Polymer Chemistry
·
2016
·Vol. 7
·期 13
·2372-2380
·
IF 5.687
Jianbo Tan,Yuhao Bai,Xuechao Zhang,Li Zhang
The photoinitiated polymerization-induced self-assembly (photo-PISA) of 2-hydroxypropyl methacrylate (HPMA) is conducted in water by using poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) based macro-RAFT agents. Polymerizations were carried out at room temperature via exposure to visible light irradiation, and quantitative monomer conversions (>99%) were achieved within 30 min of visible light irradiation. A remarkably diverse set of complex morphologies (spheres, worms, and vesicles) have been prepared by aqueous photo-PISA under mild conditions (water medium, room temperature, and visible light). The morphology of nano-objects can be tuned by changing the reaction parameters (e.g. degree of polymerization, solids concentration), and two detailed phase diagrams were constructed. The polymerization can be activated or deactivated by a simple “ON/OFF” switch of the light source. A thermo-responsive behavior of PPEGMA14-PHPMA200 nanoparticles prepared at 15% w/w was investigated by changing the temperature from 25 °C to 4 °C.
研究领域:
材料科学
·
化学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2021
·Vol. 5
·期 3
·2223-2234
·
IF 5.693
Chen Ruixia,Shi Jun,Liu Chongchong,Li Jingguo,Cao Shaokui
Multi-responsive hybrid microgels have attracted lots of attention in biomedical filed owing to the tunable degree of flexibility, high particle stability, and remarkable sensitivity to external stimuli. In this paper, a novel remote drug delivery platform based on gold nanorods (AuNRs)-P(NIPAM-co-AAc) (PNA) hybrid microgel was prepared by electrostatic self-assembly approach. The electrostatic self-assembly of mercapto-modified polyethylene glycol (mPEG) and polyallylamine hydrochloride (PAH) was utilized to safeguard AuNRs, which could greatly enhance the stability of AuNRs and endow AuNRs-PNA hybrid microgels with excellent physiological dispersibility and stability. More importantly, due to the change of electrostatic force between microgels and DOX at different pH values, as well as the thermal sensitivity of PNA and NIR response of AuNRs, AuNR-PNA hybrid microgels displayed prominently pH/temperature/NIR synergistic responsive drug release performance. This paper furnishes a green and feasible method to prepare intelligently remotely controllable hybrid microgels with great physiological stability, which has great perspectives in photothermal therapy and remotely controllable drug delivery area. Graphical abstract pH/temperature/NIR synergistic responsive AuNRs-P(NIPAM-co-AAc) hybrid microgel for smart drug delivery was prepared by in situ self-assembly.
研究领域:
生物医学工程
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材料科学
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药学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 86
·70178-70185
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IF 3.84
Mingfang Ma,Jinge Gu,Minmin Yang,Zhaolou Li,Zhuoqun Lu,Yimeng Zhang,Pengyao Xing,Shangyang Li,Xiaoxiao Chu,Yajie Wang,Qi Li,Minyan Lin,Aiyou Hao
Sodium benzoate is an important and widely used food additive, however, its self-assembly properties in diverse solvents have been rarely studied. Here, we report different self-assembled aggregates, including sodium benzoate vesicles and sodium benzoate gel, in different solvent environments. Sodium benzoate vesicles and gel were identified by Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS). Ultraviolet-visible (UV-vis) spectroscopy, Fourier Transform Infrared (FT-IR) spectroscopy, Thermal Gravity Analysis (TGA), Differential Scanning Calorimetry (DSC) and Small-Angle X-ray Scattering (SAXS) were further employed to study the formation mechanism of the sodium benzoate gel. A possible gel formation mechanism was proposed. Furthermore, sodium benzoate gel has multiple stimulus responsiveness, the addition of hydrochloric acid and metal ions can all cause disaggregation of sodium benzoate gel. Finally, sodium benzoate aggregates were found in calf serum.
