SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Chunting Feng,Chan Gao,Hanshan Luo,Zhaojiang You,Zexiao Zhang,Jingcheng Zhu,Xu Zheng,Kai Wang,Zengming Zhang
In this study, in situ high-pressure fluorescence, absorption, and Raman spectroscopy techniques were employed to systematically elucidate the spectral evolution laws and microscopic mechanisms of pyrene over the pressure range of 0–10.2 GPa. Spectroscopic observations revealed a two-stage fluorescence enhancement of pyrene, which is directly associated with its crystalline phase transitions. At 0.2 GPa, pyrene undergoes a phase transition from phase I to phase II. The pressure-induced structural rearrangement and strengthened intermolecular interactions in pyrene work synergistically to achieve luminescence enhancement and fluorescence red-shift at this pressure. Within the pressure range of 2.0–3.0 GPa, the II → IV phase transition takes place, giving rise to the second stage of fluorescence enhancement. A key finding is that an anomalous phenomenon of simultaneous fluorescence enhancement and blue-shift is observed in the fluorescence spectrum during the II → IV phase transition; multi-spectral correlation analysis demonstrates that this phenomenon originates from the synergistic effect of reduced crystal symmetry and weakened π–π orbital overlap, which significantly enhances radiative recombination efficiency, and thus breaks the traditional understanding of spectral “red-shift-quenching” under high pressure. Beyond 7.2 GPa, the IV → V phase transition of pyrene induces molecular bending and electronic structure reconstruction, leading to accelerated fluorescence red-shift and complete quenching. This work constructs a comprehensive “pressure-structure-spectra” correlation system for pyrene under high pressure, and provides direct spectroscopic evidence for understanding the high-pressure photophysical behaviors of conjugated molecules.
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高影响因子
ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 33
·24439-24447
·
IF 7.3
Wang Yaqi,Zhang Ying,Zhang Yan,Ma Xue,Zheng Ting,Xu Zhiming,Zhao Suoqi,Shi Quan,Chen Zhengyu,Xu Chunming,Zhang Linzhou
Mesophase pitch is a pivotal precursor
for advanced carbon
materials,
yet feedstock selection still relies on time-consuming thermal polycondensation
and ex situ microscopy. Here we report an Ag + -induced electrospray
ionization high-resolution mass spectrometry (ESI-HRMS) strategy for
rapid screening of mesophase-forming feedstocks in complex hydrocarbon
systems. The method exploits the structural sensitivity of Ag + -induced aromatic complexation, quantified through the response
of [2M + Ag] + multicomplex ions. Model compound studies
confirmed that Ag + preferentially complexes with high-aromaticity,
short-side-chain molecules, mirroring ideal mesophase precursor features.
Across FCC slurry oils, residual oil, and supercritical fluid extraction
fractions, the [2M + Ag] + signal correlates positively
with mesophase content and with the development of ordered mesophase
texture. Collision-induced dissociation (CID) analysis further indicates
that the dominant multicomplexes adopt an “aromatic-Ag + -aromatic” sandwich-like structure and are primarily
contributed by short-side-chain 3–5-ring aromatics.
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ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 15
·13238-13251
·
IF 5.2
Zou Jiaxin,Li Yanan,Kou Zhaojun,Wang Dayang,Lu Linlin,Cong Hailin,Yu Bing,Ma Xuezhen
Although nanodrug delivery systems
have advanced cancer therapy,
limited tumor penetration and inefficient intracellular transport
still restrict their therapeutic efficacy. Herein, we constructed
a matrix metalloproteinase (MMP)-responsive, TAT-containing polymeric
micelle, O@MTPP, for cascade delivery of oxaliplatin in gastric cancer.
O@MTPP integrates an MMP-2/9-cleavable peptide, MTP (GPLGIAG), with
the cell-penetrating and nuclear-localization-associated TAT peptide
(CYGRKKRRQRRR). In the tumor microenvironment, MMP-2/9-mediated cleavage
triggers charge conversion, enhancing tumor-cell internalization and
penetration-associated distribution. After cellular uptake, TAT further
promotes nuclear-associated accumulation of the nanocarrier-associated
payload, supporting improved intracellular delivery of oxaliplatin.
