International Journal of Peptide Research and Therapeutics
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2026
·Vol. 32
·期 5
·79
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IF 2.5
Jia Wenbo,Chen Haodong,Yuan Libo,Duan Bingchao,Lv Mingxiu,Duan Qunpeng,Fang Yuan,Zhao Dongxin
Background Peptides are versatile building blocks for nanomaterials. Their self-assembled hydrogels feature tunable properties and good biocompatibility, enabling applications in cell culture, tissue engineering, and drug delivery. Peptide self-assembly arises from the synergy of multiple noncovalent interactions; among them, π–π stacking between aromatic residues is widely considered to be associated with ordered assembly in aromatic peptides. Methods Eight aromatic heptapeptides containing a “-Y-F-F-” motif were designed to examine how subtle variations in side-chain hydrophobicity correlate with self-assembly and gelation behaviors commonly attributed to aromatic stacking. Results Fluorescence and FT-IR results indicated that replacing Gly with the slightly bulkier and more hydrophobic Ala between two Phe residues is associated with more ordered networks, and only AA, GA, Fmoc-AA, and Fmoc-GA formed hydrogels under the tested conditions. And TEM/AFM and rheological measurements further revealed qualitative differences in nanofiber morphologies and sequence-dependent self-healing behavior among these gels. As a proof of concept, AA and GA gels exhibited low cytotoxicity, and their DOX-loaded gels displayed pH-responsive release. Notably, A-DOX showed a 66.91% higher cumulative release at pH 6.0 than at pH 7.4, leading to more sustained inhibition of HeLa cell proliferation compared with free DOX. Conclusion These results revealed that aromatic stacking together with an appropriate degree of hydrophobicity favors ordered peptide assembly, and that modest sequence changes can translate into distinct gel structures and drug-release functions.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zening Pan,Yudie Fu,Jiayu Wu,Aihua Xu,Xiuying Liu,Shuaiqi Zhao,Xiaoxia Li
Vacancy electronic quality, not quantity, governs catalytic performance. • Co-doping and quenching construct asymmetric Co–Ov–Mo motifs, transforming inert deep traps into active shallow donors. • CMO-Q activates PMS through a dual non-radical pathway. The electronic structure characteristics of oxygen vacancies (O v ) - rather than their quantity - are the fundamental factors determining peroxymonosulfate (PMS) activation. This study proposes a strategy of cobalt doping and controllable quenching to precisely construct two types of O v configurations with distinct electronic properties in MoO 3 : the symmetrical Mo–O v –Mo coordination structure in MoO 3 -Q and the asymmetrical Co–O v –Mo coordination structure in CMO-Q. Comprehensive multimodal characterizations confirm that although MoO 3 -Q has the highest O v concentration (39.78%) and the strongest EPR signal, the significantly broadened tail feature in its valence band XPS spectrum clearly indicates that the vacancies exist in the form of deep-level trap states, making it difficult for the captured charges to participate in subsequent interfacial reactions, thus presenting electronic inertness. In contrast, cobalt doping plays a directional anchoring role in the lattice, guiding the vacancies to preferentially form in the Co-adjacent coordination environment. The constructed asymmetrical Co–O v –Mo structure induces an internal polarization electric field due to the difference in electronegativity between Co 2+ and Mo 6+ , forming a shallow donor state with electron-donating function, thereby endowing the vacancies with intrinsic electronic activity. The electrochemical tests quantitatively reveal the essential differences in interfacial charge transfer kinetics between the two: CMO-Q exhibits the largest open-circuit potential shift (0.59 V ) and the smallest peak potential difference (ΔE = 0.13 V ), while MoO 3 -Q shows the smallest shift (0.47 V ) and the largest ΔE (0.26 V ). Further normalization by the electrochemically active surface area (ECSA) highlights the intrinsic activity difference: the k obs /C dl of CMO-Q reaches 6.18 min −1 ·cm 2 ·mF −1 , which is ten times higher than that of MoO 3 -Q (0.62 min −1 ·cm 2 ·mF −1 ). This work establishes vacancy quality over quantity as the design principle for high-performance catalysts.