研究领域:
材料科学
·
食品科学
·
化学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 16
·4855-4862
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IF 6.641
Xinbo Gong,Chengyi Hou,Qinghong Zhang,Yaogang Li,Hongzhi Wang
Robust, washable, steam permeable fabrics that display solvatochromic structural color changes are fabricated by a solvent evaporation-driven self-assembly method using poly(styrene–butyl acrylate–acrylic acid) core–shell colloidal microspheres. The colloidal microspheres self-assemble into a periodic arrangement to form a colorless transparent film on fabrics. Because of the lack of refractive index difference between the film and fabric, the fabric retains its original color (black polyester in this work). As soon as the fabric is wetted, its color changes. When the wetted fabric is completely dried, its original black color appears again. These solvatochromic fabrics do not show apparent color fading during repeated stretching or after laundering. The structural color fabrics show promising steam permeability with only a 13% decrease compared with the original fabrics. Therefore, the wearability of the fabric meets the demands for applications in the textile industry.
研究领域:
材料科学
·
纺织工程
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Xiaoli Huang,Di Lu,Yongmin Ma,Limei Zhang,Lina Wang,Jian Deng,Zheng Wang,Yanjun Zhao
We report a self-assembly-based approach for improved iron chelation of small chelators. A model chelator, deferiprone (DFP) is covalently linked to amphiphilic poly(ethylene glycol)-polypeptide block copolymer that can assemble into micelles . The free DFP generally coordinates with iron in a ratiometric manner (3:1). However, the assembly induces DFP packing in the micelle cores, which restricts its conformational freedom. Hence DFP/iron coordination ratio in micelles is reduced (< 3:1), which leads to an enhanced chelation performance of DFP. In addition, the micellar nanocarrier usually exhibits an extended systemic circulation in contrast to the free DFP. The current work opens new avenues for developing novel nanomedicines for iron overload diseases.
研究领域:
生物化学
·
药学
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Chunyang Bao,Qiang Zhang
PEGylation and glycosylation are utilized in this research as different bioconjugation tools to modify proteins, yielding conjugates with different enzyme activity and assembled structure. Active succinimidyl esters are first synthesized through a facile one-step reaction for the alkyne-functionalization of proteins. Well-defined polymers with controlled MW, narrow dispersity and terminal azide groups, including thermoresponsive poly(PEG) and glycopolymers, are then synthesized via a combination of copper mediated living radical polymerization (Cu(0)-LRP) following azidation reaction. Copper catalyzed azide and alkyne cycloaddition reaction (CuAAC) is finally performed to conjugate poly(PEG) or glycopolymers with the alkyne-functionalized laccase from Trametes versicolor . The coupling of polymers induces further self-assembly of laccase-polymer conjugates into spherical nanoparticles with well dispersion stability and stimuli-responsive behaviours in water. Enzyme activity of the conjugates are also studied, during which the glycosylated laccase has shown relatively higher activity than the PEGylated laccase.
研究领域:
生物化学
·
材料科学
·
分子生物学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Shuo Yu,Caixia Huo,Kui Hao,Le Sun,Yuqing Peng,Aijun Li
We report a novel mild self-assembly freeze–thaw strategy for fabricating 3D graphene aerogel (GA) composite anchored with SnO 2 nanoparticles. Compared with conventional hydrothermal and freeze-drying methods, The method achieves energy-efficient synthesis (90 °C, 3 h) and eliminates complex equipment. Efficient dispersion of SnO 2 nanoparticles and precise modulation of the 3D porous structure were achieved through the synergistic effects of self-assembly, foaming, and in-situ reduction at low temperature and atmospheric pressure. The unique structure of GA/SnO 2 composites significantly buffers the volume expansion of SnO 2 and enhances the ion/electron transport kinetics. As a sodium-ion battery anode, it provides a high reversible capacity of 302.5 mAh g −1 after 300 cycles at 0.1 A g −1 and a remarkable rate capability (146 mAh g −1 at 2 A g −1 ), outperforming aggregated SnO 2 synthesized via hydrothermal routes. DFT simulations reveal enhanced sodium-ion adsorption energy and interfacial C Sn O covalent bonding, which synergistically stabilize the electrode structure. This work provides a low-cost and environmentally friendly route for designing high-performance metal oxide/carbon composites.
