INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Abdul Haleem,Xianshuang Zhu,Dost Muhammad Khan,Buriro Ghous Bakhsh,Kaixuan Huang,Hao Li,Hua Zhong
Bio-based porous materials have attracted significant attention over recent decades as environmentally sustainable alternatives to synthetic counterparts. This study synthesized a three-dimensional porous biocatalyst through UV-assisted cryopolymerization to graft acrylamide onto chitosan chains, followed by in situ integration of silver nanoparticles via a self-reduction mechanism. The composite exhibited enhanced antibacterial efficacy against Escherichia coli ( E. coli ), attributable to the synergistic effects of chitosan and silver nanoparticles. A rapid swelling ratio (20 s) corroborated the macroporous architecture of the material. The biocatalyst demonstrated exceptional catalytic performance in the hydrogenation reduction of Congo red azo dye under both deionized and tap water conditions when paired with a reducing agent. Notably, formulations with lower chitosan content achieved superior reduction kinetics, yielding apparent rate constants of 0.160 min −1 and 0.117 min −1 in deionized water and tap water, respectively. Key structural advantages such as tunable porosity, hydrophilicity, biodegradability, and an economical fabrication protocol collectively contributed to its enhanced catalytic efficiency. Critical operational parameters such as biocatalyst dosage and temperature were systematically evaluated to assess scalability potential. Thermodynamic analysis via the Arrhenius equation revealed an activation energy (Eₐ) of 35.45 kJ.mol −1 for Congo red hydrogenation. Complementary Eyring equation calculations provided enthalpy (ΔH = −33.67 kJ.mol −1 ) and entropy (ΔS = −159.15 J.mol −1 .K −1 ), consistent with an associative reaction mechanism. The biocatalyst maintained robust reusability over four consecutive cycles with negligible change in hydrogenation reduction performance. Collectively, this work establishes a green, high-performance biocatalytic platform with superior environmental compatibility compared to conventional synthetic catalysts, underscoring its potential for sustainable wastewater treatment applications.
研究领域:
环境科学
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材料科学
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生物化学
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DOI
PubMed
高影响因子
MATERIALS LETTERS
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2016
·
IF 2.437
Xingxing Jin,Yanfang Wang,Jiang Yuan,Jian Shen
Keratin-based biomaterials have emerged as potential candidates for various biomedical and biotechnological applications due to their intrinsic biocompatibility, biodegradability, mechanical durability, and natural abundance. The objective of our study is to explore the feasibility and potential applications of keratin for promoting nitric oxide (NO) release. Herein, keratin was first extracted from human hair and then modified with iodoacetic acid to afford S-carboxymethyl keratin. The amino acid residues, isoelectric point, and molecular weight of keratin were quantified with amino acid analyzer, zeta potential measurement, and SDS-PAGE method. Interestingly, human hair keratin was proved to be capable of promoting NO release from endogenous donor of S-nitrosoglutathione (GSNO) in the presence of glutathione.
研究领域:
生物医学
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生物技术
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2021
·
IF 7.328
Kecheng Quan,Zexin Zhang,Yijin Ren,Henk J. Busscher,Henny C. van der Mei,Brandon W. Peterson
Biomaterial-associated infections can occur any time after surgical implantation of biomaterial implants and limit their success rates. On-demand, antimicrobial release coatings have been designed, but in vivo release triggers uniquely relating with infection do not exist, while inadvertent leakage of antimicrobials can cause exhaustion of a coating prior to need. Here, we attach magnetic-nanoparticles to a biomaterial surface, that can be pulled-off in a magnetic field through an adhering, infectious biofilm . Magnetic-nanoparticles remained stably attached to a surface upon exposure to PBS for at least 50 days, did not promote bacterial adhesion or negatively affect interaction with adhering tissue cells. Nanoparticles could be magnetically pulled-off from a surface through an adhering biofilm, creating artificial water channels in the biofilm. At a magnetic-nanoparticle coating concentration of 0.64 mg cm −2 , these by-pass channels increased the penetrability of Staphylococcus aureus and Pseudomonas aeruginosa biofilms towards different antibiotics, yielding 10-fold more antibiotic killing of biofilm inhabitants than in absence of artificial channels. This innovative use of magnetic-nanoparticles for the eradication of biomaterial-associated infections requires no precise targeting of magnetic-nanoparticles and allows more effective use of existing antibiotics by breaking the penetration barrier of an infectious biofilm adhering to a biomaterial implant surface on-demand.
