers are known for their unique compact structure; they are not only lightweight but also strong. In this study, an in-depth look at owl feathers was made and it found that owl feathers not only have the macro branches structure between feather shafts and branches but also have fine feather structures on the branches. The presence of these fine feather structures increases the specific surface area of the plume branches and allows neighboring plume branches to hook up with each other, forming an effective mechanical interlocking structure. These structures bring owl feathers excellent mechanical properties. Inspired by the natural structure of owl feathers, a weaving technique and a sizing process were combined to prepare bionic Carbon Fiber (CF) fabrics and then to fabricate the bionic CFRP with structural characteristics similar to owl feathers. To evaluate the effect of the fine feather structure on the mechanical properties of CFRP, a mechanical property study on CFRP with and without the fine feather imitation structure were conducted. The experimental results show that the introduction of the fine feather branch structure enhance the mechanical properties of CFRP significantly. Specifically, the tensile strength of the composites increased by 6.42% and 13.06% and the flexural strength increased by 8.02% and 16.87% in the 0° and 90° sample directions, respectively. These results provide a new design idea for the improvement of the mechanical properties of the CFRP, promoting the application of CFRP in engineering fields, such as automotive transportation, rail transit, aerospace, and construction.
研究领域:
材料科学
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仿生学
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产品关联
DOI
高影响因子
ACTA PHYSICO-CHIMICA SINICA
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2023
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IF 10.9
Renjie Xue,Chao Ma,Jing He,Xuechao Li,Yanning Tang,Lifeng Chi,Haiming Zhang
Catassembly is a newly developed concept concerning the process of molecular assembly improved by a catalyst-assembler (catassembler). However, it has not been visualized in detail at the molecular level. To achieve the formation of highly complex structures with high efficiency and selectivity, a deeper understanding of catassembly is essential. In this study, we present the scanning tunneling microscopy (STM) characterization of a catassembly process within host-guest assembly. We utilize a metastable self-assembled network of 1,3,5-tris(4-carboxyphenyl)-benzene (BTB) at the liquid-solid interface between 1-octanoic acid and highly oriented pyrolytic graphite (HOPG). Different adsorption behaviors of low-concentration guest molecules (copper phthalocyanine (CuPc), and coronene (COR)) are contrastively analyzed during the host-guest assembly in both single-guest (COR/BTB or CuPc/BTB) and multi-guest molecule (COR&CuPc/BTB) systems. The spontaneous phase transition from a hexagonal to an oblique structure of BTB monolayers (high concentration, approximately 500 μmol∙L −1 in octanoic acid) provides an ideal metastable phase for studying the dynamic assembly process. In the host-guest assembly, the metastable BTB hexagonal phase serves as a host network and can be stabilized by co-assembling guest molecules under a negative bias voltage. However, the stability of the metastable phase varies with different guest molecules. We observe that the BTB metastable phase is more robust with COR guest molecules than with CuPc. In the CuPc/BTB system, we find that low-concentration CuPc (approximately 1.5 μmol∙L −1 in octanoic acid) can hardly co-assemble with BTB, leading to the gradual collapse of the metastable BTB networks into the oblique phase. The different stability of BTB metastable phase in the host-guest assembly is attributed to differences in the kinetics of trapping guest molecules. Guest COR molecules exhibit kinetic advantages over CuPc when assembling with host BTB networks under a negative sample bias. The lower trapping rate of CuPc hinders the formation of co-assembled BTB/CuPc networks. These differences in the dynamic behavior of the guest molecules are further explored in the research of catassembly. In a multi-guest molecule system (COR&CuPc/BTB), COR molecules are preferentially trapped by BTB hexagonal networks and can gradually be replaced by CuPc during continuous scanning. The more energetically stable structure of CuPc/BTB compared to COR/BTB rationalizes the exchange of the guest molecule and the evolution of the assembly phase. The involvement of COR significantly increases both the efficiency and quality of the CuPc/BTB assembly, serving as a catassembler. This observation provides insights into a complete catassembly process at the molecular level, enabling further investigations into the selectivity and efficiency of host-guest phenomena for potential applications in analysis and separation. Additionally, this work serves as a prototype for constructing highly complex 2D assembled monolayers. Download: Download high-res image (162KB) Download: Download full-size image
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
International Journal of Smart and Nano Materials
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2022
·
IF 4
Liru Yao,Huixuan Yan,Yifan He,Nan Zhao,Xiuxiu Wang,Chensha Li,Liguo Sun,Yang He,Yanju Liu,Jianqi Zhang
Liquid crystalline elastomers (LCEs) have been utilized as an important class of smart actuator materials. However, the modest actuation mechanical and robustness performances remain a challenge. Inspired by the specific structures, well mechanical properties and physico-chemical characteristics of some natural plant fibers, a composite of thiol-acrylate main-chain LCE matrix incorporated with catkin fibers is designed and developed. The catkin fibers build a network as reinforcement phase, and demonstrate effective compatibility and integration property with the matrix, their high flexibility can be adapted to the large deformational performance of LCE matrix. The prepared LCE composite demonstrates strong mechanical actuation properties. The modulus and driving force triggered by the stimuli are obviously increased. The tensile strength and fatigue failure resistant property under high loadings and repeated cycles of thermal actuation or photothermal actuation are greatly enhanced. While the stimulus response deformation rate, phase transition temperature and liquid crystal phase structure of the LCE matrix, and so on, do not weaken or change. This work promotes the LCE materials’application potential and broadens the application value of natural plant fibers.