This cascade delivery strategy enhanced tumor accumulation, strengthened
antitumor activity, and induced immunogenic cell death (ICD)-associated
immune responses, including calreticulin exposure, high mobility group
box 1 (HMGB-1) expression, increased tumor necrosis factor-α
(TNF-α), interferon-γ (IFN-γ), and interleukin-12
(IL-12) levels, and decreased interleukin-6 (IL-6). Overall, O@MTPP
provides an enzyme-activated cascade delivery strategy for overcoming
tissue-level and intracellular barriers in oxaliplatin-based gastric
cancer therapy.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Ying Huang,Yue Li,David Julian McClements,Jiamei Cai,Ziling Fang,Jianyong Wu
Pyrolytic self-assembly (PSA) was developed to synthesize starch nanoparticles (SNPs). • PSA eliminates enzyme and chemical dependence of traditional bottom-up methods. • PSA produces amorphous, micelle-like SNPs via hydrophobic self-assembly. • PSA at 170 °C achieves 96.93% yield of SNPs with Z-average size of 72.56 nm. • PSA-SNPs show exceptional cold-water redispersibility and anti-retrogradation ability. This study developed a pyrolytic self-assembly (PSA) method that produces starch nanoparticles (SNPs) through a two-step physical processing. Waxy corn starch underwent dry-heat pyrolysis at 170 °C to fragment amylopectin, followed by hot-water dispersion to release the molecular fragments that spontaneously self-assembled into amorphous SNPs via hydrophobic interactions. The resulting SNPs exhibited high cold-water redispersibility (93.3%) and enhanced anti-retrogradation capability. Although increasing the pyrolysis temperature (150–210 °C) improved SNP yield, temperatures exceeding 190 °C caused excessive molecular degradation, characterized by sharp declines in molecular weight, increased proportion of short-chain amylopectin branches (DP 6–12), extensive α-1,6 glycosidic bond cleavage, and elevated acidic and carbonyl content, leading to broader particle size distributions and pronounced color darkening. The optimal pyrolysis temperature of 170 °C yielded 96.9% SNPs with an average particle size of 72.6 nm. The PSA method eliminates dependence on chemicals or enzymes required by conventional bottom-up approaches, offering a scalable route for industrial SNP production. Download: Download high-res image (350KB) Download: Download full-size image
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Xiao-Qing Ling,Xin-Yan Zhao,Qi-Yan Lv,Jun-Yang Chen,Hai-Yang Dai,Hui-Fang Cui,XiaoJie Song
Cuproptosis has gained significant attention in cancer therapy. Use of copper-overloaded combination therapy that employs a variety of cell death mechanisms has emerged as a promising avenue in the treatment of cancer. However, integrating different modes in a system with optimal synergy and minimal side effects remains a challenge. In this study, a multifunctional copper ion-overloaded nanoparticle was fabricated via one-pot self-assembly for enhanced cuproptosis, chemo- and phototherapy. Molecular dynamics simulation was performed to study the self-assembly mechanism, demonstrating they assembled into stable nanoparticles (NPs) in 50 ns. The NPs possess dual-targeting capabilities towards tumor cells and mitochondria, and exhibit excellent stability in neutral PBS, while showing responsive payload release under acidic conditions or NIR laser irradiation. Upon reaching the mitochondria, the NPs release their payloads, where accumulated copper ions trigger aggregation of lipoylated proteins, etc. Released disulfiram chelates excessive copper ion to form toxic Cu(DTC) 2 , which induces apoptosis combining with hydroxycamptothecin. Meanwhile, indocyanine green-generated ROS and photothermal effects further enhance cuproptosis for synergistic therapy. In vitro results revealed potent cytotoxicity of the NPs against CT26 cells while negligible effects on normal cells. Furthermore, significant reactive oxygen species generation, mitochondrial membrane potential alteration, increased apoptosis, and modulated protein mRNA expression levels, confirmed the synergistic combination of chemotherapy, cuproptosis, and photothermal/photodynamic therapies. Notably, in vivo experiments demonstrated selective tumor accumulation and outstanding antitumor efficacy (89.5% inhibition rate) with excellent biosafety profile. The NPs provide a novel strategy for cuproptosis-based combination cancer therapy and shows significant clinical translation potential.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Yali Yang,Hui Ding,Kaijun Quan,Hongwei Zhao,Mingxia Sun,Zhimin Yang,Xiuhui Liu,Hongdeng Qiu,Jia Chen
Background To address the limitations of traditional single-mode stationary phases in separating complex samples, mixed-mode or multi-mode chromatographic stationary phases, which can provide two or more interaction mechanisms, have attracted extensive research interest. Among them, sulfonated pyrene derivatives present a promising candidate ligand, as they synergistically retain the hydrophobicity and π-π interaction capability of the pyrene moiety along with the hydrophilicity and strong cation-exchange capacity provided by the sulfonic acid groups. This synergistic multi-mechanism design significantly enhances separation selectivity for diverse and complex components. Results A pyrene trisulfonic acid-functionalized silica stationary phase (Sil-PyTSa) was successfully prepared and evaluated. In hydrophilic interaction liquid chromatography (HILIC) mode, Sil-PyTSa could efficiently separate nucleobases and nucleosides, ginsenosides, and alkaloids. For nucleobases and nucleosides, it utilized hydrophilic, electrostatic, and π-π interactions, showing superior retention and selectivity over a control HILIC column. In reversed-phase liquid chromatography (RPLC) mode, favorable separation of PAHs was achieved via hydrophobic and π-π interactions, enabling faster analysis and lower solvent consumption than a C18 column. In ion-exchange chromatography (IEC) mode, baseline separation of 14 rare earth elements (REEs) and removal of Fe/U impurities were accomplished. The column efficiency reached 95,920 N/m for naphthalene. Additionally, Sil-PyTSa achieved effective separation for REEs and iron (Fe) in a simulated NdFeB leaching solution and detected nucleobases and nucleosides in Angelica, indicting promising potential for analyzing complex matrices. Significance and novelty This work developed a novel multi-mode chromatographic stationary phase with multiple interactions mechanisms to enable high-performance separations in HILIC, RPLC, and IEC modes. It demonstrates good separation efficiency and selectivity, low solvent consumption, and high stability. This offers a versatile and green solution for the separation of complex samples with diverse analytes.