研究领域:
生物医学工程
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微生物学
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材料科学
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产品关联
DOI
PubMed
高影响因子
International Journal of Surgery
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2023
·Vol. 109
·期 12
·4322
·
IF 15.3
Gené-Škrabec Clara,Cremades Manel,Fernández-Pujol Andrea,Cortinovis Sara,Corral Javier,Julián Joan-F,Parés David
Objective: The aim of this review is to describe and assess the existing methods to cover colorectal anastomoses with biomaterials and their clinical impact in reducing anastomotic leakage (AL). Summary background data: The most serious complication in colorectal surgery is AL. Despite improvements in its diagnosis and management, AL remains an unresolved issue. To prevent its appearance and clinical consequences, different external reinforcement techniques with synthetic or biomaterials have been described. Methods: A systematic review search of the available literature until June 2022 was performed, looking for all literature regarding external reinforcement of colonic or colorectal anastomoses. After the review process, a classification of materials was proposed into solid and liquid materials, and an assessment of their clinical impact was performed. The study protocol has been registered at PROSPERO and has been reported in the line with PRISMA and AMSTAR Guidelines 11,12 . Results: Ninety-seven articles that fulfilled inclusion criteria, were identified and revised. Overall, 18 of the selected articles focused on human clinical trials and 79 on animal models. Only fibrin sealants, collagen patches, and omentoplasty have shown positive results in humans. Conclusions: Fibrin sealants, collagen patches, and omentoplasty are, so far, the most studied biomaterials. However, further studies are required to confirm these findings before definite recommendations can be made.
研究领域:
医学
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外科手术
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DOI
PubMed
高影响因子
Small
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2013
·Vol. 10
·期 1
·88-93
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IF 7.823
Wei Liu,Luoran Shang,Fuyin Zheng,Jie Lu,Jinglian Qian,Yuanjin Zhao,Zhongze Gu
Graphical Photonic crystal encoded biomaterials microcarriers made from silica-hybrid photonic crystal beads are reported. The characteristic reflection peak originating from the physical periodic structure is used as the code of the microcarriers. They are stable during cell adhesion and culture on their surface. Based on this method, Different biomaterials are incorporated into different PCBs and used as encoded microcarriers for the multiplex evaluation of the interaction of cells and materials in a single culture experiment. These encoded microcarriers are ideal for multiplex bioevaluation of biomaterials or drug applications.