研究领域:
材料科学
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植物学
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2018
·
IF 7.082
Zhaolan Zhai,Xinyan Yan,Ji Xu,Zhanqian Song,Shibin Shang,Xiaoping Rao
The phase behavior and aggregates induced by changes in pH in a sodium N -tetradecyl-maleimidepimaric carboxylate (C 14 -MPA-Na)/cetyltrimethylammonium bromide (CTAB) system have been investigated using rheology and cryogenic transmission electron microscopy (cryo-TEM). Viscoelastic solutions at a pH between 6.40 and 1.41, opalescent blue solutions at a pH between 1.41 and 1.32 and aqueous surfactant two-phase systems (ASTPs) at a pH between 1.32 and 0.56 are formed sequentially. The microstructures in the viscoelastic solutions are wormlike micelles that partially transform to vesicles in the opalescent blue solutions. The aggregates in the upper phase of the ASTPs are vesicles and lamellar micelles, and in the lower phase are spherical micelles. Further, Single-walled carbon nanotubes (SWNTs) were successfully hybridized into the wormlike micellar viscoelastic solutions. cryo-TEM, UV–Vis-IR, near-infrared photoluminescence (NIR-PL) and UV–Vis spectroscopy were used to study the dispersion of SWNTs in the viscoelastic solutions, and the results showed SWNTs can remain dispersed for more than 6 months at pH 6.40. The results obtained from rheology showed that the hybridization of SWNTs will not affect the aggregates and viscoelasticity compared that to the native viscoelastic solution. Above more, the SWNTs could be recycled by the pH-switched phase behaviors between viscoelastic solutions and ASTPs.
研究领域:
材料科学
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胶体化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
BMC Veterinary Research
·
2020
·Vol. 16
·期 1
·1-9
·
IF 1.835
Li Dengliang,Cui Zhanding,Li Guohua,Zhang Liangting,Zhang Ying,Zhao Han,Zhang Shuang,Guo Yanbing,Zhao Yanli,Men Fanxing,Zhao Shihui,Shao Jiang,Du Dongju,Huang Hailong,Wang Kai,Hu Guixue,Li Tiansong,Zhao Yongkun
Background Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention.Results In this study, we found that copper chloride had dose-dependent antiviral effects on FCV in F81 cells. We also found that the combination of copper chloride and ribavirin had a synergistic protective effect against FCV in F81 cells. In contrast, the combination of copper chloride and horse anti-FCV immunoglobulin F (ab’)2 showed an antagonistic effect, likely because copper chloride has an effect on F (ab’)2 immunoglobulin; however, further research is needed to clarify this supposition.Conclusion sIn summary, we found that copper chloride had low cytotoxicity and significant antiviral effects on FCV in F81 cells, providing a new drug candidate for the prevention and treatment of FCV infection.
研究领域:
兽医学
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病毒学
·
药理学
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产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
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2025
·
IF 9.8
Dongke Cai,Mingxia Tang,Shuai Jiang,Debin Yan,Yinchuan Zhu,Yan Meng,Dan Xiao,Qian Zhao,Wei Feng,Xicui Zhang
This study presents a sustainable F/O co-doped hard carbon (PD-F800) derived from panda excrement via NH 4 F-assisted hydrothermal doping for sodium-ion battery anodes. PD-F800 delivers a reversible capacity of 472.87 ± 5.1 mAh g −1 at 100 mA g −1 with an initial Coulombic efficiency of 66.2 ± 2.1 %, maintains 317.72 ± 4.0 mAh g −1 at 1000 mA g −1 , and retains 72.7 ± 3.3 % capacity after 1000 cycles. In situ XRD/Raman, EIS/DRT and GITT jointly indicate that F/O co-doping introduces non-bonded F states and regulates defect/interfacial chemistry, which lowers Na + adsorption/desorption barriers, increases Na + diffusion kinetics, and stabilizes an inorganic-rich SEI, thereby coupling fast surface-controlled storage with reversible interlayer/pore processes. This work establishes a safe, scalable route from waste biomass to high-performance anodes and clarifies the structure-interface-kinetics linkage enabling advanced Na-ion storage.