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MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.9
Ning Yang,Yule Song,Junliang Song,Jian Qin,Mingwei Fu,Feng Yao,Huan Xu
Renal fibrosis (RF), a critical pathogenic mechanism in chronic kidney disease (CKD), now has exceedingly few therapeutic alternatives. This study presents a new sigma1 receptor (σ1R)-targeted nanodelivery system utilizing the natural polyphenolic medicine resveratrol (Res) as a therapeutic agent, addressing its low bioavailability and inadequate targeting properties, thereby providing a significant advancement in the treatment of RF. We engineered and produced a multifunctional material, aminoethyl anisamide-poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate (APC)-with benefits including active targeting, prolonged circulation, and pH sensitivity. In vitro investigations demonstrated that in the high glucose-induced HK-2 cell fibrosis model, the absorption efficiency of APC-modified liposomes was markedly enhanced, effectively suppressing the expression of fibrotic and inflammatory factors. In two typical animal models of RF, namely diabetic nephropathy and glomerulonephritis, APC@Res demonstrated therapeutic advantages, including modulation of the TGF-β1/Smad3 signaling pathway to impede fibrosis, a notable reduction in oxidative stress levels, enhanced renal function parameters, and diminished expression of inflammatory and fibrotic markers. This study innovatively employs the renal microacidic environment and sigma1 targeting to develop an effective delivery system, offering a novel treatment strategy for reversing RF.
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BIOMACROMOLECULES
·
2026
·
IF 5.9
Lingyu Hua,Fengxian Ju,Zihan Shen,Ying-Zhou Li,Tianduo Li,Jing Xu,Huan Yang
Precise regulation of the collagen molecular aggregation behavior is an indispensable prerequisite for constructing functional collagen-based biomaterials. This study innovatively proposes a sustainable strategy to tune collagen molecular aggregation behavior using oxidized sodium alginate (OSA) as a cross-linker within a biphasic acetic acid/1-ethyl-3-methylimidazolium acetate solvent system. Such a polar solvent environment effectively shields electrostatic interactions between OSA and collagen, resulting in a homogeneous cross-linked network. The results indicated that the critical aggregation concentration of collagen was 1.70 mg/mL in the AA/[EMIM][Ac] solvent system and revealed a [NH2]/[CHO] ratio-governed aggregation transition. Beyond the threshold ratio of 1:20, OSA exhibited optimal cross-linking efficiency, thereby driving the formation of large-sized collagen aggregates. Finally, molecular docking simulations of the binding interactions between collagen and OSA were conducted to validate the experimental findings. This work affords a practical methodology for developing high-performance OSA-mediated collagen-based biomaterials while achieving the biological resources transformation and valorization.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Lingyu Han,Mengsi Nong,Jixin Yang,Jijuan Cao,Bing Hu,Peter A. Williams
Micelles are nanostructures capable of encapsulating hydrophobic substances within their hydrophobic cores, enabling their dispersion in aqueous media. This enhances the solubility, stability, and bioavailability of encapsulated bioactive compounds and allows for their controlled release. In this study, maltodextrin chains were chemically modified by adding hydrophobic octyl groups onto their backbone through an esterification reaction. As the degree of substitution increased, both the particle size of the micellar-like aggregates and the critical aggregation concentration (CAC) gradually decreased. The encapsulation efficiency and loading capacity exhibited a positive correlation with the degree of substitution. Furthermore, ultrasonic treatment, by inducing a cavitation effect, was found to enhance hydrophobic interactions within the micelles and significantly improve the encapsulation capacity and compensate for the lower degree of substitution. It also improved composite properties and imparted environmental stability to the micelle-like aggregates. In vitro modeling of the digestive process demonstrated that fucoxanthin-loaded micelle-like aggregates can effectively avoid gastric release while showing significantly enhanced intestinal release. As expected, the octyl-modified maltodextrin (MD-C8) markedly improved the bioaccessibility of fucoxanthin (49.57%) and increased the micellization rate (90.96%) during simulated gastrointestinal digestion. These findings indicate that MD-C8 is an effective delivery carrier for functional biomolecules. Combined with the approach of ultrasound-assisted techniques, it shows great potential for the applications in the encapsulation of hydrophobic compounds.