研究领域:
生物医学工程
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材料科学
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细胞生物学
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DOI
高影响因子
LANGMUIR
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2019
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IF 3.683
Qiangbing Wei,Xiaoqian Liu,Qinyu Yue,Shuanhong Ma,Feng Zhou
Low-friction and hydrophilic surfaces have critical applications in biomedical devices and implants. Existing methods to achieve such surfaces, for example, grafting polymer brushes, usually suffer from tedious steps and harsh reaction conditions, which limit practical applications. In this work, we propose a set of versatile ultralow-friction coatings applicable for diverse biomaterial surfaces via a one-step simple codeposition strategy with dopamine and hydrophilic monomers. The polymer coatings show ultralow-friction performance together with hydrophilic feature and antifouling property. The coefficient of friction of the as-prepared coating can be as low as 0.003 in pure water. The coating also provides superior and stable lubrication in biological fluids due to antifouling capability. Furthermore, the versatility of this strategy allows fabrication of multiple lubricious polymer coatings with different hydrophilic monomers and on diverse material surfaces. The typical application of this low-friction coating on a medical catheter was further demonstrated, which dramatically improved surface wettability and reduced friction of the outer surface of the catheter. In view of the versatility and remarkable lubrication ability, the multifunctional coatings may find important applications in biomedical devices and implants.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
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2014
·
IF 8.312
Hongjie Huang,Xin Zhang,Xiaoqing Hu,Zhenxing Shao,Jingxian Zhu,Linghui Dai,Zhentao Man,Lan Yuan,Haifeng Chen,Chunyan Zhou,Yingfang Ao
Cartilage regeneration after trauma is still a great challenge for clinicians and researchers due to many reasons, such as joint load-bearing, synovial movement and the paucity of endogenous repair cells . To overcome these limitations, we constructed a functional biomaterial using a biphasic scaffold platform and a bone-derived mesenchymal stem cells (BMSCs)-specific affinity peptide. The biphasic scaffold platform retains more cells homogeneously within the sol–gel transition of chitosan and provides sufficient solid matrix strength . This biphasic scaffold platform is functionalized with an affinity peptide targeting a cell source of interest, BMSCs. The presence of conjugated peptide gives this system a biological functionality towards BMSC-specific homing both in vitro and in vivo . The functional biomaterial can stimulate stem cell proliferation and chondrogenic differentiation during in vitro culture. Six months after in vivo implantation, compared with routine surgery or control scaffolds, the functional biomaterials induced superior cartilage repair without complications, as indicated by histological observations, magnetic resonance imaging and biomechanical properties . Beyond cartilage repair, this functional biphasic scaffold may provide a biomaterial framework for one-step tissue engineering strategy by homing endogenous cells to stimulate tissue regeneration.
研究领域:
再生医学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2017
·
IF 3.582
Yishan Li,Nianbing Zhong,Qiang Liao,Qian Fu,Yun Huang,Xun Zhu,Qiaoliang Li
A novel photothermal biomaterial , designated GeO 2 -SiO 2 -Chitosan-Medium-LaB 6 (GSCML), was prepared to improve photosynthetic bacteria (PSB) biofilm development and hydrogen production performance. This biomaterial employed spectral beam splitting technology to increase the overall utilization of the incident light spectrum, which LaB 6 nanoparticles (NPs) mainly absorb light at approximately 380–510 and 660–780 nm and convert it into heat energy ; the transmit light is around 590 nm for PSB growth. The temperature increased, and the luminous intensity of the light transmitted through the prepared biomaterial are controlled by adjusting the LaB 6 NPs' content. The average biofilm growth rate and hydrogen production rate of the biofilm on the created biomaterial were 0.05 mg/cm 2 /day and 2.92 mmol/h/m 2 , which were 3.4 and 4.1 times higher than those of the glass slide, respectively. The properties of the GSCML biomaterial provide advantages for applications in immobilized cell technologies and photobioreactors.
研究领域:
生物技术
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新能源研究
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材料科学
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2022
·
IF 6.056
Jingyimei Liang,Qian He,Yuning Zhao,Yahong Yuan,Zhouli Wang,Zhenpeng Gao,Zhongqiu Hu,Xubo Zhao,Tianli Yue
Patulin (PAT) is a common toxin in fruit juice, and adsorption is the most commonly used patulin removal method. The safety, adsorption capacity, and separation capacity of the adsorbent are the most important considerations. As a low-cost and biocompatible microbial material, bacterial cellulose gel membranes (BCMs) have many hydroxyl active sites that are readily modified, and BCMs are also stable, which facilitates their separation from aqueous solution. Therefore, BCMs are a promising material for adsorbing patulin. Through silanization, –SH was successfully connected to BCM, and the maximum content of –SH was 1.25 mmol/g. Because of facile combination of –SH and PAT, our sulfhydryl-modified bacterial cellulose gel membrane [BCM-SH(Si)] retained an adsorption capacity of 498.78 ± 35.94 μg/g in a complex apple juice solution, an adsorption capacity that is 125 × higher than that before the modification. We have thus demonstrated a promising, readily prepared biomaterial for removing of patulin from fruit juice that facilitates subsequent separation of the material from fruit juice and exhibits a good adsorption capacity.