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 5
·124602
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IF 7.5
Yunyi Wang,Ru Yang,Xiang Li,Haiping Wang,Ting Wu,Guigan Fang
Photocatalytic cleavage of lignin C–C bonds using graphitic carbon nitride (g-C 3 N 4 ) offers a sustainable route to aromatic monomers; however, its practical efficiency is critically constrained by the generation yield of superoxide radicals. Herein, we address this constraint through a simple yet effective design: replacing the edge amino groups of g-C 3 N 4 with benzene rings to construct a benzene–g-C 3 N 4 copolymer. DFT calculations suggest that the introduced benzene ring contributes an empty low-lying orbital that may serve as a temporary electron trap. This effect, together with in-situ XPS evidence for photo-induced charge redistribution, is consistent with the formation of an S-scheme charge transfer pathway and the observed suppression of picosecond-scale electron–hole recombination. The benzene ring is proposed to function as a π–π adsorption anchor, selectively binding the lignin C β carbocation in close proximity to the C–N = C sites where superoxide radicals are generated. This directed adsorption overcomes the mass-transfer limitation of superoxide radical typically encountered under chemisorption conditions, thereby enabling spontaneous and diffusion-free oxidation of the C β site. This benzene–g-C 3 N 4 copolymer exhibits a 134% higher reaction efficiency than g-C 3 N 4 in C–C bond photocleavage, while also demonstrating excellent cleavage performance on industrial lignin. Collectively, this work offers an effective approach to overcoming kinetic limitations in photocatalysis.
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Food Bioscience
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2026
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IF 6.2
Zhongqin Li,Jiazhen Shi,Yinghua Song,Yue Tang,Lian Xia,Yuangen Wu
Butylated hydroxyanisole (BHA) is a synthetic phenolic antioxidant widely used in edible oils and fat-containing foods. Excessive BHA poses significant risks to human health, thus making rapid and sensitive detection of BHA crucial for health protection. Herein, the Ag 2 CO 3 nanozyme was prepared by the simple precipitation method, which exhibits both laccase-mimic and oxidase-mimic activities. It was found that the oxidase-mimic activity of Ag 2 CO 3 facilitated the conversion of TMB to its blue oxidized form (oxTMB), and subsequent addition of BHA resulted in the formation of a characteristic purple adduct. Additionally, BHA effectively suppressed the laccase-mimic activity of the Ag 2 CO 3 nanozymes. Therefore, a novel colorimetric sensor was constructed using the dual-enzyme-mimic activities as a sensing signal for rapidly detecting BHA in edible oil. The colorimetric sensor achieves limits of detection (LOD) for BHA as low as 1.1 μM in the laccase-mimic channel and 0.08 mM in the oxidase-mimic channel, both of which are substantially lower than the maximum permissible BHA level in edible oils stipulated in Chinese National Food Safety Standard GB 2760. The sensor developed in this work shows great promise for application in the field of edible oil detection.
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iScience
·
2026
·Vol. 29
·期 8
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IF 4.5
Jie Luo,Jiang Fan,Hong Liu,Xintao Lv,Zhiqiang Tang,Xiaoxia Wang,Fangjiao An,Yongzhi Chen
This study investigated eco-friendly immobilization carriers for AnAOB to enhance nitrogen removal from low-nitrogen domestic wastewater. Natural loofah sponge was evaluated as a novel biofilm carrier, with polyurethane sponge and polyethylene carrier as references. Microbial morphology, community structure, and nitrogen metabolism-related functional genes were systematically analyzed. Although the loofah sponge biofilm possessed the lowest abundances of Planctomycetota (39.38%) and Candidatus Brocadia (38.35%), it achieved over 90% TNRE and a maximum TNRR of 0.067 kgN/(m 3 ·d). The loofah sponge biofilm carrier also exhibited a denser, more uniform biofilm structure by SEM and higher relative abundances of key functional enzyme genes ( hdh , hzs , nirS , and nirK ) and ammonium transporter genes ( amt and FNT ) via metagenomic analysis. Long-term operation and typical cycle experiments validated its superior and stable anammox performance, providing a promising, sustainable, and easily applicable carrier strategy for practical anammox wastewater treatment systems.