✓ 已验证
DOI
高影响因子
Antioxidants
·
2025
·Vol. 14
·期 6
·639
·
IF 6.6
Longjiao Wang,Qianqian Chen,Weiwei Wang,Hao Dong,Xiaohan Chang,Lishui Chen,Ran Wang,Yaoxing Chen,Pengjie Wang,Shuxing Chen,Wei Xiong,Yixuan Li
Oral diseases are highly prevalent among domestic cats, with microbiota dysbiosis as a primary etiological factor. However, effective microbiota-targeted interventions remain limited. This study evaluated the efficacy of a dietary supplement combining propolis and lysozyme (PL) in mitigating feline oral health issues, based on a cohort of 24 cats divided equally into placebo, treatment, and healthy control groups (n= 8 per group). Supragingival microbiota were analyzed via 16S rRNA gene sequencing, alongside assessments of volatile sulfur compounds (VSCs), oral health indices, and systemic inflammatory, oxidative, and immune markers. After 28 days of intervention, cats receiving PL supplementation demonstrated significant improvements, including a 35.4% reduction in VSCs and notable decreases in debris (34.9%), plaque (51.2%), and gingival indices (61.0%). Systemically, MDA and TNF-α levels decreased, while SOD, T-AOC, and IL-4 increased. Microbiota analysis revealed suppression of Porphyromonas and Selenomonas and enrichment of Moraxella and Bergeyella. Reductions in VSCs, gingival index, and TNF-α were correlated with lower Porphyromonas abundance, while Moraxella and Luteimonas were positively associated with antioxidant status. Functional predictions indicated downregulation of virulence-related pathways and increased expression of glutathione reductase. These findings highlight PL’s potential as a natural, microbiota-based intervention that improves feline oral health and modulates the oral–systemic axis, supporting its application in integrative oral care strategies.
研究领域:
兽医学
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口腔健康
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微生物学
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免疫学
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营养科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2024
·
IF 4.2
Xiaosi Lin,Le Dong,Qing Miao,Zhaobin Huang,Fang Wang
Prodiginines have been studied extensively for their anticancer activity, however, the majority of the research has focused on prodigiosin. In this study, cycloheptylprodigiosin (S-1) is extracted from marine bacterium Spartinivicinus ruber MCCC 1K03745 T , and its anticancer property was investigated. It exhibits remarkable cytotoxicity against a panel of human lung cancer cell lines, with the IC 50 values ranging from 84.89 nM to 661.2 nM. After 6 hours of treatment, S-1 gradually accumulates on mitochondria and lysosomes. While lower doses of S-1 induce cell cycle arrest, treatment with higher doses results in cell death in apoptotic independent manner in both NCI-H1299 and NCI-H460 cell lines. Interestingly, treatment with S-1 leads to the accumulation of LC3B-II via pathways that vary among different cell lines. In addition to its role as an autophagy inhibitor, S-1 also promotes autophagy initiation as demonstrated by the increment of EGFP fragment in the EGFP-LC3 degradation assay, however, inhibition of autophagy does not rescue cells from death induced by S-1. Mechanistically, S-1 impairs autophagic flux through disrupting acidic lysosomal pH and blocking the maturation of cathepsin D. Moreover, treatment with S-1 enhanced secretion of both pro- and mature forms of cathepsin D, coincident with disintegration of trans-Golgi network. Interestingly, S-1 does not induce ferroptosis, pyroptosis or necroptosis in NCI-H1299 cells. However, treatment of NCI-H460 cells with S-1 induces methuosis, which can be suppressed by Rac1 inhibitor EHT 1864. Our data demonstrate that S-1 is an effective anticancer agent with potential therapeutic application.
研究领域:
肿瘤学
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药理学
·
细胞生物学
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海洋生物学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
VETERINARY RESEARCH
·
2024
·Vol. 55
·期 1
·1-9
·
IF 3.7
Yang Jia,Li Li,Xu Fuqiang,Jia Fan
Feline herpesvirus type 1 (FHV-1), a member of the Herpesviridae family, is one of the most important pathogens that causes upper respiratory tract disease in felines. Following infection, FHV-1 can spread retrogradely to the trigeminal ganglia, establishing a life-long latency. Although vaccines are available for routine feline vaccination, FHV-1 is still an agent that poses a serious threat to feline health. There are currently no specific drugs for the treatment of FHV-1. To facilitate the screening of antiviral drugs, we constructed a reporter FHV-1 virus, which expresses a secreted Gaussia luciferase (GLuc) and a bright green fluorescent protein, mNeonGreen. The reporter virus shows slower growth than does the wild-type FHV-1. The expression of the two reporter genes, Gluc and mNeonGreen, was consistent with viral propagation and remained stable during continuous passage in CRFK cells, even after twenty rounds. In addition, the known inhibitor ganciclovir was used to confirm the characteristics of the reporter virus for drug screening. We found that the reporter FHV-1 is suitable for antiviral screening assays. Overall, our work provides a useful tool for screening drugs to combat FHV-1.
研究领域:
病毒学
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兽医学
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分子生物学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）