研究领域:
食品科学
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生物技术
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毒理学
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2021
·
IF 0
Guiyuan Chen,Yihan Wu,Kai Jin,Hongfei Lu,Mingyue Tao,Tiantian Wang,Jing Zhang,Xiaohui Zhu,Jinliang Liu,Yong Zhang
Photodynamic inactivation (PDI) has become an appealing alternative strategy to treat infections without developing resistance to microbes. In PDI treatment, near-infrared (NIR) light is preferred because it causes less damage to normal tissues and leads to better penetration in deep tissues. Here, we develop an NIR-responsive nanomedicine for efficient broad-spectrum antimicrobial photodynamic treatment. By harnessing the biosynthetic capability of a bacterial cellulose-producing microorganism, we construct a nanocomposite biomaterial to deliver and recycle the nanomedicine. Our simple one-step biosynthetic approach does not impede the antimicrobial potency of the nanomedicine under NIR activation and requires no chemical modification. The resulting nanocomposite has been tested in antimicrobial treatment of different microorganisms, exhibiting a great potential to eliminate pathogens in biofilms and to treat in vivo infections.
研究领域:
生物医学工程
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微生物学
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材料科学
✓ 已验证
DOI
PubMed
MACROMOLECULAR BIOSCIENCE
·
2018
·Vol. 18
·期 6
·1800054
·
IF 3.392
Rong Wang,Fanjun Zhang,Weiwei Lin,Wenkai Liu,Jiehua Li,Feng Luo,Yaning Wang,Hong Tan
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(ε-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP. Meanwhile, semicrystalline PCL is not only hydrolytically degradable but also vital for shape memory. Good shape memory ability under body temperature is achieved for PUUs due to the strong interactions in hard segments for permanent crosslinking and the crystallization-melt transition of PCL to switch temporary shape. The PUUs would have a great potential in application as implanting stent.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Shuquan Cui,Yiman Wei,Qiao Bian,Yan Zhu,Xiaobin Chen,Yaping Zhuang,Mingyan Cai,Jingyu Tang,Lin Yu,Jiandong Ding
Endoscopic submucosal dissection is an established method for the removal of early cancers and large lesions from the gastrointestinal tract but is faced with the risk of perforation. To decrease this risk, a submucosal fluid cushion (SFC) is needed clinically by submucosal injection of saline and so on to lift and separate the lesion from the muscular layer. Some materials have been tried as the SFC so far with disadvantages. Here, we proposed a thermogel generated by the “block blend” strategy as an SFC. This system was composed of two amphiphilic block copolymers in water, so it was called a “block blend”. We synthesized two non-thermogellable copolymers poly(d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) and blended them in water to achieve a sol–gel transition upon heating in both pure water and physiological saline. We explored the internal structure of the resultant thermogel with transmission electron microscopy, three-dimensional light scattering, 13C NMR, fluorescence resonance energy transfer, and rheological measurements, which indicated a percolated micelle network. The biosafety of the synthesized copolymer was preliminarily confirmed in vitro. The main necessary functions as an SFC, namely, injectability of a sol and the maintained mucosal elevation as a gel after injection, were verified ex vivo. This study has revealed the internal structure of the block blend thermogel and illustrated its potential application as a biomaterial. This work might be stimulating for investigations and applications of intelligent materials with both injectability and thermogellability of tunable phase-transition temperatures.
研究领域:
生物医学工程
·
材料科学
·
消化病学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）