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STAR Protocols
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2026
·Vol. 7
·期 3
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IF 1.4
Guochao Wu,Tianran Si,Han Jin
Early tumor detection is critical for improving cure rates. Here, we present a protocol for tumor detection in mice using a targeted breath-analysis strategy in which phenyl-β-D-glucuronide specifically targets β-glucuronidase, which is highly expressed in the tumor microenvironment. We describe steps for drug screening, enzymatic reaction, drug stability and toxicity evaluation, and construction of the mouse exhaled-breath extraction device. We then detail procedures for animal-model breath analysis, enabling highly sensitive early tumor detection. For complete details on the use and execution of this protocol, please refer to Xue et al. 1 1. Xue, C. ∙ Yi, C. ∙ Zhang, L. ... Unlocking pan-cancer detection via phenyl-β-D-glucuronide-induced breath analysis Cell Biomater. 2026; 2 , 100421 Full Text Full Text (PDF) Scopus (4) PubMed Google Scholar
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Wenqing Wang,Fan Wu,Hao Li,Jianming Pan
A photocatalytic self-propelled nanomotor adsorbent was developed for Pd(II) recovery. • Self-propulsion overcomes diffusion-limited adsorption kinetics. • EPR reveals the ROS-mediated mechanism of long-term propulsion. • Selective Pd(II) recovery is achieved in complex acidic wastewater. The recovery of palladium (Pd) from complex acidic industrial wastewater is severely restricted by sluggish interfacial mass transfer and inherent diffusion-limited adsorption kinetics. To address this long-standing bottleneck, asymmetric N/Se-codoped resorcinol-formaldehyde nanomotors (Se-RF@NMs) were rationally fabricated via an emulsion-confined anisotropic growth strategy for photocatalytic self-propulsion-boosted Pd(II) recovey. Under light irradiation, the photoresponsive resin framework enables continuous in-situ H 2 O 2 generation. Meanwhile, the adsorption-induced in-situ reduction of Pd(II) further accelerates catalytic H 2 O 2 decomposition to generate oxygen microbubbles, endowing nanomotors with sustainable autonomous motion and dynamically promoting interfacial ion transport. EPR characterization confirms that photogenerated holes and reactive oxygen species sustain the cyclic H 2 O 2 generation-decomposition system, effectively stabilizing the self-propulsion behavior of Se-RF@NMs. Benefiting from the synergistic coupling of photocatalytic self-propulsion and N/Se-based selective coordination adsorption, the optimized Se-RF@NMs achieve a superior Pd(II) adsorption capacity of 196.75 mg g −1 , as well as excellent selectivity in multi-metal competitive systems and practical industrial wastewater matrices. This work elucidates a photocatalysis-driven active mass transfer enhancement mechanism, establishing a feasible paradigm to break the intrinsic diffusion limitation of conventional adsorption. It provides new insights into the rational design of intelligent self-propelled catalytic adsorbents for high-efficiency precious metal recovery in complex and harsh water environments. Download: Download high-res image (152KB) Download: Download full-size image
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Sustainability
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2026
·Vol. 18
·期 16
·8079
·
IF 4.1
Hao Liu,Deli Wu,Yufan Chen,Chengsi Hou,Guojie Ye,Zhengwei Zhou,Yue Wang
4-Chlorophenol (4-CP) is a persistent and highly toxic pollutant commonly found in groundwater. However, its efficient degradation remains challenging due to the rapid agglomeration of conventional zero-valent iron (ZVI) nanoparticles, their narrow pH operating range, and the environmental risks associated with synthetic chelating agents. To address these limitations, this study presents a rationally designed catalytic system integrating cyclodextrin polymer (CDP)-supported bimetallic Cu-Fe nanoparticles (Cu-Fe-CDP) with citric acid (CA) as a green complexing agent. The porous CDP matrix effectively mitigates nanoparticle agglomeration and provides abundant active sites, while the Fe-Cu bimetallic coupling accelerates electron transfer and iron corrosion. Critically, CA acts as a biocompatible ligand that sustains Fe(II)/Fe(III) redox cycling, expands the effective pH range, and enhances hydroxyl radical (·OH) generation. The system achieves 92.13% degradation of 4-CP within 80 min at pH 9.0 and nearly complete removal at pH values between 3.0 and 7.0. Mechanistic studies, including electron paramagnetic resonance (EPR) spectroscopy and radical quenching tests, confirm the dominance of ·OH radicals (82.67% inhibition by TBA) and the essential role of surface Fe(II)/Fe(III) cycling. The catalyst exhibits excellent reusability, broad-spectrum activity toward multiple pollutants, and sustained performance in real water matrices and long-term column tests with minimal metal leaching. This work demonstrates a chemically robust strategy for chlorophenol remediation using green citric acid and biodegradable CDP without exogenous oxidant addition, showing promise for further development toward practical applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Dongcheng Li,Shenghu Wang,Huanji Song,Xianying Xu,Shihao Yang,Yuyang Dong,Yan Luo,Weiyang Lv
Efficient and sustainable Fenton-like systems are highly desired for degrading persistent pollutants. However, their development is often hindered by the slow redox kinetics and poor durability of single active sites in conventional metal-based catalysts. Herein, we developed a bimetallic Fe/Cu catalyst (FeCu-BN) with highly dispersed metal sites anchored on boron nitride (BN), which offered boosted activity and stability via the cooperative redox cycles between Fe and Cu sites. The FeCu-BN catalyst achieved nearly 100% removal of sulfamethoxazole (SMX) within 20 min through activating peroxymonosulfate (PMS), with a rate constant of 0.421 min − 1 significantly surpassing those of its monometallic counterparts and other advanced catalysts. Systematic experiments and theoretical calculations revealed that the Cu sites not only optimized the electronic structure of the Fe sites but also provided electrons extracted from pollutants to promote the Fe 2+ /Fe 3+ cycle, thereby triggering concerted radical and non-radical reactions for SMX elimination. Consequently, the FeCu-BN/PMS catalytic system operated stably over a wide pH range and exhibited exceptional tolerance to various inorganic ions and complex aqueous matrices. Furthermore, in a continuous flow membrane reactor, the system maintained efficient SMX removal over 20 h without significant performance loss. This work uncovered the synergistic redox cycling mechanism in bimetallic catalysts and offered valuable insights for designing dual-site catalysts for environmental remediation.