研究领域:
材料科学
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能源存储
·
纳米技术
✓ 已验证
DOI
高影响因子
ANALYST
·
2019
·Vol. 144
·期 9
·3072-3079
·
IF 4.019
Yuhuan Wang,Ruyan Wang,Lei Wang,Licheng Wang,Yong Guo,Xiaojing Liang,Shuai Wang
Au nanoparticle-hybridized silica (Au@sil) spheres were synthesized in one step as a liquid chromatographic stationary phase for the first time. The hybridized stationary phase showed good separation performances in reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography even without bonding with any organic groups. Compared with the bare silica stationary phase, the Au@sil stationary phase showed better separation performance under the same conditions in RPLC and HILIC modes. The effects of acetonitrile content, buffer concentration, and the pH of the mobile phase on analyte retention were further investigated. The results showed that the Au@sil stationary phase had a complex retention mechanism of electrostatic and partitioning interactions. By comparing Au solution (solAu) with different proportion volumes in silica sol, the optimum hybridized stationary phase was found to comprise 33 vol% solAu. Au@sil was further modified with 1-octadecanethiol by self-assembly and used to separate alkylbenzenes and polycyclic aromatic hydrocarbons by RPLC. The separation efficiency of the 1-octadecanethiol self-assembled modified Au@sil (C18-Au@sil) column was much better than that of Au@sil. Overall, the successful hybridization of Au nanoparticles provided a new method to prepare a stationary phase in a simple and environmentally friendly way.
研究领域:
分析化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Teng Li,Jun Zheng,Mingyue Xia,Haonan Zhu,Xianwen Song,Yaya Zhou,Chao Yin,Zhe Yu,En Hu,Zexuan Cai,Yao Wu,Wenxin Zhu,Weikang Luo,Menghan Cheng,Tao Tang,Yi Zhang,Yang Wang
Immediate hemostasis and effective treatment are foremost for acute intervention in traumatic brain injury (TBI), but the therapeutic tools and professional treatment methods are often lacking at the scene. Self-gelling powders formed by the self-assembly of pure molecular drugs can quickly deliver hemostatic and therapeutic effects without complications from chemical modifications or additional carriers. However, no clinical drugs have been reported as a self-gelling powder for this purpose. Here, a self-gelling powder is self-assembled from sodium aescinate (SA), a drug already approved for treating trauma. To generate SA self-gelling powder (SA self-gel-P), SA powder is heated and cooled in an alkaline solution to form a hydrogel, then freeze-dried and ground. The obtained SA self-gel-P has a good hydrophilicity. When sprayed onto the bleeding site after TBI, it rapidly absorbed blood and formed a gel through intermolecular hydrogen bonding, facilitating effective in situ sealing and rapid hemostasis. Furthermore, the formed hydrogel released SA over a long period, which helped reduce neuronal death, improve integrity of the blood-brain barrier, reduce brain edema, alleviate neuroinflammation, and ultimately promote recovery of neurofunction without significant toxic side effects. This self-gelling powder may serve as a powerful auxiliary tool for the pre-hospital treatment of TBI.
研究领域:
药学
·
创伤医学
·
神经科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Tong Song,Yue Zhao,Katarzyna Matras-Postolek,Ping Yang
Using carbon spheres and sucrose as the carbon sources, two kinds of color-tunable carbon dots (Cdots) named as Cdots-C and Cdots-S were prepared via change the solution concentration. As the concentration of Cdots solution increased, varying degrees of self-assembly occur between monodisperse Cdots. Hence aggregates with different types formed, which can be observed. Appearance of new excitation bands at 465 and 520 nm caused by H- and J-type Cdots aggregates caused the emission at long wavelengths. At the same time, the excitation band at 300–400 nm induced blue-green emission and the competitions of three excitation bands resulted in the color-tunable PL behaviour which cover the region from green to red emission. The difference of carbon sources of Cdots-C, Cdots-S and Cdots-G (graphite) explained the reason why concentration-dependent PL behaviour were not observed in Cdots-G at a high solution concentration. The process of self-assembly were ascribed to hydrogen bonding interaction between abundant hydroxyl groups on the surface of Cdots-C and Cdots-S. This work provided a simple approach to modulate photoluminescence (PL) color of Cdots and will extend the application in bioimaging.