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Communications Materials
·
2026
·
IF 9.1
Ma Wei,Zhang Jin-Yan,Wang Dun,Li Zhi-Cheng,Cheng Xiang-Yi,Chen Ling-Long,Liu Ying,Kang Gui-Ying,Yu Cui-Yun,Wei Hua
The leverage of synthetic polymer self-assemblies (SPSAs) as biomimetic allostery provides unique opportunities for developing bio-inspired soft species. However, the preparation of these soft species remains a challenge likely due to the synthetic difficulties toward SPSAs having four-level hierarchical structural transitions and the compromised colloidal stability of the self-assembled quaternary structures. Herein, we report self-assembly of topological polymers with hydrophilic multicycles (HMCs) for biomimetic allostery. Specifically, cationic copolymers containing HMCs are prepared via a reliable synthetic approach, whose hierarchical self-assembly affords stabilized nanoparticles that undergo biomimetic allostery into quaternary petalled self-assemblies at an intracellular acidic pH of 5.0. The quaternary petalled self-assemblies lead to a mechanical disruption effect on lysosomes like nanomachines, further resulting in enhanced drug delivery efficiency of an anticancer drug-loaded multicyclic copolymers with a tumor inhibition rate 1.6-fold greater than that of the free drug in a murine 4T1 model. Overall, our work highlights the use of HMCs as biomimetic allostery of SPSAs for enhanced biomedical applications.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Wang Weilin,Hu Qiaoying,Wu Chunyan,Ding Jiayue,Zhu Chuanxiu,Wen Jiayao,Li Yingchao,Yang Menghan,Wang Yujie,Sun Deqing,Zhai Guangxi,Zhang Yanan
Ferroptosis and sonodynamic therapy (SDT) have both been recognized as powerful weapons in cancer treatment, especially in non-small-cell lung carcinoma (NSCLC) recently. However, the lack of effective sono-sensitizer and ferroptosis regulator limited their usage. In order to overcome the limitation, a novel nanoplatform of DTX-CS/ART/PFCA@RGD (cRCAPD) was fabricated based on SDT and ferroptosis. Nanoparticles, under the action of c(RGDfk) cyclic peptides and their skeleton chondroitin sulfate (CS), could specifically target αvβ3 and CD44 receptors, respectively, thereby targeting tumor sites. Meanwhile, the peroxy-bridge structure of ART disrupted the intracellular iron homeostasis while generating highly toxic reactive oxygen species (ROS) under the SDT. Docetaxel (DTX) in nanoparticles led to the excellent apoptosis of A549 cells. Oxygen carried by PFCA alleviated the tumor hypoxic microenvironment, downregulated HIF-1α, and provided substrates for SDT. Further, the nanoparticles showed a strong immunogenic cell death (ICD) effect, modulating the number of T cells and dendritic cells in tumor-bearing mice. In summary, the proposed therapeutic strategy based on SDT and ferroptosis holds promising potential for synergistic treatment of lung cancer in future clinical applications. Graphical The alternative text for this image may have been generated using AI.
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ACS Sustainable Chemistry & Engineering
·
2026
·Vol. 14
·期 35
·15955-15966
·
IF 7.6
Wu Wanze,Xi Haoxuan,Gong Xiao
Interfacial solar evaporation represents one of the most promising strategies to mitigate the global freshwater scarcity crisis. Hydrogels have emerged as an attractive platform for water evaporation due to exceptional water transport capabilities. However, hydrophilic hydrogels with densities exceeding that of water often require external floating supports to maintain interfacial evaporation, and the utilization of the floating platform has been overlooked. In addition, there are few research studies focusing on augmenting incident solar energy through a chemical luminescent solar concentrator (LSC). In this work, a novel structure by combining an LSC with a solar evaporator was designed. We integrated an LSC with a polydopamine/polyacrylamide (PDA/PAM) hydrogel-based evaporator to enhance light harvesting and thereby improve evaporation performance. The PDA/PAM hydrogel evaporator attained an evaporation rate (central hydrogel) of 3.85 kg m –2 h –1 under 1 sun in 3.5 wt % NaCl solution. In outdoor experiments, by using local river water, the device achieved a maximum apparent evaporation rate of 3.0 kg m –2 h –1 while simultaneously enabling water purification. Furthermore, the evaporator demonstrated exceptional salt resistance, exhibiting no salt accumulation during 4 h of operation in 20 wt % NaCl solution and maintaining stable performance over 30 consecutive evaporation cycles in real seawater.
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危险品化学品经营许可证（带存储）