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JOURNAL OF CATALYSIS
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2026
·
IF 6
Haoling Yang,Qi Zhang,Kunyu Xu,Guang Wang,Yiqi Pan,Licheng Lu,Qi Mao,Zihao Yang,Zhaoxia Dong
Enhancing the catalytic activity of germanium-based catalysts can reduce their required dosage and effectively lower the production cost of high-end polyester. Numerous studies have demonstrated that variations in catalyst crystal structures exert a decisive influence on their activity, selectivity, and stability. Based on this observation, the adsorption energy of tetragonal germanium dioxide (GeO 2 ) on polyester reactants was calculated through molecular simulations, revealing that tetragonal GeO 2 possesses a stronger adsorption capacity for polyester reactants than hexagonal GeO 2 . Subsequently, a novel low-temperature hydrothermal approach was developed to synthesize small-sized tetragonal GeO 2 . This approach reduces the crystal transition temperature from 1000 °C to 240 °C, thereby significantly lowering the energy consumption of the process. The catalytic activities of GeO 2 with different crystal systems were analyzed using kinetic studies. Polyethylene terephthalate (PET) samples synthesized from GeO 2 catalysts with different crystal systems were subsequently characterized. The results indicate that tetragonal GeO 2 exhibits superior catalytic activity, and the resulting PET polyester displays improved color, transparency, and thermal stability. These findings confirm the feasibility of enhancing the catalytic performance of germanium-based catalyst systems through crystal transformation. This work provides new insights and possibilities for the future development of high-performance polyester products and efficient germanium-based polyester catalysts.
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Marine Drugs
·
2026
·Vol. 24
·期 2
·84
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IF 5.7
Wenjie Wang,Kun Gao,Guantian Li,Zongji Wang,Kecheng Li,Song Liu,Huahua Yu,Ronge Xing
Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic metabolic diseases, and inhibition of α-glucosidase activity represents an effective therapeutic strategy. Chitin is the most abundant renewable polysaccharide in the ocean, with its monosaccharide beingN-acetylglucosamine (NAG). To evaluate the potential of NAG glycosides as novel α-glucosidase inhibitors, three common phenolic compounds were modified via NAG glycosylation. Their inhibitory activities were assessed at both the enzymatic and cellular levels. In addition, density functional theory (DFT), molecular dynamics (MD) simulations, and molecular docking analyses were employed to systematically investigate the effects of NAG glycosylation on enzyme inhibition and the underlying mechanisms. Compared with the parent phenolic compounds, NAG glycosides exhibited significantly enhanced α-glucosidase inhibitory activity, with NAG introduction markedly improving their binding affinity to α-glucosidase. Among them, glycoside3adisplayed the optimal inhibitory effect, comparable to acarbose, and at the cellular level, its activity at high concentrations was comparable to or slightly higher than that of metformin. Circular dichroism (CD) and MD analyses indicated that glycoside3aincreased the conformational flexibility of key residues and enhanced the structural looseness of the enzyme, thereby inhibiting its activity. NAG glycosides constitute a promising class of marine-derived α-glucosidase inhibitors, warranting further structural optimization and rational design to enhance their activity and selectivity.
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CERAMICS INTERNATIONAL
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2026
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IF 6
Tao Liu,Nan Li,Yingbo Ruan,Hong Zhai,Wenbo Liu,Yudong Huang,Bo Jiang
The fragility of aerogel is inherited from the bead-like structure, where the fine interconnections between these spheres act as weak points under load. Herein, aerogels with tailored fibrous structures were proposed to offer mechanical properties that surpass those of raw material by order of magnitude. Wherein, sodium alginate derived nanoribbons and fibrous template were progressively exfoliated in the wake of hydrogen bonding self-assembly and solvent-induced differentiation respectively. Interconnected nanofibrous architecture, which enabling efficient load transfer and stress distribution, endowed the silicone/phenolic (SiR/PR) aerogels with ultra-high compressive strength. Given facile ambient pressure drying technology and exceptional compressive strength (9.2 MPa), fibrous SiR/PR aerogels performed superior among reported ablative aerogels. Additionally, considering the uniform distribution of phenolic pyrolyzed carbon within the matrix, aerogel escaped from devitrification up to 1400 °C, thereby preserving fibrous morphology and larger specific surface area after annealing. This strategy for constructing microfibrous aerogels will pave the way for the robust fibrous aerogel with devitrification resistance.
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