研究领域:
材料科学
·
生物成像
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Chenglong Cai,Ting Wang,Yixin Zhang,Nongyue He
A macro-scopic ensembles of graphene was considered to be very important for their extensive use. A macro-scopic ensembles of graphene was considered to be very important for their extensive use. Such as electromagnetic-interference shielding, thermal control and sensor. In this work, we developed a facile one-step strategy for ultra-large neat graphene oxide (UN-GO) film with excellent thermal conduction and photothermal conversion property. A Langmuir Blodgett was used as the reactor for self-assembling aqueous graphite oxide (GO) suspensions onto the glass slice to form UN-GO film. The wrinkling density and degree of the close-packed flat UN-GO monolayer were determined by the size of GO sheets. The defect on UN-GO film 2D structure determined the thermal conductivities of the close-packed flat UN-GO. To avoid defect on UN-GO film 2D structure, we modified the substrate with different concentration of (3-aminopropyl) triethoxysilane (APTEs). The internal structure of self-assembled monolayers (SAMs) of APTES fabricated on a glass substrate determined the defect of UN-GO film. Flat APTES-SAMs with integrated molecular structure was a determinant for UN-GO film to form 2D structure with rare defect. Graphene on the top of the substrate was 4 layers. With rare detect on 2D structure, thermal conductivity of GO film reached at 2514 W m −1 K −1 . One-step process will be with a high potential for large scale production.
研究领域:
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Xisong Mao,Xuewen Xia,Junqi Li,Chaoyi Chen,Xiaoying Gu,Song Li,Yuan-Pei Lan
In this work, various new-observed structured CeCO 3 OH were synthesized by a self-assembly hydrothermal method , and a novel tactic to produce CeO 2- x with excellent photocatalytic activity by decomposing CeCO 3 OH in H 2 was proposed and identified. By controlling the synthetic conditions, almond-like, subglobose shape and hollow-sphere of CeCO 3 OH, 3D-broom-like of Ce 2 O 3 · 2CO 2 · nH 2 O (n = (1–2)), and sheet-like of Ce 2 (CO 3 ) 3 · 6H 2 O were synthesized. The crystal growth and formation of the cerium carbonate compounds were carefully studied using XRD , SEM and TEM. TG, thermodynamic calculation and in-situ XRD were employed to reveal the decomposition behavior of almond-like CeCO 3 OH in air, Ar and H 2 . The results show that the decomposition temperatures of CeCO 3 OH in Ar and H 2 are higher than that of in air, and suggest that Ce 2 O 3 has a low thermodynamic stability during the decomposition of CeCO 3 OH in Ar and H 2 , and Ce 3+ will be mostly oxidized by H 2 O firstly and then by both of H 2 O and CO 2 . The ceria samples obtained by decomposing from CeCO 3 OH in different atmosphere maintain indistinguishable shape and particle size. The XPS , Raman spectra and ESR results indicate that the one obtained in H 2 has the richest surface oxygen vacancies (OVs), narrowest band gap of 3.12 eV, lowest intensity in PL spectra and a significantly enhanced photodegradation ratio of methylene blue. The MB photodegradation ratio after 120 min reaction with the catalysts of CeO 2 -Air, CeO 2 -Ar and CeO 2 -H 2 is 43.14%, 54.43% and 73.41%, with a calculated reaction rate constant of 0.00539, 0.00652 and 0.01097 min -1 , respectively. The offered novel tactic of decomposing CeCO 3 OH in H 2 is an efficient and facile technique for active CeO 2- x production.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）